Andrew L. Miller
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View article: Seismic DAS observations of a large underground chemical explosion in dry tuff
Seismic DAS observations of a large underground chemical explosion in dry tuff Open
View article: Computational Docking as a Tool in Guiding the Drug Design of Rutaecarpine Derivatives as Potential SARS-CoV-2 Inhibitors
Computational Docking as a Tool in Guiding the Drug Design of Rutaecarpine Derivatives as Potential SARS-CoV-2 Inhibitors Open
COVID-19 continues to spread around the world. This is mainly because new variants of the SARS-CoV-2 virus emerge due to genomic mutations, evade the immune system and result in the effectiveness of current therapeutics being reduced. We p…
View article: Dark Matter and its Effect on Gravitational Wave Signal
Dark Matter and its Effect on Gravitational Wave Signal Open
In this work, we present two gauge models for light-dark matter: one with an exotic positive charged lepton and the other one is a variant with right-handed neutrinos. The scalar self-interacting dark matters are stable without imposing ne…
View article: INVESTIGATION OF PHOTOVOLTAIC POTENTIALS OF A SILVER IMPLANTED DIAMOND-LIKE CARBON THIN FILM
INVESTIGATION OF PHOTOVOLTAIC POTENTIALS OF A SILVER IMPLANTED DIAMOND-LIKE CARBON THIN FILM Open
This paper investigated the optical response of silver implanted carbon-based thin films (deposited on quartz substrates) due to varying fluence of energetic Ag ions in the range 2.5 - 3.4 x 1016 ions/cm2. Raman spectroscopy was used to ob…
View article: Detection of anomalies amongst LIGO's glitch populations with autoencoders
Detection of anomalies amongst LIGO's glitch populations with autoencoders Open
Gravitational-wave (GW) interferometers are able to detect a change in distance of $\sim$ 1/10,000th the size of a proton. Such sensitivity leads to large appearance rates of non-Gaussian transient noise bursts in the main detector strain,…
View article: Enabling multi-messenger astronomy with continuous gravitational waves: early warning and sky localization of binary neutron stars in Einstein Telescope
Enabling multi-messenger astronomy with continuous gravitational waves: early warning and sky localization of binary neutron stars in Einstein Telescope Open
Next-generation gravitational-wave detectors will provide unprecedented sensitivity to inspiraling binary neutron stars and black holes, enabling detections at the peak of star formation and beyond. However, the signals from these systems …
View article: Actin-mediated endocytosis in the E-YSL helps drive epiboly in zebrafish
Actin-mediated endocytosis in the E-YSL helps drive epiboly in zebrafish Open
Summary In zebrafish, a punctate band of F-actin is reported to develop in the external yolk syncytial layer (E-YSL) during the latter part of epiboly in zebrafish embryos. Here, electron microscopy (EM) and fluorescence confocal microscop…
View article: A Role for Two-Pore Channel Type 2 (TPC2)-Mediated Regulation of Membrane Contact Sites During Zebrafish Notochord Biogenesis?
A Role for Two-Pore Channel Type 2 (TPC2)-Mediated Regulation of Membrane Contact Sites During Zebrafish Notochord Biogenesis? Open
We have previously shown that in the developing trunk of zebrafish embryos, two-pore channel type 2 (TPC2)-mediated Ca 2+ release from endolysosomes plays a role in the formation of the skeletal slow muscle. In addition, TPC2-mediated Ca 2…
View article: The Ethanol Extract of Evodiae Fructus and Its Ingredient, Rutaecarpine, Inhibit Infection of SARS-CoV-2 and Inflammatory Responses
The Ethanol Extract of Evodiae Fructus and Its Ingredient, Rutaecarpine, Inhibit Infection of SARS-CoV-2 and Inflammatory Responses Open
COVID-19, derived from SARS-CoV-2, has resulted in millions of deaths and caused unprecedented socioeconomic damage since its outbreak in 2019. Although the vaccines developed against SARS-CoV-2 provide some protection, they have unexpecte…
View article: Neuromasts and Olfactory Organs of Zebrafish Larvae Represent Possible Sites of SARS-CoV-2 Pseudovirus Host Cell Entry
Neuromasts and Olfactory Organs of Zebrafish Larvae Represent Possible Sites of SARS-CoV-2 Pseudovirus Host Cell Entry Open
Despite the development of effective vaccines to combat the COVID-19 pandemic, which help prevent the most life-threatening symptoms, full protection cannot be guaranteed, especially with the emergence of new viral variants. Moreover, some…
View article: The Extracts of Polygonum cuspidatum Root and Rhizome Block the Entry of SARS-CoV-2 Wild-Type and Omicron Pseudotyped Viruses via Inhibition of the S-Protein and 3CL Protease
The Extracts of Polygonum cuspidatum Root and Rhizome Block the Entry of SARS-CoV-2 Wild-Type and Omicron Pseudotyped Viruses via Inhibition of the S-Protein and 3CL Protease Open
COVID-19, resulting from infection by the SARS-CoV-2 virus, caused a contagious pandemic. Even with the current vaccines, there is still an urgent need to develop effective pharmacological treatments against this deadly disease. Here, we s…
View article: Distinguishing between dark-matter interactions with gravitational-wave detectors
Distinguishing between dark-matter interactions with gravitational-wave detectors Open
Ground-based gravitational-wave interferometers could directly probe the existence of ultralight dark matter ($\mathcal{O}(10^{-14}-10^{-11})$ eV/$c^2$) that couples to standard-model particles in the detectors. Recently, many techniques h…
View article: Polygoni multiflori radix extracts inhibit SARS-CoV-2 pseudovirus entry in HEK293T cells and zebrafish larvae
Polygoni multiflori radix extracts inhibit SARS-CoV-2 pseudovirus entry in HEK293T cells and zebrafish larvae Open
View article: First person – Keira L. Rice
First person – Keira L. Rice Open
First Person is a series of interviews with the first authors of a selection of papers published in Journal of Cell Science, helping early-career researchers promote themselves alongside their papers. Keira L. Rice is first author on ‘ Loc…
View article: Localized TPC1-mediated Ca2+ release from endolysosomes contributes to myoseptal junction development in zebrafish
Localized TPC1-mediated Ca2+ release from endolysosomes contributes to myoseptal junction development in zebrafish Open
In the trunk of developing zebrafish embryos, adjacent myotome blocks transmit contractile force via myoseptal junctions (MJs), dynamic structures that connect the actin cytoskeleton of skeletal muscle cells to extracellular matrix compone…
View article: Transmembrane H<sup>+</sup>fluxes and the regulation of neural induction in<i>Xenopus laevis</i>
Transmembrane H<sup>+</sup>fluxes and the regulation of neural induction in<i>Xenopus laevis</i> Open
Summary It has previously been reported that in ex vivo planar explants prepared from Xenopus laevis embryos, the intracellular pH (pH i ) increases in cells of the dorsal ectoderm from stage 10.5 to 11.5 (i.e. 11–12.5 hpf). It was propose…
View article: Identification of Environmental Factors that Influence the Upstream Migration of Sea Trout Salmo trutta in Shetland Waters
Identification of Environmental Factors that Influence the Upstream Migration of Sea Trout Salmo trutta in Shetland Waters Open
Migrating sea trout Salmo trutta L. in the waters of the Shetland Islands (UK) were once found in abundant numbers but they have been in decline since the mid-1980s. Therefore, it is becoming ever more critical to investigate sea trout beh…
View article: Has stocking contributed to an increase in the rod catch of anadromous trout (<scp><i>Salmo trutta</i> L.)</scp> in the <scp>Shetland Islands</scp>, <scp>UK</scp>?
Has stocking contributed to an increase in the rod catch of anadromous trout (<span><i>Salmo trutta</i> L.)</span> in the <span>Shetland Islands</span>, <span>UK</span>? Open
The stocking of hatchery‐origin fish into rivers and lakes has long been used in fisheries management to try to enhance catches, especially for trout and salmon species. Frequently, however, the long‐term impacts of stocking programmes hav…
View article: Daily rhythms in heartbeat rate are intrinsic to the zebrafish heart
Daily rhythms in heartbeat rate are intrinsic to the zebrafish heart Open
View article: Investigating the role of <i>dachshund b</i> in the development of the pancreatic islet in zebrafish
Investigating the role of <i>dachshund b</i> in the development of the pancreatic islet in zebrafish Open
Aims/Introduction β‐Cell dysfunction is a hallmark of type 2 diabetes. In a previous pilot study, we identified an association between genetic variants within the human DACH1 gene and young‐onset type 2 diabetes. Here, we characterized the…
View article: A simple bioluminescence-based method for recording Ca<sup>2+</sup> signaling in the cytosol or mitochondria of neural progenitor cells from the adult zebrafish brain
A simple bioluminescence-based method for recording Ca<sup>2+</sup> signaling in the cytosol or mitochondria of neural progenitor cells from the adult zebrafish brain Open
Neurospheres derived from the adult zebrafish brain are a convenient model for investigating the initial stages of neurogenesis. Neurospheres are composed of stem cells, which have the ability to either self-renew or differentiate into spe…
View article: Adapting a semi-coherent method to directly detect dark photon dark matter interacting with gravitational-wave interferometers
Adapting a semi-coherent method to directly detect dark photon dark matter interacting with gravitational-wave interferometers Open
We adapt a method, originally developed for continuous gravitational-wave searches, to directly detect dark photon dark matter. The method involves optimally choosing the analysis coherence time as a function of the frequency band analyzed…
View article: Short‐term homeostatic regulation of blood/interstitial fluid <scp>Ca<sup>2+</sup></scp> concentration by the scales of anadromous sea trout <scp><i>Salmo trutta</i> L.</scp> during smoltification and migration
Short‐term homeostatic regulation of blood/interstitial fluid <span>Ca<sup>2+</sup></span> concentration by the scales of anadromous sea trout <span><i>Salmo trutta</i> L.</span> during smoltification and migration Open
The elasmoid scales of anadromous sea trout Salmo trutta L. represent a significant internal reservoir of Ca 2+ . Although more is known about long‐term remodelling of scales in response to calciotropic challenges encountered during smolti…
View article: TPC2-mediated Ca2+ signaling is required for axon extension in caudal primary motor neurons in zebrafish embryos
TPC2-mediated Ca2+ signaling is required for axon extension in caudal primary motor neurons in zebrafish embryos Open
The role of two-pore channel type 2 (TPC2, encoded by tcpn2)-mediated Ca2+ release was recently characterized in zebrafish during establishment of the early spinal circuitry, one of the key events in the coordination of neuromuscular activ…
View article: On the Positivity of the Discrete Green's Function for Unstructured Finite Elements Discretizations in Three Dimensions
On the Positivity of the Discrete Green's Function for Unstructured Finite Elements Discretizations in Three Dimensions Open
The aim of this thesis is twofold. First, we will establish new estimates for the discrete Green's function and obtain some positivity results. In particular, we establish that the discrete Green's functions with singularity in the interio…
View article: Development of a 3D Multi-Parameter Method to Evaluate Heart Looping and Chamber Volume in Zebrafish Embryos
Development of a 3D Multi-Parameter Method to Evaluate Heart Looping and Chamber Volume in Zebrafish Embryos Open
Heart disease remains a leading cause of death worldwide. Some congenital cardiac malformations can result from defects in heart looping, which is a key process that ensures the correct alignment of the future chambers. The zebrafish is a …
View article: Trpc1 as the Missing Link Between the Bmp and Ca2+ Signalling Pathways During Neural Specification in Amphibians
Trpc1 as the Missing Link Between the Bmp and Ca2+ Signalling Pathways During Neural Specification in Amphibians Open
In amphibians, the inhibition of bone morphogenetic protein (BMP) in the dorsal ectoderm has been proposed to be responsible for the first step of neural specification, called neural induction. We previously demonstrated that in Xenopus la…
View article: Role of Two-Pore Channels in Embryonic Development and Cellular Differentiation
Role of Two-Pore Channels in Embryonic Development and Cellular Differentiation Open
Since the identification of nicotinic acid adenine dinucleotide phosphate (NAADP) and its putative target, the two-pore channel (TPC), the NAADP/TPC/Ca2+ signaling pathway has been reported to play a role in a diverse range of f…
View article: Real-world use of rescue inhaler sensors, electronic symptom questionnaires and physical activity monitors in COPD
Real-world use of rescue inhaler sensors, electronic symptom questionnaires and physical activity monitors in COPD Open
Background Chronic obstructive pulmonary disease (COPD) is a heterogeneous disease characterised by airflow obstruction and other morbidities such as respiratory symptoms, reduced physical activity and frequent bronchodilator use. Recent a…
View article: Characterization of ADP-ribosyl cyclase 1-like (ARC1-like) activity and NAADP signaling during slow muscle cell development in zebrafish embryos
Characterization of ADP-ribosyl cyclase 1-like (ARC1-like) activity and NAADP signaling during slow muscle cell development in zebrafish embryos Open