Andrew C. Chang
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View article: Improved outcomes with robotic-assisted laparoscopic paraesophageal hernia repairs compared with laparoscopic and transthoracic approaches: A single high-volume institution experience
Improved outcomes with robotic-assisted laparoscopic paraesophageal hernia repairs compared with laparoscopic and transthoracic approaches: A single high-volume institution experience Open
Robotic paraesophageal hernia repairs had generally lower 2-year recurrence and reoperation than lap and shorter hospital stays and fewer immediate complications than transthoracic.
View article: Nutrient-gene therapy as a strategy to enhance CAR T cell function and overcome barriers in the tumor microenvironment
Nutrient-gene therapy as a strategy to enhance CAR T cell function and overcome barriers in the tumor microenvironment Open
Cancer immunotherapy is transforming the treatment landscape of both hematological and solid cancers. Although T-cell-based adoptive cell transfer (ACT) therapies have demonstrated initial success, several recurrent obstacles limit their l…
View article: Maintenance Fluids for Late Preterm and Term Infants: Is it Time to Reconsider?
Maintenance Fluids for Late Preterm and Term Infants: Is it Time to Reconsider? Open
BACKGROUND Late preterm and term infants represent the majority of neonatal intensive care unit admissions globally, yet their fluid management remains underexplored. METHODS We conducted a retrospective medical record review of 174 infant…
View article: Dysregulated Proline Metabolism Contributes to Subretinal Fibrosis in Neovascular AMD: Therapeutic Potential of Prolyl-4-Hydroxylase Inhibition
Dysregulated Proline Metabolism Contributes to Subretinal Fibrosis in Neovascular AMD: Therapeutic Potential of Prolyl-4-Hydroxylase Inhibition Open
Subretinal fibrosis, a major cause of irreversible vision loss in neovascular age-related macular degeneration (nAMD), is driven by excessive deposition of extracellular matrix such as collagens. While proline metabolism is known to play a…
View article: Morphomic predictors for post-esophagectomy pulmonary complications and overall survival
Morphomic predictors for post-esophagectomy pulmonary complications and overall survival Open
Increased VAT density and decreased SM area were associated with pulmonary complications, while decreased SM density was linked to poorer overall survival. Preoperative analytic morphomics aids in predicting both postoperative pulmonary co…
View article: Rapid prediction of key residues for foldability by machine learning model enables the design of highly functional libraries with hyperstable constrained peptide scaffolds
Rapid prediction of key residues for foldability by machine learning model enables the design of highly functional libraries with hyperstable constrained peptide scaffolds Open
Peptides are an emerging modality for developing therapeutics that can either agonize or antagonize cellular pathways associated with disease, yet peptides often suffer from poor chemical and physical stability, which limits their potentia…
View article: 463. ISOFORM SWITCHING EVENTS IN ESOPHAGEAL ADENOCARCINOMA MAY INFORM NEW THERAPEUTIC TARGETS THROUGH IDENTIFYING MOLECULAR MECHANISMS CONTRIBUTING TO POOR PATIENT OUTCOMES
463. ISOFORM SWITCHING EVENTS IN ESOPHAGEAL ADENOCARCINOMA MAY INFORM NEW THERAPEUTIC TARGETS THROUGH IDENTIFYING MOLECULAR MECHANISMS CONTRIBUTING TO POOR PATIENT OUTCOMES Open
Background Esophageal adenocarcinoma (EAC) represents a growing health problem characterized by rising incidence and poor prognosis due to late-stage diagnosis coupled with therapeutic resistance. Moreover, EAC is a cancer with a high muta…
View article: Rural Women Have a Prolonged Recovery Process after Esophagectomy
Rural Women Have a Prolonged Recovery Process after Esophagectomy Open
Background: Gender and geographic access to care play a large role in health disparities in esophageal cancer care. The aim of our study was to evaluate disparities in peri-operative outcomes for patients undergoing esophagectomy based on …
View article: Impact of cryoablation on operative outcomes in thoracotomy patients
Impact of cryoablation on operative outcomes in thoracotomy patients Open
OBJECTIVES Cryoablation is increasingly being utilized as an alternative to epidurals for patients undergoing thoracotomies. Current evidence suggests cryoablation may decrease postoperative analgesia utilization, but could increase operat…
View article: Factors affecting timing of surgery following neoadjuvant chemoradiation for esophageal cancer
Factors affecting timing of surgery following neoadjuvant chemoradiation for esophageal cancer Open
Delayed esophagectomy following chemoradiotherapy is associated with prior cardiothoracic surgery and absent nodal metastasis. Further investigations should focus on understanding how these factors contribute to delays to guide treatment p…
View article: Comprehensive sampling of the lung microbiome in early-stage non–small cell lung cancer
Comprehensive sampling of the lung microbiome in early-stage non–small cell lung cancer Open
View article: Epidemiology of Postoperative Complications After Esophagectomy: Implications for Management
Epidemiology of Postoperative Complications After Esophagectomy: Implications for Management Open
View article: An Extremely Rare Cause of Restrictive Lung Disease: Intrapulmonary Mature Teratoma
An Extremely Rare Cause of Restrictive Lung Disease: Intrapulmonary Mature Teratoma Open
Intrapulmonary mature teratomas are extremely rare, benign neoplasms that arise from the lung. In this case, we present a 40-year-old man with a 1.5-year history of mild exertional dyspnea during physical exercise. Pulmonary function tests…
View article: 451. ISOFORM SWITCHING EVENTS MAY PROVIDE NEW INSIGHT FOR THE IDENTIFICATION OF PROGNOSTIC AND THERAPEUTIC TARGETS IN ESOPHAGEAL ADENOCARCINOMA
451. ISOFORM SWITCHING EVENTS MAY PROVIDE NEW INSIGHT FOR THE IDENTIFICATION OF PROGNOSTIC AND THERAPEUTIC TARGETS IN ESOPHAGEAL ADENOCARCINOMA Open
Background Esophageal adenocarcinoma (EAC) represents a growing health problem characterized by rising incidence and poor prognosis due to late-stage diagnosis coupled with treatment resistance. Although EAC is a cancer with a high mutatio…
View article: 375. RURAL PATIENTS HAVE A PROLONGED INPATIENT RECOVERY PROCESS AFTER ESOPHAGECTOMY COMPARED TO NON-RURAL PATIENTS AT A HIGH-VOLUME ESOPHAGEAL PROGRAM
375. RURAL PATIENTS HAVE A PROLONGED INPATIENT RECOVERY PROCESS AFTER ESOPHAGECTOMY COMPARED TO NON-RURAL PATIENTS AT A HIGH-VOLUME ESOPHAGEAL PROGRAM Open
Background Geographic access to care plays a large role in health disparities in esophageal cancer care, with rural individuals often travelling further to access complex healthcare services. We sought to characterize peri-operative outcom…
View article: 423. DYSPHAGIA AND RE-INTERVENTION AFTER MYOTOMY FOR ACHALASIA: A MATTER OF TECHNIQUE, OR A MATTER OF TIME?
423. DYSPHAGIA AND RE-INTERVENTION AFTER MYOTOMY FOR ACHALASIA: A MATTER OF TECHNIQUE, OR A MATTER OF TIME? Open
Background Achalasia is an incurable neurodegenerative disease of the esophagus. Palliative treatment includes disruption of the lower esophageal sphincter via multiple techniques, including open Heller myotomy (OHM), laparoscopic Heller m…
View article: 374. RADIOGRAPHICALLY-DETERMINED FRAILTY IS ASSOCIATED WITH IMPAIRED GASTRIC CONDUIT PERFUSION DURING ESOPHAGECTOMY
374. RADIOGRAPHICALLY-DETERMINED FRAILTY IS ASSOCIATED WITH IMPAIRED GASTRIC CONDUIT PERFUSION DURING ESOPHAGECTOMY Open
Background Frailty is considered a preoperative risk factor for complications after esophagectomy while impaired gastric conduit perfusion is associated with anastomotic leaks. Patients with impaired conduit perfusion may be candidates for…
View article: Predicting chronic postsurgical pain: current evidence and a novel program to develop predictive biomarker signatures
Predicting chronic postsurgical pain: current evidence and a novel program to develop predictive biomarker signatures Open
Chronic pain affects more than 50 million Americans. Treatments remain inadequate, in large part, because the pathophysiological mechanisms underlying the development of chronic pain remain poorly understood. Pain biomarkers could potentia…
View article: Evidence-based opioid prescribing guidelines after lung resection: a prospective, multicenter analysis
Evidence-based opioid prescribing guidelines after lung resection: a prospective, multicenter analysis Open
Patient-reported post-discharge opioid use, surgical approach, and in-hospital opioid use before discharge should be used to inform prescribing recommendations after lung resection.
View article: Implementation and Effectiveness of Opioid Prescribing Guidelines After Hiatal Hernia Repair
Implementation and Effectiveness of Opioid Prescribing Guidelines After Hiatal Hernia Repair Open
Evidence-based opioid prescribing guidelines can be successfully implemented for open and laparoscopic HHR with a high rate of compliance and without an associated increase in opioid refills.
View article: Geospatial characterization of immune cell distributions and dynamics across the microenvironment in clear cell renal cell carcinoma
Geospatial characterization of immune cell distributions and dynamics across the microenvironment in clear cell renal cell carcinoma Open
Introduction In clear cell renal cell carcinoma (ccRCC), tumor-associated macrophage (TAM) induction of CD8+T cells into a terminally exhausted state has been implicated as a major mechanism of immunotherapy resistance, but a deeper biolog…
View article: Supplementary Figure S3 from Epigenetic Inactivation of microRNA-34b/c Predicts Poor Disease-Free Survival in Early-Stage Lung Adenocarcinoma
Supplementary Figure S3 from Epigenetic Inactivation of microRNA-34b/c Predicts Poor Disease-Free Survival in Early-Stage Lung Adenocarcinoma Open
PDF file 68K, Frequency of miR-34b/c promoter methylation and correlation of tumors miR-34b/c expression with methylation status
View article: Supplementary Figure S5 from Epigenetic Inactivation of microRNA-34b/c Predicts Poor Disease-Free Survival in Early-Stage Lung Adenocarcinoma
Supplementary Figure S5 from Epigenetic Inactivation of microRNA-34b/c Predicts Poor Disease-Free Survival in Early-Stage Lung Adenocarcinoma Open
PDF file 74K, Kaplan-Meier plot of DFS according to miR-34b/c methylation level in 97 stage I lung AC patients
View article: Supplementary Figure S5 from Epigenetic Inactivation of microRNA-34b/c Predicts Poor Disease-Free Survival in Early-Stage Lung Adenocarcinoma
Supplementary Figure S5 from Epigenetic Inactivation of microRNA-34b/c Predicts Poor Disease-Free Survival in Early-Stage Lung Adenocarcinoma Open
PDF file 74K, Kaplan-Meier plot of DFS according to miR-34b/c methylation level in 97 stage I lung AC patients
View article: Supplementary Figure S7 from Epigenetic Inactivation of microRNA-34b/c Predicts Poor Disease-Free Survival in Early-Stage Lung Adenocarcinoma
Supplementary Figure S7 from Epigenetic Inactivation of microRNA-34b/c Predicts Poor Disease-Free Survival in Early-Stage Lung Adenocarcinoma Open
PDF file 103K, Cisplatin chemosensitivity in SK-LU-1 miR-34b/c transfected cells
View article: Data from Poor Prognosis Indicated by Venous Circulating Tumor Cell Clusters in Early-Stage Lung Cancers
Data from Poor Prognosis Indicated by Venous Circulating Tumor Cell Clusters in Early-Stage Lung Cancers Open
Early detection of metastasis can be aided by circulating tumor cells (CTC), which also show potential to predict early relapse. Because of the limited CTC numbers in peripheral blood in early stages, we investigated CTCs in pulmonary vein…
View article: Supplementary Tables S1-S6 from Epigenetic Inactivation of microRNA-34b/c Predicts Poor Disease-Free Survival in Early-Stage Lung Adenocarcinoma
Supplementary Tables S1-S6 from Epigenetic Inactivation of microRNA-34b/c Predicts Poor Disease-Free Survival in Early-Stage Lung Adenocarcinoma Open
PDF file115K, Suppl.Table S1. Patient characteristics. Suppl.Table S2. Lung AC lines with TP53 mutation. Suppl.Table S3. Primers used for qRT-PCR. Suppl.Table S4. Correlation between tumors miR-34b/c expression and clinical and molecular v…
View article: Supplementary Figure S8 from Epigenetic Inactivation of microRNA-34b/c Predicts Poor Disease-Free Survival in Early-Stage Lung Adenocarcinoma
Supplementary Figure S8 from Epigenetic Inactivation of microRNA-34b/c Predicts Poor Disease-Free Survival in Early-Stage Lung Adenocarcinoma Open
PDF file 263K, Representative examples of invasion assay in SK-LU-1 cells
View article: Supplementary Figure S2 from Epigenetic Inactivation of microRNA-34b/c Predicts Poor Disease-Free Survival in Early-Stage Lung Adenocarcinoma
Supplementary Figure S2 from Epigenetic Inactivation of microRNA-34b/c Predicts Poor Disease-Free Survival in Early-Stage Lung Adenocarcinoma Open
PDF file 167K, Restoration of miR-34b/c expression by treating lung AC cell lines with 5-Aza-2'-Deoxycytidine
View article: Supplementary Figures 1 - 8 from A MicroRNA Cluster at 14q32 Drives Aggressive Lung Adenocarcinoma
Supplementary Figures 1 - 8 from A MicroRNA Cluster at 14q32 Drives Aggressive Lung Adenocarcinoma Open
PDF file - 1289KB, Fig S1- Box plots of the risk score values in the training and test set. Fig S2- SAM plot of 10 lung AC versus 10 matched nonmalignant lung samples. Fig S3- Pathway enrichment analysis based on predicted genes targeted b…