Andrew Conroy
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View article: Krüppel-like Factor 4-Deficient Cells Are Sensitive to Etoposide-Induced DNA Damage
Krüppel-like Factor 4-Deficient Cells Are Sensitive to Etoposide-Induced DNA Damage Open
Krüppel-like factor 4 (KLF4) is a highly conserved zinc-finger transcription factor involved in cellular processes such as development, differentiation, and cell cycle regulation. Previous studies show that mouse embryonic fibroblasts (MEF…
View article: 123 Landscape analysis of the neoepitope-specific T cell responses in patients with and without clinical benefit from immune checkpoint blockade therapy
123 Landscape analysis of the neoepitope-specific T cell responses in patients with and without clinical benefit from immune checkpoint blockade therapy Open
Background The primary target of T-cell responses to cancer cells are peptides derived from non-synonymous mutations presented by HLA. However, the large diversity of HLA alleles and restricted availability of clinical samples has limited …
View article: 320 Rapid identification of a TCR library targeting the HPV E6/E7 oncoproteins to enable multi-TCR T-cell therapies for patients with HPV16+ epithelial cancers
320 Rapid identification of a TCR library targeting the HPV E6/E7 oncoproteins to enable multi-TCR T-cell therapies for patients with HPV16+ epithelial cancers Open
Background In the United States, the HPV16 strain is responsible for nearly 60% of newly diagnosed HPV-driven cancers. HPV16 drives oncogenesis through persistent expression of the E6 and E7 oncoproteins.1 The viral antigens E6 and E7 are …