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View article: Positive Airway Pressure Therapies and Oxygen Therapy in Obstructive Sleep Apnea (OSA): 5-Year Survival
Positive Airway Pressure Therapies and Oxygen Therapy in Obstructive Sleep Apnea (OSA): 5-Year Survival Open
Background: Obstructive sleep apnea (OSA) is a highly prevalent disorder associated with increased morbidity and mortality. Continuous positive airway pressure (CPAP) remains the first-line therapy, but its long-term effectiveness is limit…
View article: Remodelación inversa del ventrículo derecho en un paciente con hipertensión arterial pulmonar tras un trasplante pulmonar
Remodelación inversa del ventrículo derecho en un paciente con hipertensión arterial pulmonar tras un trasplante pulmonar Open
La hipertensión pulmonar es una enfermedad progresiva, que genera alta morbilidad y mortalidad, y que conduce a la dilatación, hipertrofia y disfunción del ventrículo derecho, así como a la insuficiencia tricúspide y a la desviación septal…
View article: Late-Onset Immune-Mediated Hepatotoxicity Induced by the Immune Checkpoint Inhibitor Pembrolizumab in Lung Cancer: A Case Report
Late-Onset Immune-Mediated Hepatotoxicity Induced by the Immune Checkpoint Inhibitor Pembrolizumab in Lung Cancer: A Case Report Open
View article: Everolimus-Induced Pulmonary Toxicity in a Lung Transplant Recipient: A Case Report
Everolimus-Induced Pulmonary Toxicity in a Lung Transplant Recipient: A Case Report Open
Drug-induced pneumonitis is a recognized yet often underdiagnosed complication of mammalian target of rapamycin (mTOR) inhibitors - immunosuppressive agents such as everolimus that block cellular proliferation pathways - particularly among…
View article: Dementia as a risk factor for 30-day mortality in community-acquired pneumonia in Colombia (CAP): A survival study
Dementia as a risk factor for 30-day mortality in community-acquired pneumonia in Colombia (CAP): A survival study Open
Background Community-acquired pneumonia (CAP) represents a significant clinical challenge, particularly in patients with comorbidities, such as dementia, which increases the risk of mortality and hospitalization. Despite its relevance, dem…
View article: Comorbidome and community-acquired pneumonia: Analysis by age, sex, and intensive care unit admission
Comorbidome and community-acquired pneumonia: Analysis by age, sex, and intensive care unit admission Open
Objective To evaluate the influence of age, sex, and the need for intensive care unit admission on the clinical outcomes of patients with community-acquired pneumonia (CAP), considering the impact of comorbidities such as cardiovascular di…
View article: Five-Year Survival and Associated Factors in COPD Patients in Colombia: A Retrospective Cohort Study
Five-Year Survival and Associated Factors in COPD Patients in Colombia: A Retrospective Cohort Study Open
The five-year survival rate in this cohort was 89.7%. Lower survival was observed in patients over 65 years of age, with heart failure, on home oxygen therapy, and with FEV1 ≤ 35%. A trend toward lower survival was identified in the GOLD g…
View article: Tomographic assessment of glenoid fossa morphology and position in symmetric and asymmetric patients
Tomographic assessment of glenoid fossa morphology and position in symmetric and asymmetric patients Open
Objective To assess positional and morphological characteristics of the glenoid fossa in patients with and without craniofacial asymmetry using cone-beam computed tomography (CBCT), and to identify structural adaptations associated with te…
View article: Tamizaje en cáncer de pulmón: estrategias de detección en pacientes fumadores y en no fumadores: una revisión exploratoria
Tamizaje en cáncer de pulmón: estrategias de detección en pacientes fumadores y en no fumadores: una revisión exploratoria Open
La detección temprana del cáncer de pulmón CP es fundamental para reducir la mortalidad, debido que permite diagnosticar la enfermedad en sus fases iniciales, cuando las opciones terapéuticas son más efectivas. En este contexto, la tomogra…
View article: Performance study of a new diagnostic questionnaire for (Chronic obstructive pulmonary disease) COPD with information on exposure to wood smoke, COPD-WS
Performance study of a new diagnostic questionnaire for (Chronic obstructive pulmonary disease) COPD with information on exposure to wood smoke, COPD-WS Open
Background: To determine the diagnostic performance of a new questionnaire (COPD-WS) that considers also exposure to wood smoke for diagnosing Chronic Obstructive Pulmonary Disease (COPD) in a Colombian population. Methods: A cross-section…
View article: Association between oxygen debt (DEOx) variability over time and clinical outcomes in critically ill COVID-19 patients: an observational study
Association between oxygen debt (DEOx) variability over time and clinical outcomes in critically ill COVID-19 patients: an observational study Open
DEOx variability in critically ill COVID-19 patients was significantly associated with IMV need and mortality. Higher DEOx values at ≤6h and persistent metabolic derangement beyond 24h correlated with worse outcomes.
View article: Incidental diagnosis of pulmonary tuberculosis in patients referred for diagnostic bronchoscopy or clinical follow-up due to malignant tumor disease: a cross-sectional study
Incidental diagnosis of pulmonary tuberculosis in patients referred for diagnostic bronchoscopy or clinical follow-up due to malignant tumor disease: a cross-sectional study Open
Introduction: Incidental pulmonary tuberculosis is unexpectedly diagnosed in patients without prior clinical suspicion, usually during investigations of other diseases. Few studies have been conducted on this type of diagnosis. Here, we de…
View article: Clinical and Procedural Characteristics of Patients Undergoing Endobronchial Ultrasound-Guided Transbronchial Mediastinal Cryobiopsy (CryoEBUS): A Descriptive Study in a Colombian Population
Clinical and Procedural Characteristics of Patients Undergoing Endobronchial Ultrasound-Guided Transbronchial Mediastinal Cryobiopsy (CryoEBUS): A Descriptive Study in a Colombian Population Open
Endobronchial ultrasound-guided transbronchial mediastinal cryobiopsy (CryoEBUS) is an emerging minimally invasive technique that provides larger, better-preserved samples compared to conventional needle aspiration, improving suitability f…
View article: Survival analysis in a high-altitude lung transplant program: insights from a real-life observational study
Survival analysis in a high-altitude lung transplant program: insights from a real-life observational study Open
View article: Association of hemodynamic and functional variables with pulmonary vasculopathy in lung transplant recipients living at high altitude: A retrospective study
Association of hemodynamic and functional variables with pulmonary vasculopathy in lung transplant recipients living at high altitude: A retrospective study Open
Objective Pulmonary hypertension is a heterogeneous syndrome with diverse underlying etiologies. This study aimed to evaluate the association between preoperative hemodynamic parameters—assessed by right heart catheterization (RHC) and tra…
View article: Characterization of the Population With Intermediate‐Risk Status in Pulmonary Arterial Hypertension: Patients in a Latin American Country: The CAPRI Registry
Characterization of the Population With Intermediate‐Risk Status in Pulmonary Arterial Hypertension: Patients in a Latin American Country: The CAPRI Registry Open
Pulmonary arterial hypertension (PAH) in intermediate‐risk patients poses a challenge for clinicians, particularly in determining the optimal timing for escalating pharmacological treatment. We conducted a multicenter cross‐sectional study…
View article: Optimizing diagnostic yield in pulmonary lesions: impact of combined sampling tools and EBUS-TBNA during radial EBUS
Optimizing diagnostic yield in pulmonary lesions: impact of combined sampling tools and EBUS-TBNA during radial EBUS Open
Background: Radial endobronchial ultrasound (r-EBUS) is a minimally invasive procedure used to evaluate pulmonary lesions suspicious of cancer. Current information on the effect of combining different sampling tools used during r-EBUS or t…
View article: Análisis de la supervivencia en un programa de trasplante pulmonar en alta altitud: conocimientos de un estudio observacional de la vida real
Análisis de la supervivencia en un programa de trasplante pulmonar en alta altitud: conocimientos de un estudio observacional de la vida real Open
Patients with pulmonary fibrosis with a N-UIP pattern demonstrated superior survival after 1 year of follow-up, while those with pulmonary fibrosis with a UIP pattern described the highest survival at the 5th year. COVID-19 decr…
View article: Long term survival and factors associated with mortality in patients with Community Acquired Pneumonia and COVID 19: A retrospective cohort study
Long term survival and factors associated with mortality in patients with Community Acquired Pneumonia and COVID 19: A retrospective cohort study Open
Introduction: Community acquired pneumonia (CAP) is a leading cause of infectious deaths globally (1). In the United States, the estimated incidence of CAP ranges from 106 cases to 164 cases per 10,000 inhabitants. The main objective of th…
View article: Raro caso de melioidosis en Colombia: neumonía adquirida en la comunidad, bacteriemia y choque séptico causado por Burkholderia pseudomallei
Raro caso de melioidosis en Colombia: neumonía adquirida en la comunidad, bacteriemia y choque séptico causado por Burkholderia pseudomallei Open
La melioidosis es una enfermedad tropical subdiagnosticada en muchas zonas geográficas. En Sudamérica, Colombia el segundo lugar con mayor frecuencia de reportes de melioidosis. Sus manifestaciones clínicas son inespecíficas, de allí que s…
View article: Comparison of the predictive capacity of the Alvarado and AIR scores in the diagnosis of acute appendicitis: A prospective study
Comparison of the predictive capacity of the Alvarado and AIR scores in the diagnosis of acute appendicitis: A prospective study Open
The Alvarado and AIR scores have a similar predictive capacity for acute appendicitis. The low cutoff points of the risk scales are related to greater diagnostic sensitivity of the disease.
View article: Mapping the comorbidome: A novel analysis of the associations between obstructive sleep apnea and its comorbidities in Colombia
Mapping the comorbidome: A novel analysis of the associations between obstructive sleep apnea and its comorbidities in Colombia Open
Introduction Obstructive sleep apnea (OSA) is linked to a complex network of comorbidities, including cardiovascular, metabolic, neurological, and oncological diseases. The comorbidome visually maps disease associations, highlighting the i…
View article: Survival rates at one and five years for patients with group 1 pulmonary arterial hypertension at high altitude: A retrospective cohort study
Survival rates at one and five years for patients with group 1 pulmonary arterial hypertension at high altitude: A retrospective cohort study Open
Objectives Group 1 pulmonary arterial hypertension (PAH) causes increased vascular resistance, right heart failure, and reduced survival. High-altitude PAH survival data are limited despite chronic hypoxia's potential impact on disease pro…
View article: Survival outcomes among hospitalized patients with dementia: a propensity score matching analysis
Survival outcomes among hospitalized patients with dementia: a propensity score matching analysis Open
View article: Role of the very low frequencies of the renal oxygen saturation signal in acute kidney injury in newborns with perinatal asphyxia
Role of the very low frequencies of the renal oxygen saturation signal in acute kidney injury in newborns with perinatal asphyxia Open
Objective Renal autoregulation, hemodynamic response, and endothelial dysfunction play significant roles in acute kidney injury (AKI) during perinatal asphyxia. A third mechanism of autoregulation, involving very low-frequency oscillations…
View article: CAD-Q (COPD-Asthma Differentiation Questionnaire): Performance of a new diagnostic score to differentiate between COPD and asthma in adults
CAD-Q (COPD-Asthma Differentiation Questionnaire): Performance of a new diagnostic score to differentiate between COPD and asthma in adults Open
The CAD-Q questionnaire effectively discriminated between COPD and asthma, outperforming previous tools. These findings support further research and refinement of diagnostic tools and call for validation in diverse clinical settings.
View article: Tacrolimus‐Related Posterior Reversible Encephalopathy Syndrome in a Postlung Transplant Patient: A Case Report
Tacrolimus‐Related Posterior Reversible Encephalopathy Syndrome in a Postlung Transplant Patient: A Case Report Open
We present the case of a 58‐year‐old woman with fibrotic hypersensitivity pneumonitis, without significant comorbidities, who developed posterior reversible encephalopathy syndrome (PRES) 7 days after a bilateral lung transplant. Initial s…
View article: Machine learning to predict extubation success using the spontaneous breathing trial, objective cough measurement, and diaphragmatic contraction velocity: Secondary analysis of the COBRE-US trial
Machine learning to predict extubation success using the spontaneous breathing trial, objective cough measurement, and diaphragmatic contraction velocity: Secondary analysis of the COBRE-US trial Open
Introduction Determining the optimal timing for extubation in critically ill patients is essential to prevent complications. Predictive models based on Machine Learning (ML) have proven effective in anticipating weaning success, thereby im…
View article: Comparison of the Predictive Capacity of Oxygenation Parameters, Oxygenation Indices, and CURB‐65 to Mortality, Mechanical Ventilation, and Vasopressor Support in Community‐Acquired Pneumonia at Different Altitudes
Comparison of the Predictive Capacity of Oxygenation Parameters, Oxygenation Indices, and CURB‐65 to Mortality, Mechanical Ventilation, and Vasopressor Support in Community‐Acquired Pneumonia at Different Altitudes Open
Background: Populations residing at high altitudes display distinct physiological adaptations that are essential for understanding respiratory diseases. However, there is limited research on how these adaptations affect the assessment and …
View article: Impact of Pulmonary Hypertension on Posttransplant Survival of Patients With Pulmonary Fibrosis at High Altitude: A Prospective Cohort Study
Impact of Pulmonary Hypertension on Posttransplant Survival of Patients With Pulmonary Fibrosis at High Altitude: A Prospective Cohort Study Open
Background: Pulmonary hypertension (PH) in patients undergoing lung transplantation (LT) for pulmonary fibrosis can impair lung function, reduce physical activity, and decrease survival. However, data on outcomes at 1 and 5 years of follow…