Andrew C. Lysaght
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View article: Deep immune profiling of patients treated with lenalidomide and dexamethasone with or without daratumumab
Deep immune profiling of patients treated with lenalidomide and dexamethasone with or without daratumumab Open
CD38-targeted antibody, daratumumab, is approved for the treatment of multiple myeloma (MM). Phase 1/2 studies GEN501/SIRIUS revealed a novel immunomodulatory mechanism of action (MOA) of daratumumab that enhanced the immune response, redu…
View article: Proteome of normal human perilymph and perilymph from people with disabling vertigo
Proteome of normal human perilymph and perilymph from people with disabling vertigo Open
The vast majority of hearing loss, the most common sensory impairment, and vertigo, which commonly causes falls, both reflect underlying dysfunction of inner ear cells. Perilymph sampling can thus provide molecular cues to hearing and bala…
View article: Pridopidine activates neuroprotective pathways impaired in Huntington Disease
Pridopidine activates neuroprotective pathways impaired in Huntington Disease Open
Pridopidine has demonstrated improvement in Huntington Disease (HD) motor symptoms as measured by secondary endpoints in clinical trials. Originally described as a dopamine stabilizer, this mechanism is insufficient to explain the clinical…
View article: Immediate and Delayed Cochlear Neuropathy after Noise Exposure in Pubescent Mice
Immediate and Delayed Cochlear Neuropathy after Noise Exposure in Pubescent Mice Open
Moderate acoustic overexposure in adult rodents is known to cause acute loss of synapses on sensory inner hair cells (IHCs) and delayed degeneration of the auditory nerve, despite the completely reversible temporary threshold shift (TTS) a…