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View article: Real-world health status changes with mavacamten in symptomatic obstructive hypertrophic cardiomyopathy (oHCM) - Early findings from COMPASS-HCM
Real-world health status changes with mavacamten in symptomatic obstructive hypertrophic cardiomyopathy (oHCM) - Early findings from COMPASS-HCM Open
Background Pivotal clinical trials evaluating symptomatic patients with oHCM demonstrated significant improvements in symptoms, physical function, and quality of life with mavacamten. Whether such benefits occur in clinical practice is unk…
View article: Positioned at Extremes: Future Job Placements of Immigrant Students at U.S. Colleges
Positioned at Extremes: Future Job Placements of Immigrant Students at U.S. Colleges Open
View article: Preoperative Use of Liraglutide in Weight Loss Surgery: Limitations and Future Research
Preoperative Use of Liraglutide in Weight Loss Surgery: Limitations and Future Research Open
View article: Smartwatch bradycardia alarms leading to a diagnosis of lamin A/C cardiomyopathy: a case report
Smartwatch bradycardia alarms leading to a diagnosis of lamin A/C cardiomyopathy: a case report Open
Background Genetic aetiologies of early-onset arrhythmias and cardiomyopathy (CM) are common, but timely diagnosis requires a high index of suspicion. Case summary An asymptomatic 47-year-old man presented to cardiology clinic for smartwat…
View article: Trace-Based Reconstruction of Quantum Circuit Dataflow in Surface Codes
Trace-Based Reconstruction of Quantum Circuit Dataflow in Surface Codes Open
Practical applications of quantum computing depend on fault-tolerant devices that employ error correction. A promising quantum error-correcting code for large-scale quantum computing is the surface code. For this code, Fault-Tolerant Quant…
View article: Privacy Preserving Inference of Personalized Content for Out of Matrix Users
Privacy Preserving Inference of Personalized Content for Out of Matrix Users Open
Recommender systems for niche and dynamic communities face persistent challenges from data sparsity, cold start users and items, and privacy constraints. Traditional collaborative filtering and content-based approaches underperform in thes…
View article: Structural Effects of Low Social Status and Obesogenic Diet on Social and Emotional Neurocircuits in Female Macaques: A Longitudinal Study from Infancy to Adulthood
Structural Effects of Low Social Status and Obesogenic Diet on Social and Emotional Neurocircuits in Female Macaques: A Longitudinal Study from Infancy to Adulthood Open
A substantial body of literature has demonstrated a consistent link between psychosocial stress and obesity in children, particularly in those from low socioeconomic backgrounds. Despite evidence indicating a complex interplay between stre…
View article: A qualitative study of the family caregiver burden for caregivers of children with congenital cataracts from a social ecosystem theory perspective
A qualitative study of the family caregiver burden for caregivers of children with congenital cataracts from a social ecosystem theory perspective Open
Not applicable.
View article: El Agente: An autonomous agent for quantum chemistry
El Agente: An autonomous agent for quantum chemistry Open
Computational chemistry tools are widely used to study the behaviour of chemical phenomena. Yet, the complexity of these tools can make them inaccessible to non-specialists and challenging even for experts. In this work, we introduce El Ag…
View article: Causal relationships between mitochondrial DNA copy number and hypertensive disorders in pregnancy: A Mendelian randomization study
Causal relationships between mitochondrial DNA copy number and hypertensive disorders in pregnancy: A Mendelian randomization study Open
Introduction: The association between mitochondrial DNA (mtDNA) copy number and hypertensive disorders in pregnancy has been explored in several observational studies; however, due to methodological limitations and confounding factors, con…
View article: Breakpoint: Scalable evaluation of system-level reasoning in LLM code agents
Breakpoint: Scalable evaluation of system-level reasoning in LLM code agents Open
Benchmarks for large language models (LLMs) have predominantly assessed short-horizon, localized reasoning. Existing long-horizon suites (e.g. SWE-bench) rely on manually curated issues, so expanding or tuning difficulty demands expensive …
View article: Principled Out-of-Distribution Generalization via Simplicity
Principled Out-of-Distribution Generalization via Simplicity Open
Modern foundation models exhibit remarkable out-of-distribution (OOD) generalization, solving tasks far beyond the support of their training data. However, the theoretical principles underpinning this phenomenon remain elusive. This paper …
View article: Calcium Channel Blockers Increased the Risk of Aortic Aneurysm and Dissection
Calcium Channel Blockers Increased the Risk of Aortic Aneurysm and Dissection Open
Aortic aneurysm and dissection (AAD) are life-threatening conditions for which there is a lack of effective pharmacological therapies. Hypertension is a known risk factor for AAD, leading to the common prescription of antihypertensive medi…
View article: Correction to: Mavacamten in Patients With Hypertrophic Cardiomyopathy Referred for Septal Reduction: Week 128 Results from VALOR-HCM
Correction to: Mavacamten in Patients With Hypertrophic Cardiomyopathy Referred for Septal Reduction: Week 128 Results from VALOR-HCM Open
View article: Cardiometabolic multimorbidity and frailty in middle-aged and older adults: a cross-nationally harmonized study
Cardiometabolic multimorbidity and frailty in middle-aged and older adults: a cross-nationally harmonized study Open
Background Cardiometabolic diseases are prevalent among ageing populations and have a close association with frailty. However, the cumulative impact multiple cardiometabolic diseases have on frailty remains underexplored. Methods This stud…
View article: Associations between procedural volume, costs, and outcomes of septal reduction therapies for obstructive hypertrophic cardiomyopathy in US hospitals
Associations between procedural volume, costs, and outcomes of septal reduction therapies for obstructive hypertrophic cardiomyopathy in US hospitals Open
Resource utilization and in-hospital costs for patients undergoing SRT are lower in high procedural volume hospitals than low procedural volume hospitals. SRT procedure volume remains low even in hospitals with the highest relative procedu…
View article: The FACTS Grounding Leaderboard: Benchmarking LLMs' Ability to Ground Responses to Long-Form Input
The FACTS Grounding Leaderboard: Benchmarking LLMs' Ability to Ground Responses to Long-Form Input Open
We introduce FACTS Grounding, an online leaderboard and associated benchmark that evaluates language models' ability to generate text that is factually accurate with respect to given context in the user prompt. In our benchmark, each promp…
View article: Alfieri Stitch (Edge To Edge) in Degenerative Mitral Valve Repair: Characteristics and Late Durability in 648 Patients
Alfieri Stitch (Edge To Edge) in Degenerative Mitral Valve Repair: Characteristics and Late Durability in 648 Patients Open
Background: Mitral valve repair with the edge‐to‐edge technique (Alfieri stitch) has been described for over 20 years, yet little is published on late durability and potential risk of mitral stenosis remains controversial. The primary obje…
View article: Prognostic Implication of Left Ventricular Global Longitudinal Strain in Patients With Hypertrophic Cardiomyopathy and Coexisting Hypertension
Prognostic Implication of Left Ventricular Global Longitudinal Strain in Patients With Hypertrophic Cardiomyopathy and Coexisting Hypertension Open
Patients with HCM and coexisting hypertension were older, had more prevalent CV comorbidities, and exhibited a lower LV-GLS compared to those without hypertension. LV-GLS provides important prognostic information in patients with both HCM …
View article: El Agente: An Autonomous Agent for Quantum Chemistry
El Agente: An Autonomous Agent for Quantum Chemistry Open
View article: Association of Echocardiographic Parameters and Health Status in Patients With Obstructive Hypertrophic Cardiomyopathy: Insights From EXPLORER-HCM
Association of Echocardiographic Parameters and Health Status in Patients With Obstructive Hypertrophic Cardiomyopathy: Insights From EXPLORER-HCM Open
View article: Aficamten and Cardiopulmonary Exercise Test Performance
Aficamten and Cardiopulmonary Exercise Test Performance Open
Importance Impaired exercise capacity is a cardinal manifestation of obstructive hypertrophic cardiomyopathy (HCM). The Phase 3 Trial to Evaluate the Efficacy and Safety of Aficamten Compared to Placebo in Adults With Symptomatic Obstructi…
View article: Mavacamten-Associated Temporal Changes in Left Atrial Function in Obstructive HCM
Mavacamten-Associated Temporal Changes in Left Atrial Function in Obstructive HCM Open
In VALOR-HCM, mavacamten resulted in an improvement in LAVI and LA strain at week 56, suggesting sustained favorable LA remodeling and improved function, except in the atrial fibrillation subgroup. Whether the advantageous LA remodeling as…
View article: Long-term effect of mavacamten in obstructive hypertrophic cardiomyopathy
Long-term effect of mavacamten in obstructive hypertrophic cardiomyopathy Open
Background and Aims Long-term safety and efficacy of mavacamten in patients with obstructive hypertrophic cardiomyopathy (HCM) are unknown. MAVA-LTE (NCT03723655) is an ongoing, 5-year, open-label extension study designed to evaluate the l…
View article: Serial Changes in Ventricular Strain in Symptomatic Obstructive Hypertrophic Cardiomyopathy Treated With Mavacamten: Insights From the VALOR-HCM Trial
Serial Changes in Ventricular Strain in Symptomatic Obstructive Hypertrophic Cardiomyopathy Treated With Mavacamten: Insights From the VALOR-HCM Trial Open
BACKGROUND: In severely symptomatic patients with obstructive hypertrophic cardiomyopathy, VALOR-HCM (A Study to Evaluate Mavacamten in Adults With Symptomatic Obstructive Hypertrophic Cardiomyopathy Who Are Eligible for Septal Reduction T…
View article: Incidence and Risk Factors for Permanent Pacemaker Implantation After Tricuspid Valve Repair
Incidence and Risk Factors for Permanent Pacemaker Implantation After Tricuspid Valve Repair Open
View article: Functional maturation in visual pathways predicts attention to the eyes in infant rhesus macaques: Effects of social status
Functional maturation in visual pathways predicts attention to the eyes in infant rhesus macaques: Effects of social status Open
View article: CURRENT ROLE AND OUTCOMES OF BARBED SUTURES IN FASCIAL CLOSURE OF VENTRAL HERNIA REPAIR: A MULTICENTER STUDY USING THE ABDOMINAL CORE HEALTH QUALITY COLLABORATIVE DATABASE
CURRENT ROLE AND OUTCOMES OF BARBED SUTURES IN FASCIAL CLOSURE OF VENTRAL HERNIA REPAIR: A MULTICENTER STUDY USING THE ABDOMINAL CORE HEALTH QUALITY COLLABORATIVE DATABASE Open
Barbed sutures (BS) have been increasingly used in the last decades but little is known about their adoption in ventral hernia repair (VHR). The aim of this study was to document the use and outcomes of BS in VHR. Prospectively collected d…
View article: Long‐Term Safety and Efficacy of Mavacamten in Symptomatic Obstructive Hypertrophic Cardiomyopathy: Interim Results of the PIONEER‐OLE Study
Long‐Term Safety and Efficacy of Mavacamten in Symptomatic Obstructive Hypertrophic Cardiomyopathy: Interim Results of the PIONEER‐OLE Study Open
Background The phase 2 PIONEER‐HCM (Phase 2 Open‐label Pilot Study Evaluating Mavacamten in Subjects With Symptomatic Hypertrophic Cardiomyopathy and Left Ventricular Outflow Tract Obstruction) study showed that mavacamten improved left ve…
View article: AnaloBench: Benchmarking the Identification of Abstract and Long-context Analogies
AnaloBench: Benchmarking the Identification of Abstract and Long-context Analogies Open
Humans regularly engage in analogical thinking, relating personal experiences to current situations (X is analogous to Y because of Z). Analogical thinking allows humans to solve problems in creative ways, grasp difficult concepts, and art…