Andrew Dang
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View article: Graded opsin co-expression along the butterfly retina fine tunes the spectral sensitivity of a colour-opponent cell across the visual field
Graded opsin co-expression along the butterfly retina fine tunes the spectral sensitivity of a colour-opponent cell across the visual field Open
Compound eyes deliver a vast stream of information to the tiny insect brains. To maximize the information content and minimize the redundancy of neural signals, insect eyes are built so to encode the relevant and filter out the unimportant…
View article: Evolution of opsin genes in closely-related species of butterflies specialized in different microhabitats
Evolution of opsin genes in closely-related species of butterflies specialized in different microhabitats Open
Multiple selective pressures can shape the evolution of color vision in animals, by acting on the co- evolution of the opsin genes. How do adaptive processes shape the duplications of opsins, the evolution of their amino acids and the modi…
View article: Trichromacy is insufficient for mate detection in a mimetic butterfly
Trichromacy is insufficient for mate detection in a mimetic butterfly Open
Color vision is thought to play a key role in the evolution of animal coloration, while achromatic vision is rarely considered as a mechanism for species recognition. Here we test the hypothesis that brightness vision rather than color vis…
View article: Mimetic butterfly wings through mimetic butterfly eyes
Mimetic butterfly wings through mimetic butterfly eyes Open
Color vision is thought to play a key role in the evolution of animal coloration, while achromatic vision is rarely considered as a mechanism for species recognition. Here we test the hypothesis that brightness vision rather than color vis…
View article: Sex-linked gene traffic underlies the acquisition of sexually dimorphic UV color vision in <i>Heliconius</i> butterflies
Sex-linked gene traffic underlies the acquisition of sexually dimorphic UV color vision in <i>Heliconius</i> butterflies Open
The acquisition of novel sexually dimorphic traits poses an evolutionary puzzle: How do new traits arise and become sex-limited? Recently acquired color vision, sexually dimorphic in animals like primates and butterflies, presents a compel…
View article: Data from Downregulation of Human DAB2IP Gene Expression in Renal Cell Carcinoma Results in Resistance to Ionizing Radiation
Data from Downregulation of Human DAB2IP Gene Expression in Renal Cell Carcinoma Results in Resistance to Ionizing Radiation Open
Purpose:Renal cell carcinoma (RCC) is known to be highly radioresistant but the mechanisms associated with radioresistance have remained elusive. We found DOC-2/DAB2 interactive protein (DAB2IP) frequently downregulated in RCC, is associat…
View article: Supplemental Information from Downregulation of Human DAB2IP Gene Expression in Renal Cell Carcinoma Results in Resistance to Ionizing Radiation
Supplemental Information from Downregulation of Human DAB2IP Gene Expression in Renal Cell Carcinoma Results in Resistance to Ionizing Radiation Open
Figure S1. DAB2IP expression does not affect key repair factors in NHEJ (Ku70, Ku80) and HR (RAD51, BRCA1) and PARP-1 mRNA expression. Figure S2. RANBP2, TRIP12, and RNF40 interact with both DAB2IP and PARP-1. Figure S3. Radiotherapy of RC…
View article: Data from Downregulation of Human DAB2IP Gene Expression in Renal Cell Carcinoma Results in Resistance to Ionizing Radiation
Data from Downregulation of Human DAB2IP Gene Expression in Renal Cell Carcinoma Results in Resistance to Ionizing Radiation Open
Purpose:Renal cell carcinoma (RCC) is known to be highly radioresistant but the mechanisms associated with radioresistance have remained elusive. We found DOC-2/DAB2 interactive protein (DAB2IP) frequently downregulated in RCC, is associat…
View article: Supplemental Information from Downregulation of Human DAB2IP Gene Expression in Renal Cell Carcinoma Results in Resistance to Ionizing Radiation
Supplemental Information from Downregulation of Human DAB2IP Gene Expression in Renal Cell Carcinoma Results in Resistance to Ionizing Radiation Open
Figure S1. DAB2IP expression does not affect key repair factors in NHEJ (Ku70, Ku80) and HR (RAD51, BRCA1) and PARP-1 mRNA expression. Figure S2. RANBP2, TRIP12, and RNF40 interact with both DAB2IP and PARP-1. Figure S3. Radiotherapy of RC…
View article: Sex-linked gene traffic underlies the acquisition of sexually dimorphic UV color vision in <i>Heliconius</i> butterflies
Sex-linked gene traffic underlies the acquisition of sexually dimorphic UV color vision in <i>Heliconius</i> butterflies Open
Butterflies have photoreceptor cells that are sensitive to the ultraviolet part of the spectrum due to ultraviolet-sensitive rhodopsin ( UVRh ), a gene that has been duplicated in the Heliconius genus. In individuals expressing UVRh1 and U…
View article: DAB2IP modulates primary cilia formation associated with renal tumorigenesis
DAB2IP modulates primary cilia formation associated with renal tumorigenesis Open
View article: Hyperfluorescence Imaging of Kidney Cancer Enabled by Renal Secretion Pathway Dependent Efflux Transport
Hyperfluorescence Imaging of Kidney Cancer Enabled by Renal Secretion Pathway Dependent Efflux Transport Open
Renal tubular secretion is an active efflux pathway for the kidneys to remove molecules but has yet to be used to enhance kidney cancer targeting. We report indocyanine green (ICG) conjugated with a 2100 Da PEG molecule (ICG‐PEG45) as a re…
View article: Epigenetic silencing of the ubiquitin ligase subunit FBXL7 impairs c-SRC degradation and promotes epithelial-to-mesenchymal transition and metastasis
Epigenetic silencing of the ubiquitin ligase subunit FBXL7 impairs c-SRC degradation and promotes epithelial-to-mesenchymal transition and metastasis Open
View article: The effect of age, sex, race/ethnicity, health insurance, and food specific serum immunoglobulin E on outcomes of oral food challenges
The effect of age, sex, race/ethnicity, health insurance, and food specific serum immunoglobulin E on outcomes of oral food challenges Open
OFCs confirm the food allergy diagnosis in about one-third of patients tested, and they should continue to be used when possible for an accurate diagnosis. Age, sex, and insurance status do not have a significant association with the outco…
View article: The paracrine induction of prostate cancer progression by caveolin-1
The paracrine induction of prostate cancer progression by caveolin-1 Open
A subpopulation of cancer stem cells (CSCs) plays a critical role of cancer progression, recurrence, and therapeutic resistance. Many studies have indicated that castration-resistant prostate cancer (CRPC) is associated with stem cell phen…
View article: Histone lysine demethylase KDM4B regulates the alternative splicing of the androgen receptor in response to androgen deprivation
Histone lysine demethylase KDM4B regulates the alternative splicing of the androgen receptor in response to androgen deprivation Open
Alternative splicing is emerging as an oncogenic mechanism. In prostate cancer, generation of constitutively active forms of androgen receptor (AR) variants including AR-V7 plays an important role in progression of castration-resistant pro…
View article: Downregulation of Human DAB2IP Gene Expression in Renal Cell Carcinoma Results in Resistance to Ionizing Radiation
Downregulation of Human DAB2IP Gene Expression in Renal Cell Carcinoma Results in Resistance to Ionizing Radiation Open
Purpose: Renal cell carcinoma (RCC) is known to be highly radioresistant but the mechanisms associated with radioresistance have remained elusive. We found DOC-2/DAB2 interactive protein (DAB2IP) frequently downregulated in RCC, is associa…
View article: The Role and Mechanism of SPARC in Renal Cancer Metastasis
The Role and Mechanism of SPARC in Renal Cancer Metastasis Open
View article: Investigating innate immune mechanisms in early-life development and outcomes of food allergy
Investigating innate immune mechanisms in early-life development and outcomes of food allergy Open
View article: IFN-γ induces epithelial-to-mesenchymal transition of cancer cells via an unique microRNA processing
IFN-γ induces epithelial-to-mesenchymal transition of cancer cells via an unique microRNA processing Open
Interferon-γ (IFNγ) is a potent cytokine in modulating tumor immunity and tumoricidal effects. We demonstrate a new function of IFNγ in inducing epithelial-to-mesenchymal transition (EMT) in normal and cancer cells from different cell type…
View article: Platelet Activation is Increased in IgE-mediated Systemic Anaphylaxis but not in IgE-mediated Oral Antigen-induced Anaphylaxis in Mice
Platelet Activation is Increased in IgE-mediated Systemic Anaphylaxis but not in IgE-mediated Oral Antigen-induced Anaphylaxis in Mice Open
View article: An unusual cause of fever in a patient with common variable immunodeficiency
An unusual cause of fever in a patient with common variable immunodeficiency Open
View article: Lipopolysaccharide suppresses IgE‐mast cell‐mediated reactions
Lipopolysaccharide suppresses IgE‐mast cell‐mediated reactions Open
Summary Background Clinical and experimental analyses have identified a central role for IgE/Fcε RI /mast cells in promoting IgE‐mediated anaphylaxis. Recent data from human studies suggest that bacterial infections can alter susceptibilit…
View article: A Case of Histoplasmosis and Renal Extranodal Marginal Zone Lymphoma in a Patient with Common Variable Immunodeficiency (CVID) and Granulomatous-Lymphocytic Interstitial Lung Disease (GLILD)
A Case of Histoplasmosis and Renal Extranodal Marginal Zone Lymphoma in a Patient with Common Variable Immunodeficiency (CVID) and Granulomatous-Lymphocytic Interstitial Lung Disease (GLILD) Open
View article: Safety of Performing Oral Food Challenges to Food Protein-Induced Enterocolitis Syndrome Patients in the Outpatient Clinic
Safety of Performing Oral Food Challenges to Food Protein-Induced Enterocolitis Syndrome Patients in the Outpatient Clinic Open