Andrew D. Patterson
YOU?
Author Swipe
View article: Microbiota modulation by a Human Paneth cell α-defensin fragment protects against DSS-induced colitis
Microbiota modulation by a Human Paneth cell α-defensin fragment protects against DSS-induced colitis Open
View article: A synthetic gut microbiota provides an understanding of the maintenance and functional impact of phage
A synthetic gut microbiota provides an understanding of the maintenance and functional impact of phage Open
Phages are under intense study as therapeutics and mediators of microbial community behavior; however, tractable models are needed to study phages in the context of the mammalian gut. To address this gap, we isolated phages against members…
View article: <i>Lactobacillus Salivarius</i> ‐Derived Indole‐3‐Acetic Acid Promotes AHR‐PARP1 Axis‐Mediated DNA Repair to Mitigate Intestinal Aging
<i>Lactobacillus Salivarius</i> ‐Derived Indole‐3‐Acetic Acid Promotes AHR‐PARP1 Axis‐Mediated DNA Repair to Mitigate Intestinal Aging Open
Increasing evidence suggests that the aryl hydrocarbon receptor (AHR) and poly (ADP‐ribose) polymerase 1 (PARP1) are closely linked to aging and aging‐related disorders. However, the underlying mechanisms of AHR‐PARP1 axis‐mediated DNA rep…
View article: Effect of Varying Quantities of Lean Beef as Part of a Mediterranean‐Style Dietary Pattern on Gut Microbiota and Plasma, Fecal, and Urinary Metabolites: A Randomized Crossover Controlled Feeding Trial
Effect of Varying Quantities of Lean Beef as Part of a Mediterranean‐Style Dietary Pattern on Gut Microbiota and Plasma, Fecal, and Urinary Metabolites: A Randomized Crossover Controlled Feeding Trial Open
Background Consumption of trimethylamine N ‐oxide (TMAO) precursors, such as carnitine found in lean beef, raises circulating TMAO concentrations; however, a healthy dietary pattern may attenuate these effects. Methods This randomized, 4‐p…
View article: Maternal emulsifier consumption alters the offspring early-life microbiota and goblet cell function leading to long-lasting diseases susceptibility
Maternal emulsifier consumption alters the offspring early-life microbiota and goblet cell function leading to long-lasting diseases susceptibility Open
View article: The gut microbiome shapes pharmacology and treatment outcomes for a key anti-inflammatory therapy
The gut microbiome shapes pharmacology and treatment outcomes for a key anti-inflammatory therapy Open
The human gut microbiome encodes a formidable metabolic repertoire that harvests nutrients from the diet, but these same pathways may also metabolize medications. Indeed, large screens have revealed extensive microbial metabolism of drugs …
View article: Glucuronidation Metabolomic Fingerprinting to Map Host-Microbe Metabolism
Glucuronidation Metabolomic Fingerprinting to Map Host-Microbe Metabolism Open
Glucuronidation is an important detoxification pathway that operates in balance with gastrointestinal microbial β-glucuronidase (GUS) enzymes that can regenerate active metabolites from their glucuronidated forms. Although significant prog…
View article: 468 Effects of butyrate supplementation in modulation of gut microbiome and its metabolites in new-onset rheumatoid arthritis
468 Effects of butyrate supplementation in modulation of gut microbiome and its metabolites in new-onset rheumatoid arthritis Open
Objectives/Goals: The gut microbiome and its metabolites, such as short-chain fatty acids (SCFA), are dysregulated in rheumatoid arthritis (RA); however, the significance of this observation and its implications in pathogenesis and therape…
View article: Almond snacking modulates gut microbiome and metabolome in association with improved cardiometabolic and inflammatory markers
Almond snacking modulates gut microbiome and metabolome in association with improved cardiometabolic and inflammatory markers Open
View article: Microbiota and metabolite-based prediction tool for colonic polyposis with and without a known genetic driver
Microbiota and metabolite-based prediction tool for colonic polyposis with and without a known genetic driver Open
Despite extensive investigations into the microbiome and metabolome changes associated with colon polyps and colorectal cancer (CRC), the microbiome and metabolome profiles of individuals with colonic polyposis, including those with (Gene-…
View article: Discovery of metabolites prevails amid in-source fragmentation
Discovery of metabolites prevails amid in-source fragmentation Open
View article: Phytochemical-Mediated Ah Receptor Activity Is Dependent on Dietary Context
Phytochemical-Mediated Ah Receptor Activity Is Dependent on Dietary Context Open
Background/Objective: The aryl hydrocarbon receptor (AHR) is an important mediator of intestinal homeostasis. The AHR senses certain classes of phytochemicals, including many flavonoids and tryptophan metabolites generated in the intestina…
View article: Itaconate promotes the differentiation of murine stress erythroid progenitors by increasing Nrf2 activity
Itaconate promotes the differentiation of murine stress erythroid progenitors by increasing Nrf2 activity Open
View article: Differential hepatic activation of mouse and human peroxisome proliferator-activated receptor-α by perfluorohexane sulfonate
Differential hepatic activation of mouse and human peroxisome proliferator-activated receptor-α by perfluorohexane sulfonate Open
Exposure of perfluorohexane sulfonate (PFHxS) is associated with hepatomegaly and accumulation of lipids that may be mediated by nuclear receptors like peroxisome proliferator-activated receptor-α (PPARα), constitutive androstane receptor …
View article: <i>In vitro</i> microbiota model recapitulates and predicts individualised sensitivity to dietary emulsifier
<i>In vitro</i> microbiota model recapitulates and predicts individualised sensitivity to dietary emulsifier Open
Background Non-absorbed dietary emulsifiers, including carboxymethylcellulose (CMC), directly disturb intestinal microbiota, thereby promoting chronic intestinal inflammation in mice. A randomised controlled-feeding study (Functional Resea…
View article: Systemic Rhythmicity of Host and Bacterial Bile Acid Amidates Across the Mammalian Body
Systemic Rhythmicity of Host and Bacterial Bile Acid Amidates Across the Mammalian Body Open
View article: The Effect of Treatment with Calcareous Marine Algae or Subcutaneous Calcium Injection on Blood Calcium and Milk Yield in Holstein Cattle Fed a Prepartum Anionic Diet
The Effect of Treatment with Calcareous Marine Algae or Subcutaneous Calcium Injection on Blood Calcium and Milk Yield in Holstein Cattle Fed a Prepartum Anionic Diet Open
View article: A diet-dependent host metabolite shapes the gut microbiota to protect from autoimmunity
A diet-dependent host metabolite shapes the gut microbiota to protect from autoimmunity Open
View article: Demonstrating real-time and low-latency quantum error correction with superconducting qubits
Demonstrating real-time and low-latency quantum error correction with superconducting qubits Open
Data associated with results presented in "Demonstrating real-time and low-latency quantum error correction with superconducting qubits". HDF5 files include raw data collected during experiments. Datasets for experiments performed with dif…
View article: Therapeutic targeting of differentiation-state dependent metabolic vulnerabilities in diffuse midline glioma
Therapeutic targeting of differentiation-state dependent metabolic vulnerabilities in diffuse midline glioma Open
View article: Chlorpyrifos modulates the mouse gut microbiota and metabolic activity
Chlorpyrifos modulates the mouse gut microbiota and metabolic activity Open
The organophosphate chlorpyrifos is a commonly used pesticide for fruits and vegetables despite its association with neurotoxicity in humans. While some studies suggest that organophosphates may impact the gut microbiota, no studies to dat…
View article: Elevated systemic total bile acids escalate susceptibility to alcohol-associated liver disease
Elevated systemic total bile acids escalate susceptibility to alcohol-associated liver disease Open
View article: Sphingosine Kinase 2 Regulates Aryl Hydrocarbon Receptor Nuclear Translocation and Target Gene Activation
Sphingosine Kinase 2 Regulates Aryl Hydrocarbon Receptor Nuclear Translocation and Target Gene Activation Open
Sphingolipids play vital roles in metabolism and regulation. Previously, the aryl hydrocarbon receptor (AHR), a ligand‐activated transcription factor, was reported to directly regulate ceramide synthesis genes by binding to their promoters…
View article: Quantum Computation of Electronic Structure with Projector Augmented-Wave Method and Plane Wave Basis Set
Quantum Computation of Electronic Structure with Projector Augmented-Wave Method and Plane Wave Basis Set Open
Quantum simulation of materials is a promising application area of quantum computers. To practically realize this promise, we must reduce quantum resources while maintaining accuracy. In electronic structure calculations on classical compu…
View article: Modulation of Ceramide-Induced Apoptosis in Enteric Neurons by Aryl Hydrocarbon Receptor Signaling: Unveiling a New Pathway beyond ER Stress
Modulation of Ceramide-Induced Apoptosis in Enteric Neurons by Aryl Hydrocarbon Receptor Signaling: Unveiling a New Pathway beyond ER Stress Open
2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD), a persistent organic pollutant and a potent aryl hydrocarbon receptor (AHR) ligand, causes delayed intestinal motility and affects the survival of enteric neurons. In this study, we investigated …
View article: Effects of Early Life Exposures to the Aryl Hydrocarbon Receptor Ligand TCDF on Gut Microbiota and Host Metabolic Homeostasis in C57BL/6J Mice
Effects of Early Life Exposures to the Aryl Hydrocarbon Receptor Ligand TCDF on Gut Microbiota and Host Metabolic Homeostasis in C57BL/6J Mice Open
These data obtained in a mouse model point to the complex effects of POPs on the host and microbiota, providing strong evidence that early life, short-term, and self-limiting POP exposure can adversely impact the microbiome, with effects p…
View article: The Cross-environment Hyperparameter Setting Benchmark for Reinforcement Learning
The Cross-environment Hyperparameter Setting Benchmark for Reinforcement Learning Open
This paper introduces a new empirical methodology, the Cross-environment Hyperparameter Setting Benchmark, that compares RL algorithms across environments using a single hyperparameter setting, encouraging algorithmic development which is …
View article: Investigating the Interplay of Prioritized Replay and Generalization
Investigating the Interplay of Prioritized Replay and Generalization Open
Experience replay, the reuse of past data to improve sample efficiency, is ubiquitous in reinforcement learning. Though a variety of smart sampling schemes have been introduced to improve performance, uniform sampling by far remains the mo…
View article: Effect of High-Fat Diet-Induced Obesity on the Metabolism of (-)-Epigallocatechin-3-Gallate at Non-Toxic and Toxic Doses in Mice
Effect of High-Fat Diet-Induced Obesity on the Metabolism of (-)-Epigallocatechin-3-Gallate at Non-Toxic and Toxic Doses in Mice Open
View article: Changes in Gut Microbiota and Plasma, Fecal, and Urinary Metabolites Following Mediterranean Diets With Varying Quantities of Lean Beef Compared to an Average American Diet
Changes in Gut Microbiota and Plasma, Fecal, and Urinary Metabolites Following Mediterranean Diets With Varying Quantities of Lean Beef Compared to an Average American Diet Open