Andrej Fischer
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View article: Clonal Heterogeneity Influences the Fate of New Adaptive Mutations
Clonal Heterogeneity Influences the Fate of New Adaptive Mutations Open
The joint contribution of pre-existing and de novo genetic variation to clonal adaptation is poorly understood but essential to designing successful antimicrobial or cancer therapies. To address this, we evolve genetically diverse populati…
View article: Clonal heterogeneity influences the fate of new adaptive mutations
Clonal heterogeneity influences the fate of new adaptive mutations Open
In Brief Vázquez-García et al. examine the role of clonal heterogeneity in the acquisition of antimicrobial resistance. They report that pre-existing and de novo genetic variation jointly contribute to clonal evolution. By building a libra…
View article: Adenoma development in familial adenomatous polyposis and <i><scp>MUTYH</scp></i>‐associated polyposis: somatic landscape and driver genes
Adenoma development in familial adenomatous polyposis and <i><span>MUTYH</span></i>‐associated polyposis: somatic landscape and driver genes Open
Familial adenomatous polyposis ( FAP ) and MUTYH ‐associated polyposis ( MAP ) are inherited disorders associated with multiple colorectal adenomas that lead to a very high risk of colorectal cancer. The somatic mutations that drive adenom…
View article: The value of monitoring to control evolving populations
The value of monitoring to control evolving populations Open
Significance Evolution of drug resistance, as observed in bacteria, viruses, parasites, and cancer, is a key challenge for global health. We approach the problem using the mathematical concepts of stochastic optimal control to study what i…