Andreas W. Heumüller
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View article: Circular RNA circPLOD2 regulates pericyte function by targeting the transcription factor KLF4
Circular RNA circPLOD2 regulates pericyte function by targeting the transcription factor KLF4 Open
Circular RNAs are generated by backsplicing and control cellular signaling and phenotypes. Pericytes stabilize capillary structures and play important roles in the formation and maintenance of blood vessels. Here, we characterize hypoxia-r…
View article: Circular RNA circPLOD2 regulates pericyte function by targeting the transcription factor KLF4
Circular RNA circPLOD2 regulates pericyte function by targeting the transcription factor KLF4 Open
Circular RNAs (circRNAs) are generated by back-splicing and control cellular signaling and phenotypes. Pericytes stabilize the capillary structure and play an important role in the formation and maintenance of new blood vessels. Here, we c…
View article: The G3BP1-UPF1-Associated Long Non-Coding RNA CALA Regulates RNA Turnover in the Cytoplasm
The G3BP1-UPF1-Associated Long Non-Coding RNA CALA Regulates RNA Turnover in the Cytoplasm Open
Besides transcription, RNA decay accounts for a large proportion of regulated gene expression and is paramount for cellular functions. Classical RNA surveillance pathways, like nonsense-mediated decay (NMD), are also implicated in the turn…
View article: The splicing‐regulatory lncRNA NTRAS sustains vascular integrity
The splicing‐regulatory lncRNA NTRAS sustains vascular integrity Open
View article: Locus-Conserved Circular RNA cZNF292 Controls Endothelial Cell Flow Responses
Locus-Conserved Circular RNA cZNF292 Controls Endothelial Cell Flow Responses Open
Background: Circular RNAs (circRNAs) are generated by back splicing of mostly mRNAs and are gaining increasing attention as a novel class of regulatory RNAs that control various cellular functions. However, their physiological roles and fu…
View article: Deep Characterization of Circular RNAs from Human Cardiovascular Cell Models and Cardiac Tissue
Deep Characterization of Circular RNAs from Human Cardiovascular Cell Models and Cardiac Tissue Open
For decades, cardiovascular disease (CVD) has been the leading cause of death throughout most developed countries. Several studies relate RNA splicing, and more recently also circular RNAs (circRNAs), to CVD. CircRNAs originate from linear…
View article: Correction for Glaser et al., The histone demethylase JMJD2B regulates endothelial-to-mesenchymal transition
Correction for Glaser et al., The histone demethylase JMJD2B regulates endothelial-to-mesenchymal transition Open
Correction for “The histone demethylase JMJD2B regulates endothelial-to-mesenchymal transition,” by Simone F. Glaser, Andreas W. Heumüller, Lukas Tombor, Patrick Hofmann, Marion Muhly-Reinholz, Ariane Fischer, Stefan Günther, Karoline E. K…
View article: The histone demethylase JMJD2B regulates endothelial-to-mesenchymal transition
The histone demethylase JMJD2B regulates endothelial-to-mesenchymal transition Open
Endothelial cells play an important role in maintenance of the vascular system and the repair after injury. Under proinflammatory conditions, endothelial cells can acquire a mesenchymal phenotype by a process named endothelial-to-mesenchym…
View article: A combined computational pipeline to detect circular RNAs in human cancer cells under hypoxic stress
A combined computational pipeline to detect circular RNAs in human cancer cells under hypoxic stress Open
Hypoxia is associated with several diseases, including cancer. Cells that are deprived of adequate oxygen supply trigger transcriptional and post-transcriptional responses, which control cellular pathways such as angiogenesis, proliferatio…
View article: VGLL4 plays a critical role in heart valve development and homeostasis
VGLL4 plays a critical role in heart valve development and homeostasis Open
Heart valve disease is a major clinical problem worldwide. Cardiac valve development and homeostasis need to be precisely controlled. Hippo signaling is essential for organ development and tissue homeostasis, while its role in valve format…