Andreea Milan
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View article: Newly Synthesized CoFe2−yPryO4 (y = 0; 0.01; 0.03; 0.05; 0.1; 0.15; 0.2) Nanoparticles Reveal Promising Selective Anticancer Activity Against Melanoma (A375), Breast Cancer (MCF-7), and Colon Cancer (HT-29) Cells
Newly Synthesized CoFe2−yPryO4 (y = 0; 0.01; 0.03; 0.05; 0.1; 0.15; 0.2) Nanoparticles Reveal Promising Selective Anticancer Activity Against Melanoma (A375), Breast Cancer (MCF-7), and Colon Cancer (HT-29) Cells Open
In this study, praseodymium-doped cobalt ferrite nanoparticles (CoFe2−yPryO4, y = 0–0.2) were synthesized via sol-gel auto-combustion and systematically characterized to assess their structural, morphological, magnetic, and biological prop…
View article: Newly Synthesized CoFe2-xPrxO4 (x = 0; 0.01; 0.03; 0.05; 0.1; 0.15; 0.2) Nanoparticles Reveal Promising Selective Anticancer Activity against Melanoma (A375), Breast Cancer (MCF-7) and Colon Cancer (HT-29) Cells
Newly Synthesized CoFe2-xPrxO4 (x = 0; 0.01; 0.03; 0.05; 0.1; 0.15; 0.2) Nanoparticles Reveal Promising Selective Anticancer Activity against Melanoma (A375), Breast Cancer (MCF-7) and Colon Cancer (HT-29) Cells Open
In this study, praseodymium-doped cobalt ferrite nanoparticles (CoFe₂₋yPryO₄, y = 0–0.2) were synthesized via sol-gel auto-combustion and systematically characterized to assess their structural, morphological, magnetic, and biological prop…
View article: In Vitro and In Silico Evaluation of Syzygium aromaticum Essential Oil: Effects on Mitochondrial Function and Cytotoxic Potential Against Cancer Cells
In Vitro and In Silico Evaluation of Syzygium aromaticum Essential Oil: Effects on Mitochondrial Function and Cytotoxic Potential Against Cancer Cells Open
The current study proposes the in vitro and in silico anticancer evaluation of clove (Syzygium aromaticum L.) essential oil (CEO). The steam hydrodistillation method used yielded 10.7% (wt) CEO. GC-MS analysis revealed that the obtained oi…
View article: Cytotoxic Potential of Betulinic Acid Fatty Esters and Their Liposomal Formulations: Targeting Breast, Colon, and Lung Cancer Cell Lines
Cytotoxic Potential of Betulinic Acid Fatty Esters and Their Liposomal Formulations: Targeting Breast, Colon, and Lung Cancer Cell Lines Open
Betulinic acid is a lupane-type pentacyclic triterpene mostly found in birch bark and thoroughly explored for its wide range of pharmacological activities. Despite its impressive biological potential, its low bioavailability has challenged…
View article: Exploring the Antimelanoma Potential of Betulinic Acid Esters and Their Liposomal Nanoformulations
Exploring the Antimelanoma Potential of Betulinic Acid Esters and Their Liposomal Nanoformulations Open
Betulinic acid is a naturally occurring pentacyclic triterpene belonging to the lupane-group that exhibits a wide range of pharmacological activities. BA derivatives are continuously being researched due to their improved anticancer effica…
View article: Lactiplantibacillus plantarum Induces Apoptosis in Melanoma and Breast Cancer Cells
Lactiplantibacillus plantarum Induces Apoptosis in Melanoma and Breast Cancer Cells Open
Despite the notable advancements witnessed in the past decade in medical and health research domain, cancer remains a prominent global cause of mortality. Moreover, the conventional treatments employed to combat this disease have been foun…
View article: Novel Betulin-1,2,4-Triazole Derivatives Promote In Vitro Dose-Dependent Anticancer Cytotoxicity
Novel Betulin-1,2,4-Triazole Derivatives Promote In Vitro Dose-Dependent Anticancer Cytotoxicity Open
Betulin is a birch bark-derived lupane-type pentacyclic triterpene with a wide spectrum of biological activities. Given their enhanced antiproliferative potential and enhanced pharmacological profile, betulin derivatives are continuously i…
View article: Newly Synthesized CoFe2−xDyxO4 (x = 0; 0.1; 0.2; 0.4) Nanoparticles Reveal Promising Anticancer Activity against Melanoma (A375) and Breast Cancer (MCF-7) Cells
Newly Synthesized CoFe2−xDyxO4 (x = 0; 0.1; 0.2; 0.4) Nanoparticles Reveal Promising Anticancer Activity against Melanoma (A375) and Breast Cancer (MCF-7) Cells Open
The current study focuses on the synthesis via combustion of dysprosium-doped cobalt ferrites that were subsequently physicochemically analyzed in terms of morphological and magnetic properties. Three types of doped nanoparticles were prep…
View article: Lacticaseibacillus rhamnosus—A Promising Tool for Colorectal Cancer Treatment
Lacticaseibacillus rhamnosus—A Promising Tool for Colorectal Cancer Treatment Open
Probiotic strains such as Lactobacillus spp. are already known for their beneficial effect on human health and new research supports their role in colon cancer prevention and treatment. The current study reports the effect of different con…
View article: The Antimelanoma Biological Assessment of Triterpenic Acid Functionalized Gold Nanoparticles
The Antimelanoma Biological Assessment of Triterpenic Acid Functionalized Gold Nanoparticles Open
One of several promising strategies for increasing the bioavailability and therapeutic potential of high-lipophilic biologically active compounds is gold nanoparticle formulation. The current study describes the synthesis and biological an…
View article: Novel Semisynthetic Betulinic Acid−Triazole Hybrids with In Vitro Antiproliferative Potential
Novel Semisynthetic Betulinic Acid−Triazole Hybrids with In Vitro Antiproliferative Potential Open
Betulinic acid, BA, is a lupane derivative that has caught the interest of researchers due to the wide variety of pharmacological properties it exhibits towards tumor cells. Because of their prospective increased anti−proliferative efficac…
View article: The C30-Modulation of Betulinic Acid Using 1,2,4-Triazole: A Promising Strategy for Increasing Its Antimelanoma Cytotoxic Potential
The C30-Modulation of Betulinic Acid Using 1,2,4-Triazole: A Promising Strategy for Increasing Its Antimelanoma Cytotoxic Potential Open
Cancer, in all its types and manifestations, remains one of the most frequent causes of death worldwide; an important number of anticancer drugs have been developed from plants, fungi and animals, starting with natural compounds that were …
View article: The Anti-Melanoma Effect of Betulinic Acid Functionalized Gold Nanoparticles: A Mechanistic In Vitro Approach
The Anti-Melanoma Effect of Betulinic Acid Functionalized Gold Nanoparticles: A Mechanistic In Vitro Approach Open
Implementing metallic nanoparticles as research instruments for the transport of therapeutically active compounds remains a fundamentally vital work direction that can still potentially generate novelties in the field of drug formulation d…
View article: Structural Investigation of Betulinic Acid Plasma Metabolites by Tandem Mass Spectrometry
Structural Investigation of Betulinic Acid Plasma Metabolites by Tandem Mass Spectrometry Open
Betulinic acid (BA) has been extensively studied in recent years mainly for its antiproliferative and antitumor effect in various types of cancers. Limited data are available regarding the pharmacokinetic profile of BA, particularly its me…
View article: Semisynthetic Derivatives of Pentacyclic Triterpenes Bearing Heterocyclic Moieties with Therapeutic Potential
Semisynthetic Derivatives of Pentacyclic Triterpenes Bearing Heterocyclic Moieties with Therapeutic Potential Open
Medicinal plants have been used by humans since ancient times for the treatment of various diseases and currently represent the main source of a variety of phytocompounds, such as triterpenes. Pentacyclic triterpenes have been subjected to…
View article: Novel Triterpenic Acid—Benzotriazole Esters Act as Pro-Apoptotic Antimelanoma Agents
Novel Triterpenic Acid—Benzotriazole Esters Act as Pro-Apoptotic Antimelanoma Agents Open
Pentacyclic triterpenes, such as betulinic, ursolic, and oleanolic acids are efficient and selective anticancer agents whose underlying mechanisms of action have been widely investigated. The introduction of N-bearing heterocycles (e.g., t…
View article: Recent Advances Regarding the Molecular Mechanisms of Triterpenic Acids: A Review (Part II)
Recent Advances Regarding the Molecular Mechanisms of Triterpenic Acids: A Review (Part II) Open
Triterpenic acids are a widespread class of phytocompounds which have been found to possess valuable therapeutic properties such as anticancer, anti-inflammatory, hepatoprotective, cardioprotective, antidiabetic, neuroprotective, lipolytic…
View article: Recent Advances Regarding the Molecular Mechanisms of Triterpenic Acids: A Review (Part I)
Recent Advances Regarding the Molecular Mechanisms of Triterpenic Acids: A Review (Part I) Open
Triterpenic acids are phytocompounds with a widespread range of biological activities that have been the subject of numerous in vitro and in vivo studies. However, their underlying mechanisms of action in various pathologies are not comple…
View article: The Optimized Delivery of Triterpenes by Liposomal Nanoformulations: Overcoming the Challenges
The Optimized Delivery of Triterpenes by Liposomal Nanoformulations: Overcoming the Challenges Open
The last decade has witnessed a sustained increase in the research development of modern-day chemo-therapeutics, especially for those used for high mortality rate pathologies. However, the therapeutic landscape is continuously changing as …
View article: The Role of Cyclodextrins in the Design and Development of Triterpene-Based Therapeutic Agents
The Role of Cyclodextrins in the Design and Development of Triterpene-Based Therapeutic Agents Open
Triterpenic compounds stand as a widely investigated class of natural compounds due to their remarkable therapeutic potential. However, their use is currently being hampered by their low solubility and, subsequently, bioavailability. In or…
View article: Ring-Modified Triterpene Derivatives as Potential Pharmacological Active Compounds
Ring-Modified Triterpene Derivatives as Potential Pharmacological Active Compounds Open
Pentacyclic triterpenes represent an important class of intensively studied substances in the past two decades due to their wide spectrum of pharmacological effects. Even though this class is being thoroughly researched for the development…
View article: Venlafaxine Chiral Separation by Capillary Electrophoresis Using Cyclodextrin Derivatives as Chiral Selector and Experimental Design Method Optimization
Venlafaxine Chiral Separation by Capillary Electrophoresis Using Cyclodextrin Derivatives as Chiral Selector and Experimental Design Method Optimization Open
Venlafaxine (VFX) is a modern antidepressant from the serotonin and norepinephrine reuptake inhibitor (SNRI) class. It is a chiral substance used in therapy as a racemate, but differences between the pharmacological properties of the two e…
View article: Wood Bark as Valuable Raw Material for Compounds with a Bioregulator Effect in Lemon Balm (Melissa officinalis L.) Plants
Wood Bark as Valuable Raw Material for Compounds with a Bioregulator Effect in Lemon Balm (Melissa officinalis L.) Plants Open
Over the past few years, special attention has been paid to biomass valorization. The aim of this paper is to evaluate the effect of the phenolic rich extracts obtained from raw materials on the growth and development of lemon balm (Meliss…