Mark A. Chambers
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View article: Single-cell profiling reveals a role for tuberculosis-induced myofibroblasts in the immunopathology of infected lungs 3060
Single-cell profiling reveals a role for tuberculosis-induced myofibroblasts in the immunopathology of infected lungs 3060 Open
Description Tuberculosis (TB) remains a serious global health challenge, where most cases are pulmonary and frequently lead to post-tuberculosis lung disease (PTLD) with gross tissue destruction and fibrosis. However, the mechanisms of TB …
View article: Neutrophil proteins as potential biomarkers for a sputum-based tuberculosis screening test
Neutrophil proteins as potential biomarkers for a sputum-based tuberculosis screening test Open
Introduction The development of a rapid and affordable assay to screen participants for Q12 additional testing could streamline TB screening in resource-limited settings and for community-wide health screens. Sputum remains the primary tes…
View article: Data-driven analysis of fine-scale badger movement in the UK
Data-driven analysis of fine-scale badger movement in the UK Open
Understanding animal movements at different spatial scales presents a significant challenge as their patterns can vary widely from daily foraging behaviours to broader migration or territorial movements. This challenge is of general intere…
View article: Mapping the evidence of the effects of environmental factors on the prevalence of antibiotic resistance in the non-built environment
Mapping the evidence of the effects of environmental factors on the prevalence of antibiotic resistance in the non-built environment Open
Significant evidence gaps persist in understanding antibiotic resistance in non-built environments, particularly in marine, atmospheric, and non-agricultural settings. Stressors such as climate change and microplastics remain notably under…
View article: Impact of manure and artificial fertilizer application on metal and metalloid distributions in agricultural soils and crops
Impact of manure and artificial fertilizer application on metal and metalloid distributions in agricultural soils and crops Open
The application of animal manure to agricultural soil is a very common practice to improve soils fertility, providing a rich source of organic matter and nutrients. However, the presence of certain trace elements in the manure can result i…
View article: Assessment of Elemental Deficiency of Crossbred Dairy Cows and Mineral Composition in Natural Feed and Nutritional Supplements in the Northern and Northwestern Provinces in Sri Lanka
Assessment of Elemental Deficiency of Crossbred Dairy Cows and Mineral Composition in Natural Feed and Nutritional Supplements in the Northern and Northwestern Provinces in Sri Lanka Open
This study assessed the elemental status of cross-bred dairy cows in small holder farms in Sri Lanka, with the aim to establish the elemental baseline and identify possible deficiencies. For this purpose, 458 milk, hair, serum and whole bl…
View article: Measurement of isoniazid in tuberculosis patients using finger sweat with creatinine normalisation: A controlled administration study
Measurement of isoniazid in tuberculosis patients using finger sweat with creatinine normalisation: A controlled administration study Open
We describe the time-course measurement of isoniazid (or drug-to-creatinine ratio) in finger sweat compared to the pharmacokinetic profile in blood for the first time. This technique, adaptable for other drugs, could reduce the burden on c…
View article: Detailed phenotyping reveals diverse and highly skewed neutrophil subsets in both the blood and airways during active tuberculosis infection
Detailed phenotyping reveals diverse and highly skewed neutrophil subsets in both the blood and airways during active tuberculosis infection Open
Introduction Neutrophils play a complex and important role in the immunopathology of TB. Data suggest they are protective during early infection but become a main driver of immunopathology if infection progresses to active disease. Neutrop…
View article: B cell heterogeneity in human tuberculosis highlights compartment-specific phenotype and functional roles
B cell heterogeneity in human tuberculosis highlights compartment-specific phenotype and functional roles Open
B cells are important in tuberculosis (TB) immunity, but their role in the human lung is understudied. Here, we characterize B cells from lung tissue and matched blood of patients with TB and found they are decreased in the blood and incre…
View article: Myeloid cell expression of CD200R is modulated in active TB disease and regulates Mycobacterium tuberculosis infection in a biomimetic model
Myeloid cell expression of CD200R is modulated in active TB disease and regulates Mycobacterium tuberculosis infection in a biomimetic model Open
A robust immune response is required for resistance to pulmonary tuberculosis (TB), the primary disease caused by Mycobacterium tuberculosis ( Mtb ). However, pharmaceutical inhibition of T cell immune checkpoint molecules can result in th…
View article: Variation in drug penetration does not account for the natural resistance of<i>Mycobacterium abscessus</i>biofilms to antibiotic
Variation in drug penetration does not account for the natural resistance of<i>Mycobacterium abscessus</i>biofilms to antibiotic Open
Mycobacterium abscessus , an inherently drug-resistant, opportunistic, nontuberculous mycobacterium (NTM) predominantly causes pulmonary infections in immunocompromised patients, notably those with cystic fibrosis. M. abscessus subspecies …
View article: Investigation of nasal epithelial cells as a surrogate for bronchial epithelial cells in the research of equine asthma
Investigation of nasal epithelial cells as a surrogate for bronchial epithelial cells in the research of equine asthma Open
Equine asthma, previously known as Recurrent Airway Obstruction (RAO) or Inflammatory Airway Disease (IAD), is an often-debilitating condition that may severely affect both performance and quality of life. Research is hindered by the low s…
View article: B cell heterogeneity in human tuberculosis highlights compartment-specific phenotype and putative functional roles
B cell heterogeneity in human tuberculosis highlights compartment-specific phenotype and putative functional roles Open
B cells are important in tuberculosis (TB) immunity, but their role in the human lung is understudied. Here, we characterize B cells from lung tissue and matched blood of TB patients and found they are decreased in the blood and increased …
View article: Noninvasive drug adherence monitoring of antipsychotic patients via finger sweat testing
Noninvasive drug adherence monitoring of antipsychotic patients via finger sweat testing Open
Collection of finger sweat is explored here as a rapid and convenient way of monitoring patient adherence to antipsychotic drugs. Finger sweat samples ( n = 426) collected from patients receiving treatment with clozapine, quetiapine and ol…
View article: D-JRP15-FED-AMR-WP5.13 (Results of the soil microcosm experiments regarding environmental effects on competence gene expression)_Version 2
D-JRP15-FED-AMR-WP5.13 (Results of the soil microcosm experiments regarding environmental effects on competence gene expression)_Version 2 Open
OHEJP Project: FED-AMR
View article: D-JRP15-FED-AMR-WP2.1 FINAL REPORT
D-JRP15-FED-AMR-WP2.1 FINAL REPORT Open
OHEJP Project: FED-AMR (Final Report)
View article: D-JRP15-FED-AMR-WP5.2 Optimal growth parameters for cultivating E. coli within the porcine gut model
D-JRP15-FED-AMR-WP5.2 Optimal growth parameters for cultivating E. coli within the porcine gut model Open
OHEJP Project: FED-AMR
View article: Final report JRP15-AMR2.1-FED-AMR
Final report JRP15-AMR2.1-FED-AMR Open
current version of the final report of the FED-AMR project
View article: deliverable D-JRP15-FED-AMR-WP5.13 (Results of the soil microcosm experiments regarding environmental effects on competence gene expression
deliverable D-JRP15-FED-AMR-WP5.13 (Results of the soil microcosm experiments regarding environmental effects on competence gene expression Open
Since the aim of work package 5 was to identify effects of environmental conditions that influence bacterial transformation, in task 5.3 a soil microcosm setting was created by utilizing non-manured agricultural soil. After initial tests, …
View article: Publisher Correction: Development and evaluation of a bovine lung-on-chip (bLOC) to study bovine respiratory diseases
Publisher Correction: Development and evaluation of a bovine lung-on-chip (bLOC) to study bovine respiratory diseases Open
[This corrects the article DOI: 10.1007/s44164-022-00030-z.].
View article: Deliverable D-JRP15-FED-AMR-WP4.7 Quantitative results of trace elements in environmental samples
Deliverable D-JRP15-FED-AMR-WP4.7 Quantitative results of trace elements in environmental samples Open
OHEJP Project: FED-AMR
View article: Colocation of Lipids, Drugs, and Metal Biomarkers Using Spatially Resolved Lipidomics with Elemental Mapping
Colocation of Lipids, Drugs, and Metal Biomarkers Using Spatially Resolved Lipidomics with Elemental Mapping Open
Elemental imaging is widely used for imaging cells and tissues but rarely in combination with organic mass spectrometry, which can be used to profile lipids and measure drug concentrations. Here, we demonstrate how elemental imaging and a …
View article: Development and evaluation of a bovine lung-on-chip (bLOC) to study bovine respiratory diseases
Development and evaluation of a bovine lung-on-chip (bLOC) to study bovine respiratory diseases Open
Purpose Current air-liquid interface (ALI) models of bovine proximal airways have their limitations. They do not simulate blood flow necessary to mimic systemic drug administration, and repeated sampling requires multiple, independent cult…
View article: Uptake of baits by wild badgers: Influences of deployment method, badger age and activity patterns on potential delivery of an oral vaccine
Uptake of baits by wild badgers: Influences of deployment method, badger age and activity patterns on potential delivery of an oral vaccine Open
In parts of the United Kingdom and Ireland, the European badger is a wildlife host for Mycobacterium bovis (the causative agent of bovine tuberculosis). Badger vaccination is one management option for reducing disease spread. Vaccination i…
View article: Modelling the dynamics and long-term stability of perturbed gut microbiota
Modelling the dynamics and long-term stability of perturbed gut microbiota Open
Poster for the ONE Conference 2022 The gut microbiota play a key role in the health of animals and humans. However, the dynamic properties and stability of the microbiota are poorly understood. We propose a regression technique for parame…
View article: Potential to Use Fingerprints for Monitoring Therapeutic Levels of Isoniazid and Treatment Adherence
Potential to Use Fingerprints for Monitoring Therapeutic Levels of Isoniazid and Treatment Adherence Open
A fingerprint offers a convenient, noninvasive sampling matrix for monitoring therapeutic drug use. However, a barrier to widespread adoption of fingerprint sampling is the fact that the sample volume is uncontrolled. Fingerprint samples (…
View article: Development of an in vitro pig gut model for evaluating factors driving antimicrobial resistance
Development of an in vitro pig gut model for evaluating factors driving antimicrobial resistance Open
The study aimed to further develop an in vitro continuous flow model representing the large intestine of the pig. The model was employed to determine the factors driving the transfer of antimicrobial resistance (AMR) through transformation…