Explanipedia

PENTAGON (Predicting Clinical Trials in Gynecologic Oncology): A Retrospective Study Assessing Study Design Factors That Affect Enrollment in Gynecologic Cancer Trials Open

Margaret J. Klein, Humza A. Pirzadah, LaMiah Hall, Andrew Chapple, Navya Nair , et al. · 2025

Objective: Clinical trials are the cornerstone of medical innovation and set the standard for medical care. Cancer clinical trials drive critical innovation and availability of new treatments. However, obstacles to successful recruitment a…

The effect of pH on the mechanical properties of beta titanium orthodontic arch wires Open

John C. Huffman, Andrew Chapple, Paul Armbruster, Richard Ballard, Sarah Dawson , et al. · 2025

Evaluation of demineralization changes utilizing the Canary Caries Detection System and various toothpastes on incipient enamel lesions Open

S. A. Steel, Htwe Mon, Xiaoming Xu, Andrew Chapple, Hope Grandy , et al. · 2025

Bayesian adaptive randomization in the I-SPY2 sequential multiple assignment randomized trial Open

Peter Norwood, Christina Yau, Denise M. Wolf, Philip Beineke, Andrew Chapple , et al. · 2025

The I-SPY2 phase 2 clinical trial is a long-running platform trial that evaluates neoadjuvant treatments for locally advanced breast cancer, assigning subjects to novel agents using response-adaptive randomization. Recently, I-SPY2 was rec…

Impact of coronavirus disease 2019 on Dental Match residency applicant statistics in the United States of America: a cross sectional analysis Open

Vinayak Joshi, Eswar Kandaswamy, Sivaraman Prakasam, Veerasathpurush Allareddy, Andrew Chapple · 2025

Background The purpose of this paper is to do a cross-sectional analysis to evaluate the impact of the Coronavirus Disease 2019 pandemic on Dental Match Residency statistics from the year 2019–2023. Methods The Dental Match Residency stati…

“Developing a manual clinical trials screening process in a diverse southern gynecologic oncology practice” Open

Margaret J. Klein, Humza Pirzadah, Yasmeen Magharehabed, Andrew Chapple, Navya Nair , et al. · 2024

We show that we improved understanding of the patient population, built a clinical trial portfolio better matched to population served, exceeded national averages for enrolling patients on trials, and are improving number eligible.

Nutritional Indicators of Bone Nonunion: A Systematic Review Open

Eleanor Christianson, Margaret Thomas, Sheila Sprague, Jessica Rivera, Andrew Chapple , et al. · 2024

Background/Objectives: Bone nonunion remains a clinical challenge in orthopedic surgery with significant impacts on mental and physical wellbeing for patients. There are several previously established risk factors of nonunion that are conn…

Blood Pressure During Hospital Stay for Delivery and Risk for Postpartum Readmission for Hypertension Open

Kaitlyn Taylor, Sai S Pochana, Andrew Chapple, Maureen Dempsey, Elizabeth F. Sutton · 2024

OBJECTIVE: To evaluate the association of changes in peripartum blood pressure (BP) with risk for postpartum readmission for hypertension. METHODS: We conducted a retrospective cohort study of birthing individuals delivering from January 1…

Quantifying Radiographs in Endodontics: A Survey Open

Pavneet K. Bains, Albert F. McMullen, Haley D. Kessler, Andrew Chapple · 2024

Purpose: The aim of this study was to investigate the average quantity of radiographs obtained during non-surgical endodontic treatment and trends in endodontic radiography among U.S. members of the AAE. Materials & Methods: A survey was s…

A Modified Switching Procedure from Temporary to Tunneled Central Venous Dialysis Catheters Open

Johannes Eberhard, Constantin Bedau, Andrew Chapple, Julia Klein, Christoph Reißfelder , et al. · 2024

Background: Tunneled central venous catheters are commonly used for dialysis in patients without a functional permanent vascular access. In an emergent setting, a non-tunneled, temporary central venous catheter is often placed for immediat…

Attitudes and barriers to breastfeeding among women at high-risk for not breastfeeding: a prospective observational study Open

Jessica Cole, Ateshi Bhatt, Andrew Chapple, Sarah Buzhardt, Elizabeth F. Sutton · 2024

Background Rates of breastfeeding are lower among minority and underserved populations in the United States. Our study objective was to assess pregnant persons attitudes and barriers to breastfeeding among a cohort at high risk for not bre…

Cannabis Use Associates With Reduced Proviral Burden and Inflammatory Cytokine in Tissues From Men With Clade C HIV-1 on Suppressive Antiretroviral Therapy Open

Zhou Liu, Peter Julius, Cordilia Himwaze, Luchenga Adam Mucheleng’anga, Andrew Chapple , et al. · 2024

Background Human immunodeficiency virus 1 (HIV-1) tissue reservoirs remain the main obstacle against an HIV cure. Limited information exists regarding cannabis’s effects on HIV-1 infections in vivo, and the impact of cannabis use on HIV-1 …

Pentagon (Predicting Clinical Trials in Gynecologic Oncology): A Retrospective Study Assessing Study Design Factors that Affect Enrollment in Gynecologic Cancer Trials Open

Margaret J. Klein, Humza Pirzadah, Yasmeen Magharehabed, LaMiah Hall, Andrew Chapple , et al. · 2024

Developing a Manual Clinical Trials Screening Process in a Diverse Southern Gynecologic Oncology Practice Open

Margaret J. Klein, Humza Pirzadah, Yasmeen Magharehabed, Andrew Chapple, Navya Nair , et al. · 2024

Journal of Dental Education Volume 87 Number 12/December 2023 Open

Karen P. West, Jordan B. Ringer, Andrew Chapple, Richard W. Ballard, Paul Armbruster , et al. · 2023

Journal of Dental Education is published in 15 issues per year.FTE-based pricing, based on the overall demand and on the size and type of the subscribing institution (academic, government, hospital or corporate), applies for this Journal.

Novel Clinical Trial Designs with Dose Optimization to Improve Long-term Outcomes Open

Peter F. Thall, Yong Zang, Andrew Chapple, Ying Yuan, Ruitao Lin , et al. · 2023

Conventional designs for choosing a dose for a new therapy may select doses that are unsafe or ineffective and fail to optimize progression-free survival time, overall survival time, or response/remission duration. We explain and illustrat…

Design, analysis, and interpretation of treatment response heterogeneity in personalized nutrition and obesity treatment research Open

Roger S. Zoh, Bridget A. Hannon, Xiaoxin Yu, Amanda J. Fairchild, Ana I. Vázquez , et al. · 2023

Summary It is increasingly assumed that there is no one‐size‐fits‐all approach to dietary recommendations for the management and treatment of chronic diseases such as obesity. This phenomenon that not all individuals respond uniformly to a…

RADIANCE1 (Reducing delAys in enDometrIAl caNcer CarE) symptoms through gynecologic oncology referral (171) Open

Amelia Jernigan, Jessica Anderson, Hannah Sibley, Rebecca Maitski, Nicole Catalano , et al. · 2023

Diversifying clinical trials: Does presentation at gynecologic oncology tumor board increase equitable access to clinical trials for Black and LatinX patients? (2205) Open

Afryea Dunbar, Fraya King, Madison Keller, Yaseen Khan, Amber Bardarson , et al. · 2023

Genitourinary and sexual health care for women with cancer: Overlooked quality of life indicators (2217) Open

Hannah DellaCroce, Nancy Ren, Andrew Chapple, Sydni Barras, Shawna Morron , et al. · 2023

Comparative polar and lipid plasma metabolomics differentiate KSHV infection and disease states Open

Sara R. Privatt, Camila Pereira Braga, Alicia Johnson, Salum J. Lidenge, Luke Berry , et al. · 2023

Parenteral Corticosteroids After Fragility Fracture Increases the Odds of a Repeat Fracture Open

Justin David, Gregory Benes, Vinod Dasa, P Krause, Lauren Leslie , et al. · 2023

Purpose To determine if corticosteroid use is associated with repeat fragility fractures and the trends in corticosteroid usage in this population. Methods 2,643 patients with repeat fractures were identified in the Research Action for Hea…

Inclusion of binary proxy variables in logistic regression improves treatment effect estimation in observational studies in the presence of binary unmeasured confounding variables Open

Cornelius Rosenbaum, Qingzhao Yu, Sarah Buzhardt, Elizabeth F. Sutton, Andrew Chapple · 2023

We present a simulation study and application that shows inclusion of binary proxy variables related to binary unmeasured confounders improves the estimate of a related treatment effect in binary logistic regression. The simulation study i…

Severity of Chronic Venous Insufficiency on Primary Total Knee Arthroplasty Outcomes Open

Kaleb J. Robin, Mark A. Maier, Lauren Leslie, Vinod Dasa, Peter C. Krause , et al. · 2023

Immune profiling in Puerto Rican injection drug users with and without HIV-1 infection Open

Sydney J. Bennett, Carmen A. Davila, Zahiraliz Reyes, Anibal Valentín-Acevedo, Kim Gocchi Carrasco , et al. · 2023

Antiretroviral therapy has been effective in suppressing HIV viral load and enabling people living with HIV to experience longer, more conventional lives. However, as people living with HIV are living longer, they are developing aging-rela…

Co-occurrence of depression, anxiety, and perinatal posttraumatic stress in postpartum persons Open

Shelby Howard, Caitlin A. Witt, Karla Martin, Ateshi Bhatt, Emily M. Venable , et al. · 2023

Background The study aim was to describe the incidence of depression, anxiety, perinatal-post-traumatic stress disorder (PTSD), and their co-occurrences in the early postpartum period in a low-resource OB/GYN clinic serving majority Medica…

The Use of Eculizumab for the Treatment of Atypical Hemolytic Uremic Syndrome in an Academic Hematology Center Open

Katharine Thomas, Aneesha Ananthula, Ruby Lopez-Flores, Alejandra del Toro, Andrew Chapple , et al. · 2023

Introduction Eculizumab is a complement inhibitor used in treating atypical hemolytic uremic syndrome (aHUS). This study showcases patient demographics, clinical and laboratory results of these patients, and overall outcomes of patients wi…

Total Joint Arthroplasty Patient Demographics Before and After Coronavirus Disease 2019 Elective Surgery Restrictions Open

Morgan H. McCoy, Natalie Touchet, Andrew Chapple, Anna Cohen‐Rosenblum · 2023

Background: In 2020, the coronavirus disease 2019 (COVID-19) pandemic caused the cessation of nonemergent total joint arthroplasty (TJA, referring to total hip and total knee arthroplasty) operations between mid-March and April 2020. The p…

Implementation of and Barriers to Optimizing Postpartum Care by Resident and Attending Physicians Open

Paige G. Pettus, Lucey W. Gavlinski, Shannon Beermann, Andrew Chapple, Stacey A. Scheib , et al. · 2023

Background: The American College of Obstetricians and Gynecologists released Committee Opinion No. 736: Optimizing Postpartum Care (CO No. 736) to address severe maternal morbidity and mortality in the United States by outlining rec…

10 Risks for complications and need for repeat excisional procedures of the uterine cervix Open

Katherine R. Robichaux, Claire Bise, Andrew Chapple, Amelia Jernigan, Tara Castellano · 2022

This study aims to identify the risk factors associated with needing a repeat excisional procedure of the cervix, either Cold Knife Conization (CKC) or Loop Electrical Excision Procedure (LEEP), within one year of the index excision and to…

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