Andrew D. Grotzinger
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View article: Immune Markers Mediate Genetic Relationships between Immune Diseases and Psychiatric Disorders
Immune Markers Mediate Genetic Relationships between Immune Diseases and Psychiatric Disorders Open
This study explored the genetic links between 11 immune-mediated diseases and 13 psychiatric disorders, addressing the limited understanding of what links these illnesses. Utilizing genomic structural equation modeling, we investigated whe…
View article: Modeling the genomic architecture of adiposity and anthropometrics across the lifespan
Modeling the genomic architecture of adiposity and anthropometrics across the lifespan Open
Obesity-related conditions are among the leading causes of preventable death and are increasing in prevalence worldwide. Body size and composition are complex traits that are challenging to characterize due to environmental and genetic inf…
View article: Uncovering the multivariate genetic architecture of frailty with genomic structural equation modeling
Uncovering the multivariate genetic architecture of frailty with genomic structural equation modeling Open
View article: Examining the genetic links between clusters of immune-mediated diseases and psychiatric disorders
Examining the genetic links between clusters of immune-mediated diseases and psychiatric disorders Open
View article: Measurement characteristics and genome-wide correlates of lifetime brain atrophy estimated from a single MRI
Measurement characteristics and genome-wide correlates of lifetime brain atrophy estimated from a single MRI Open
As a cardinal marker of brain ageing, lifetime brain atrophy obtained from a cross-sectional magnetic resonance image promises to boost statistical power to uncover novel genetic mechanisms of neurodegeneration. By analysing five young and…
View article: Molecular genetic influences on attentional control and other executive processes and their links with psychopathology in the AFFECT study
Molecular genetic influences on attentional control and other executive processes and their links with psychopathology in the AFFECT study Open
Background Attentional control is a critical component of executive functioning involved in numerous psychiatric and neurological disorders, yet its etiological relationships with many cognitive and behavioral phenotypes remain underexplor…
View article: Correction: Assessment and ascertainment in psychiatric molecular genetics: challenges and opportunities for cross-disorder research
Correction: Assessment and ascertainment in psychiatric molecular genetics: challenges and opportunities for cross-disorder research Open
View article: The Landscape of Shared and Divergent Genetic Influences across 14 Psychiatric Disorders
The Landscape of Shared and Divergent Genetic Influences across 14 Psychiatric Disorders Open
Psychiatric disorders display high levels of comorbidity and genetic overlap 1,2 . Genomic methods have shown that even for schizophrenia and bipolar disorder, two disorders long-thought to be etiologically distinct 3 , the majority of gen…
View article: Impulsivity facets and substance use involvement: insights from genomic structural equation modeling
Impulsivity facets and substance use involvement: insights from genomic structural equation modeling Open
Background Impulsivity is a multidimensional trait associated with substance use disorders (SUDs), but the relationship between distinct impulsivity facets and stages of substance use involvement remains unclear. Methods We used genomic st…
View article: Examining the genetic relationship between Alzheimer’s disease, schizophrenia and their shared risk factors using genomic structural equation modelling
Examining the genetic relationship between Alzheimer’s disease, schizophrenia and their shared risk factors using genomic structural equation modelling Open
Epidemiological studies have demonstrated an association between dementia and schizophrenia. There is a significant symptom overlap between the two disorders—psychosis is seen in 50% of patients with Alzheimer’s disease and cognitive impai…
View article: Assessment and ascertainment in psychiatric molecular genetics: challenges and opportunities for cross-disorder research
Assessment and ascertainment in psychiatric molecular genetics: challenges and opportunities for cross-disorder research Open
View article: Multivariate analysis of 1.5 million people identifies genetic associations with traits related to self-regulation and addiction
Multivariate analysis of 1.5 million people identifies genetic associations with traits related to self-regulation and addiction Open
View article: Author Correction: Multivariate analysis of 1.5 million people identifies genetic associations with traits related to self-regulation and addiction
Author Correction: Multivariate analysis of 1.5 million people identifies genetic associations with traits related to self-regulation and addiction Open
Correction to "Multivariate analysis of 1.5 million people identifies genetic associations with traits related to self-regulation and addiction"
View article: Author Correction: Multivariate analysis of 1.5 million people identifies genetic associations with traits related to self-regulation and addiction
Author Correction: Multivariate analysis of 1.5 million people identifies genetic associations with traits related to self-regulation and addiction Open
View article: Genomic network analysis characterizes genetic architecture and identifies trait-specific biology
Genomic network analysis characterizes genetic architecture and identifies trait-specific biology Open
Pervasive genetic overlap across human complex traits necessitates developing multivariate methods that can parse pleiotropic and trait-specific genetic signals. Here, we introduce Genomic Network Analysis (GNA), an analytic framework that…
View article: Multivariate genomic analyses of frailty reveal the unique importance of cognitive and multimorbidity pathways for aging‐related health outcomes
Multivariate genomic analyses of frailty reveal the unique importance of cognitive and multimorbidity pathways for aging‐related health outcomes Open
Background Frailty is a complex clinical state that is associated with poorer health outcomes and increased dementia risk in older adults. It is routinely measured using the Frailty Index, which is a proportional score based on the number …
View article: Lifetime brain atrophy estimated from a single MRI: measurement characteristics and genome-wide correlates
Lifetime brain atrophy estimated from a single MRI: measurement characteristics and genome-wide correlates Open
A measure of lifetime brain atrophy (LBA) obtained from a single magnetic resonance imaging (MRI) scan could be an attractive candidate to boost statistical power in uncovering novel genetic signals and mechanisms of neurodegeneration. We …
View article: Characterizing genetic pathways unique to autism spectrum disorder at multiple levels of biological analysis
Characterizing genetic pathways unique to autism spectrum disorder at multiple levels of biological analysis Open
Our findings delineate the unique genetic underpinnings of ASD that are independent of ADHD at the genome-wide, functional, and gene expression level of analysis. In addition, we identify novel associations previously masked by their diame…
View article: Genome-wide meta-analysis of ascertainment and symptom structures of major depression in case-enriched and community cohorts
Genome-wide meta-analysis of ascertainment and symptom structures of major depression in case-enriched and community cohorts Open
Background Diagnostic criteria for major depressive disorder allow for heterogeneous symptom profiles but genetic analysis of major depressive symptoms has the potential to identify clinical and etiological subtypes. There are several chal…
View article: Genetic associations between non-cognitive skills and academic achievement over development
Genetic associations between non-cognitive skills and academic achievement over development Open
View article: Modeling the genomic architecture of adiposity and anthropometrics across the lifespan
Modeling the genomic architecture of adiposity and anthropometrics across the lifespan Open
Obesity-related conditions are among the leading causes of preventable death and are increasing in prevalence worldwide. Body size and composition are complex traits that are challenging to characterize due to environmental and genetic inf…
View article: Shared Genetic Liability across Systems of Psychiatric and Physical Illness
Shared Genetic Liability across Systems of Psychiatric and Physical Illness Open
Epidemiological literature has shown that there are extensive comorbidity patterns between psychiatric and physical illness. However, our understanding of the multivariate systems of relationships underlying these patterns is poorly unders…
View article: Uncovering the multivariate genetic architecture of frailty with genomic structural equation modelling
Uncovering the multivariate genetic architecture of frailty with genomic structural equation modelling Open
Frailty is a multifaceted clinical state associated with accelerated aging and adverse health outcomes. Informed etiological models of frailty hold promise for producing widespread health improvements across the aging population. Frailty i…
View article: Examining the Genetic Links between Clusters of Immune-mediated Diseases and Psychiatric Disorders
Examining the Genetic Links between Clusters of Immune-mediated Diseases and Psychiatric Disorders Open
Importance Autoimmune and autoinflammatory diseases have been linked to psychiatric disorders in the phenotypic and genetic literature. However, a comprehensive model that investigates the association between a broad range of psychiatric d…
View article: Characterizing Genetic Pathways Unique to Autism Spectrum Disorder at Multiple Levels of Biological Analysis
Characterizing Genetic Pathways Unique to Autism Spectrum Disorder at Multiple Levels of Biological Analysis Open
Autism spectrum disorder (ASD) is a neurodevelopmental condition characterized by atypical patterns of social functioning and repetitive/restricted behaviors. ASD commonly co-occurs with ADHD and, despite their clinical distinctiveness, th…
View article: Evidence for strong genetic correlations among internalizing psychopathology and related self-reported measures using both genomic and twin/adoptive approaches.
Evidence for strong genetic correlations among internalizing psychopathology and related self-reported measures using both genomic and twin/adoptive approaches. Open
The internalizing construct captures shared variance underlying risk for mood and anxiety disorders. Internalizing factors based on diagnoses (or symptoms) of major depressive disorder (MDD) and generalized anxiety disorder (GAD) are well …
View article: Examining Differences in the Genetic and Functional Architecture of Attention-Deficit/Hyperactivity Disorder Diagnosed in Childhood and Adulthood
Examining Differences in the Genetic and Functional Architecture of Attention-Deficit/Hyperactivity Disorder Diagnosed in Childhood and Adulthood Open
This study demonstrated that ADHD diagnosed later in life shows much stronger genetic overlap with internalizing disorders and related traits. This may indicate the potential clinical relevance of distinguishing these subgroups or increase…
View article: Partitioning the Genomic Components of Behavioral Disinhibition and Substance Use (Disorder) Using Genomic Structural Equation Modeling
Partitioning the Genomic Components of Behavioral Disinhibition and Substance Use (Disorder) Using Genomic Structural Equation Modeling Open
Externalizing behaviors encompass manifestations of risk-taking, self-regulation, aggression, sensation-/reward-seeking, and impulsivity. Externalizing research often includes substance use (SU), substance use disorder (SUD), and other (no…
View article: Beyond the factor indeterminacy problem using genome-wide association data
Beyond the factor indeterminacy problem using genome-wide association data Open
View article: A Multivariate Genome‐Wide Association Study of the Shared Genetic Architecture Among Modifiable Risk Factors for Dementia: 590 Loci Associated with Brain Health
A Multivariate Genome‐Wide Association Study of the Shared Genetic Architecture Among Modifiable Risk Factors for Dementia: 590 Loci Associated with Brain Health Open
Background Targeting modifiable risk factors may prevent or delay dementia. The mechanisms by which some risk factors influence dementia remain unclear and commonality between risk factors is often overlooked. We aimed to characterize the …