Andrew D. Duckworth
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View article: Baseline Characteristics of the TOPaZ Study: Randomised Trial of Teriparatide and Zoledronic Acid Compared with Standard Care in Adults with Osteogenesis Imperfecta
Baseline Characteristics of the TOPaZ Study: Randomised Trial of Teriparatide and Zoledronic Acid Compared with Standard Care in Adults with Osteogenesis Imperfecta Open
View article: Operative management of displaced fractures of the distal radius is associated with improved function but not in older adults
Operative management of displaced fractures of the distal radius is associated with improved function but not in older adults Open
Aims This systematic review and meta-analysis aimed to compare the patient-reported outcomes of operative and nonoperative management in adults with a fracture of the distal radius, with a focus on the outcomes in older patients (aged ≥ 65…
View article: Joint Aspiration for the Diagnosis of Suspected Native Septic Arthritis
Joint Aspiration for the Diagnosis of Suspected Native Septic Arthritis Open
View article: Enhanced recovery following neck of femur fractures – improving outcomes
Enhanced recovery following neck of femur fractures – improving outcomes Open
Aims The number of hip fractures is increasing, with significant mortality and morbidity, particularly among frail and comorbid patients. Enhanced recovery after surgery (ERAS) pathways have proven effective in elective orthopaedics, but t…
View article: The association of umbilical cord blood neurofilament light with non‐reassuring fetal status: A prospective observational study
The association of umbilical cord blood neurofilament light with non‐reassuring fetal status: A prospective observational study Open
Objective Early detection of hypoxic–ischemic encephalopathy (HIE) in neonates is critical. We conducted a pilot cohort study to determine the feasibility of collecting umbilical cord blood samples for neurofilament light (NfL) and to asse…
View article: 481 | ADAPTIVE RESISTANCE IN LYMPHOPROLIFERATIVE DISORDERS: POTENTIAL ROLES OF SNHG32, A NOVEL NON‐CODING TUMOUR SUPPRESSOR
481 | ADAPTIVE RESISTANCE IN LYMPHOPROLIFERATIVE DISORDERS: POTENTIAL ROLES OF SNHG32, A NOVEL NON‐CODING TUMOUR SUPPRESSOR Open
View article: Influence of polyfunctional Tbet+ T cells on specific clinical events in chronic lymphocytic leukaemia
Influence of polyfunctional Tbet+ T cells on specific clinical events in chronic lymphocytic leukaemia Open
Introduction T-cell dysfunction is a hallmark of chronic lymphocytic leukemia (CLL), but the extent to which individual CD4 + or CD8 + T-cell subpopulations influence specific clinical events remains unclear. To address this knowledge gap,…
View article: Adductor canal block in total knee arthroplasty: a scoping review of the literature
Adductor canal block in total knee arthroplasty: a scoping review of the literature Open
View article: The association of umbilical cord blood neurofilament light with non-reassuring fetal status: a prospective observational study
The association of umbilical cord blood neurofilament light with non-reassuring fetal status: a prospective observational study Open
Objective Early detection of hypoxic–ischaemic encephalopathy (HIE) in neonates is critical. We conducted a pilot cohort study to determine the feasibility of collecting umbilical cord blood samples for neurofilament light (NfL) and to ass…
View article: An open source convolutional neural network to detect and localize distal radius fractures on plain radiographs
An open source convolutional neural network to detect and localize distal radius fractures on plain radiographs Open
Purpose Distal radius fractures (DRFs) are often initially assessed by junior doctors under time constraints, with limited supervision, risking significant consequences if missed. Convolutional Neural Networks (CNNs) can aid in diagnosing …
View article: Suture Fixation Versus Tension Band Wiring for Simple Olecranon Fracture Fixation in Adults. Simple Olecranon Fracture Fixation Trial (SOFFT): A Multi-Centre, Parallel Group, Two Arm, Non-Inferiority Randomised Controlled Trial
Suture Fixation Versus Tension Band Wiring for Simple Olecranon Fracture Fixation in Adults. Simple Olecranon Fracture Fixation Trial (SOFFT): A Multi-Centre, Parallel Group, Two Arm, Non-Inferiority Randomised Controlled Trial Open
View article: Umbilical cord blood pTau217 and BD-tau are associated with markers of neonatal hypoxia: a prospective cohort study
Umbilical cord blood pTau217 and BD-tau are associated with markers of neonatal hypoxia: a prospective cohort study Open
Objective Current methods for early detection of hypoxic–ischemic encephalopathy (HIE) are limited by lack of specificity, cost, and time constraints. Blood tau protein concentrations reflect neuropathology in adults. This study examines t…
View article: Outcomes for Younger Patients with Femoral Neck Fractures
Outcomes for Younger Patients with Femoral Neck Fractures Open
Background: There is a paucity of longer-term outcome data in younger adult patients who undergo fixation for an intracapsular hip fracture. The aims of this study were to evaluate the outcomes for young adult patients undergoing intracaps…
View article: Impact of household characteristics on patient outcomes post hip fracture: a Welsh nationwide observational cohort study
Impact of household characteristics on patient outcomes post hip fracture: a Welsh nationwide observational cohort study Open
Background Hip fracture is common in older people and has significant health and care implications. This study aimed to examine the impact of household characteristics (living alone or living with someone who is themselves ill) on adverse …
View article: Protocol for a prospective randomized trial of surgical versus conservative management for unstable fractures of the distal radius in patients aged 65 years and older
Protocol for a prospective randomized trial of surgical versus conservative management for unstable fractures of the distal radius in patients aged 65 years and older Open
Aims The primary aim of this study is to quantify and compare outcomes following a dorsally displaced fracture of the distal radius in elderly patients (aged ≥ 65 years) who are managed conservatively versus with surgical fixation (open re…
View article: Delayed admission of patients with hip fracture from the emergency department is associated with an increased mortality risk and increased length of hospital stay
Delayed admission of patients with hip fracture from the emergency department is associated with an increased mortality risk and increased length of hospital stay Open
Background The aims of this study were to assess whether delayed admission from the ED influenced mortality risk, length of acute hospital stay, risk of developing delirium and return to domicile for patients presenting with a hip fracture…
View article: The incidence of surgical intervention following a suspected scaphoid fracture
The incidence of surgical intervention following a suspected scaphoid fracture Open
Aims The underlying natural history of suspected scaphoid fractures (SSFs) is unclear and assumed poor. There is an urgent requirement to develop the literature around SSFs to quantify the actual prevalence of intervention following SSF. D…
View article: The incidence of subsequent contralateral hip fracture and factors associated with increased risk: the IMPACT Contralateral Fracture Study
The incidence of subsequent contralateral hip fracture and factors associated with increased risk: the IMPACT Contralateral Fracture Study Open
View article: Early mobilisation after hip fracture surgery is associated with improved patient outcomes: A systematic review and meta‐analysis
Early mobilisation after hip fracture surgery is associated with improved patient outcomes: A systematic review and meta‐analysis Open
Introduction The aims of this systematic review and meta‐analysis were to determine if after hip fracture surgery (1) early mobilisation is associated with improved clinical outcomes, and if so (2) are benefits directly proportional to how…
View article: Lateral wall thickness is not associated with revision risk of medially stable intertrochanteric fractures fixed with a sliding hip screw
Lateral wall thickness is not associated with revision risk of medially stable intertrochanteric fractures fixed with a sliding hip screw Open
Aims This study aimed to determine whether lateral femoral wall thickness (LWT) < 20.5 mm was associated with increased revision risk of intertrochanteric fracture (ITF) of the hip following sliding hip screw (SHS) fixation when the medial…
View article: A national multicentre study of outcomes and patient satisfaction with the virtual fracture clinic and the influence of the COVID-19 pandemic: The MAVCOV study
A national multicentre study of outcomes and patient satisfaction with the virtual fracture clinic and the influence of the COVID-19 pandemic: The MAVCOV study Open
View article: Delirium detection tools show varying completion rates and positive score rates when used at scale in routine practice in general hospital settings: A systematic review
Delirium detection tools show varying completion rates and positive score rates when used at scale in routine practice in general hospital settings: A systematic review Open
Background Multiple short delirium detection tools have been validated in research studies and implemented in routine care, but there has been little study of these tools in real‐world conditions. This systematic review synthesized literat…
View article: Operative vs Nonoperative Management of Unstable Medial Malleolus Fractures
Operative vs Nonoperative Management of Unstable Medial Malleolus Fractures Open
Importance Unstable ankle fractures are routinely managed operatively. However, because of soft tissue and implant-related complications, recent literature has reported on the nonoperative management of well-reduced medial malleolus fractu…
View article: Soluble CTLA-4 attenuates T cell activation and modulates anti-tumor immunity
Soluble CTLA-4 attenuates T cell activation and modulates anti-tumor immunity Open
View article: VACCINATION AGAINST COVID-19 REDUCED THE MORTALITY RISK OF COVID-POSITIVE HIP FRACTURE PATIENTS TO BASELINE LEVELS: THE NATIONWIDE DATA-LINKED IMPACT PROTECT STUDY
VACCINATION AGAINST COVID-19 REDUCED THE MORTALITY RISK OF COVID-POSITIVE HIP FRACTURE PATIENTS TO BASELINE LEVELS: THE NATIONWIDE DATA-LINKED IMPACT PROTECT STUDY Open
COVID-19 confers a three-fold increased mortality risk among hip fracture patients. The aims were to investigate whether vaccination was associated with: i) lower mortality risk, and ii) lower likelihood of contracting COVID-19 within 30 d…
View article: Ultrasound assessment of humeral shaft nonunion risk: a feasibility and proof of concept study
Ultrasound assessment of humeral shaft nonunion risk: a feasibility and proof of concept study Open
View article: What differences exist between the lead and trail wrist in extensor carpi ulnaris activity and golf swing joint kinematics in sub-elite golfers?
What differences exist between the lead and trail wrist in extensor carpi ulnaris activity and golf swing joint kinematics in sub-elite golfers? Open
This study assessed the lead and trail arm peak and average extensor carpi ulnaris (ECU) muscle activity in association with tri-planar angular velocities of the lead and trail wrists during the golf swing. Fifteen sub-elite, male right-ha…
View article: Completion of the Emergency Department “Big 6” in Patients with an Acute Hip Fracture Is Associated with a Lower Mortality Risk and Shorter Length of Hospital Stay
Completion of the Emergency Department “Big 6” in Patients with an Acute Hip Fracture Is Associated with a Lower Mortality Risk and Shorter Length of Hospital Stay Open
The aims of this study were to assess whether completion of the emergency department (ED) Big 6 interventions (provision of pain relief, screening for delirium, early warning score (EWS) system, full blood investigation and electrocardiogr…
View article: SIRVA: Shoulder injury related to vaccine administration
SIRVA: Shoulder injury related to vaccine administration Open
Shoulder injury related to vaccine administration (SIRVA) is a prolonged episode of shoulder dysfunction that commences within 24 to 48 hours of a vaccination. Symptoms include a combination of shoulder pain, stiffness, and weakness. There…
View article: QuickDASH and PRWE Are Not Optimal Patient-Reported Outcome Measures After Distal Radial Fracture Due to Ceiling Effect
QuickDASH and PRWE Are Not Optimal Patient-Reported Outcome Measures After Distal Radial Fracture Due to Ceiling Effect Open
Background: The aim of this study was to determine the floor and ceiling effects for both the QuickDASH (shortened version of the Disabilities of the Arm, Shoulder and Hand [DASH] questionnaire) and the PRWE (Patient-Rated Wrist Evaluation…