Andrew D. Hildreth
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View article: PPARγ-dependent remodeling of translational machinery in adipose progenitors is impaired in obesity
PPARγ-dependent remodeling of translational machinery in adipose progenitors is impaired in obesity Open
Adipose tissue regulates energy homeostasis and metabolic function, but its adaptability is impaired in obesity. In this study, we investigate the impact of acute PPARγ agonist treatment in obese mice and find significant transcriptional r…
View article: Warming experiments test the temperature sensitivity of an endangered butterfly across life history stages
Warming experiments test the temperature sensitivity of an endangered butterfly across life history stages Open
The Karner blue butterfly (Lycaeides melissa samuelis) (hereafter Karner blue) is a federally listed endangered species occurring in disjunct locations within the Midwest and Eastern United States. As a hostplant specialist and an ectother…
View article: Sterile liver injury induces a protective tissue-resident cDC1-ILC1 circuit through cDC1-intrinsic cGAS-STING-dependent IL-12 production
Sterile liver injury induces a protective tissue-resident cDC1-ILC1 circuit through cDC1-intrinsic cGAS-STING-dependent IL-12 production Open
Tissue-resident immune cells are critical to the initiation and potentiation of inflammation. However, the tissue-protective cellular communication networks initiated by resident immunity during sterile inflammation are not well understood…
View article: Warming experiments test the sensitivity of an endangered butterfly across life history stages
Warming experiments test the sensitivity of an endangered butterfly across life history stages Open
Introduction: The Karner blue butterfly ( Lycaeides melissa samuelis , KBB) is a federally listed endangered species living in disjunct habitats within the Midwest and Eastern United States. As a hostplant specialist and an ectotherm, the …
View article: Single-cell sequencing of human white adipose tissue identifies new cell states in health and obesity
Single-cell sequencing of human white adipose tissue identifies new cell states in health and obesity Open
View article: CRISPR-Cas9 Ribonucleoprotein-Mediated Genomic Editing in Primary Innate Immune Cells
CRISPR-Cas9 Ribonucleoprotein-Mediated Genomic Editing in Primary Innate Immune Cells Open
View article: CRISPR-Cas9 Ribonucleoprotein-Mediated Genomic Editing in Mature Primary Innate Immune Cells
CRISPR-Cas9 Ribonucleoprotein-Mediated Genomic Editing in Mature Primary Innate Immune Cells Open
View article: Type 1 Innate Lymphoid Cells Protect Mice from Acute Liver Injury via Interferon-γ Secretion for Upregulating Bcl-xL Expression in Hepatocytes
Type 1 Innate Lymphoid Cells Protect Mice from Acute Liver Injury via Interferon-γ Secretion for Upregulating Bcl-xL Expression in Hepatocytes Open
View article: Novel antimicrobial peptide discovery using machine learning and biophysical selection of minimal bacteriocin domains
Novel antimicrobial peptide discovery using machine learning and biophysical selection of minimal bacteriocin domains Open
Bacteriocins, the ribosomally produced antimicrobial peptides of bacteria, represent an untapped source of promising antibiotic alternatives. However, bacteriocins display diverse mechanisms of action, a narrow spectrum of activity, and in…
View article: Mouse cytomegalovirus-experienced ILC1s acquire a memory response dependent on the viral glycoprotein m12
Mouse cytomegalovirus-experienced ILC1s acquire a memory response dependent on the viral glycoprotein m12 Open
View article: Tissue-Resident Innate and Innate-Like Lymphocyte Responses to Viral Infection
Tissue-Resident Innate and Innate-Like Lymphocyte Responses to Viral Infection Open
Infection is restrained by the concerted activation of tissue-resident and circulating immune cells. Recent discoveries have demonstrated that tissue-resident lymphocyte subsets, comprised of innate lymphoid cells (ILCs) and unconventional…
View article: Novel antimicrobial peptide discovery using machine learning and biophysical selection of minimal bacteriocin domains
Novel antimicrobial peptide discovery using machine learning and biophysical selection of minimal bacteriocin domains Open
Bacteriocins are ribosomally produced antimicrobial peptides that represent an untapped source of promising antibiotic alternatives. However, inherent challenges in isolation and identification of natural bacteriocins in substantial yield …