Explanipedia

Relative burden of lung and pleural cancers from exposure to asbestos: a cross-sectional analysis of occupational mortality in England and Wales Open

E Clare Harris, Stefania D’Angelo, Andrew Darnton, David Coggon · 2020

Objectives To explore the extent to which asbestos-exposed jobs vary in the ratio of excess mortality from lung cancer to deaths from pleural cancer. Design Using data on underlying cause of death and last full-time occupation for 3 688 91…

Lifetime cumulative exposure to rubber dust, fumes and N-nitrosamines and non-cancer mortality: a 49-year follow-up of UK rubber factory workers Open

Mira Hidajat, Damien McElvenny, Peter Ritchie, Andrew Darnton, William A. Mueller , et al. · 2020

Objectives To examine associations between occupational exposures to rubber dust, rubber fumes and N-nitrosamines and non-cancer mortality. Methods A cohort of 36 441 males aged 35+ years employed in British rubber factories was followed-u…

The occupations at increased risk of COPD: analysis of lifetime job-histories in the population-based UK Biobank Cohort Open

Sara De Matteis, Deborah Jarvis, Andrew Darnton, Sally Hutchings, Steven Sadhra , et al. · 2019

Occupational exposures are important, preventable causes of chronic obstructive pulmonary disease (COPD). Identification of COPD high-risk jobs is key to focus preventive strategies, but a definitive job-list is unavailable. We addressed t…

Lifetime exposure to rubber dusts, fumes and N-nitrosamines and cancer mortality in a cohort of British rubber workers with 49 years follow-up Open

Mira Hidajat, Damien McElvenny, Peter Ritchie, Andrew Darnton, William A. Mueller , et al. · 2019

Objectives To quantitatively evaluate exposure-response associations between occupational exposures to rubber dust, fumes and N-nitrosamines and cancer mortality in the UK rubber industry. Methods Competing risk survival analyses were used…

Job-exposure matrix for historical exposures to rubber dust, rubber fumes and n-Nitrosamines in the British rubber industry Open

Mira Hidajat, Damien McElvenny, William A. Mueller, Peter Ritchie, John W. Cherrie , et al. · 2019

Objectives To develop a quantitative historical job-exposure matrix (JEM) for rubber dust, rubber fumes and n-Nitrosamines in the British rubber industry for 1915–2002 to estimate lifetime cumulative exposure (LCE) for a cohort of workers …

British rubber and cable industry cohort: 49-year mortality follow-up Open

Damien McElvenny, William A. Mueller, Peter Ritchie, John W. Cherrie, Mira Hidajat , et al. · 2018

Background The International Agency for Research on Cancer (IARC) has determined there is sufficient evidence that working in the rubber manufacturing industry increases the risk of cancers of the stomach, lung, bladder and leukaemia and l…

Past and current asbestos exposure and future mesothelioma risks in Britain: The Inhaled Particles Study (TIPS) Open

Clare Gilham, Christine Rake, John T. Hodgson, Andrew Darnton, Garry Burdett , et al. · 2017

The average lifetime mesothelioma risk caused by recent environmental asbestos exposure in Britain will be about 1 in 10 000. The risk is an order of magnitude higher in a subgroup of exposed workers and probably in occupants in the most c…

Chest physician-reported, work-related, long-latency respiratory disease in Great Britain Open

Melanie Carder, Andrew Darnton, Matthew Gittins, Susan Jill Stocks, David J. Ross , et al. · 2017

Much of the current burden of long-latency respiratory disease (LLRD) in Great Britain is attributed to historical asbestos exposure. However, continuing exposure to other agents, notably silica, also contributes to disease burden. The aim…

0380 Mesothelioma mortality in great britain: an updated analysis of trends by geographical area and occupation 1981–2014 Open

Kevin P. Shepherd, Damien McElvenny, Andrew Darnton · 2017

Background mesothelioma mortality rates in GB have increased tenfold over the last four decades and are currently the highest of any country worldwide. The mesothelioma register contains all deaths mentioning mesothelioma and includes area…

0024 The occupations at increased risk of copd in the uk biobank cohort Open

Sara De Matteis, Deborah Jarvis, Andrew Darnton, David Fishwick, Lesley Rushton , et al. · 2017

Background Occupational hazards are important, preventable causes of COPD but the high-risk occupations are uncertain. In an analysis of current occupation in the UK Biobank cohort we reported 14 jobs of increased risk (De Matteis, S. et a…

0270 Mortality from lung cancer in occupations with exposure to asbestos among men in england and wales (1979–2010) Open

E Clare Harris, Stefania D’Angelo, Keith T Palmer, Vanessa Cox, Andrew Darnton , et al. · 2017

Background Estimating national burdens of lung cancer from occupational exposure to asbestos is challenging because of the potential for confounding by smoking. Methods To generate a refined estimate, we analysed data on underlying cause …

0249 Job-exposure matrix for historical exposure to rubber dust, rubber fumes, and n-nitrosamines in the british rubber industry Open

Mira Hidajat, Damien McElvenny, William Mueller, Peter Ritchie, John W. Cherrie , et al. · 2017

In 1982 IARC concluded that there was sufficient evidence for a causal association between occupational exposures in the rubber manufacturing industry and urinary bladder cancer and leukaemia. To enable evaluations of exposure-response ass…

0255 Lifetime cancer risk in the british rubber industry: a retrospective cohort with 49 year follow-up Open

Mira Hidajat, Damien McElvenny, William Mueller, Peter Ritchie, John W. Cherrie , et al. · 2017

IARC concluded (IARC, 1982, 1987) there is sufficient evidence of a causal association between occupational exposures in the rubber-manufacturing industry and cancer. However, because of the complexity and variety of substances used in the…

0361 A 49 year follow-up of mortality in the british rubber industry Open

William Mueller, Damien McElvenny, Peter Ritchie, John W. Cherrie, Mira Hidajat , et al. · 2017

Rubber workers in Great Britain were historically exposed to various carcinogenic substances, including β-naphthylamine, which was removed from industrial processes in 1949. The Health and Safety Executive (HSE) initiated in 1967 a prospec…

Mortality from multiple sclerosis in British military personnel Open

E Clare Harris, K. T. Palmer, Vanessa Cox, Andrew Darnton, J Osman , et al. · 2017

These findings suggest that the high proportional mortality from MS in British military personnel is unlikely to have occurred by chance, or as an artefact of the method of investigation. However, the only military cohort study with publis…

The occupations at increased COPD risk in the large population-vased UK Biobank Cohort Open

Sara De Matteis, Deborah Jarvis, Andrew Darnton, Lesley Rushton, Paul Cullinan · 2017

Occupational self-coding and automatic recording (OSCAR): a novel web-based tool to collect and code lifetime job histories in large population-based studies Open

Sara De Matteis, Deborah Jarvis, Heather Young, A. P. Young, Naomi E. Allen , et al. · 2016

Objectives The standard approach to the assessment of occupational exposures is through the manual collection and coding of job histories. This method is time-consuming and costly and makes it potentially unfeasible to perform high quality…

S121 The occupations at increased copd risk in the large population-based uk biobank cohort Open

Sara De Matteis, Deborah Jarvis, Andrew Darnton, Lesley Rushton, Paul Cullinan · 2016

Background Occupational exposures are important and preventable causes of COPD. In a cross-sectional study of current occupation among over 220,000 workers in the UK Biobank cohort (over 500,000 subjects) we previously reported that 14 job…

Authors' reply to letters from Egilman<i>et al</i>and Oliver<i>et al</i> Open

Julian Peto, Clare Gilham, Christine Rake, Andrew Darnton, John T. Hodgson , et al. · 2016

Dr Egilman and colleagues claim our report1 implies that chrysotile does not cause mesothelioma. So did the International Chrysotile Association, the website of which highlighted our paper with the misleading headline ‘reliable scientific …

Trends in mortality from occupational hazards among men in England and Wales during 1979–2010 Open

E Clare Harris, Keith T Palmer, Vanessa Cox, Andrew Darnton, J Osman , et al. · 2016

The highest priority for future prevention of work-related fatalities is the minority of occupational disorders for which excess mortality remains static or is increasing, in particular asbestos-related disease among certain occupations in…

Pleural mesothelioma and lung cancer risks in relation to occupational history and asbestos lung burden Open

Clare Gilham, Christine Rake, Garry Burdett, Andrew G. Nicholson, Leslie Davison , et al. · 2015

The approximate linearity of the dose-response together with lung burden measurements in younger people will provide reasonably reliable predictions of future mesothelioma rates in those born since 1965 whose risks cannot yet be seen in na…

P55 The occupations associated with COPD risk in the large population-based UK Biobank cohort study Open

Sara De Matteis, Deborah Jarvis, Sally Hutchings, Andrew Darnton, Lesley Rushton , et al. · 2015

Introduction and objectives COPD is one of the leading causes of morbidity and mortality worldwide. Exposure to occupational hazards is an important and preventable risk factor. However, the contribution of each occupation to COPD risk in …

Mortality of a cohort of workers in Great Britain with blood lead measurements Open

Damien McElvenny, Brian G. Miller, Laura MacCalman, Anne Sleeuwenhoek, Martie van Tongeren , et al. · 2015

This study found an excess of lung cancer, although the risk was not clearly associated with increasing BLLs. It also found marginally significant excesses of IHD and CVD, the former being related to mean and maximum BLLs. The finding for …

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