Andrew Chancellor
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View article: Mitochondria regulate MR1 protein expression and produce self-metabolites that activate MR1-restricted T cells
Mitochondria regulate MR1 protein expression and produce self-metabolites that activate MR1-restricted T cells Open
Mitochondria coordinate several metabolic pathways, producing metabolites that influence the immune response in various ways. It remains unclear whether mitochondria impact antigen presentation by the MHC-class-I-related antigen-presenting…
View article: Recognition of MR1-antigen complexes by TCR Vγ9Vδ2
Recognition of MR1-antigen complexes by TCR Vγ9Vδ2 Open
The TCR-mediated activation of T cells expressing the TCR Vγ9Vδ2 relies on an innate-like mechanism involving the butyrophilin 3A1, 3A2 and 2A1 molecules and phospho-antigens, without the participation of classical antigen-presenting molec…
View article: The carbonyl nucleobase adduct M3Ade is a potent antigen for adaptive polyclonal MR1-restricted T cells
The carbonyl nucleobase adduct M3Ade is a potent antigen for adaptive polyclonal MR1-restricted T cells Open
The major histocompatibility complex (MHC) class I-related molecule MHC-class-I-related protein 1 (MR1) presents metabolites to distinct MR1-restricted T cell subsets, including mucosal-associated invariant T (MAIT) and MR1T cells. However…
View article: Table S2 from MR1 Gene and Protein Expression Are Enhanced by Inhibition of the Extracellular Signal-Regulated Kinase ERK
Table S2 from MR1 Gene and Protein Expression Are Enhanced by Inhibition of the Extracellular Signal-Regulated Kinase ERK Open
Phenotype and TCR gene expression by MR1T cell clones
View article: Supplementary Figure S5 from MR1 Gene and Protein Expression Are Enhanced by Inhibition of the Extracellular Signal-Regulated Kinase ERK
Supplementary Figure S5 from MR1 Gene and Protein Expression Are Enhanced by Inhibition of the Extracellular Signal-Regulated Kinase ERK Open
Supplementary Figure S5
View article: Supplementary Figure S2 from MR1 Gene and Protein Expression Are Enhanced by Inhibition of the Extracellular Signal-Regulated Kinase ERK
Supplementary Figure S2 from MR1 Gene and Protein Expression Are Enhanced by Inhibition of the Extracellular Signal-Regulated Kinase ERK Open
Supplementary Figure S2
View article: Data from MR1 Gene and Protein Expression Are Enhanced by Inhibition of the Extracellular Signal-Regulated Kinase ERK
Data from MR1 Gene and Protein Expression Are Enhanced by Inhibition of the Extracellular Signal-Regulated Kinase ERK Open
The MHC class I–related molecule MR1 is ubiquitously expressed, is highly conserved among mammals, and presents bacterial and endogenous antigens in tumor cells. These features indicate that tumor-specific T cells restricted to MR1 may rep…
View article: Supplementary Figure S4 from MR1 Gene and Protein Expression Are Enhanced by Inhibition of the Extracellular Signal-Regulated Kinase ERK
Supplementary Figure S4 from MR1 Gene and Protein Expression Are Enhanced by Inhibition of the Extracellular Signal-Regulated Kinase ERK Open
Supplementary Figure S4
View article: Supplementary Figure S1 from MR1 Gene and Protein Expression Are Enhanced by Inhibition of the Extracellular Signal-Regulated Kinase ERK
Supplementary Figure S1 from MR1 Gene and Protein Expression Are Enhanced by Inhibition of the Extracellular Signal-Regulated Kinase ERK Open
Supplementary Figure S1
View article: Table S1 from MR1 Gene and Protein Expression Are Enhanced by Inhibition of the Extracellular Signal-Regulated Kinase ERK
Table S1 from MR1 Gene and Protein Expression Are Enhanced by Inhibition of the Extracellular Signal-Regulated Kinase ERK Open
List of genes regulated by BRAF inhibition
View article: Supplementary Figure S3 from MR1 Gene and Protein Expression Are Enhanced by Inhibition of the Extracellular Signal-Regulated Kinase ERK
Supplementary Figure S3 from MR1 Gene and Protein Expression Are Enhanced by Inhibition of the Extracellular Signal-Regulated Kinase ERK Open
Supplementary Figure S3
View article: Surface protein and functional analyses identify CD4+CD39+ TCR αβ+ and activated TCR Vδ1+ cells with distinct pro-inflammatory functions in Crohn’s disease lesions
Surface protein and functional analyses identify CD4+CD39+ TCR αβ+ and activated TCR Vδ1+ cells with distinct pro-inflammatory functions in Crohn’s disease lesions Open
Crohn’s disease (CD) is a chronic immune-mediated disorder of the gastrointestinal tract. Extensive screening studies have revealed the accumulation of immune cell subsets with unique plasticity and immunoregulatory properties in patients …
View article: Promiscuous recognition of MR1 drives self-reactive mucosal-associated invariant T cell responses
Promiscuous recognition of MR1 drives self-reactive mucosal-associated invariant T cell responses Open
Mucosal-associated invariant T (MAIT) cells use canonical semi-invariant T cell receptors (TCR) to recognize microbial riboflavin precursors displayed by the antigen-presenting molecule MR1. The extent of MAIT TCR crossreactivity toward ph…
View article: Nucleobase adduct-containing metabolites are MR1 ligands that stimulate self-reactive MR1T cells
Nucleobase adduct-containing metabolites are MR1 ligands that stimulate self-reactive MR1T cells Open
Summary MR1T lymphocytes are a recently identified population of T cells that recognize unknown self-antigens presented by the non-polymorphic MHC-I-related molecule, MR1. MR1T cells can kill tumor cells and modulate the functions of other…
View article: MR1, an immunological periscope of cellular metabolism
MR1, an immunological periscope of cellular metabolism Open
The discovery that major histocompatibility complex (MHC) class I-related molecule 1 (MR1) presents microbial antigens to mucosal-associated invariant T (MAIT) cells was a significant scientific milestone in the last decade. Surveillance f…
View article: Immunophenotypic characterization of TCR γδ T cells and MAIT cells in HIV-infected individuals developing Hodgkin’s lymphoma
Immunophenotypic characterization of TCR γδ T cells and MAIT cells in HIV-infected individuals developing Hodgkin’s lymphoma Open
View article: The Pathology of the Vestibular System in CANVAS
The Pathology of the Vestibular System in CANVAS Open
Objective: To describe the site of lesion responsible for the severe, bilateral, symmetrical, selective loss of vestibular function in Cerebellar Ataxia with Neuronopathy and Vestibular Areflexia Syndrome (CANVAS), an adult-onset recessive…
View article: Antigen specificities and functional properties of MR1-restricted T cells
Antigen specificities and functional properties of MR1-restricted T cells Open
MR1 is an MHC class I-like molecule with unique structural and biological features that make it an important member among the molecules involved in antigen presentation to T cells. Distinctive features include ubiquitous expression of the …
View article: MR1-Restricted T Cells Are Unprecedented Cancer Fighters
MR1-Restricted T Cells Are Unprecedented Cancer Fighters Open
Non-polymorphic MHC class I-related molecule MR1 presents antigenic bacterial metabolites to mucosal-associated invariant T (MAIT) cells and self-antigens to MR1-restricted T (MR1T) cells. Both MR1-restricted T cell populations are readily…
View article: Cerebellar ataxia, neuropathy, vestibular areflexia syndrome due to RFC1 repeat expansion
Cerebellar ataxia, neuropathy, vestibular areflexia syndrome due to RFC1 repeat expansion Open
Ataxia, causing imbalance, dizziness and falls, is a leading cause of neurological disability. We have recently identified a biallelic intronic AAGGG repeat expansion in replication factor complex subunit 1 (RFC1) as the cause of cerebella…
View article: Bioinformatics-Based Identification of Expanded Repeats: A Non-reference Intronic Pentamer Expansion in RFC1 Causes CANVAS
Bioinformatics-Based Identification of Expanded Repeats: A Non-reference Intronic Pentamer Expansion in RFC1 Causes CANVAS Open
View article: [Letter to the Editor] Calcineurin inhibitors compromise the performance of interferon-gamma release assays used for TB diagnosis
[Letter to the Editor] Calcineurin inhibitors compromise the performance of interferon-gamma release assays used for TB diagnosis Open
View article: Differences in monocyte: lymphocyte ratio and Tuberculosis disease progression in genetically distinct populations of macaques
Differences in monocyte: lymphocyte ratio and Tuberculosis disease progression in genetically distinct populations of macaques Open
View article: The γδTCR combines innate immunity with adaptive immunity by utilizing spatially distinct regions for agonist selection and antigen responsiveness
The γδTCR combines innate immunity with adaptive immunity by utilizing spatially distinct regions for agonist selection and antigen responsiveness Open
View article: The versatility of the <scp>CD</scp>1 lipid antigen presentation pathway
The versatility of the <span>CD</span>1 lipid antigen presentation pathway Open
Summary The family of non‐classical major histocompatibility complex ( MHC ) class‐I like CD 1 molecules has an emerging role in human disease. Group 1 CD 1 includes CD 1a, CD 1b and CD 1c, which function to display lipids on the cell surf…
View article: CD1b-restricted GEM T cell responses are modulated by<i>Mycobacterium tuberculosis</i>mycolic acid meromycolate chains
CD1b-restricted GEM T cell responses are modulated by<i>Mycobacterium tuberculosis</i>mycolic acid meromycolate chains Open
Significance Tuberculosis is a major global pandemic responsible for more deaths than any other infectious disease, yet no effective vaccine exists. Here, we demonstrate CD1b expression within human tuberculous granulomas, supporting a rol…
View article: Quantitative and qualitative iNKT repertoire associations with disease susceptibility and outcome in macaque tuberculosis infection
Quantitative and qualitative iNKT repertoire associations with disease susceptibility and outcome in macaque tuberculosis infection Open
View article: Dissection of the host-pathogen interaction in human tuberculosis using a bioengineered 3-dimensional model
Dissection of the host-pathogen interaction in human tuberculosis using a bioengineered 3-dimensional model Open
Cell biology differs between traditional cell culture and 3-dimensional (3-D) systems, and is modulated by the extracellular matrix. Experimentation in 3-D presents challenges, especially with virulent pathogens. Mycobacterium tuberculosis…
View article: Author response: Dissection of the host-pathogen interaction in human tuberculosis using a bioengineered 3-dimensional model
Author response: Dissection of the host-pathogen interaction in human tuberculosis using a bioengineered 3-dimensional model Open
Article Figures and data Abstract Introduction Results Discussion Materials and methods References Decision letter Author response Article and author information Metrics Abstract Cell biology differs between traditional cell culture and 3-…
View article: Assessment for benign paroxysmal positioning vertigo in medical patients admitted with falls in a district general hospital
Assessment for benign paroxysmal positioning vertigo in medical patients admitted with falls in a district general hospital Open