Andrew Forbes
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View article: Participant and facilitator perspectives on a psychoeducational intervention for individuals at risk of bipolar disorder
Participant and facilitator perspectives on a psychoeducational intervention for individuals at risk of bipolar disorder Open
Background Bipolar disorder often goes unrecognised for several years, leading to delayed treatment and negative outcomes. To help address this, we have developed a novel telehealth-based group psychoeducational and resilience enhancement …
View article: Structured light meets machine intelligence
Structured light meets machine intelligence Open
Structured light, where light is tailored in all its degrees of freedom, has shown tremendous power in unlocking new modalities of light, with its impact felt across dimensions, disciplines, and applications. This richly textured light com…
View article: Characterising anthelmintic resistance against benzimidazoles and macrocyclic lactones in gastrointestinal nematode populations of dairy cattle
Characterising anthelmintic resistance against benzimidazoles and macrocyclic lactones in gastrointestinal nematode populations of dairy cattle Open
Anthelmintic resistance in gastrointestinal nematode populations is endemic across all grazing livestock production systems, particularly in small ruminants, but also in cattle. In this study resistance in Cooperia oncophora and Ostertagia…
View article: Tranexamic Acid Timing and Mortality Impact After Trauma
Tranexamic Acid Timing and Mortality Impact After Trauma Open
The optimal therapeutic window for TXA after trauma may be within 90 minutes.
View article: 305. CT-152, A PRESCRIPTION DIGITAL THERAPEUTIC FOR MAJOR DEPRESSIVE DISORDER: A REAL-WORLD ANALYSIS OF DURABILITY OF TREATMENT EFFECT
305. CT-152, A PRESCRIPTION DIGITAL THERAPEUTIC FOR MAJOR DEPRESSIVE DISORDER: A REAL-WORLD ANALYSIS OF DURABILITY OF TREATMENT EFFECT Open
Background CT-152 is a US Food and Drug Administration cleared prescription digital therapeutic for treating patients with major depressive disorder (MDD) as an adjunct to antidepressant medication. The durability of CT-152 beyond the clin…
View article: 313. ADHERENCE AND ENGAGEMENT METRICS WITH THE NOVEL PRESCRIPTION DIGITAL THERAPEUTIC, CT-152
313. ADHERENCE AND ENGAGEMENT METRICS WITH THE NOVEL PRESCRIPTION DIGITAL THERAPEUTIC, CT-152 Open
Background Based on the results of the pivotal Mirai trial (NCT04770285), CT-152 received US Food and Drug administration clearance as a prescription digital therapeutic adjunct to antidepressant medication in patients with major depressiv…
View article: 306. EMOTIONAL FACES MEMORY TASK PERFORMANCE AND CLINICAL OUTCOMES FOR THE NOVEL PRESCRIPTION DIGITAL THERAPEUTIC, CT-152
306. EMOTIONAL FACES MEMORY TASK PERFORMANCE AND CLINICAL OUTCOMES FOR THE NOVEL PRESCRIPTION DIGITAL THERAPEUTIC, CT-152 Open
Background CT-152 received US Food and Drug Administration 510(k)-clearance as a prescription digital therapeutic adjunct to antidepressant medication in patients with major depressive disorder (MDD). CT-152 provides a novel mechanism of a…
View article: High-Resolution Ultrasound Data for AI-Based Segmentation in Mouse Brain Tumor
High-Resolution Ultrasound Data for AI-Based Segmentation in Mouse Brain Tumor Open
Glioblastoma multiforme (GBM) is the most aggressive type of brain cancer, making effective treatments essential to improve patient survival. To advance the understanding of GBM and develop more effective therapies, preclinical studies com…
View article: Balancing Efficiency and Accuracy in Hepatitis C Rapid Antibody Testing: Insights From a Cluster Randomised Crossover Trial
Balancing Efficiency and Accuracy in Hepatitis C Rapid Antibody Testing: Insights From a Cluster Randomised Crossover Trial Open
Hepatitis C remains a significant global health problem, particularly among people who inject drugs. To achieve Australia's 2030 elimination targets, efficient testing strategies are needed. The OraQuick rapid antibody test provides result…
View article: Platform trials: key features, when to use them and methodological challenges
Platform trials: key features, when to use them and methodological challenges Open
View article: A Bayesian approach to the survivor average causal effect in cluster-randomized crossover trials
A Bayesian approach to the survivor average causal effect in cluster-randomized crossover trials Open
In cluster-randomized crossover (CRXO) trials, groups of individuals are randomly assigned to two or more sequences of alternating treatments. Since clusters act as their own control, the CRXO design is typically more statistically efficie…
View article: Early Psychoeducational Intervention for Youth and Young Adults at Risk for Bipolar Disorder: A Feasibility Study: Intervention psychoéducative précoce pour les adolescents et les jeunes adultes à risque de trouble bipolaire : Une étude de faisabilité
Early Psychoeducational Intervention for Youth and Young Adults at Risk for Bipolar Disorder: A Feasibility Study: Intervention psychoéducative précoce pour les adolescents et les jeunes adultes à risque de trouble bipolaire : Une étude de faisabilité Open
Objective: Bipolar disorder (BD) often goes unrecognized and untreated for several years leading to serious consequences. We have recently developed a manualized telehealth-based group psychoeducational and resilience enhancement program f…
View article: Inference for the treatment effect in staircase designs with continuous outcomes: a simulation study
Inference for the treatment effect in staircase designs with continuous outcomes: a simulation study Open
Background Staircase designs are incomplete stepped wedge designs that, unlike standard stepped wedge designs, require clusters to contribute data for only a limited number of trial periods. Previous work has provided formulae based on asy…
View article: What is estimated in cluster randomized crossover trials with informative sizes? -- A survey of estimands and common estimators
What is estimated in cluster randomized crossover trials with informative sizes? -- A survey of estimands and common estimators Open
In the analysis of cluster randomized trials (CRTs), previous work has defined two meaningful estimands: the individual-average treatment effect (iATE) and cluster-average treatment effect (cATE) estimand, to address individual and cluster…
View article: Identifying Less Burdensome and More Cost‐Efficient Incomplete Stepped Wedge Designs for Continuous Outcomes Collected via Repeated Cross‐Sections
Identifying Less Burdensome and More Cost‐Efficient Incomplete Stepped Wedge Designs for Continuous Outcomes Collected via Repeated Cross‐Sections Open
Stepped wedge trials can be costly and burdensome. Recent work has investigated the iterative removal of cluster‐period cells from stepped wedge designs, producing a series of candidate incomplete designs that are less burdensome. We propo…
View article: Comprehensive geriatric assessment for frail older people with chronic kidney disease to increase attainment of patient-identified goals: Statistical analysis plan for a cluster-randomised controlled trial
Comprehensive geriatric assessment for frail older people with chronic kidney disease to increase attainment of patient-identified goals: Statistical analysis plan for a cluster-randomised controlled trial Open
ClinicalTrials.govNCT04538157.
View article: Guidelines for the content of statistical analysis plans in clinical trials: protocol for an extension to cluster randomized trials
Guidelines for the content of statistical analysis plans in clinical trials: protocol for an extension to cluster randomized trials Open
Background Guidance exists to inform the content of statistical analysis plans in clinical trials. Though not explicitly stated, this guidance is generally focused on clinical trials in which the randomization units are individual patients…
View article: The relative efficiency of staircase and stepped wedge cluster randomised trial designs
The relative efficiency of staircase and stepped wedge cluster randomised trial designs Open
The stepped wedge design is an appealing longitudinal cluster randomised trial design. However, it places a large burden on participating clusters by requiring all clusters to collect data in all periods of the trial. The staircase design …
View article: Interrupted time series datasets from studies investigating the impact of interventions or exposures in public health and social science: a data note
Interrupted time series datasets from studies investigating the impact of interventions or exposures in public health and social science: a data note Open
Objectives The interrupted time series (ITS) design is commonly used to investigate the impact of an intervention or exposure in public health. There are many statistical methods that can be used to analyse ITS data and to meta-analyse the…
View article: Reporting of cluster randomised crossover trials: extension of the CONSORT 2010 statement with explanation and elaboration
Reporting of cluster randomised crossover trials: extension of the CONSORT 2010 statement with explanation and elaboration Open
This article presents the CONSORT (consolidated standards of reporting trials) extension for cluster randomised crossover trials. A cluster randomised crossover trial involves randomisation of groups of individuals (known as clusters) to d…
View article: Rapid Skull Decalcification for Improved Ultrasound Transmission in Brain Imaging and Histotripsy: A Proof-of-Concept Study in Rat
Rapid Skull Decalcification for Improved Ultrasound Transmission in Brain Imaging and Histotripsy: A Proof-of-Concept Study in Rat Open
View article: The Performance of Small Sample Correction Methods for Controlling Type I Error When Analysing Parallel Cluster Randomised Trials: A Systematic Review of Simulation Studies
The Performance of Small Sample Correction Methods for Controlling Type I Error When Analysing Parallel Cluster Randomised Trials: A Systematic Review of Simulation Studies Open
View article: Investigation of reporting bias in interrupted time series (ITS) studies: a study protocol
Investigation of reporting bias in interrupted time series (ITS) studies: a study protocol Open
Background Interrupted time-series (ITS) studies are commonly used to examine the effects of interventions targeted at populations. Suppression of ITS studies or results within these studies, known as reporting bias, has the potential to b…
View article: Roadmap on computational methods in optical imaging and holography [invited]
Roadmap on computational methods in optical imaging and holography [invited] Open
Computational methods have been established as cornerstones in optical imaging and holography in recent years. Every year, the dependence of optical imaging and holography on computational methods is increasing significantly to the extent …
View article: A simple and effective method for simulating nested exchangeable correlated binary data for longitudinal cluster randomised trials
A simple and effective method for simulating nested exchangeable correlated binary data for longitudinal cluster randomised trials Open
View article: Same-visit hepatitis C testing and treatment to accelerate cure among people who inject drugs (the QuickStart Study): a cluster randomised cross-over trial protocol
Same-visit hepatitis C testing and treatment to accelerate cure among people who inject drugs (the QuickStart Study): a cluster randomised cross-over trial protocol Open
Introduction Despite universal access to government-funded direct-acting antivirals (DAAs) in 2016, the rate of hepatitis C treatment uptake in Australia has declined substantially. Most hepatitis C is related to injecting drug use; reduci…
View article: Inefficacy of ivermectin and moxidectin treatments against <i>Dictyocaulus viviparus</i> in dairy calves
Inefficacy of ivermectin and moxidectin treatments against <i>Dictyocaulus viviparus</i> in dairy calves Open
Background The bovine lungworm Dictyocaulus viviparus negatively impacts bovine health and leads to substantial economic losses. Lungworm infections can be difficult to manage due to the unpredictable and severe nature of clinical outbreak…
View article: Maintaining the validity of inference from linear mixed models in stepped-wedge cluster randomized trials under misspecified random-effects structures
Maintaining the validity of inference from linear mixed models in stepped-wedge cluster randomized trials under misspecified random-effects structures Open
Linear mixed models are commonly used in analyzing stepped-wedge cluster randomized trials. A key consideration for analyzing a stepped-wedge cluster randomized trial is accounting for the potentially complex correlation structure, which c…
View article: A longitudinal qualitative exploration of Victorian healthcare workers’ and organisations’ evolving views and experiences during COVID-19
A longitudinal qualitative exploration of Victorian healthcare workers’ and organisations’ evolving views and experiences during COVID-19 Open
Background The COVID-19 pandemic has profoundly impacted individuals, society, and healthcare organisations worldwide. Recent international research suggests that concerns, needs, and experiences of healthcare workers (HCWs) have evolved t…
View article: Reporting of cluster randomised crossover trials 2023: extension of the CONSORT 2010 statement with explanation and elaboration
Reporting of cluster randomised crossover trials 2023: extension of the CONSORT 2010 statement with explanation and elaboration Open
In this report we present the Consolidated Standards of Reporting Trials (CONSORT) extension for the cluster randomised crossover (CRXO) trial. A CRXO trial involves randomisation of groups of individuals (‘clusters’) to different sequence…