Andreas Weiß
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View article: Stratifying the Rate of Disease Progression by Progression Likelihood Scores in Children and Adolescents With Stage 1 and Stage 2 Type 1 Diabetes in Germany
Stratifying the Rate of Disease Progression by Progression Likelihood Scores in Children and Adolescents With Stage 1 and Stage 2 Type 1 Diabetes in Germany Open
OBJECTIVE To stratify the progression rate to clinical stage 3 type 1 diabetes in children with early-stage disease. RESEARCH DESIGN AND METHODS The Fr1da study tested 211,464 children aged 1.75–10 years for islet autoantibodies. Children …
View article: Efficacy of once-daily, high-dose, oral insulin immunotherapy in children genetically at risk for type 1 diabetes (POInT): a European, randomised, placebo-controlled, primary prevention trial
Efficacy of once-daily, high-dose, oral insulin immunotherapy in children genetically at risk for type 1 diabetes (POInT): a European, randomised, placebo-controlled, primary prevention trial Open
Leona M and Harry B Helmsley Charitable Trust.
View article: Enterococcus faecalis modulates phase variation in Clostridioides difficile
Enterococcus faecalis modulates phase variation in Clostridioides difficile Open
To adapt and persist in the gastrointestinal tract, many enteric pathogens, including Clostridioides difficile, employ strategies such as phase variation to generate phenotypically heterogeneous populations. Notably, the role of the gut mi…
View article: Anti-viral action against type 1 diabetes autoimmunity: The GPPAD-AVAnT1A study protocol
Anti-viral action against type 1 diabetes autoimmunity: The GPPAD-AVAnT1A study protocol Open
Viral infections in the first year of life are associated with islet autoimmunity and type 1 diabetes risk. The Anti-Viral Action against Type 1 Diabetes Autoimmunity (AVAnT1A)- study is a clinical phase IV investigator initiated, randomis…
View article: HELIO4CAST Interplanetary Coronal Mass Ejection Catalog v2.3
HELIO4CAST Interplanetary Coronal Mass Ejection Catalog v2.3 Open
This is the HELIO4CAST interplanetary coronal mass ejection (ICME) catalog, based on in situ magnetic field and bulk plasma observations in the heliosphere.This is version 2.3, released 2025-April-9, updated 2025-October-15See also: https:…
View article: Solar wind in situ data for creating catalogs and statistics of interplanetary coronal mass ejections and high speed streams (Solar Orbiter, Parker Solar Probe, STEREO-A/B, MAVEN, Wind, MESSENGER, VEX, Ulysses, Juno) 1995-2025
Solar wind in situ data for creating catalogs and statistics of interplanetary coronal mass ejections and high speed streams (Solar Orbiter, Parker Solar Probe, STEREO-A/B, MAVEN, Wind, MESSENGER, VEX, Ulysses, Juno) 1995-2025 Open
These are solar wind in situ data arrays in python pickle format suitable for creating catalogs, plots and movies of interplanetary coronal mass ejections (ICME). They are used to calculate parameters in this ICME catalog:https://heliofore…
View article: Distorted Magnetic Flux Ropes within Interplanetary Coronal Mass Ejections
Distorted Magnetic Flux Ropes within Interplanetary Coronal Mass Ejections Open
Magnetic flux ropes (MFRs) at the center of interplanetary coronal mass ejections (ICMEs) are often characterized as simplistic cylindrical or toroidal tubes with field lines that twist around the cylinder or torus axis. Recent multipoint …
View article: Understanding the Effects of Spacecraft Trajectories through Solar Coronal Mass Ejection Flux Ropes Using 3DCOREweb
Understanding the Effects of Spacecraft Trajectories through Solar Coronal Mass Ejection Flux Ropes Using 3DCOREweb Open
This study investigates the impact of spacecraft positioning and trajectory on in situ signatures of coronal mass ejections (CMEs). Employing the 3DCORE model, a 3D flux rope model that can generate in situ profiles for any given point in …
View article: Risk Factors for Postoperative Major Morbidity, Anastomotic Leakage, Re-Surgery and Mortality in Patients with Colonic Perforation
Risk Factors for Postoperative Major Morbidity, Anastomotic Leakage, Re-Surgery and Mortality in Patients with Colonic Perforation Open
Background/Objectives: This study aimed to determine the risk factors associated with postoperative major morbidity, anastomotic/suture leakage, re-surgery and mortality in patients undergoing emergency surgery for colonic perforation. Met…
View article: Flux Rope Modeling of the 2022 September 5 Coronal Mass Ejection Observed by Parker Solar Probe and Solar Orbiter from 0.07 to 0.69 au
Flux Rope Modeling of the 2022 September 5 Coronal Mass Ejection Observed by Parker Solar Probe and Solar Orbiter from 0.07 to 0.69 au Open
As both Parker Solar Probe (PSP) and Solar Orbiter (SolO) reach heliocentric distances closer to the Sun, they present an exciting opportunity to study the structure of coronal mass ejections (CMEs) in the inner heliosphere. We present an …
View article: Automatic Detection of Large-scale Flux Ropes and Their Geoeffectiveness with a Machine-learning Approach
Automatic Detection of Large-scale Flux Ropes and Their Geoeffectiveness with a Machine-learning Approach Open
Detecting large-scale flux ropes (FRs) embedded in interplanetary coronal mass ejections (ICMEs) and assessing their geoeffectiveness are essential, since they can drive severe space weather. At 1 au, these FRs have an average duration of …
View article: Neutrophil-to-Lymphocyte Ratio and Prognostic Nutritional Index Are Predictors for Overall Survival after Primary Pancreatic Resection of Pancreatic Ductal Adenocarcinoma: A Single Centre Evaluation
Neutrophil-to-Lymphocyte Ratio and Prognostic Nutritional Index Are Predictors for Overall Survival after Primary Pancreatic Resection of Pancreatic Ductal Adenocarcinoma: A Single Centre Evaluation Open
Purpose: Prognostic inflammation-based parameters have been reported as useful tools in various oncologic diseases. Pancreatic ductal adenocarcinoma (PDAC) is characterized by a high mortality rate, making reliable prognostic markers highl…
View article: Distorted Magnetic Flux Ropes within Interplanetary Coronal Mass Ejections
Distorted Magnetic Flux Ropes within Interplanetary Coronal Mass Ejections Open
Magnetic flux ropes within interplanetary coronal mass ejections are often characterized as simplistic cylindrical or toroidal tubes with field lines that twist around the cylinder or torus axis. Recent multi-point observations suggest tha…
View article: Infection episodes and islet autoantibodies in children at increased risk for type 1 diabetes before and during the COVID-19 pandemic
Infection episodes and islet autoantibodies in children at increased risk for type 1 diabetes before and during the COVID-19 pandemic Open
Objectives To determine the impact of the COVID-19 pandemic on the incidence rates of infection and islet autoimmunity in children at risk for type 1 diabetes. Methods 1050 children aged 4 to 7 months with an elevated genetic risk for type…
View article: Flux rope modeling of the 2022 Sep 5 CME observed by Parker Solar Probe and Solar Orbiter from 0.07 to 0.69 au
Flux rope modeling of the 2022 Sep 5 CME observed by Parker Solar Probe and Solar Orbiter from 0.07 to 0.69 au Open
As both Parker Solar Probe (PSP) and Solar Orbiter (SolO) reach heliocentric distances closer to the Sun, they present an exciting opportunity to study the structure of CMEs in the inner heliosphere. We present an analysis of the global fl…
View article: Understanding the effects of spacecraft trajectories through solar coronal mass ejection flux ropes using 3DCOREweb
Understanding the effects of spacecraft trajectories through solar coronal mass ejection flux ropes using 3DCOREweb Open
This study investigates the impact of spacecraft positioning and trajectory on in situ signatures of coronal mass ejections (CMEs). Employing the 3DCORE model, a 3D flux rope model that can generate in situ profiles for any given point in …
View article: How well does 3DCORE perform at fitting flux rope signatures in real-time?
How well does 3DCORE perform at fitting flux rope signatures in real-time? Open
The 3D coronal rope ejection (3DCORE) method has been used to fit magnetic fields of CME flux ropes to in situ observations. Its assumed Gold-Hoyle-like flux rope has an elliptical cross-section and expands self-similarly, thereby staying …
View article: Understanding the effects of spacecraft trajectories through solar coronal mass ejection flux ropes using 3DCOREweb
Understanding the effects of spacecraft trajectories through solar coronal mass ejection flux ropes using 3DCOREweb Open
A special observational signature in ICMEs that has puzzled researchers for a long time are so-called ”back regions” or ”magnetic-cloud-like (MCL)” parts of ICMEs which follow after the main flux rope rotation has p…
View article: On the Mesoscale Structure of Coronal Mass Ejections at Mercury’s Orbit: BepiColombo and Parker Solar Probe Observations
On the Mesoscale Structure of Coronal Mass Ejections at Mercury’s Orbit: BepiColombo and Parker Solar Probe Observations Open
On 2022 February 15, an impressive filament eruption was observed off the solar eastern limb from three remote-sensing viewpoints, namely, Earth, STEREO-A, and Solar Orbiter. In addition to representing the most-distant observed filament a…
View article: Exploring Observational Heliophysics Across All Scales: Reflections and Insights From the 2023 NASA Heliophysics Summer School
Exploring Observational Heliophysics Across All Scales: Reflections and Insights From the 2023 NASA Heliophysics Summer School Open
The field of heliophysics encompasses a diverse range of research areas and rich plasma environments, from the solar dynamo and solar wind turbulence, to the complex terrestrial thermosphere‐ionosphere‐magnetosphere (TIM) system, to invest…
View article: On the Mesoscale Structure of CMEs at Mercury's Orbit: BepiColombo and Parker Solar Probe Observations
On the Mesoscale Structure of CMEs at Mercury's Orbit: BepiColombo and Parker Solar Probe Observations Open
On 2022 February 15, an impressive filament eruption was observed off the solar eastern limb from three remote-sensing viewpoints, namely Earth, STEREO-A, and Solar Orbiter. In addition to representing the most-distant observed filament at…
View article: Applying molecular genetic data at different scales to support conservation assessment of European Habitats Directive listed species: A case study of Eurasian otter in Austria
Applying molecular genetic data at different scales to support conservation assessment of European Habitats Directive listed species: A case study of Eurasian otter in Austria Open
Evaluating intraspecific genetic structure and diversity is fundamental to assessing a species’ conservation status, but direct incorporation of such information into legal frameworks such as the EU's Habitats Directive is surprisingly rar…
View article: SARS-CoV-2 Infection and Development of Islet Autoimmunity in Early Childhood
SARS-CoV-2 Infection and Development of Islet Autoimmunity in Early Childhood Open
Importance The incidence of diabetes in childhood has increased during the COVID-19 pandemic. Elucidating whether SARS-CoV-2 infection is associated with islet autoimmunity, which precedes type 1 diabetes onset, is relevant to disease etio…
View article: Global insight into a complex-structured heliosphere based on the local multi-point analysis
Global insight into a complex-structured heliosphere based on the local multi-point analysis Open
From 29 January to 7 February 2022, the heliosphere was structured with large-scale interacting substructures that appeared with significant dissimilarities at distant observations separated longitudinally by . Probing the complexity of t…
View article: Supplementary Table S2 from FGF401, A First-In-Class Highly Selective and Potent FGFR4 Inhibitor for the Treatment of FGF19-Driven Hepatocellular Cancer
Supplementary Table S2 from FGF401, A First-In-Class Highly Selective and Potent FGFR4 Inhibitor for the Treatment of FGF19-Driven Hepatocellular Cancer Open
Pharmacologic profiling of FGF401 in cancer cell lines
View article: Supplementary Table S4 from FGF401, A First-In-Class Highly Selective and Potent FGFR4 Inhibitor for the Treatment of FGF19-Driven Hepatocellular Cancer
Supplementary Table S4 from FGF401, A First-In-Class Highly Selective and Potent FGFR4 Inhibitor for the Treatment of FGF19-Driven Hepatocellular Cancer Open
Activity of FGF401 in PDXs
View article: Supplementary Table S2 from FGF401, A First-In-Class Highly Selective and Potent FGFR4 Inhibitor for the Treatment of FGF19-Driven Hepatocellular Cancer
Supplementary Table S2 from FGF401, A First-In-Class Highly Selective and Potent FGFR4 Inhibitor for the Treatment of FGF19-Driven Hepatocellular Cancer Open
Pharmacologic profiling of FGF401 in cancer cell lines
View article: Supplementary Figure S4 from FGF401, A First-In-Class Highly Selective and Potent FGFR4 Inhibitor for the Treatment of FGF19-Driven Hepatocellular Cancer
Supplementary Figure S4 from FGF401, A First-In-Class Highly Selective and Potent FGFR4 Inhibitor for the Treatment of FGF19-Driven Hepatocellular Cancer Open
PK and anti-tumor activity of FGF401 in rats
View article: Supplementary Table S4 from FGF401, A First-In-Class Highly Selective and Potent FGFR4 Inhibitor for the Treatment of FGF19-Driven Hepatocellular Cancer
Supplementary Table S4 from FGF401, A First-In-Class Highly Selective and Potent FGFR4 Inhibitor for the Treatment of FGF19-Driven Hepatocellular Cancer Open
Activity of FGF401 in PDXs
View article: Data from FGF401, A First-In-Class Highly Selective and Potent FGFR4 Inhibitor for the Treatment of FGF19-Driven Hepatocellular Cancer
Data from FGF401, A First-In-Class Highly Selective and Potent FGFR4 Inhibitor for the Treatment of FGF19-Driven Hepatocellular Cancer Open
Hepatocellular carcinoma (HCC) is the most common primary malignancy of the liver and it is the third leading cause of cancer-related deaths worldwide. Recently, aberrant signaling through the FGF19/FGFR4 axis has been implicated in HCC. H…