Andreja Erman
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View article: P.104 A portrait of generalized Myasthenia Gravis in Canada: analysis of the Adelphi MG II disease specific programme
P.104 A portrait of generalized Myasthenia Gravis in Canada: analysis of the Adelphi MG II disease specific programme Open
Background: Generalized myasthenia gravis (gMG) is a rare, chronic, autoimmune disease characterized by muscle weakness and fatigue. This study aims to describe the natural history, disease burden and treatment patterns of gMG patients in …
View article: The Effect of Tff3 Deficiency on the Liver of Mice Exposed to a High-Fat Diet
The Effect of Tff3 Deficiency on the Liver of Mice Exposed to a High-Fat Diet Open
Background/Objectives: Trefoil factor protein 3 (Tff3) is a small peptide known as an epithelial tissue-protective protein, and it is also identified as a novel participant in complex metabolic processes. In numerous mouse models of obesit…
View article: Trefoil Factor Protein 3 (TFF3) as a Guardian of the Urinary Bladder Epithelium
Trefoil Factor Protein 3 (TFF3) as a Guardian of the Urinary Bladder Epithelium Open
Summary Trefoil factor family (TFF) peptides have been examined primarily in the gastrointestinal tract, where they play an important role in the epithelial regeneration. The therapeutic effects of TFFs, particularly the TFF3 protein, have…
View article: D3 Interim results for Myasthenia Gravis-resource utilization, epidemiology, survival & treatment patterns (MG-REST) study in Ontario, Canada
D3 Interim results for Myasthenia Gravis-resource utilization, epidemiology, survival & treatment patterns (MG-REST) study in Ontario, Canada Open
Background: Reliable real-world data on the burden of MG is needed to inform Canadian clinical and policy decisions in the era of new MG therapeutics, including FcRn inhibitors. Given the lack of recent Canadian data on MG disease burden, …
View article: Sex-Dependent Differences in Blood–Urine Barrier Are Subtle but Significant in Healthy and Chronically Inflamed Mouse Bladders
Sex-Dependent Differences in Blood–Urine Barrier Are Subtle but Significant in Healthy and Chronically Inflamed Mouse Bladders Open
The urothelium is a vital permeability barrier that prevents the uncontrolled flow of urinary components into and out of the bladder interstitium. Our study addressed the question of possible sex-specific variations in the urothelium of he…
View article: Molecular Profiling of Inflammatory Processes in a Mouse Model of IC/BPS: From the Complete Transcriptome to Major Sex-Related Histological Features of the Urinary Bladder
Molecular Profiling of Inflammatory Processes in a Mouse Model of IC/BPS: From the Complete Transcriptome to Major Sex-Related Histological Features of the Urinary Bladder Open
Animal models are invaluable in the research of the pathophysiology of interstitial cystitis/bladder pain syndrome (IC/BPS), a chronic aseptic urinary bladder disease of unknown etiology that primarily affects women. Here, a mouse model of…
View article: Molecular and Cellular Markers in Chlorhexidine-Induced Peritoneal Fibrosis in Mice
Molecular and Cellular Markers in Chlorhexidine-Induced Peritoneal Fibrosis in Mice Open
Understanding the tissue changes and molecular mechanisms of preclinical models is essential for creating an optimal experimental design for credible translation into clinics. In our study, a chlorhexidine (CHX)-induced mouse model of peri…
View article: Comprehensive transcriptome profiling of urothelial cells following TNFα stimulation in an in vitro interstitial cystitis/bladder pain syndrome model
Comprehensive transcriptome profiling of urothelial cells following TNFα stimulation in an in vitro interstitial cystitis/bladder pain syndrome model Open
Urothelial cells of the urinary bladder play a critical role in the development and progression of interstitial cystitis/bladder pain syndrome (IC/BPS), a chronic and debilitating inflammatory disease. Given the lack of data on the exact p…
View article: Cobalt Ferrite Magnetic Nanoparticles for Tracing Mesenchymal Stem Cells in Tissue: A Preliminary Study
Cobalt Ferrite Magnetic Nanoparticles for Tracing Mesenchymal Stem Cells in Tissue: A Preliminary Study Open
Therapy with mesenchymal stem cells (MSCs) is promising in many diseases. Evaluation of their efficacy depends on adequate follow-up of MSCs after transplantation. Several studies have shown that MSCs can be labeled and subsequently visual…
View article: Oleic Acid Protects Endothelial Cells from Silica-Coated Superparamagnetic Iron Oxide Nanoparticles (SPIONs)-Induced Oxidative Stress and Cell Death
Oleic Acid Protects Endothelial Cells from Silica-Coated Superparamagnetic Iron Oxide Nanoparticles (SPIONs)-Induced Oxidative Stress and Cell Death Open
Superparamagnetic iron oxide nanoparticles (SPIONs) have great potential for use in medicine, but they may cause side effects due to oxidative stress. In our study, we investigated the effects of silica-coated SPIONs on endothelial cells a…
View article: Lectins as Biomarkers of IC/BPS Disease: A Comparative Study of Glycosylation Patterns in Human Pathologic Urothelium and IC/BPS Experimental Models
Lectins as Biomarkers of IC/BPS Disease: A Comparative Study of Glycosylation Patterns in Human Pathologic Urothelium and IC/BPS Experimental Models Open
Pathophysiology of interstitial cystitis/bladder pain syndrome (IC/BPS) remains poorly understood, as well as its effective diagnosis and therapy. Studying changes in tissue glycosylation patterns under pathological conditions is a promisi…
View article: Just Seeing Is Not Enough for Believing: Immunolabelling as Indisputable Proof of SARS-CoV-2 Virions in Infected Tissue
Just Seeing Is Not Enough for Believing: Immunolabelling as Indisputable Proof of SARS-CoV-2 Virions in Infected Tissue Open
Background: There is increasing evidence that identification of SARS-CoV-2 virions by transmission electron microscopy could be misleading due to the similar morphology of virions and ubiquitous cell structures. This study thus aimed to es…
View article: A Systematic Review of Therapeutic Approaches Used in Experimental Models of Interstitial Cystitis/Bladder Pain Syndrome
A Systematic Review of Therapeutic Approaches Used in Experimental Models of Interstitial Cystitis/Bladder Pain Syndrome Open
Interstitial cystitis/bladder pain syndrome (IC/BPS) is a multifactorial, chronic bladder disorder with limited therapeutic options currently available. The present review provides an extensive overview of therapeutic approaches used in in…
View article: How Cancer Cells Invade Bladder Epithelium and Form Tumors: The Mouse Bladder Tumor Model as a Model of Tumor Recurrence in Patients
How Cancer Cells Invade Bladder Epithelium and Form Tumors: The Mouse Bladder Tumor Model as a Model of Tumor Recurrence in Patients Open
Non-muscle-invasive bladder cancer is the most common form of bladder cancer. The main problem in managing bladder tumors is the high recurrence after the transurethral resection of bladder tumors (TURBT). Our study aimed to examine the fa…
View article: Does the Urothelium of Old Mice Regenerate after Chitosan Injury as Quickly as the Urothelium of Young Mice?
Does the Urothelium of Old Mice Regenerate after Chitosan Injury as Quickly as the Urothelium of Young Mice? Open
The aging of organisms leads to a decreased ability of tissue to regenerate after injury. The regeneration of the bladder urothelium after induced desquamation with biopolymer chitosan has been studied in young mice but not in old mice. Ch…
View article: Characterization of Plasma-Derived Small Extracellular Vesicles Indicates Ongoing Endothelial and Platelet Activation in Patients with Thrombotic Antiphospholipid Syndrome
Characterization of Plasma-Derived Small Extracellular Vesicles Indicates Ongoing Endothelial and Platelet Activation in Patients with Thrombotic Antiphospholipid Syndrome Open
Antiphospholipid syndrome (APS) is a systemic autoimmune disease, characterized by thrombosis, obstetric complications and the presence of antiphospholipid antibodies (aPL), which drive endothelial injury and thrombophilia. Extracellular v…
View article: Poly-L-lysine as an Effective and Safe Desquamation Inducer of Urinary Bladder Epithelium
Poly-L-lysine as an Effective and Safe Desquamation Inducer of Urinary Bladder Epithelium Open
Induced desquamation of urinary bladder epithelial cells, also called urothelial cells, is frequently used in studies of bladder epithelial regeneration and also in treating recurrent bacterial cystitis. Positively charged polymer chitosan…
View article: The Use of Polymer Chitosan in Intravesical Treatment of Urinary Bladder Cancer and Infections
The Use of Polymer Chitosan in Intravesical Treatment of Urinary Bladder Cancer and Infections Open
The most frequent diseases of the urinary bladder are bacterial infections and bladder cancers. For both diseases, very high recurrence rates are characteristic: 50–80% for bladder cancer and more than 50% for bladder infections, causing l…
View article: ADHD, Lifestyles and Comorbidities: A Call for an Holistic Perspective – from Medical to Societal Intervening Factors
ADHD, Lifestyles and Comorbidities: A Call for an Holistic Perspective – from Medical to Societal Intervening Factors Open
The review examines Attention Deficit Hyperactivity Disorder (ADHD in its Child and Adult form) and its various presentations (Hyperactive Impulsive, Inattentive, and Combined) with a particular focus on environmental (incl. social factors…
View article: Harmful at non-cytotoxic concentrations: SiO<sub>2</sub>-SPIONs affect surfactant metabolism and lamellar body biogenesis in A549 human alveolar epithelial cells
Harmful at non-cytotoxic concentrations: SiO<sub>2</sub>-SPIONs affect surfactant metabolism and lamellar body biogenesis in A549 human alveolar epithelial cells Open
The pulmonary delivery of nanoparticles (NPs) is a promising approach in nanomedicine. For the efficient and safe use of inhalable NPs, understanding of NP interference with lung surfactant metabolism is needed. Lung surfactant is predomin…
View article: Repeated treatments with chitosan in combination with antibiotics completely eradicate uropathogenic <i>Escherichia coli</i> from infected mouse urinary bladders
Repeated treatments with chitosan in combination with antibiotics completely eradicate uropathogenic <i>Escherichia coli</i> from infected mouse urinary bladders Open
Uropathogenic Escherichia coli (UPEC), the primary causative agents of urinary tract infections, colonize and invade the epithelial cells of the bladder urothelium. Infection of immature urothelial cells can result in the formation of pers…
View article: Improved Protective Effect of Umbilical Cord Stem Cell Transplantation on Cisplatin‐Induced Kidney Injury in Mice Pretreated with Antithymocyte Globulin
Improved Protective Effect of Umbilical Cord Stem Cell Transplantation on Cisplatin‐Induced Kidney Injury in Mice Pretreated with Antithymocyte Globulin Open
Mesenchymal stem cells (MSCs) are recognised as a promising tool to improve renal recovery in experimental models of cisplatin‐induced acute kidney injury. However, these preclinical studies were performed on severely immunodeficient anima…
View article: Electron micrographs of lipofuscin in superficial cells of aging mice urothelium.
Electron micrographs of lipofuscin in superficial cells of aging mice urothelium. Open
(a) Ultrastructural appearance of lipofuscin granules (arrowheads), heterogeneous in their size and structure. (b) Lipofuscin surrounded by double membrane (arrowheads), indicating that the structure is an early autophagic vacuole (autopha…
View article: Immunolabeling of Ki-67, active caspase 3, uroplakins and cytokeratin 20 in aging mice urothelium.
Immunolabeling of Ki-67, active caspase 3, uroplakins and cytokeratin 20 in aging mice urothelium. Open
(a) Individual Ki-67 positive cells with red fluorescent signal (asterisk) are present in the urothelium of aging mice. Nuclei are stained with DAPI (blue). Arrows show lipofuscin granules. (b) No apoptotic cells (red fluorescence) were de…