Explanipedia

HTRS2025.O6A.5 Fibrinolysis plays a critical role in myelorecovery after 5-FU-mediated myeloablation Open

Lakmali M. Silva, Trung Thành Nguyễn, Yong Jiang, Andrew D. Doyle, Matthew J. Flick , et al. · 2025

Long Prehensile Protrusions Can Facilitate Cancer Cell Invasion through the Basement Membrane Open

Shayan Nazari, Andrew D. Doyle, Christopher K. E. Bleck, Kenneth M. Yamada · 2023

A basic process in cancer is the breaching of basement-membrane barriers to permit tissue invasion. Cancer cells can use proteases and physical mechanisms to produce initial holes in basement membranes, but how cells squeeze through this b…

Maintenance of pluripotency-like signature in the entire ectoderm leads to neural crest stem cell potential Open

Ceren Pajanoja, Jenny Hsin, Bradley Olinger, Andrew T. Schiffmacher, Rita M. Yazejian , et al. · 2023

A ubiquitin-based effector-to-inhibitor switch coordinates early brain, craniofacial, and skin development Open

Anthony J. Asmar, Shaun R. Abrams, Jenny Hsin, Jason C. Collins, Rita M. Yazejian , et al. · 2023

Biglycan regulates bone development and regeneration Open

Reut Shainer, Vardit Kram, Tina M. Kilts, Li Li, Andrew D. Doyle , et al. · 2023

Endochondral bone development and regeneration relies on activation and proliferation of periosteum derived-cells (PDCs). Biglycan (Bgn), a small proteoglycan found in extracellular matrix, is known to be expressed in bone and cartilage, h…

Maintenance of pluripotency in the entire ectoderm enables neural crest formation Open

Ceren Pajanoja, Jenny Hsin, Bradley Olinger, Andrew T. Schiffmacher, Shaun R. Abrams , et al. · 2023

The ability of the pluripotent epiblast to contribute progeny to all three germ layers is thought to be lost after gastrulation. The later-forming neural crest (NC) rises from ectoderm and it remains poorly understood how its exceptionally…

Data for Nazari et al 2023.zip in Cells: doi: 10.3390/cells12202474 Open

Kenneth M. Yamada, Shayan Nazari, Andrew D. Doyle, Christopher K. E. Bleck · 2023

Data underlying the manuscript "Long prehensile protrusions can facilitate cancer cell invasion through the basement membrane" in the journal Cells by Nazari et al. 2023: doi: 10.3390/cells12202474

Stretching attenuates tumor growth and improves tumor-associated collagen signatures in mouse orthotopic PyMT cancer model Open

Lisbeth Berrueta, Rebecca D. Thompson, Andrew D. Doyle, Gary J. Badger, Hélène M. Langevin · 2022

Both mechanical forces and tumor-associated stroma architecture have been demonstrated to impact the growth and invasiveness of cancer cells. Tumor associated collagen signatures (TACS) aligned perpendicular to the boundary of tumors promo…

A tissue-specific ubiquitin switch coordinates brain, craniofacial, and skin development Open

Anthony J. Asmar, Rita M. Yazejian, Youmei Wu, Jason C. Collins, Jenny Hsin , et al. · 2022

The molecular mechanisms that coordinate patterning of the embryonic ectoderm into spatially distinct lineages to form the nervous system, epidermis, and craniofacial structures are unclear. Here, biochemical disease-variant profiling reve…

Mechanisms of Basement Membrane Micro-Perforation during Cancer Cell Invasion into a 3D Collagen Gel Open

Shayan Nazari, Andrew D. Doyle, Kenneth M. Yamada · 2022

Cancer invasion through basement membranes represents the initial step of tumor dissemination and metastasis. However, little is known about how human cancer cells breach basement membranes. Here, we used a three-dimensional in vitro invas…

Mechanisms of Basement Membrane Micro-Perforation During Cancer Cell Invasion Into a 3D Collagen Gel Open

Shayan Nazari, Andrew D. Doyle, Kenneth M. Yamada · 2022

Cancer invasion through basement membranes represents the initial step of tumor dissemination and metastasis. However, little is known about how human cancer cells breach basement membranes. Here, we used a 3-dimensional in vitro invasion …

Cell–3D matrix interactions: recent advances and opportunities Open

Kenneth M. Yamada, Andrew D. Doyle, Jiao Lu · 2022

Visualization of trigeminal ganglion sensory neuronal signaling regulated by Cdk5 Open

Minghan Hu, Andrew D. Doyle, Kenneth M. Yamada, Ashok B. Kulkarni · 2022

The mechanisms underlying facial pain are still incompletely understood, posing major therapeutic challenges. Cyclin-dependent kinase 5 (Cdk5) is a key neuronal kinase involved in pain signaling. However, the regulatory roles of Cdk5 in fa…

Atto 465 Derivative Is a Nuclear Stain with Unique Excitation and Emission Spectra Useful for Multiplex Immunofluorescence Histochemistry Open

Joshua Dodge, Andrew D. Doyle, Ana Caroline Costa-da-Silva, Christopher T. Hogden, Éva Mezey , et al. · 2022

Multiplex immunofluorescence (mIF) is an effective technique for the maximal visualization of multiple target proteins in situ. This powerful tool is mainly limited by the spectral overlap of the currently available synthetic fluorescent d…

Cell–extracellular matrix dynamics Open

Andrew D. Doyle, Shayan Nazari, Kenneth M. Yamada · 2021

The sites of interaction between a cell and its surrounding microenvironment serve as dynamic signaling hubs that regulate cellular adaptations during developmental processes, immune functions, wound healing, cell migration, cancer invasio…

Live Imaging and Quantification of Neutrophil Extracellular Trap Formation Open

Lakmali M. Silva, Niki M. Moutsopoulos, Thomas Bugge, Andrew D. Doyle · 2021

N eutrophil E xtracellular T rap (NET) formation (NETosis) is a unique process that occurs in response to numerous stimuli. To investigate NETosis, we created a method that can be used easily without the need for complex programming abilit…

3D mesenchymal cell migration is driven by anterior cellular contraction that generates an extracellular matrix prestrain Open

Andrew D. Doyle, Daniel J. Sykora, Gustavo G. Pacheco, Matthew L. Kutys, Kenneth M. Yamada · 2021

Pannexin 3 regulates skin development via Epiprofin Open

Peipei Zhang, Masaki Ishikawa, Andrew D. Doyle, Takashi Nakamura, Bing He , et al. · 2021

Pannexin 3 (Panx3), a member of the gap junction pannexin family is required for the development of hard tissues including bone, cartilage and teeth. However, the role of Panx3 in skin development remains unclear. Here, we demonstrate that…

Fibrin is a critical regulator of neutrophil effector function at mucosal barrier sites Open

Lakmali M. Silva, Andrew D. Doyle, Collin L. Tran, Teresa Greenwell‐Wild, Nicolás Dutzan , et al. · 2021

Tissue-specific cues are critical for homeostasis at mucosal barriers. Here, we document that the clotting factor fibrin is a critical regulator of neutrophil function at mucosal barriers. We demonstrate that fibrin engages neutrophils thr…

Visualization of Trigeminal Ganglion Sensory Neuronal Signaling Regulated by Cdk5 Open

Minghan Hu, Andrew D. Doyle, Kenneth M. Yamada, Ashok B. Kulkarni · 2021

Retraction: Btbd7 is essential for region-specific epithelial cell dynamics and branching morphogenesis <i>in vivo</i> Open

William P. Daley, Kazue Matsumoto, Andrew D. Doyle, Shaohe Wang, Brian J. DuChez , et al. · 2020

The authors are retracting Development (2017) 144, 2200-2211 (doi:10.1242/dev.146894).The authors state: 'We request retraction of our article because we have discovered that a major conclusion is not correct. We had reported that Btbd7 is…

Direct comparison of five different <span>3D</span> extracellular matrix model systems for characterization of cancer cell migration Open

Yoshinari Shinsato, Andrew D. Doyle, Weimin Li, Kenneth M. Yamada · 2020

Background Three‐dimensional (3D) in vitro model systems can bridge the gap between regular two‐dimensional cell culture and whole‐animal studies. Analyses of cancer cell migration and invasion increasingly use differing 3D systems, which …

Basement Membrane Regulates Fibronectin Organization Using Sliding Focal Adhesions Driven by a Contractile Winch Open

Jiao Lu, Andrew D. Doyle, Yoshinari Shinsato, Shaohe Wang, Molly A. Bodendorfer , et al. · 2020

Mechanics and Mechanisms of 3D Mesenchymal Cell Migration Open

Andrew D. Doyle, Daniel J. Sykora, Gustavo G. Pacheco, Matthew L. Kutys, Kenneth M. Yamada · 2020

Correction Notice: Fluorescent Labeling of Rat-tail Collagen for 3D Fluorescence Imaging Open

Andrew D. Doyle · 2020

[This corrects the article .].

Tissue Architectural Cues Drive Organ Targeting of Tumor Cells in Zebrafish Open

Colin D. Paul, Kevin Bishop, Alexus Devine, Elliott L. Paine, Jack R. Staunton , et al. · 2019

Extracellular matrix dynamics in cell migration, invasion and tissue morphogenesis Open

Kenneth M. Yamada, Joshua W. Collins, David A. Cruz Walma, Andrew D. Doyle, Shaimar Gonzalez Morales , et al. · 2019

Summary This review describes how direct visualization of the dynamic interactions of cells with different extracellular matrix microenvironments can provide novel insights into complex biological processes. Recent studies have moved chara…

Basement membrane regulates fibronectin organization using sliding focal adhesions driven by a contractile winch Open

Jiao Lu, Andrew D. Doyle, Yoshinari Shinsato, Shaohe Wang, Molly A. Bodendorfer , et al. · 2019

We have discovered that basement membrane and its major components can induce rapid, strikingly robust fibronectin organization. In this new matrix assembly mechanism, α5β1 integrin-based focal adhesions slide actively on the underlying ma…

Myosin II governs intracellular pressure and traction by distinct tropomyosin-dependent mechanisms Open

Kimheak Sao, Tia M. Jones, Andrew D. Doyle, Debonil Maity, Galina Schevzov , et al. · 2019

Two-dimensional (2D) substrate rigidity promotes myosin II activity to increase traction force in a process negatively regulated by tropomyosin (Tpm) 2.1. We recently discovered that actomyosin contractility can increase intracellular pres…

Durotaxis by Human Cancer Cells Open

Brian J. DuChez, Andrew D. Doyle, Emilios K. Dimitriadis, Kenneth M. Yamada · 2019

Andrew D. Doyle YOU? Author Swipe