Explanipedia

PATH-57. The GLIOSCREEN trial: Feasibility, genomic landscape, and clinical impact of prospective comprehensive molecular profiling in newly diagnosed glioma Open

Thomas Zeyen, Lea L Friker, Cathrina Duffy, Gerrit H. Gielen, Azadeh Ebrahimi , et al. · 2025

BACKGROUND Advances in molecular profiling have significantly improved the diagnostic precision of diffuse gliomas. However, translating genomic data into individualized clinical strategies remains challenging due to the heterogeneity of g…

P01.24.B CORE2EDGE: A HUMAN GLIOBLASTOMA ORGANOID AND BRAIN SLICE CO-CULTURE MODEL CAPTURING TUMOR INFILTRATION AND TRANSCRIPTIONAL HETEROGENEITY FROM CORE TO SINGLE-CELL DISPERSION Open

Matthias Schneider, Anna‐Laura Potthoff, A Melhem, Benedikt Pregler, Juan Eduardo Rodriguez-Gatica , et al. · 2025

BACKGROUND Glioblastomas function as intricate cellular networks that extend into the surrounding brain tissue enabling long distance communication. This malignant connectivity spans from the tumor core to remote infiltration zones, suppor…

Flow cytometry protocol for cell death analysis in glioblastoma organoids: A technical note Open

Anna‐Laura Potthoff, Meng‐Chun Hsieh, Ahmad Melhem, Susanna S. Ng, Benedikt Pregler , et al. · 2025

Tumor organoid models have emerged as a promising tool in cancer research. By preserving intra- and intertumoral heterogeneity and structural integrity they provide a physiologically relevant platform for drug-response studies. However, va…

Pitfalls in the evaluation of CDKN2A copy number status in meningioma Open

Valentina Zschernack, Giuseppe Pinto, Lea L. Friker, Rebecca C. Klein, Tobias Goschzik , et al. · 2025

MSH2, MSH6, MLH1, and PMS2 immunohistochemistry as highly sensitive screening method for DNA mismatch repair deficiency syndromes in pediatric high-grade glioma Open

Lea L. Friker, Thomas Perwein, Andreas Waha, Evelyn Dörner, Rebecca C. Klein , et al. · 2025

Pediatric high-grade glioma (pedHGG) can occur as first manifestation of cancer predisposition syndromes resulting from pathogenic germline variants in the DNA mismatch repair (MMR) genes MSH2 , MSH6 , MLH1 , and PMS2 . The aim of this stu…

Tonabersat enhances temozolomide‐mediated cytotoxicity in glioblastoma by disrupting intercellular connectivity through connexin 43 inhibition Open

Elena N. C. Schmidt, Bernd O. Evert, Benedikt Pregler, Ahmad Melhem, Meng‐Chun Hsieh , et al. · 2024

Glioblastoma cells rely on connexin 43 (Cx43)‐based gap junctions (GJs) for intercellular communication, enabling them to integrate into a widely branched malignant network. Although there are promising prospects for new targeted therapies…

Cerebellar glioblastoma in adults: a comparative single-center matched pair analysis and systematic review of the literature Open

Yauhen Lizunou, Anna‐Laura Potthoff, Niklas Schäfer, Andreas Waha, Valeri Borger , et al. · 2024

Melanoma Brain Metastases Patient-Derived Organoids: An In Vitro Platform for Drug Screening Open

Saif-Eldin Abedellatif, Racha Hosni, Andreas Waha, Gerrit H. Gielen, Mohammed Banat , et al. · 2024

Background and aims: Brain metastases are prevalent in the late stages of malignant melanoma. Multimodal therapy remains challenging. Patient-derived organoids (PDOs) represent a valuable pre-clinical model, faithfully recapitulating key a…

Cerebellar glioblastoma in adults: a comparative single-center matched pair analysis and systematic review of the literature Open

Yauhen Lizunou, Anna‐Laura Potthoff, Niklas Schäfer, Andreas Waha, Valeri Borger , et al. · 2024

Purpose The rarity of cerebellar glioblastoma presents a significant challenge in clinical practice due to the lack of extensive prognostic data on long-term survival rates, rendering it an underrepresented entity compared to its supratent…

Melanoma Brain Metastases Patient-Derived Organoids: an in Vitro Platform for Drug Screening Open

Saif-Eldin Abedellatif, Racha Hosni, Andreas Waha, Gerrit H. Gielen, Mohammed Banat , et al. · 2024

Background and aims: Brain metastases are prevalent in the late stages of malignant melanoma. Multimodal therapy remains challenging. Patient-derived organoids (PDOs) represent a valuable pre-clinical model, faithfully recapitulating key a…

HGG-26. MLH1, MSH2, MSH6, AND PMS2 IMMUNOHISTOCHEMISTRY REPRESENTS A HIGHLY SENSITIVE SCREENING METHOD FOR MISMATCH REPAIR DEFICIENCY SYNDROMES IN PEDIATRIC HIGH-GRADE GLIOMA Open

Lea L. Friker, Thomas Perwein, Andreas Waha, Evelyn Dörner, Rebecca C. Klein , et al. · 2024

BACKGROUND Pediatric central nervous system (CNS) tumors can occur as first manifestations of cancer predisposition syndromes (CPS) resulting from pathogenic variants in DNA mismatch repair (MMR) genes MLH1, MSH2, MSH6, and PMS2. Early det…

FH-mutant glioma displaying the epigenetic signature of IDH-mutant astrocytomas Open

Valentina Zschernack, Christian Thomas, Christina Schaub, Glen Kristiansen, Andreas Waha , et al. · 2024

TRIM28 inactivation in epithelial nephroblastoma is frequent and often associated with predisposing TRIM28 germline variants Open

Jenny Wegert, Anne Kristin Fischer, Balazs Palhazi, Taryn D. Treger, Cäcilia Hilgers , et al. · 2023

Wilms tumors (WTs) are histologically diverse childhood cancers with variable contributions of blastema, stroma, and epithelia. A variety of cancer genes operate in WTs, including the tripartite‐motif‐containing‐28 gene ( TRIM28 ). Case re…

Downregulation of MGMT expression by targeted editing of DNA methylation enhances temozolomide sensitivity in glioblastoma Open

Xinyu Han, Mohammed O. E. Abdallah, Péter Breuer, Fabian Stahl, Yousuf Bakhit , et al. · 2023

Glioblastoma is the most common and aggressive primary tumor of the central nervous system with poor outcome. Current gold standard treatment is surgical resection followed by a combination of radio- and chemotherapy. Efficacy of temozolom…

Supplemental Figure 4 from Anticancer Effects of Niclosamide in Human Glioblastoma Open