Andréï Tchirkov
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View article: P-041 Impact of ionizing radiation on human spermatozoa integrity
P-041 Impact of ionizing radiation on human spermatozoa integrity Open
Study question Do ionizing radiations affect human sperm integrity? If so, at what dose? Summary answer In vitro exposure of human ejaculated spermatozoa significantly reduces vitality, motility, and chromatin integrity without causing DNA…
View article: Multiplex digital PCR enables sensitive detection of resistance to BTK inhibitors
Multiplex digital PCR enables sensitive detection of resistance to BTK inhibitors Open
The advent of BTK inhibitors has been transformative in the management of patients with chronic lymphocytic leukemia or other B-cell lymphoproliferative disorders. However, emergence of BTK or PLCG2 mutations lead to resistance to these co…
View article: The initial molecular response predicts the deep molecular response but not treatment-free remission maintenance in a real-world chronic myeloid leukemia cohort
The initial molecular response predicts the deep molecular response but not treatment-free remission maintenance in a real-world chronic myeloid leukemia cohort Open
In chronic myeloid leukemia, the identification of early molecular predictors of stable treatment-free remission (TFR) after tyrosine kinase inhibitor (TKI) discontinuation is challenging. The predictive values of residual disease (BCR::AB…
View article: Feasibility of Optical Genome Mapping from Placental and Umbilical Cord Sampled after Spontaneous or Therapeutic Pregnancy Termination
Feasibility of Optical Genome Mapping from Placental and Umbilical Cord Sampled after Spontaneous or Therapeutic Pregnancy Termination Open
Optical genome mapping (OGM) is an alternative to classical cytogenetic techniques to improve the detection rate of clinically significant genomic abnormalities. The isolation of high-molecular-weight (HMW) DNA is critical for a successful…
View article: Scale-Up of Academic Mesenchymal Stromal Cell Production
Scale-Up of Academic Mesenchymal Stromal Cell Production Open
Background: Many clinical trials have reported the use of mesenchymal stromal cells (MSCs) following the indication of severe SARS-CoV-2 infection. However, in the COVID19 pandemic context, academic laboratories had to adapt a production p…
View article: Freezing Does Not Alter Sperm Telomere Length despite Increasing DNA Oxidation and Fragmentation
Freezing Does Not Alter Sperm Telomere Length despite Increasing DNA Oxidation and Fragmentation Open
Correlations were reported between sperm telomere length (STL) and male fertility, sperm DNA fragmentation, and oxidation. Sperm freezing is widely used for assisted reproductive techniques, fertility preservation, and sperm donation. Howe…
View article: Optical Genome Mapping in Routine Cytogenetic Diagnosis of Acute Leukemia
Optical Genome Mapping in Routine Cytogenetic Diagnosis of Acute Leukemia Open
Cytogenetic aberrations are found in 65% of adults and 75% of children with acute leukemia. Specific aberrations are used as markers for the prognostic stratification of patients. The current standard cytogenetic procedure for acute leukem…
View article: Supplementary Tables 1-3 from Early Telomere Shortening and Genomic Instability in Tubo-Ovarian Preneoplastic Lesions
Supplementary Tables 1-3 from Early Telomere Shortening and Genomic Instability in Tubo-Ovarian Preneoplastic Lesions Open
Supplementary Tables 1-3 - PDF file 74K, aCGH data; minimal regions of interest in tubo-ovarian dysplasia and in STIC; Table S1 : Minimal regions of interest in ovarian dyaplasia (n=5); Table S2 : Minimal regions of interest in the common …
View article: Data from Early Telomere Shortening and Genomic Instability in Tubo-Ovarian Preneoplastic Lesions
Data from Early Telomere Shortening and Genomic Instability in Tubo-Ovarian Preneoplastic Lesions Open
Purpose: Genetic instability plays an important role in ovarian carcinogenesis. We investigated the level of telomere shortening and genomic instability in early and preinvasive stages of ovarian cancer, serous tubal intraepithelial…
View article: Supplementary Tables 1-3 from Early Telomere Shortening and Genomic Instability in Tubo-Ovarian Preneoplastic Lesions
Supplementary Tables 1-3 from Early Telomere Shortening and Genomic Instability in Tubo-Ovarian Preneoplastic Lesions Open
Supplementary Tables 1-3 - PDF file 74K, aCGH data; minimal regions of interest in tubo-ovarian dysplasia and in STIC; Table S1 : Minimal regions of interest in ovarian dyaplasia (n=5); Table S2 : Minimal regions of interest in the common …
View article: Data from Early Telomere Shortening and Genomic Instability in Tubo-Ovarian Preneoplastic Lesions
Data from Early Telomere Shortening and Genomic Instability in Tubo-Ovarian Preneoplastic Lesions Open
Purpose: Genetic instability plays an important role in ovarian carcinogenesis. We investigated the level of telomere shortening and genomic instability in early and preinvasive stages of ovarian cancer, serous tubal intraepithelial…
View article: Telomere Status of Advanced Non-Small-Cell Lung Cancer Offers a Novel Promising Prognostic and Predictive Biomarker
Telomere Status of Advanced Non-Small-Cell Lung Cancer Offers a Novel Promising Prognostic and Predictive Biomarker Open
Telomere length appears to correlate with survival in early non-small-cell lung cancer (NSCLC), but the prognostic impact of telomere status in advanced NSCLC remains undetermined. Our purpose was to evaluate telomere parameters as prognos…
View article: The Spliceosome: A New Therapeutic Target in Chronic Myeloid Leukaemia
The Spliceosome: A New Therapeutic Target in Chronic Myeloid Leukaemia Open
RNA splicing factors are frequently altered in cancer and can act as both oncoproteins and tumour suppressors. They have been found mutated or deregulated, justifying the growing interest in the targeting of splicing catalysis, splicing re…
View article: Evaluation of the effects of a semi-automated vitrification performed before or after in vitro maturation (IVM) on the kinetic of oocyte maturation and chromosome segregation.
Evaluation of the effects of a semi-automated vitrification performed before or after in vitro maturation (IVM) on the kinetic of oocyte maturation and chromosome segregation. Open
International audience
View article: Predicting outcomes with circulating adrenergic neuroblastoma mRNAs in children with relapsed and refractory neuroblastoma: A BEACON-Neuroblastoma biomarker study.
Predicting outcomes with circulating adrenergic neuroblastoma mRNAs in children with relapsed and refractory neuroblastoma: A BEACON-Neuroblastoma biomarker study. Open
10039 Background: Children with relapsed and refractory neuroblastoma (RR-NBL) have poor outcomes. Early identification of children at greatest risk of relapse could mean timelier modifications of treatment to improve outcomes. High levels…
View article: Mast cell density and its clinical relevance in Waldenström's macroglobulinemia
Mast cell density and its clinical relevance in Waldenström's macroglobulinemia Open
The presence of numerous mast cells (MCs) mixed with tumor cells in the bone marrow (BM) is a hallmark of the diagnosis of Waldenström's macroglobulinemia (WM). MCs have been shown to support lymphoplasmacytic cell growth, but there is thu…
View article: Vasculitis associated with myelodysplastic syndrome and chronic myelomonocytic leukemia: French multicenter case-control study
Vasculitis associated with myelodysplastic syndrome and chronic myelomonocytic leukemia: French multicenter case-control study Open
View article: Sensitive and specific detection of Ewing sarcoma minimal residual disease in ovarian and testicular tissues
Sensitive and specific detection of Ewing sarcoma minimal residual disease in ovarian and testicular tissues Open
International audience
View article: Sensitive and Specific Detection of Ewing Sarcoma Minimal Residual Disease in Ovarian and Testicular Tissues in an In Vitro Model
Sensitive and Specific Detection of Ewing Sarcoma Minimal Residual Disease in Ovarian and Testicular Tissues in an In Vitro Model Open
Ewing sarcoma (EWS) is a common pediatric solid tumor with high metastatic potential. Due to toxic effects of treatments on reproductive functions, the cryopreservation of ovarian tissue (OT) or testicular tissue (TT) is recommended to pre…
View article: Outcome and impact of post‐remission strategy after MIDAM regimen in patients with relapsing or refractory acute myeloid leukemia
Outcome and impact of post‐remission strategy after MIDAM regimen in patients with relapsing or refractory acute myeloid leukemia Open
International audience
View article: Event‐free survival of infants and toddlers enrolled in the HR‐NBL‐1/SIOPEN trial is associated with the level of neuroblastoma mRNAs at diagnosis
Event‐free survival of infants and toddlers enrolled in the HR‐NBL‐1/SIOPEN trial is associated with the level of neuroblastoma mRNAs at diagnosis Open
Background The purpose of this study was to evaluate whether levels of neuroblastoma mRNAs in bone marrow and peripheral blood from stage M infants (≤12 months of age at diagnosis, MYCN amplified) and toddlers (between 12 and 18 months, an…
View article: <i>TERT</i> promoter status and gene copy number gains: effect on <i>TERT</i> expression and association with prognosis in breast cancer
<i>TERT</i> promoter status and gene copy number gains: effect on <i>TERT</i> expression and association with prognosis in breast cancer Open
Upregulation of the telomerase reverse transcriptase (TERT) gene in human cancers leads to telomerase activation, which contributes to the growth advantage and survival of tumor cells. Molecular mechanisms of TERT upregulatio…
View article: RT-qPCR for PHOX2B mRNA is a highly specific and sensitive method to assess neuroblastoma minimal residual disease in testicular tissue
RT-qPCR for PHOX2B mRNA is a highly specific and sensitive method to assess neuroblastoma minimal residual disease in testicular tissue Open
Neuroblastoma (NB) is the most common type of extracranial solid tumor in children with a high prevalence in toddlers. For childhood cancer survivors, preservation of reproductive potential is an important factor for quality of life. The o…
View article: Telomeres and Genomic Instability from Precancerous Lesions to Advanced Cancer – Understanding Through Ovarian Cancer
Telomeres and Genomic Instability from Precancerous Lesions to Advanced Cancer – Understanding Through Ovarian Cancer Open
Genetic instability plays an important role in ovarian carcinogenesis. Genetic instability is one of the characteristics shared by most human cancers and seems to exist (at various levels) at all stages of the disease, from precancerous le…
View article: Telomere status in chronic lymphocytic leukemia with <i>TP53</i> disruption
Telomere status in chronic lymphocytic leukemia with <i>TP53</i> disruption Open
In chronic lymphocytic leukemia (CLL), telomere dysfunction is associated with poor outcomes. TP53 is involved in cellular responses to dysfunctional telomeres, and its inactivation is the strongest adverse prognostic factor for CLL. Given…
View article: Different dose rate-dependent responses of human melanoma cells and fibroblasts to low dose fast neutrons
Different dose rate-dependent responses of human melanoma cells and fibroblasts to low dose fast neutrons Open
Melanoma cells or fibroblasts exert their own survival behaviour at very low doses of neutrons, suggesting that in some cases there is a differential between cancer and normal cells radiation responses. Only the survival of fibroblasts at …
View article: ERCC1 and telomere status in breast tumours treated with neoadjuvant chemotherapy and their association with patient prognosis
ERCC1 and telomere status in breast tumours treated with neoadjuvant chemotherapy and their association with patient prognosis Open
Dysfunctional telomeres and DNA damage repair (DDR) play important roles in cancer progression. Studies have reported correlations between these factors and tumour aggressiveness and clinical outcome in breast cancer. We studied the charac…
View article: Characterization by microarray and meiotic segregation study of a der(10)t(10;18) in a patient with infertility and normal phenotype
Characterization by microarray and meiotic segregation study of a der(10)t(10;18) in a patient with infertility and normal phenotype Open
International audience
View article: Highly efficient radiosensitization of human glioblastoma and lung cancer cells by a G-quadruplex DNA binding compound
Highly efficient radiosensitization of human glioblastoma and lung cancer cells by a G-quadruplex DNA binding compound Open