Andrej Kral
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View article: Threshold-distance functions predict speech recognition with cochlear implants
Threshold-distance functions predict speech recognition with cochlear implants Open
Cochlear implantation shows unexplained outcome variability. Among the key factors affecting outcomes measured by speech understanding is the functional state of the auditory nerve and the amount of its degeneration due to hearing loss. In…
View article: Sensorimotor contingencies in congenital hearing loss: The critical first nine months
Sensorimotor contingencies in congenital hearing loss: The critical first nine months Open
In the recent two decades it became possible to compensate severe-to-profound hearing loss using cochlear implants (CIs). The data from implanted children demonstrate that hearing and language acquisition is well-possible within an early c…
View article: Vibrotactile speech cues are associated with enhanced auditory processing in middle and superior temporal gyri
Vibrotactile speech cues are associated with enhanced auditory processing in middle and superior temporal gyri Open
Combined auditory and tactile stimuli have been found to enhance speech-in-noise perception both in individuals with normal hearing and in those with hearing loss. While behavioral benefits of audio-tactile enhancements in speech understan…
View article: Cochlear health alters the polarity effect and spike-initiation sites in guinea pigs
Cochlear health alters the polarity effect and spike-initiation sites in guinea pigs Open
While cochlear implants (CIs) historically use cathodic-leading pulses for stimulation, studies in humans found that anodic-leading pulses are perceived louder than cathodic-leading ones. Modeling studies proposed that cathodic pulses exci…
View article: Limitations on Temporal Processing by Cochlear Implant Users: A Compilation of Viewpoints
Limitations on Temporal Processing by Cochlear Implant Users: A Compilation of Viewpoints Open
Cochlear implant (CI) users are usually poor at using timing information to detect changes in either pitch or sound location. This deficit occurs even for listeners with good speech perception and even when the speech processor is bypassed…
View article: Surgical Transcanal Procedure for Injection of Cells and Substances into the Human Cochlear Modiolus
Surgical Transcanal Procedure for Injection of Cells and Substances into the Human Cochlear Modiolus Open
Introduction Cochlear implants (CIs) enhance hearing by stimulating spiral ganglion neurons (SGNs) but are less effective in individuals with compromised SGN functionality. Advances in regenerative medicine suggest that local delivery of m…
View article: Auditory working memory in noise in cochlear implant users: Insights from behavioural and neuronal measures
Auditory working memory in noise in cochlear implant users: Insights from behavioural and neuronal measures Open
These results suggest that alpha and theta show distinct relationships to behaviour, providing additional insight into neurocognitive (auditory working-memory) processes in CI users.
View article: An Electrically Evoked Compound Action Potential Marker for Local Spiral Ganglion Neuron Degeneration: The Failure Index
An Electrically Evoked Compound Action Potential Marker for Local Spiral Ganglion Neuron Degeneration: The Failure Index Open
Spiral ganglion neuron (SGN) degeneration is a candidate factor for reduced hearing outcomes in cochlear implant (CI) users. However, there is no procedure available to identify CI contacts close to focal SGN degeneration in human patients…
View article: Exploring the cognitive effects of hearing loss in adult rats: Implications for visuospatial attention, social behavior, and prefrontal neural activity
Exploring the cognitive effects of hearing loss in adult rats: Implications for visuospatial attention, social behavior, and prefrontal neural activity Open
Age-related hearing loss in humans has been associated with cognitive decline, though the underlying mechanisms remain unknown. We investigated the long-term effects of hearing loss on attention, impulse control, social interaction, and ne…
View article: Effects of Total Hip or Knee Arthroplasty on Median Survival in Patients Aged 80 Years and Older
Effects of Total Hip or Knee Arthroplasty on Median Survival in Patients Aged 80 Years and Older Open
total hip arthroplasty, total knee arthroplasty, osteoarthritis, hip fracture, life expectancy.
View article: The role of pressure and friction forces in automated insertion of cochlear implants
The role of pressure and friction forces in automated insertion of cochlear implants Open
Objectives Despite the success of cochlear implant (CI) surgery for hearing restoration, reducing CI electrode insertion forces is an ongoing challenge with the goal to further reduce post-implantation hearing loss. While research in this …
View article: Dissociated Representation of Binaural Cues in Single-Sided Deafness: Implications for Cochlear Implantation
Dissociated Representation of Binaural Cues in Single-Sided Deafness: Implications for Cochlear Implantation Open
Congenital single-sided deafness (SSD) leads to an aural preference syndrome that is characterized by overrepresentation of the hearing ear in the auditory system. Cochlear implantation (CI) of the deaf ear is an effective treatment for SS…
View article: Theta and alpha oscillatory signatures of auditory sensory and cognitive loads during complex listening
Theta and alpha oscillatory signatures of auditory sensory and cognitive loads during complex listening Open
The neuronal signatures of sensory and cognitive load provide access to brain activities related to complex listening situations. Sensory and cognitive loads are typically reflected in measures like response time (RT) and event-related pot…
View article: Tripolar configuration and pulse shape in cochlear implants reduce channel interactions in the temporal domain
Tripolar configuration and pulse shape in cochlear implants reduce channel interactions in the temporal domain Open
The present study investigates effects of current focusing and pulse shape on threshold, dynamic range, spread of excitation and channel interaction in the time domain using cochlear implant stimulation. The study was performed on 20 adult…
View article: Automatic Landmark Localization in 3D Medical CT Images: Few-Shot Learning through Optimized Data Pre-Processing and Network Design
Automatic Landmark Localization in 3D Medical CT Images: Few-Shot Learning through Optimized Data Pre-Processing and Network Design Open
As surgeons increasingly rely on computed tomography (CT) scans, including low-dose cone beam CT, it has become critical to effectively understand and annotate these medical images, not only for improved treatment planning, but also for ro…
View article: The relation between implicit statistical learning and proactivity as revealed by EEG
The relation between implicit statistical learning and proactivity as revealed by EEG Open
Environmental events often occur on a probabilistic basis but can sometimes be predicted based on specific cues and thus approached proactively. Incidental statistical learning enables the acquisition of knowledge about probabilistic cue-t…
View article: Hearing loss in juvenile rats leads to excessive play fighting and hyperactivity, mild cognitive deficits and altered neuronal activity in the prefrontal cortex
Hearing loss in juvenile rats leads to excessive play fighting and hyperactivity, mild cognitive deficits and altered neuronal activity in the prefrontal cortex Open
Background In children, hearing loss has been associated with hyperactivity, disturbed social interaction, and risk of cognitive disturbances. Mechanistic explanations of these relations sometimes involve language. To investigate the effec…
View article: Stability of complex sound representations in the auditory midbrain across the lifespan despite age-related brainstem delays
Stability of complex sound representations in the auditory midbrain across the lifespan despite age-related brainstem delays Open
The extent to which aging of the central auditory pathway impairs auditory perception in the elderly independent of peripheral cochlear decline is debated. To cause auditory deficits in normal hearing elderly, central aging needs to degrad…
View article: Crossmodal plasticity in hearing loss
Crossmodal plasticity in hearing loss Open
Crossmodal plasticity is a textbook example of the ability of the brain to reorganize based on use. We review evidence from the auditory system showing that such reorganization has significant limits, is dependent on pre-existing circuitry…
View article: Virtual cochlear implantation for personalized rehabilitation of profound hearing loss
Virtual cochlear implantation for personalized rehabilitation of profound hearing loss Open
In cochlear implantation, current preoperative planning procedures allow for estimating how far a specific implant will reach into the inner ear of the patient, which is important to optimize hearing preservation and speech perception outc…
View article: Anodic Polarity Minimizes Facial Nerve Stimulation as a Side Effect of Cochlear Implantation
Anodic Polarity Minimizes Facial Nerve Stimulation as a Side Effect of Cochlear Implantation Open
One severe side effect of the use of cochlear implants (CI) is coincidental facial nerve stimulation (FNS). Clinical methods to alleviate FNS range from the reprogramming of processor settings to revision surgery. We systematically assesse…
View article: Stability of neural representations in the auditory midbrain across the lifespan despite age-related brainstem delays
Stability of neural representations in the auditory midbrain across the lifespan despite age-related brainstem delays Open
The extent to which aging of the central auditory pathway impairs auditory perception in the elderly independent of peripheral cochlear decline is debated. To cause auditory deficits in normal hearing elderly, central aging needs to degrad…
View article: Processing of auditory information in forebrain regions after hearing loss in adulthood: Behavioral and electrophysiological studies in a rat model
Processing of auditory information in forebrain regions after hearing loss in adulthood: Behavioral and electrophysiological studies in a rat model Open
Background Hearing loss was proposed as a factor affecting development of cognitive impairment in elderly. Deficits cannot be explained primarily by dysfunctional neuronal networks within the central auditory system. We here tested the imp…