Andrei Segal
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View article: Placental TRPV2 is indispensable for normal fetal development.
Placental TRPV2 is indispensable for normal fetal development. Open
TRPV2 is a calcium-permeable ion channel with a broad expression pattern that contributes to neuronal outgrowth, immune response, and cardiac function. Mice lacking Trpv2 are more susceptible to perinatal lethality, a phenotype that cannot…
View article: TRPM4 inhibition by meclofenamate suppresses Ca2+-dependent triggered arrhythmias
TRPM4 inhibition by meclofenamate suppresses Ca2+-dependent triggered arrhythmias Open
Aims Cardiac arrhythmias are a major factor in the occurrence of morbidity and sudden death in patients with cardiovascular disease. Disturbances of Ca2+ homeostasis in the heart contribute to the initiation and maintenance of cardiac arrh…
View article: X-ray videocystometry for high-speed monitoring of urinary tract function in mice
X-ray videocystometry for high-speed monitoring of urinary tract function in mice Open
Videocystometry, combining x-ray and cystometry, provides unprecedented details on urinary tract function in rodents.
View article: The Agonist Action of Alkylphenols on TRPA1 Relates to Their Effects on Membrane Lipid Order: Implications for TRPA1-Mediated Chemosensation
The Agonist Action of Alkylphenols on TRPA1 Relates to Their Effects on Membrane Lipid Order: Implications for TRPA1-Mediated Chemosensation Open
The Transient Receptor Potential Ankyrin 1 cation channel (TRPA1) is a broadly-tuned chemosensor expressed in nociceptive neurons. Multiple TRPA1 agonists are chemically unrelated non-electrophilic compounds, for which the mechanisms of ch…
View article: Pharmacological properties of TRPM3 isoforms are determined by the length of the pore loop
Pharmacological properties of TRPM3 isoforms are determined by the length of the pore loop Open
Background and Purpose Transient receptor potential melastatin 3 (TRPM3) is a non‐selective cation channel that plays a pivotal role in the peripheral nervous system as a transducer of painful heat signals. Alternative splicing gives rise …
View article: Steviol glycosides enhance pancreatic beta-cell function and taste sensation by potentiation of TRPM5 channel activity
Steviol glycosides enhance pancreatic beta-cell function and taste sensation by potentiation of TRPM5 channel activity Open
Steviol glycosides (SGs), such as stevioside and rebaudioside A, are natural, non-caloric sweet-tasting organic molecules, present in extracts of the scrub plant Stevia rebaudiana , which are widely used as sweeteners in consumer foods and…
View article: TRPM4-dependent post-synaptic depolarization is essential for the induction of NMDA receptor-dependent LTP in CA1 hippocampal neurons
TRPM4-dependent post-synaptic depolarization is essential for the induction of NMDA receptor-dependent LTP in CA1 hippocampal neurons Open
TRPM4 is a calcium-activated but calcium-impermeable non-selective cation (CAN) channel. Previous studies have shown that TRPM4 is an important regulator of Ca(2+)-dependent changes in membrane potential in excitable and non-excitable cell…
View article: TRPM4 is a key mediator for NMDA-receptor dependent hippocampal LTP but not LTD
TRPM4 is a key mediator for NMDA-receptor dependent hippocampal LTP but not LTD Open
Event Abstract Back to Event TRPM4 is a key mediator for NMDA-receptor dependent hippocampal LTP but not LTD Aurelie Menigoz1, Tariq Ahmed2, Victor Sabanov2*, Kasper Vinken2, Silvia Pinto1, Sara Kerselaers1, Andrei Segal1, Marc Freichel3, …