Jorge Sierra
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View article: Patrones de tratamiento en el mundo real y eficacia comparativa en pacientes no candidatos con leucemia mieloide aguda (CURRENT): resultados de la población Española
Patrones de tratamiento en el mundo real y eficacia comparativa en pacientes no candidatos con leucemia mieloide aguda (CURRENT): resultados de la población Española Open
View article: Precision targeting of CXCR4+ leukemia cells by a humanized MMAE-nanoconjugate in an AML mouse model
Precision targeting of CXCR4+ leukemia cells by a humanized MMAE-nanoconjugate in an AML mouse model Open
Acute myeloid leukemia (AML) presents major clinical challenges due to chemoresistance and high relapse rates, primarily driven by therapy-resistant leukemic stem cells (LSCs) within the bone marrow. To address this issue, we developed T22…
View article: Prevalence of <i>Fms‐Like Tyrosine Kinase 3 (FLT3)</i> Mutations in Patients With Acute Myeloid Leukaemia: A Systematic Literature Review and Meta‐Analysis
Prevalence of <i>Fms‐Like Tyrosine Kinase 3 (FLT3)</i> Mutations in Patients With Acute Myeloid Leukaemia: A Systematic Literature Review and Meta‐Analysis Open
Background Fms‐like tyrosine kinase 3 ( FLT3 ) mutations are associated with poor prognosis in patients with acute myeloid leukaemia (AML). Aims We conducted a systematic literature review and meta‐analyses of studies reporting FLT3 mutati…
View article: SGK1 repression by WT1 may confer a survival advantage to leukemic cells under stress conditions
SGK1 repression by WT1 may confer a survival advantage to leukemic cells under stress conditions Open
View article: Clinical complications and sociodemographic characteristics of pediatric patients with sickle cell anemia admitted to a Pediatric Intensive Care Unit in a level IV complexity hospital
Clinical complications and sociodemographic characteristics of pediatric patients with sickle cell anemia admitted to a Pediatric Intensive Care Unit in a level IV complexity hospital Open
View article: Outcomes within 100 days of hematopoietic cell transplantation in pediatric patients: Insights from an intensive care unit in Colombia
Outcomes within 100 days of hematopoietic cell transplantation in pediatric patients: Insights from an intensive care unit in Colombia Open
View article: Postoperative complications after central nervous system tumor resection in pediatric patients admitted to an intensive care unit in Colombia
Postoperative complications after central nervous system tumor resection in pediatric patients admitted to an intensive care unit in Colombia Open
View article: Prognostic value of measurable residual disease (MRD) for venetoclax in combination with hypomethylating agents in patients diagnosed with acute myeloid leukemia: validation of the ELN-2021 MRD recommendations
Prognostic value of measurable residual disease (MRD) for venetoclax in combination with hypomethylating agents in patients diagnosed with acute myeloid leukemia: validation of the ELN-2021 MRD recommendations Open
View article: Measurable Residual Disease in <i>UBTF</i>‐TD Adult Acute Myeloid Leukemia
Measurable Residual Disease in <i>UBTF</i>‐TD Adult Acute Myeloid Leukemia Open
View article: Fitness assessment in acute myeloid leukemia: recommendations from an expert panel on behalf of the European LeukemiaNet
Fitness assessment in acute myeloid leukemia: recommendations from an expert panel on behalf of the European LeukemiaNet Open
Fitness assessment in patients with acute myeloid leukemia (AML) is critical to deliver the right therapy to the right patient. Although several scoring systems are available to aid in determining fitness, the absence of validation studies…
View article: Virtual 3D models, augmented reality systems and virtual laparoscopic simulations in complicated pancreatic surgeries: state of art, future perspectives, and challenges
Virtual 3D models, augmented reality systems and virtual laparoscopic simulations in complicated pancreatic surgeries: state of art, future perspectives, and challenges Open
Pancreatic surgery is considered one of the most challenging interventions by many surgeons, mainly due to retroperitoneal location and proximity to key and delicate vascular structures. These factors make pancreatic resection a demanding …
View article: Real-life outcome after failure to venetoclax and hypomethylating-based therapy for acute myeloid leukemia
Real-life outcome after failure to venetoclax and hypomethylating-based therapy for acute myeloid leukemia Open
Not available.
View article: Diverse real-life outcomes after intensive risk-adapted therapy for 1034 AML patients from the CETLAM Group
Diverse real-life outcomes after intensive risk-adapted therapy for 1034 AML patients from the CETLAM Group Open
View article: Dietary Supplements for Weight Loss and Drug Interactions
Dietary Supplements for Weight Loss and Drug Interactions Open
Food supplements are used for a variety of purposes, one of which is weight reduction. As excess weight is a long-term condition, some supplements are expected to be used for long periods of time. The long-term use of these dietary supplem…
View article: Postoperative complications after central nervous system tumor resection in pediatric patients admitted to an intensive care unit in Colombia
Postoperative complications after central nervous system tumor resection in pediatric patients admitted to an intensive care unit in Colombia Open
Introduction Central nervous system (CNS) tumors are the second most prevalent malignant neoplasms in childhood, with surgical resection as the primary therapeutic approach. The immediate postoperative period following CNS tumor resection …
View article: Numerical Comparison of Three Rotors For Gravitational Water Vortex Turbine
Numerical Comparison of Three Rotors For Gravitational Water Vortex Turbine Open
Renewable energy sources have gained significant attention due to the increasing demand for clean energy production. The gravitational vortex turbine (GVT) is one of the emerging technologies in the field of renewable energy that has gaine…
View article: Outcomes within 100 days of hematopoietic cell transplantation in pediatric patients: insights from an intensive care unit in Colombia
Outcomes within 100 days of hematopoietic cell transplantation in pediatric patients: insights from an intensive care unit in Colombia Open
Introduction Hematopoietic cell transplantation (HCT) has become an essential therapeutic modality for pediatric patients with malignant and non-malignant conditions. Despite its effectiveness, many patients experience post-transplant comp…
View article: Outcomes with intensive treatment for acute myeloid leukemia: an analysis of two decades of data from the HARMONY Alliance
Outcomes with intensive treatment for acute myeloid leukemia: an analysis of two decades of data from the HARMONY Alliance Open
Since 2017, targeted therapies combined with conventional intensive chemotherapy have started to improve outcome of patients with acute myeloid leukemia (AML). However, even before these innovations outcomes with intensive chemotherapy hav…
View article: Genetic risk classification for adults with AML receiving less-intensive therapies: the 2024 ELN recommendations
Genetic risk classification for adults with AML receiving less-intensive therapies: the 2024 ELN recommendations Open
The European LeukemiaNet (ELN) genetic risk classifications were developed based on data from younger adults receiving intensive chemotherapy. Emerging analyses from patients receiving less-intensive therapies prompted a proposal for an EL…
View article: Numerical Simulation of Different Splitter Angles of a Pelton Bucket to Increase the Power Generated by The Pelton Wheel
Numerical Simulation of Different Splitter Angles of a Pelton Bucket to Increase the Power Generated by The Pelton Wheel Open
The efficiency of a Pelton turbine depends mostly on its geometry. A design with suitable dimensions, offers higher generation of energy. However, some of these dimensions are underappreciated because of their low influence. Therefore, thi…
View article: Preliminary results of the effect of music therapy treatment on anxiety, sadness, physical discomfort, mood, and quality of life in hospitalized onco-haematological patients
Preliminary results of the effect of music therapy treatment on anxiety, sadness, physical discomfort, mood, and quality of life in hospitalized onco-haematological patients Open
View article: Cord blood transplantation for AML: Comparable LFS in patients with de novo versus secondary AML in CR1, an ALWP/EBMT study
Cord blood transplantation for AML: Comparable LFS in patients with de novo versus secondary AML in CR1, an ALWP/EBMT study Open
Summary We investigated whether secondary versus de novo acute myeloid leukaemia (AML) would be associated with poor outcomes in adult acute AML patients in first complete remission (CR1) receiving unrelated cord blood transplantation (CBT…
View article: Midostaurin plus daunorubicin or idarubicin for young and older adults with <i>FLT3</i>-mutated AML: a phase 3b trial
Midostaurin plus daunorubicin or idarubicin for young and older adults with <i>FLT3</i>-mutated AML: a phase 3b trial Open
The pivotal RATIFY study demonstrated midostaurin (50 mg twice daily) with standard chemotherapy significantly reduced mortality in adult patients (<60 years) with newly diagnosed (ND) FLT3mut acute myeloid leukemia (AML). Considering t…
View article: P1534: MRNA-1273 SARS-COV-2 VACCINE IN RECENTLY TRANSPLANTED ALLOGENEIC HEMATOPOIETIC CELL TRANSPLANT RECIPIENTS: CELLULAR AND HUMORAL IMMUNE RESPONSES AND BOOSTER EFFECT
P1534: MRNA-1273 SARS-COV-2 VACCINE IN RECENTLY TRANSPLANTED ALLOGENEIC HEMATOPOIETIC CELL TRANSPLANT RECIPIENTS: CELLULAR AND HUMORAL IMMUNE RESPONSES AND BOOSTER EFFECT Open
Topic: 30. Infections in hematology (incl. supportive care/therapy) Background: Allogeneic hematopoietic stem cell transplant (HCT) recipients are at high risk of severe COVID-19 despite vaccination. Few studies have analyzed cellular resp…
View article: PB1923: NON-HEMATOLOGIC AUTOIMMUNE DISORDERS IN CLL: PREVALENCE AND PROGNOSTIC IMPACT IN A REAL-LIFE COHORT FROM A SINGLE-CENTRE
PB1923: NON-HEMATOLOGIC AUTOIMMUNE DISORDERS IN CLL: PREVALENCE AND PROGNOSTIC IMPACT IN A REAL-LIFE COHORT FROM A SINGLE-CENTRE Open
Topic: 6. Chronic lymphocytic leukemia and related disorders - Clinical Background: Chronic lymphocytic leukemia (CLL) is marked by severe immune dysfunction, which results in an increased risk of autoimmune disorders (AID). The associatio…
View article: mRNA-1273 SARS-CoV-2 vaccine in recently transplanted allogeneic hematopoietic cell transplant recipients: Dynamics of cellular and humoral immune responses and booster effect
mRNA-1273 SARS-CoV-2 vaccine in recently transplanted allogeneic hematopoietic cell transplant recipients: Dynamics of cellular and humoral immune responses and booster effect Open
View article: Survival improvement of patients with FLT3 mutated acute myeloid leukemia: results from a prospective 9 years cohort
Survival improvement of patients with FLT3 mutated acute myeloid leukemia: results from a prospective 9 years cohort Open
View article: Sequence matters: Total body irradiation (TBI)‐based myeloablative conditioning with post‐transplant cyclophosphamide may reduce the early nonrelapse mortality compared with pretransplant cyclophosphamide plus <scp>TBI</scp>
Sequence matters: Total body irradiation (TBI)‐based myeloablative conditioning with post‐transplant cyclophosphamide may reduce the early nonrelapse mortality compared with pretransplant cyclophosphamide plus <span>TBI</span> Open
Objectives High‐dose total body irradiation (TBI) is considered a cornerstone of myeloablative conditioning for allogeneic stem cell transplantation (allo‐SCT). We retrospectively compared the main outcomes of an HLA matched or 1‐allele mi…
View article: T22-PE24-H6 Nanotoxin Selectively Kills CXCR4-High Expressing AML Patient Cells In Vitro and Potently Blocks Dissemination In Vivo
T22-PE24-H6 Nanotoxin Selectively Kills CXCR4-High Expressing AML Patient Cells In Vitro and Potently Blocks Dissemination In Vivo Open
Despite advances in the development of targeted therapies for acute myeloid leukemia (AML), most patients relapse. For that reason, it is still necessary to develop novel therapies that improve treatment effectiveness and overcome drug res…
View article: Effect of Music Therapy Treatment on Hospitalized Onco-Hematological Patients’ Anxiety, Sadness, Physical Discomfort, Mood and Quality of Life
Effect of Music Therapy Treatment on Hospitalized Onco-Hematological Patients’ Anxiety, Sadness, Physical Discomfort, Mood and Quality of Life Open
Physical and psychological distress may be present when facing an onco-hematological diagnosis and undergoing complex therapies such as intensive chemotherapy, stem cell transplantation, and immunotherapy. Studies show the need for incorpo…