Explanipedia

Tumor-Infiltrating Clonal Hematopoiesis Open

Oriol Pich, Elsa Bernard, Maria Zagorulya, Andrew Rowan, Constandina Pospori , et al. · 2025

TI-CH increased the risk of disease recurrence or death among patients with NSCLC and the risk of death from any cause among patients with solid tumors. TI-CH remodeled the tumor immune microenvironment and accelerated tumor organoid growt…

The Interplay Between Innate Immunity and Nonimmune Cells in Lung Damage, Inflammation, and Repair Open

Chrysante S. Iliakis, Stefania Crotta, Andreas Wack · 2025

As the site of gas exchange, the lung is critical for organismal survival. It is also subject to continual environmental insults inflicted by pathogens, particles, and toxins. Sometimes, these insults result in structural damage and the in…

Respiratory viruses: New frontiers—a Keystone Symposia report Open

Jennifer Cable, Jian Sun, Cheon I.S, Vaughan A.E, Castro I.A , et al. · 2024

Respiratory viruses are a common cause of morbidity and mortality around the world. Viruses like influenza, RSV, and most recently SARS-CoV-2 can rapidly spread through a population, causing acute infection and, in vulnerable populations, …

The FAM13A Long Isoform Regulates Cilia Movement and Coordination in Airway Mucociliary Transport Open

Ashleigh Howes, Clare Rogerson, Nikolai N. Belyaev, Tina Karagyozova, Radu Rapiteanu , et al. · 2024

Single nucelotide polymorphisms (SNPs) at the FAM13A locus are among the most commonly reported risk alleles associated with chronic obstructive pulmonary disease (COPD) and other respiratory diseases; however, the physiological rol…

Regulation of BCR-mediated Ca 2+ mobilization by MIZ1-TMBIM4 safeguards IgG1 + GC B cell–positive selection Open

Lingling Zhang, Amparo Toboso-Navasa, Arief Gunawan, Abdouramane Camara, Rinako Nakagawa , et al. · 2024

The transition from immunoglobulin M (IgM) to affinity-matured IgG antibodies is vital for effective humoral immunity. This is facilitated by germinal centers (GCs) through affinity maturation and preferential maintenance of IgG + B cells …

The role of recruitment versus training in influenza-induced lasting changes to alveolar macrophage function Open

Chrysante S. Iliakis, Justina Kulikauskaite, Helena Aegerter, Fengqi Li, Federica Piattini , et al. · 2023

Endothelial AHR activity prevents lung barrier disruption in viral infection Open

Jack Major, Stefania Crotta, Katja Finsterbusch, Probir Chakravarty, Kathleen Shah , et al. · 2023

Interplay between CXCR4 and CCR2 regulates bone marrow exit of dendritic cell progenitors Open

Mariana Pereira da Costa, Carlos M. Minutti, Cécile Piot, Evangelos Giampazolias, Ana Cardoso , et al. · 2023

Conventional dendritic cells (cDCs) are found in most tissues and play a key role in initiation of immunity. cDCs require constant replenishment from progenitors called pre-cDCs that develop in the bone marrow (BM) and enter the blood circ…

Type I interferons drive MAIT cell functions against bacterial pneumonia Open

Juan Carlos López‐Rodríguez, Steven J. Hancock, Kelin Li, Stefania Crotta, Christopher Barrington , et al. · 2023

Mucosal-associated invariant T (MAIT) cells are abundant in the lung and contribute to host defense against infections. During bacterial infections, MAIT cell activation has been proposed to require T cell receptor (TCR)–mediated recogniti…

Regulation of BCR-mediated Ca2+mobilization by MIZ1-TIMBIM4 safeguards IgG1+GC B cell positive selection Open

Lingling Zhang, Amparo Toboso-Navasa, Arief Gunawan, Abdouramane Camara, Rinako Nakagawa , et al. · 2023

Summary The transition from IgM to affinity-matured IgG antibodies is vital for effective humoral immunity. This is facilitated by germinal centers (GCs) through affinity maturation and preferential accumulation of IgG + B cells over IgM +…

Repair of airway epithelia requires metabolic rewiring towards fatty acid oxidation Open

Stefania Crotta, Matteo Villa, Jack Major, Katja Finsterbusch, Miriam Llorian , et al. · 2023

Respiratory viruses: New frontiers—a Keystone Symposia report Open

Jennifer Cable, Jie Sun, In Su Cheon, Andrew E. Vaughan, Ítalo A. Castro , et al. · 2023

Respiratory viruses are a common cause of morbidity and mortality around the world. Viruses like influenza, RSV, and most recently SARS‐CoV‐2 can rapidly spread through a population, causing acute infection and, in vulnerable populations, …

Hypoxia inducible factors regulate infectious SARS-CoV-2, epithelial damage and respiratory symptoms in a hamster COVID-19 model Open

Peter A. C. Wing, Maria Prange‐Barczynska, Amy Cross, Stefania Crotta, Claudia Orbegozo Rubio , et al. · 2022

Understanding the host pathways that define susceptibility to Severe-acute-respiratory-syndrome-coronavirus-2 (SARS-CoV-2) infection and disease are essential for the design of new therapies. Oxygen levels in the microenvironment define th…

Impaired immune response drives age-dependent severity of COVID-19 Open

Julius Beer, Stefania Crotta, Angele Breithaupt, Annette Ohnemus, Jan Becker , et al. · 2022

Severity of COVID-19 shows an extraordinary correlation with increasing age. We generated a mouse model for severe COVID-19 and show that the age-dependent disease severity is caused by the disruption of a timely and well-coordinated innat…

SARS-CoV-2 S2–targeted vaccination elicits broadly neutralizing antibodies Open

Kevin W. Ng, Nikhil Faulkner, Katja Finsterbusch, Mary Wu, Ruth Harvey , et al. · 2022

Several variants of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) have emerged during the current coronavirus disease 2019 (COVID-19) pandemic. Although antibody cross-reactivity with the spike glycoproteins (S) of diverse c…

Anti-type I interferon antibodies as a cause of severe COVID-19 Open

David C. Fajgenbaum, Adrian Hayday, Angela J. Rogers, Greg J. Towers, Andreas Wack , et al. · 2022

COVID-19 ranges from asymptomatic through to respiratory failure and death. Although specific pre-existing conditions such as age and male sex have been associated with poor outcomes, we remain largely ignorant of the mechanisms predisposi…

Host-directed immunotherapy of viral and bacterial infections: past, present and future Open

Robert S. Wallis, Anne O’Garra, Alan Sher, Andreas Wack · 2022

A family of conserved bacterial virulence factors dampens interferon responses by blocking calcium signaling Open

Noémie Alphonse, Joseph J. Wanford, Andrew A. Voak, Jack Gay, Shayla Venkhaya , et al. · 2022

Impaired immune response drives age-dependent severity of COVID-19 Open

Julius Beer, Stefania Crotta, Angele Breithaupt, Annette Ohnemus, Jan Becker , et al. · 2022

SARS-CoV-2 is a highly contagious respiratory virus and the causative agent for COVID-19. The severity of disease varies from mildly symptomatic to lethal and shows an extraordinary correlation with increasing age, which represents the maj…

Hypoxia inducible factors regulate infectious SARS-CoV-2, epithelial damage and respiratory symptoms in a hamster COVID-19 model Open

Peter A. C. Wing, Maria Prange‐Barczynska, Amy Cross, Stefania Crotta, Claudia Orbegozo Rubio , et al. · 2022

Understanding the host pathways that define susceptibility to SARS-CoV-2 infection and disease are essential for the design of new therapies. Oxygen levels in the microenvironment define the transcriptional landscape, however the influence…

Recruitment of dendritic cell progenitors to foci of influenza A virus infection sustains immunity Open

Mar Cabeza-Cabrerizo, Carlos M. Minutti, Mariana Pereira da Costa, Ana Cardoso, Robert P. Jenkins , et al. · 2021

Effective T cell–dependent immunity to influenza A virus requires recruitment of cDC progenitors to foci of infection via CCR2.

Influenza A induces lactate formation to inhibit type I IFN in primary human airway epithelium Open

Jacob Thyrsted, Jacob Storgaard, Julia Blay‐Cadanet, Alexander Heinz, Anne L. Thielke , et al. · 2021

A TLR7 antagonist restricts interferon-dependent and -independent immunopathology in a mouse model of severe influenza Open

Julie C. F. Rappe, Katja Finsterbusch, Stefania Crotta, Matthias Mack, Simon L. Priestnall , et al. · 2021

Cytokine-mediated immune-cell recruitment and inflammation contribute to protection in respiratory virus infection. However, uncontrolled inflammation and the “cytokine storm” are hallmarks of immunopathology in severe infection. Cytokine …

The interferon landscape along the respiratory tract impacts the severity of COVID-19 Open

Benedetta Sposito, Achille Broggi, Laura Pandolfi, Stefania Crotta, Nicola Clementi , et al. · 2021

Rotavirus susceptibility of antibiotic-treated mice ascribed to diminished expression of interleukin-22 Open

Daniel Schnepf, Pedro P. Hernández, Tanel Mahlakõiv, Stefania Crotta, Meagan E. Sullender , et al. · 2021

The commensal microbiota regulates susceptibility to enteric pathogens by fine-tuning mucosal innate immune responses, but how susceptibility to enteric viruses is shaped by the microbiota remains incompletely understood. Past reports have…

Selective Janus kinase inhibition preserves interferon-λ–mediated antiviral responses Open

Daniel Schnepf, Stefania Crotta, Thiprampai Thamamongood, Megan L. Stanifer, Laura Polcik , et al. · 2021

TYK2 is required for efficient IFN-α/β signaling but dispensable for IFN-λ–mediated antiviral protection in epithelial cells.

Monocyte and dendritic cell defects in COVID-19 Open

Andreas Wack · 2021

Severity of SARS-CoV-2 infection as a function of the interferon landscape across the respiratory tract of COVID-19 patients Open

Benedetta Sposito, Achille Broggi, Laura Pandolfi, Stefania Crotta, Roberto Ferrarese , et al. · 2021

Summary The COVID-19 outbreak driven by SARS-CoV-2 has caused more than 2.5 million deaths globally, with the most severe cases characterized by over-exuberant production of immune-mediators, the nature of which is not fully understood. In…

Rotavirus susceptibility of antibiotic-treated mice ascribed to diminished expression of interleukin-22 Open

Daniel Schnepf, Pedro P. Hernández, Tanel Mahlakõiv, Stefania Crotta, Meagan E. Sullender , et al. · 2021

The commensal microbiota regulates susceptibility to enteric pathogens by fine-tuning mucosal innate immune responses, but how susceptibility to enteric viruses is shaped by the microbiota remains incompletely understood. Past reports have…

Influenza A Virus Induces LDHA Expression and Lactate Formation to Inhibit Type I IFN and Promote Replication in Primary Human Airway Epithelium Open

Jacob Thyrsted, Jacob Storgaard, Julia Blay‐Cadanet, Anne Louise Hansen, Alexander Heinz , et al. · 2021

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