Explanipedia

Skull–meninges–brain connectivity and extra-axial brain tumours Open

Abdurrahman I. Islim, Alexandros Vyziotis, Omar Pathmanaban, David Coope, Andrew T. King , et al. · 2025

The cortex of the brain is covered by three meningeal layers: the dura, the arachnoid, and the pia mater. Substantial discoveries have been made demonstrating the structural and functional relationships between these layers, and with other…

Basement membranes’ role in immune cell recruitment to the central nervous system Open

Stephen Wright, Rachel Lennon, Andrew D. Greenhalgh · 2024

Basement membranes form part of the extracellular matrix (ECM), which is the structural basis for all tissue. Basement membranes are cell-adherent sheets found between cells and vascular endothelia, including those of the central nervous s…

Acute Myopericarditis as the First Manifestation of Familial Mediterranean Fever: A Case Report Open

Abdalla Khalil, Andrew D. Greenhalgh, Shovhit Gurung, Harmeet Chana · 2024

Familial Mediterranean fever (FMF) is an autoinflammatory disorder, characterized by recurrent episodes of fever and polyserositis, and usually presents during the first two decades of life. Acute pericarditis is a rare manifestation of FM…

Microglia states and nomenclature: A field at its crossroads Open

Rosa Chiara Paolicelli, Amanda Sierra, Beth Stevens, Marie‐Ève Tremblay, Adriano Aguzzi , et al. · 2022

N-3 PUFA Deficiency Affects the Ultrastructural Organization and Density of White Matter Microglia in the Developing Brain of Male Mice Open

Fanny Decoeur, Katherine Picard, Marie‐Kim St‐Pierre, Andrew D. Greenhalgh, Jean-Christophe Delpech , et al. · 2022

Over the last century, westernization of dietary habits has led to a dramatic reduction in dietary intake of n-3 polyunsaturated fatty acids (n-3 PUFAs). In particular, low maternal intake of n-3 PUFAs throughout gestation and lactation ca…

Defining Microglial States and Nomenclature: A Roadmap to 2030 Open

Rosa Chiara Paolicelli, Amanda Sierra, Beth Stevens, Marie‐Ève Tremblay, Adriano Aguzzi , et al. · 2022

The Immune System's Role in the Consequences of Mild Traumatic Brain Injury (Concussion) Open

Laura N. Verboon, Hiren C. Patel, Andrew D. Greenhalgh · 2021

Mild traumatic brain injury (mild TBI), often referred to as concussion, is the most common form of TBI and affects millions of people each year. A history of mild TBI increases the risk of developing emotional and neurocognitive disorders…

Essential omega-3 fatty acids tune microglial phagocytosis of synaptic elements in the mouse developing brain Open

Charlotte Madore, Quentin Leyrolle, Lydie Morel, Moïra Rossitto, Andrew D. Greenhalgh , et al. · 2020

Omega-3 fatty acids (n-3 PUFAs) are essential for the functional maturation of the brain. Westernization of dietary habits in both developed and developing countries is accompanied by a progressive reduction in dietary intake of n-3 PUFAs.…

B cells on the brain: meningeal IgA and a novel gut–brain firewall Open

Matthew R. Hepworth, Andrew D. Greenhalgh, Peter C. Cook · 2020

Fitzpatrick et al. describe how IgA secretion by B cells and plasma cells in the mengines is crucial for protection against microbial invasion into the brain and the CNS.

Essential omega-3 fatty acids tune microglial phagocytosis of synaptic elements in the developing brain Open

Charlotte Madore, Quentin Leyrolle, Lydie Morel, Jean-Christophe Delpech, Andrew D. Greenhalgh , et al. · 2019

SUMMARY Omega-3 fatty acids (n-3 polyunsaturated fatty acids; n-3 PUFAs) are essential for the functional maturation of the brain. Westernization of dietary habits in both developed and developing countries is accompanied by a progressive …

Peripherally derived macrophages modulate microglial function to reduce inflammation after CNS injury Open

Andrew D. Greenhalgh, Juan G. Zarruk, Luke M. Healy, Sam Joshva Baskar Jesudasan, Priya Jhelum , et al. · 2018

Infiltrating monocyte-derived macrophages (MDMs) and resident microglia dominate central nervous system (CNS) injury sites. Differential roles for these cell populations after injury are beginning to be uncovered. Here, we show evidence th…

Dietary n-3 long chain PUFA supplementation promotes a pro-resolving oxylipin profile in the brain Open

Charlotte Rey, Jean-Christophe Delpech, Charlotte Madore, Agnès Nadjar, Andrew D. Greenhalgh , et al. · 2018

Myeloid cell responses after spinal cord injury Open

Samuel David, Antje Kroner, Andrew D. Greenhalgh, Juan G. Zarruk, Rubén López‐Vales · 2018

EP-1859: How useful are Dose Reference Levels in Radiotherapy? A regional treatment planning CT dose audit Open

H. McCallum, A R Lecomber, Rachael Tulip, Andrew D. Greenhalgh, K. Pilling , et al. · 2018

Neutrophil infiltration to the brain is platelet‐dependent, and is reversed by blockade of platelet GPIb<i>α</i> Open

James Giles, Andrew D. Greenhalgh, Ádám Dénes, Bernhard Nieswandt, Graham Coutts , et al. · 2018

Summary Neutrophils are key components of the innate immune response, providing host defence against infection and being recruited to non‐microbial injury sites. Platelets act as a trigger for neutrophil extravasation to inflammatory sites…

Microglia and macrophages differ in their inflammatory profile after permanent brain ischemia Open

Juan G. Zarruk, Andrew D. Greenhalgh, Samuel David · 2017

Docosahexaenoic acid-containing choline phospholipid modulates LPS-induced neuroinflammation in vivo and in microglia in vitro Open

Célia Fourrier, Julie Rémus-Borel, Andrew D. Greenhalgh, Michel Guichardant, Nathalie Bernoud‐Hubac , et al. · 2017

Novel Influences of IL-10 on CNS Inflammation Revealed by Integrated Analyses of Cytokine Networks and Microglial Morphology Open

Warren D. Anderson, Andrew D. Greenhalgh, Aditya Takwale, Samuel David, Rajanikanth Vadigepalli · 2017

Coordinated interactions between cytokine signaling and morphological dynamics of microglial cells regulate neuroinflammation in CNS injury and disease. We found that pro-inflammatory cytokine gene expression in vivo showed a pronou…

Arginase-1 is expressed exclusively by infiltrating myeloid cells in CNS injury and disease Open

Andrew D. Greenhalgh, Rosmarini Passos dos Santos, Juan G. Zarruk, Christopher Salmon, Antje Kroner , et al. · 2016

Microglial TNF-α Suppresses Cocaine-Induced Plasticity and Behavioral Sensitization Open

Gil M. Lewitus, Sarah C. Konefal, Andrew D. Greenhalgh, Horia Pribiag, Keanan Augereau , et al. · 2016

TNF and Increased Intracellular Iron Alter Macrophage Polarization to a Detrimental M1 Phenotype in the Injured Spinal Cord Open

Antje Kroner, Andrew D. Greenhalgh, Juan G. Zarruk, Rosmarini Passos dos Santos, Matthias Gaestel , et al. · 2015

Microglia and Macrophage Responses and Their Role after Spinal Cord Injury Open

Antje Kroner, Andrew D. Greenhalgh, Samuel David · 2015

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