Andreas Willerslev-Olsen
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View article: Data from Divergent Evolution of Malignant Subclones Maintains a Balance between Induced Aggressiveness and Intrinsic Drug Resistance in T-cell Cancer
Data from Divergent Evolution of Malignant Subclones Maintains a Balance between Induced Aggressiveness and Intrinsic Drug Resistance in T-cell Cancer Open
Evolution and outgrowth of drug-resistant cancer cells are common causes of treatment failure. Patients with leukemic cutaneous T-cell lymphoma have a poor prognosis because of the development of drug resistance and severe bacterial infect…
View article: Table S2 from Divergent Evolution of Malignant Subclones Maintains a Balance between Induced Aggressiveness and Intrinsic Drug Resistance in T-cell Cancer
Table S2 from Divergent Evolution of Malignant Subclones Maintains a Balance between Induced Aggressiveness and Intrinsic Drug Resistance in T-cell Cancer Open
Antibodies used (with vendor, catalogue number and RRID)
View article: Table S1 from Divergent Evolution of Malignant Subclones Maintains a Balance between Induced Aggressiveness and Intrinsic Drug Resistance in T-cell Cancer
Table S1 from Divergent Evolution of Malignant Subclones Maintains a Balance between Induced Aggressiveness and Intrinsic Drug Resistance in T-cell Cancer Open
Patient information
View article: Supplementary Figures S1-S17 from Divergent Evolution of Malignant Subclones Maintains a Balance between Induced Aggressiveness and Intrinsic Drug Resistance in T-cell Cancer
Supplementary Figures S1-S17 from Divergent Evolution of Malignant Subclones Maintains a Balance between Induced Aggressiveness and Intrinsic Drug Resistance in T-cell Cancer Open
S1 shows sample and analysis pipeline overview. S2 shows malignant-associated gene and surface marker expression in PT17. S3 shows single-cell subclone identification by scTCR-seq, transcriptome and copy-number aberration inference. S4 sho…
View article: Divergent Evolution of Malignant Subclones Maintains a Balance between Induced Aggressiveness and Intrinsic Drug Resistance in T-cell Cancer
Divergent Evolution of Malignant Subclones Maintains a Balance between Induced Aggressiveness and Intrinsic Drug Resistance in T-cell Cancer Open
Evolution and outgrowth of drug-resistant cancer cells are common causes of treatment failure. Patients with leukemic cutaneous T-cell lymphoma have a poor prognosis because of the development of drug resistance and severe bacterial infect…
View article: <i>Staphylococcus aureus</i>induces drug resistance in cancer T cells in Sézary syndrome
<i>Staphylococcus aureus</i>induces drug resistance in cancer T cells in Sézary syndrome Open
Patients with Sézary syndrome (SS), a leukemic variant of cutaneous T-cell lymphoma (CTCL), are prone to Staphylococcus aureus infections and have a poor prognosis due to treatment resistance. Here, we report that S aureus and staphylococc…
View article: Malignant T cells induce skin barrier defects through cytokine-mediated JAK/STAT signaling in cutaneous T-cell lymphoma
Malignant T cells induce skin barrier defects through cytokine-mediated JAK/STAT signaling in cutaneous T-cell lymphoma Open
Cutaneous T-cell lymphoma (CTCL) is a devastating lymphoid malignancy characterized by the accumulation of malignant T cells in the dermis and epidermis. Skin lesions cause serious symptoms that hamper quality of life and are entry sites f…
View article: miRNA Signature in Early-stage Mycosis Fungoides
miRNA Signature in Early-stage Mycosis Fungoides Open
Altered miRNA expressions are assigned pathogenic properties in several cancers including mycosis fungoides and could play a role in the early onset of the disease. The aim of this study was to examine disease-specific miRNA expression in …
View article: JAK3 Is Expressed in the Nucleus of Malignant T Cells in Cutaneous T Cell Lymphoma (CTCL)
JAK3 Is Expressed in the Nucleus of Malignant T Cells in Cutaneous T Cell Lymphoma (CTCL) Open
Perturbation in JAK-STAT signaling has been reported in the pathogenesis of cutaneous T cell lymphoma (CTCL). JAK3 is predominantly associated with the intra-cytoplasmic part of IL-2Rγc located in the plasma membrane of hematopoietic cells…
View article: Inhibition of succinate dehydrogenase activity impairs human T cell activation and function
Inhibition of succinate dehydrogenase activity impairs human T cell activation and function Open
T cell activation is intimately linked to metabolism, as distinct metabolic requirements support the functional and phenotypical differences between quiescent and activated T cells. Metabolic transition from mitochondrial oxidative phospho…
View article: Cellular Interactions and Inflammation in the Pathogenesis of Cutaneous T-Cell Lymphoma
Cellular Interactions and Inflammation in the Pathogenesis of Cutaneous T-Cell Lymphoma Open
Cutaneous T-cell lymphoma (CTCL) comprises a group of lymphoproliferative diseases characterized by the accumulation of malignant T cells in chronically inflamed skin lesions. In early stages, the disease presents as skin patches or plaque…
View article: MicroRNAs in the Pathogenesis, Diagnosis, Prognosis and Targeted Treatment of Cutaneous T-Cell Lymphomas
MicroRNAs in the Pathogenesis, Diagnosis, Prognosis and Targeted Treatment of Cutaneous T-Cell Lymphomas Open
Cutaneous T-cell lymphoma (CTCL) represents a heterogeneous group of potentially devastating primary skin malignancies. Despite decades of intense research efforts, the pathogenesis is still not fully understood. In the early stages, both …
View article: Supplementary Material for: MicroRNA-93 Targets p21 and Promotes Proliferation in Mycosis Fungoides T Cells
Supplementary Material for: MicroRNA-93 Targets p21 and Promotes Proliferation in Mycosis Fungoides T Cells Open
Background: Mycosis fungoides (MF), the most common form of cutaneous T-cell lymphoma (CTCL), is a lymphoproliferative disorder characterized by proliferation of malignant T cells in a chronic inflammatory environment in the skin. The natu…
View article: Supplementary Material for: The Thioredoxin-Interacting Protein TXNIP Is a Putative Tumour Suppressor in Cutaneous T-Cell Lymphoma
Supplementary Material for: The Thioredoxin-Interacting Protein TXNIP Is a Putative Tumour Suppressor in Cutaneous T-Cell Lymphoma Open
Background: The thioredoxin-interacting protein (TXNIP) is involved in cellular metabolism and cell proliferation, and recently, deficient expression of TXNIP has been associated with progression and poor outcome for cancer patients. Objec…
View article: <i>Staphylococcus aureus</i> alpha-toxin inhibits CD8 <sup>+</sup> T cell-mediated killing of cancer cells in cutaneous T-cell lymphoma
<i>Staphylococcus aureus</i> alpha-toxin inhibits CD8 <sup>+</sup> T cell-mediated killing of cancer cells in cutaneous T-cell lymphoma Open
Staphylococcus aureus and its toxins have been linked to disease progression and mortality in advanced stages of cutaneous T-cell lymphoma (CTCL). CD8+ T cells play a crucial role in anti-cancer responses and high CD8+ T cell numbers in tu…
View article: MicroRNA-106b Regulates Expression of the Tumour Suppressors p21 and TXNIP and Promotes Tumour Cell Proliferation in Mycosis Fungoides
MicroRNA-106b Regulates Expression of the Tumour Suppressors p21 and TXNIP and Promotes Tumour Cell Proliferation in Mycosis Fungoides Open
A prognostic 3-miRNA classifier for early-stage mycosis fungoides has been developed recently, with miR-106b providing the strongest prognostic power. The aim of this study was to investigate the molecular function of miR-106b in mycosis f…
View article: Expression and function of Kv1.3 channel in malignant T cells in Sézary syndrome
Expression and function of Kv1.3 channel in malignant T cells in Sézary syndrome Open
The voltage-gated potassium channel Kv1.3 (KCNA3) is expressed by a subset of chronically activated memory T cells and plays an important role in their activation and proliferation. Here, we show that primary malignant T cells isolated fro…
View article: Antibiotics inhibit tumor and disease activity in cutaneous T-cell lymphoma
Antibiotics inhibit tumor and disease activity in cutaneous T-cell lymphoma Open
This paper reports that aggressive antibiotic treatment inhibits disease activity and lymphocyte proliferation in cutaneous T-cell lymphoma (CTCL). The study offers important evidence for a link between bacterial infection, activation of t…
View article: Staphylococcal alpha-toxin tilts the balance between malignant and non-malignant CD4 <sup>+</sup> T cells in cutaneous T-cell lymphoma
Staphylococcal alpha-toxin tilts the balance between malignant and non-malignant CD4 <sup>+</sup> T cells in cutaneous T-cell lymphoma Open
Staphylococcus aureus is implicated in disease progression in cutaneous T-cell lymphoma (CTCL). Here, we demonstrate that malignant T cell lines derived from CTCL patients as well as primary malignant CD4+ T cells from Sézary syndrome pati…
View article: Supplementary Material for: Expression of the Voltage-Gated Potassium Channel Kv1.3 in Lesional Skin from Patients with Cutaneous T-Cell Lymphoma and Benign Dermatitis
Supplementary Material for: Expression of the Voltage-Gated Potassium Channel Kv1.3 in Lesional Skin from Patients with Cutaneous T-Cell Lymphoma and Benign Dermatitis Open
Background: The voltage-gated potassium channel Kv1.3 (KCNA3) is expressed by effector memory T cells (TEM) and plays an important role in their activation and proliferation. Mycosis fungoides (MF), the most common subtype of cutaneous T-c…
View article: Single-cell heterogeneity in Sézary syndrome
Single-cell heterogeneity in Sézary syndrome Open
Key Points Individual patients with Sézary syndrome contain several distinct malignant subpopulations and show marked single-cell heterogeneity. Malignant subpopulations exhibit differences in their sensitivity to treatment warranting prec…
View article: Prognostic miRNA classifier in early-stage mycosis fungoides: development and validation in a Danish nationwide study
Prognostic miRNA classifier in early-stage mycosis fungoides: development and validation in a Danish nationwide study Open
Key Points A validated 3-miRNA classifier can effectively predict progression from early- to advanced-stage MF and survival at time of diagnosis. This classifier outperforms existing clinical prognostic factors and paves the way for implem…
View article: Butyrate and propionate inhibit antigen-specific CD8+ T cell activation by suppressing IL-12 production by antigen-presenting cells
Butyrate and propionate inhibit antigen-specific CD8+ T cell activation by suppressing IL-12 production by antigen-presenting cells Open
Short chain fatty acids (SCFAs), such as acetate, butyrate and propionate, are products of microbial macronutrients fermentation that distribute systemically and are believed to modulate host immune responses. Recent data have indicated th…
View article: A novel BLK-induced tumor model
A novel BLK-induced tumor model Open
B-lymphoid tyrosine kinase (BLK) is a non-receptor tyrosine kinase belonging to the SRC family kinases. BLK is known to be functionally involved in B-cell receptor signaling and B-cell development. New evidence suggests that B-lymphoid tyr…