Andrei Bombin
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View article: Respiratory Virus Detection and Sequencing from SARS-CoV-2–Negative Rapid Antigen Tests
Respiratory Virus Detection and Sequencing from SARS-CoV-2–Negative Rapid Antigen Tests Open
Genomic epidemiology offers insight into the transmission and evolution of respiratory viruses. We used metagenomic sequencing from negative SARS-CoV-2 rapid antigen tests to identify a wide range of respiratory viruses and generate full g…
View article: Viral and host factors associated with SARS-CoV-2 disease severity in Georgia, USA
Viral and host factors associated with SARS-CoV-2 disease severity in Georgia, USA Open
While SARS-CoV-2 vaccines have shown strong efficacy, the continued emergence of new viral variants raises concerns about the ongoing and future public health impact of COVID-19, especially in locations with suboptimal vaccination uptake. …
View article: Application of Environmental DNA Metabarcoding to Differentiate Algal Communities by Littoral Zonation and Detect Unreported Algal Species
Application of Environmental DNA Metabarcoding to Differentiate Algal Communities by Littoral Zonation and Detect Unreported Algal Species Open
Coastal areas are the most biologically productive and undoubtedly among the most complex ecosystems. Algae are responsible for most of the gross primary production in these coastal regions. However, despite the critical importance of alga…
View article: Respiratory virus detection and sequencing from negative SARS-CoV-2 rapid antigen tests
Respiratory virus detection and sequencing from negative SARS-CoV-2 rapid antigen tests Open
Genomic epidemiology offers important insight into the transmission and evolution of respiratory viruses. We used metagenomic sequencing from negative SARS-CoV-2 antigen tests to identify a wide range of respiratory viruses and generate fu…
View article: Genotype-based “virtual” metabolomics in a clinical biobank identifies novel metabolite-disease associations
Genotype-based “virtual” metabolomics in a clinical biobank identifies novel metabolite-disease associations Open
Introduction: Circulating metabolites act as biomarkers of dysregulated metabolism and may inform disease pathophysiology. A portion of the inter-individual variability in circulating metabolites is influenced by common genetic variation. …
View article: The Burden and Impact of Early Post-transplant Multidrug-Resistant Organism Detection Among Renal Transplant Recipients, 2005–2021
The Burden and Impact of Early Post-transplant Multidrug-Resistant Organism Detection Among Renal Transplant Recipients, 2005–2021 Open
Background Reducing the burden of multidrug-resistant organism (MDRO) colonization and infection among renal transplant recipients (RTRs) may improve patient outcomes. We aimed to assess whether the detection of an MDRO or a comparable ant…
View article: 2469. Comparative Genomics Uncovers Strain Diversity and Possible Unrecognized Transmission of MDROs among Hospitalized Patients
2469. Comparative Genomics Uncovers Strain Diversity and Possible Unrecognized Transmission of MDROs among Hospitalized Patients Open
Background Contamination of the healthcare environment by colonized patients is an important source of multidrug-resistant organism (MDRO) transmission. We aimed to determine MDRO room contamination of patients with MDRO clinical cultures …
View article: 1281. Ongoing Transmission of Clonal Strains of Invasive Nontypeable <i>Haemophilus influenzae</i> Disproportionately Affecting Persons with HIV in Metropolitan Atlanta, 2019—2022
1281. Ongoing Transmission of Clonal Strains of Invasive Nontypeable <i>Haemophilus influenzae</i> Disproportionately Affecting Persons with HIV in Metropolitan Atlanta, 2019—2022 Open
Background Nontypeable Haemophilus influenzae (NTHi) is a genetically diverse pathogen that typically causes mucosal infections or invasive NTHi (iNTHi) disease in persons at the extremes of age. In 2017-2018, we reported a significant inc…
View article: Viral and host factors associated with SARS-CoV-2 disease severity in Georgia, USA
Viral and host factors associated with SARS-CoV-2 disease severity in Georgia, USA Open
While SARS-CoV-2 vaccines have shown strong efficacy, their suboptimal uptake combined with the continued emergence of new viral variants raises concerns about the ongoing and future public health impact of COVID-19. We investigated viral …
View article: Genotype-based “virtual” metabolomics in a clinical biobank identifies novel metabolite-disease associations
Genotype-based “virtual” metabolomics in a clinical biobank identifies novel metabolite-disease associations Open
Circulating metabolites act as biomarkers of dysregulated metabolism, and may inform disease pathophysiology. A portion of the inter-individual variability in circulating metabolites is influenced by common genetic variation. We evaluated …
View article: Genotype-based “virtual” metabolomics in a clinical biobank identifies novel metabolite-disease associations
Genotype-based “virtual” metabolomics in a clinical biobank identifies novel metabolite-disease associations Open
View article: <i>ABO</i> O blood group as a risk factor for platelet reactivity in heparin-induced thrombocytopenia
<i>ABO</i> O blood group as a risk factor for platelet reactivity in heparin-induced thrombocytopenia Open
Heparin-induced thrombocytopenia (HIT) is an unpredictable, potentially catastrophic adverse effect resulting from an immune response to platelet factor 4 (PF4)/heparin complexes. We performed a genome-wide association study (GWAS) with po…
View article: Obesity influences composition of salivary and fecal microbiota and impacts the interactions between bacterial taxa
Obesity influences composition of salivary and fecal microbiota and impacts the interactions between bacterial taxa Open
Obesity is an increasing global health concern and is associated with a broad range of morbidities. The gut microbiota are increasingly recognized as important contributors to obesity and cardiometabolic health. This study aimed to charact…
View article: Obesity influences composition of salivary and fecal microbiota and impacts the interactions between bacterial taxa
Obesity influences composition of salivary and fecal microbiota and impacts the interactions between bacterial taxa Open
Obesity is an increasing global health concern and is associated with a broad range of morbidities. The gut microbiota are increasingly recognized as important contributors to obesity and cardiometabolic health. This study aimed to charact…
View article: Symbiotic bacterial community of<i>Drosophila melanogaster</i>changes with nutritional modifications of the diet but can alleviate negative effects on larval phenotypes
Symbiotic bacterial community of<i>Drosophila melanogaster</i>changes with nutritional modifications of the diet but can alleviate negative effects on larval phenotypes Open
Obesity is an increasing pandemic and is caused by multiple factors including genotype, psychological stress, and gut microbiota. Our project investigated the effects produced by high fat and high sugar dietary modifications on microbiota …
View article: Influence of Lab Adapted Natural Diet and Microbiota on Life History and Metabolic Phenotype of Drosophila melanogaster
Influence of Lab Adapted Natural Diet and Microbiota on Life History and Metabolic Phenotype of Drosophila melanogaster Open
Symbiotic microbiota can help its host to overcome nutritional challenges, which is consistent with a holobiont theory of evolution. Our project investigated the effects produced by the microbiota community, acquired from the environment a…
View article: Influence of the lab adopted natural diet and environmental and parental microbiota on life history and metabolic phenotype of<i>Drosophila melanogaster</i>larvae
Influence of the lab adopted natural diet and environmental and parental microbiota on life history and metabolic phenotype of<i>Drosophila melanogaster</i>larvae Open
Obesity is an increasing worldwide epidemic and contributes to physical and mental health losses. The development of obesity is caused by multiple factors including genotype, hormonal misregulation, psychological stress, and gut microbiota…
View article: The changing biodiversity of Alabama <i>Drosophila</i>: important impacts of seasonal variation, urbanization, and invasive species
The changing biodiversity of Alabama <i>Drosophila</i>: important impacts of seasonal variation, urbanization, and invasive species Open
Global warming and anthropogenic disturbances significantly influence the biosphere, tremendously increasing species extinction rates. In Central Alabama, we analyzed Drosophilidae species composition change nearly 100 years after the prev…