Andres Kaech
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View article: Coordination between ESCRT function and Rab conversion during endosome maturation
Coordination between ESCRT function and Rab conversion during endosome maturation Open
The endosomal pathway is essential for regulating cell signaling and cellular homeostasis. Rab5 positive early endosomes receive proteins from the plasma membrane. Dependent on a ubiquitin mark on the protein, they will be either recycled …
View article: Astrocytes adopt a progenitor-like migratory strategy for regeneration in adult brain
Astrocytes adopt a progenitor-like migratory strategy for regeneration in adult brain Open
Mature astrocytes become activated upon non-specific tissue damage and contribute to glial scar formation. Proliferation and migration of adult reactive astrocytes after injury is considered very limited. However, the regenerative behavior…
View article: Coordination between ESCRT function and Rab conversion during endosome maturation
Coordination between ESCRT function and Rab conversion during endosome maturation Open
The endosomal pathway is essential for regulating cell signaling and cellular homeostasis. Rab5-positive early endosomes receive proteins from the plasma membrane. Dependent on a ubiquitin mark on the protein, they will be either recycled …
View article: Saddles as rotational locks within shape-assisted self-assembled nanosheets
Saddles as rotational locks within shape-assisted self-assembled nanosheets Open
Two-dimensional (2D) materials are a key target for many applications in the modern day. Self-assembly is one approach that can bring us closer to this goal, which usually relies upon strong, directional interactions instead of covalent bo…
View article: Insights into energy balance dysregulation from a mouse model of methylmalonic aciduria
Insights into energy balance dysregulation from a mouse model of methylmalonic aciduria Open
Inherited disorders of mitochondrial metabolism, including isolated methylmalonic aciduria, present unique challenges to energetic homeostasis by disrupting energy-producing pathways. To better understand global responses to energy shortag…
View article: Saddles as rotational locks within shape-assisted self-assembled nanosheets
Saddles as rotational locks within shape-assisted self-assembled nanosheets Open
Two-dimensional (2D) materials are a key target for many applications in the modern day. Self-assembly is one approach that can bring us closer to this goal, which usually relies upon strong, directional interactions instead of covalent bo…
View article: Detection of silver nanoparticles inside leaf of European beech (Fagus sylvatica L.)
Detection of silver nanoparticles inside leaf of European beech (Fagus sylvatica L.) Open
In a greenhouse experiment, silver nanoparticles (Ag-NPs) were applied on European beech ( Fagus sylvatica L.) leaves using the droplet application method. Scanning electron microscopy (SEM) analyses showed that after 24 h silver nanoparti…
View article: Spatiotemporal organisation of protein processing in the kidney
Spatiotemporal organisation of protein processing in the kidney Open
View article: ER-misfolded proteins become sequestered with mitochondria and impair mitochondrial function
ER-misfolded proteins become sequestered with mitochondria and impair mitochondrial function Open
View article: Insights into energy balance dysregulation from a mouse model of methylmalonic aciduria
Insights into energy balance dysregulation from a mouse model of methylmalonic aciduria Open
Inherited disorders of mitochondrial metabolism, including isolated methylmalonic aciduria (MMAuria), present unique challenges to energetic homeostasis by disrupting energy producing pathways. To better understand global responses to ener…
View article: Characterization of Deposits in Calcific Tendinitis of the Shoulder: Deposits Are Composed of Large Aggregates of Highly Crystalline, Rod-Like Crystals
Characterization of Deposits in Calcific Tendinitis of the Shoulder: Deposits Are Composed of Large Aggregates of Highly Crystalline, Rod-Like Crystals Open
Background: In the current literature, deposits in calcific tendinitis are described as amorphous masses of hydroxyapatite with a size in the range of 5 to 20 μm. Theoretically, these are too big to be phagocytized by macrophages and induc…
View article: Imaging of retina cellular and subcellular structures using ptychographic hard X-ray tomography
Imaging of retina cellular and subcellular structures using ptychographic hard X-ray tomography Open
Ptychographic hard X-ray computed tomography (PXCT) is a recent method allowing imaging with quantitative electron-density contrast. Here, we imaged, at cryogenic temperature and without sectioning, cellular and subcellular structures of a…
View article: The <i>Caenorhabditis elegans</i> Patched domain protein PTR-4 is required for proper organization of the precuticular apical extracellular matrix
The <i>Caenorhabditis elegans</i> Patched domain protein PTR-4 is required for proper organization of the precuticular apical extracellular matrix Open
The Patched-related superfamily of transmembrane proteins can transport lipids or other hydrophobic molecules across cell membranes. While the Hedgehog receptor Patched has been intensively studied, much less is known about the biological …
View article: Patched regulates lipid homeostasis by controlling cellular cholesterol levels
Patched regulates lipid homeostasis by controlling cellular cholesterol levels Open
Hedgehog (Hh) signaling is essential during development and in organ physiology. In the canonical pathway, Hh binding to Patched (PTCH) relieves the inhibition of Smoothened (SMO). Yet, PTCH may also perform SMO-independent functions. Whil…
View article: Quorum sensing governs a transmissive <i>Legionella</i> subpopulation at the pathogen vacuole periphery
Quorum sensing governs a transmissive <i>Legionella</i> subpopulation at the pathogen vacuole periphery Open
View article: Mitochondrial damage in renal epithelial cells is potentiated by protein exposure in propionic aciduria
Mitochondrial damage in renal epithelial cells is potentiated by protein exposure in propionic aciduria Open
Propionic aciduria (PA) is caused by deficiency of the mitochondrial enzyme propionyl‐CoA carboxylase (PCC). Due to inefficient propionate catabolism patients are endangered by life‐threatening ketoacidotic crisis. Protein and amino acid r…
View article: The<i>C. elegans</i>PTCHD homolog PTR-4 is required for proper organization of the pre-cuticular apical extracellular matrix
The<i>C. elegans</i>PTCHD homolog PTR-4 is required for proper organization of the pre-cuticular apical extracellular matrix Open
The Patched-related (PTR) superfamily of transmembrane proteins can transport lipids or other hydrophobic molecules across cell membranes. While the hedgehog receptor Patched has been intensively studied, much less is known about the biolo…
View article: Defective lysosomal storage in Fabry disease modifies mitochondrial structure, metabolism and turnover in renal epithelial cells
Defective lysosomal storage in Fabry disease modifies mitochondrial structure, metabolism and turnover in renal epithelial cells Open
Fabry disease (FD) is an X‐linked lysosomal storage disorder. Deficiency of the lysosomal enzyme alpha‐galactosidase (GLA) leads to accumulation of potentially toxic globotriaosylceramide (Gb3) on a multisystem level. Cardiac and cerebrova…
View article: <i>In vivo</i> active organometallic-containing antimycotic agents
<i>In vivo</i> active organometallic-containing antimycotic agents Open
Fungal infections represent a global problem and there is an urgent need for new drugs. In this work, we prepared four novel organometallic derivatives of the frontline antifungal drug fluconazole with very promising in vivo activity.
View article: Metabolism of HSAN1- and T2DM-associated 1-deoxy-sphingolipids inhibits the migration of fibroblasts
Metabolism of HSAN1- and T2DM-associated 1-deoxy-sphingolipids inhibits the migration of fibroblasts Open
View article: From Design to in Vivo Active Organometallic-Containing Antimycotic Agents
From Design to in Vivo Active Organometallic-Containing Antimycotic Agents Open
Fungal infections are an alarming global problem, most importantly for immunocompromised patients in a hospital environment. The appearance of multidrug resistance in several fungal species is a strong indication that alternative treatment…
View article: From Design to in Vivo Active Organometallic-Containing Antimycotic Agents
From Design to in Vivo Active Organometallic-Containing Antimycotic Agents Open
Fungal infections are an alarming global problem, most importantly for immunocompromised patients in a hospital environment. The appearance of multidrug resistance in several fungal species is a strong indication that alternative treatment…
View article: Facile generation of giant unilamellar vesicles using polyacrylamide gels
Facile generation of giant unilamellar vesicles using polyacrylamide gels Open
View article: Fenretinide induces a new form of dynamin-dependent cell death in pediatric sarcoma
Fenretinide induces a new form of dynamin-dependent cell death in pediatric sarcoma Open
View article: The iron chelator Deferasirox causes severe mitochondrial swelling without depolarization due to a specific effect on inner membrane permeability
The iron chelator Deferasirox causes severe mitochondrial swelling without depolarization due to a specific effect on inner membrane permeability Open
View article: Patched regulates lipid homeostasis by controlling cellular cholesterol levels
Patched regulates lipid homeostasis by controlling cellular cholesterol levels Open
Hedgehog (Hh) signaling is essential during development and in organ physiology. In the canonical pathway, Hh binding to Patched (PTCH) relieves the inhibition of Smoothened (SMO). Yet, PTCH may also perform SMO-independent functions. Whil…
View article: Nuclear envelope impairment is facilitated by the herpes simplex virus 1 Us3 kinase
Nuclear envelope impairment is facilitated by the herpes simplex virus 1 Us3 kinase Open
Background: Capsids of herpes simplex virus 1 (HSV-1) are assembled in the nucleus, translocated either to the perinuclear space by budding at the inner nuclear membrane acquiring tegument and envelope, or released to the cytosol in a “nak…
View article: MINA-1 and WAGO-4 are part of regulatory network coordinating germ cell death and RNAi in C. elegans
MINA-1 and WAGO-4 are part of regulatory network coordinating germ cell death and RNAi in C. elegans Open
View article: Nuclear envelope impairment is facilitated by the herpes simplex virus 1 Us3 kinase
Nuclear envelope impairment is facilitated by the herpes simplex virus 1 Us3 kinase Open
Nuclear pores elarge in cells infected with herpes simplex virus 1 (HSV-1). Capsids, which are assembled in the nucleus, may gain access to the cytosol through impared nuclear pores in addition to bdudding at the inner nuclear membrane. In…
View article: Direct imaging of uncoated biological samples enables correlation of super-resolution and electron microscopy data
Direct imaging of uncoated biological samples enables correlation of super-resolution and electron microscopy data Open
A simple method for imaging biological tissue samples by electron microscopy and its correlation with super-resolution light microscopy is presented. This room temperature protocol, based on protecting thin biological specimens with methyl…