Andrew R. Mayer
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View article: The influence of intermittent hypercapnia on cerebrospinal fluid flow and clearance in Parkinson’s disease and healthy older adults
The influence of intermittent hypercapnia on cerebrospinal fluid flow and clearance in Parkinson’s disease and healthy older adults Open
A failure of the glymphatic pathway to clear brain byproducts implicated in neurodegeneration may contribute to the pathophysiology of Parkinson's disease. The glymphatic pathway relies on vasomotion (rhythmic constriction and dilation of …
View article: The kynurenine pathway in pediatric “mild-to-moderate” traumatic brain injury: translational insights from a prospective human study and a large-animal model
The kynurenine pathway in pediatric “mild-to-moderate” traumatic brain injury: translational insights from a prospective human study and a large-animal model Open
Elucidating the biochemical pathways affected by pediatric traumatic brain injury (TBI) is essential for identifying informative blood-based biomarkers that may support future precision medicine and clinical trials. The kynurenine pathway …
View article: The Relationship of Prior Concussion and Contact Sport Exposure With Cortical Macro and Microstructure
The Relationship of Prior Concussion and Contact Sport Exposure With Cortical Macro and Microstructure Open
Changes in cortical gray matter are a key feature of neurodegenerative diseases that have been linked with concussion and repetitive head impacts (RHIs). Prior evidence implicates prior concussion and RHI in reduced cortical thickness or v…
View article: Blunted Reward Prediction Error Encoding Drives Diminished Motivation to Explore in Apathy Associated With Traumatic Brain Injury
Blunted Reward Prediction Error Encoding Drives Diminished Motivation to Explore in Apathy Associated With Traumatic Brain Injury Open
Clinical apathy might result from either a diminished willingness to exert effort for known rewards or from reduced motivation to explore potentially beneficial future opportunities. To identify the underlying cognitive and neural bases of…
View article: A - 04 Associations of Concussion and Contact Sport Exposure History With Brain Microstructure Using Quantitative Susceptibility Mapping
A - 04 Associations of Concussion and Contact Sport Exposure History With Brain Microstructure Using Quantitative Susceptibility Mapping Open
Purpose The goal of this work was to characterize the association of prior concussion and years of contact sport exposure with quantitative susceptibility mapping (QSM) MRI. We hypothesized that concussion and contact sport exposure would …
View article: Regional and Global Changes in Brain Structure 1‐Year Post Pediatric “Mild” Traumatic Brain Injury
Regional and Global Changes in Brain Structure 1‐Year Post Pediatric “Mild” Traumatic Brain Injury Open
Objective Despite the high prevalence of pediatric “mild” traumatic brain injury (pmTBI), very little is known about the long‐term effects of injury on brain structure and how injuries manifest in the context of dynamic and regionally spec…
View article: Neuroimaging Characterization of Acute Traumatic Brain Injury with Focus on Frontline Clinicians: Recommendations from the 2024 National Institute of Neurological Disorders and Stroke Traumatic Brain Injury Classification and Nomenclature Initiative Imaging Working Group
Neuroimaging Characterization of Acute Traumatic Brain Injury with Focus on Frontline Clinicians: Recommendations from the 2024 National Institute of Neurological Disorders and Stroke Traumatic Brain Injury Classification and Nomenclature Initiative Imaging Working Group Open
Neuroimaging screening and surveillance is one of the first frontline diagnostic tools leveraged in the acute assessment (first 24 h postinjury) of patients suspected to have traumatic brain injury (TBI). While imaging, in particular compu…
View article: Investigating the Association of Concussion and Contact Sport Exposure History With Brain Microstructure Using Quantitative Susceptibility Mapping
Investigating the Association of Concussion and Contact Sport Exposure History With Brain Microstructure Using Quantitative Susceptibility Mapping Open
A growing body of evidence suggests that repeated concussions and exposure to repetitive head impacts may be associated with subtle abnormalities in neurological health. Prior studies have demonstrated associations of prior concussion and …
View article: TRANSCENDENT (Transforming Research by Assessing Neuroinformatics across the Spectrum of Concussion by Embedding iNterdisciplinary Data-collection to Enable Novel Treatments): protocol for a prospective observational cohort study of concussion patients with embedded comparative effectiveness research within a network of learning health system concussion clinics in Canada
TRANSCENDENT (Transforming Research by Assessing Neuroinformatics across the Spectrum of Concussion by Embedding iNterdisciplinary Data-collection to Enable Novel Treatments): protocol for a prospective observational cohort study of concussion patients with embedded comparative effectiveness research within a network of learning health system concussion clinics in Canada Open
Introduction Concussion affects over 400 000 Canadians annually, with a range of causes and impacts on health-related quality of life. Research to date has disproportionately focused on athletes, military personnel and level I trauma centr…
View article: Evaluation of Theta <scp>EEG</scp> Neurofeedback Procedure for Cognitive Training Using Simultaneous <scp>fMRI</scp> in Counterbalanced Active‐Sham Study Design
Evaluation of Theta <span>EEG</span> Neurofeedback Procedure for Cognitive Training Using Simultaneous <span>fMRI</span> in Counterbalanced Active‐Sham Study Design Open
Evaluation of mechanisms of action of EEG neurofeedback (EEG‐nf) using simultaneous fMRI is highly desirable to ensure its effective application for clinical rehabilitation and therapy. Counterbalancing training runs with active neurofeedb…
View article: Quantifying brain development in the HEALthy Brain and Child Development (HBCD) Study: The magnetic resonance imaging and spectroscopy protocol
Quantifying brain development in the HEALthy Brain and Child Development (HBCD) Study: The magnetic resonance imaging and spectroscopy protocol Open
The HEALthy Brain and Child Development (HBCD) Study, a multi-site prospective longitudinal cohort study, will examine human brain, cognitive, behavioral, social, and emotional development beginning prenatally and planned through early chi…
View article: Diffusion magnetic resonance spectroscopy captures microglial reactivity related to gut-derived systemic lipopolysaccharide: A preliminary study
Diffusion magnetic resonance spectroscopy captures microglial reactivity related to gut-derived systemic lipopolysaccharide: A preliminary study Open
Neuroinflammation is a key component underlying multiple neurological disorders, yet non-invasive and cost-effective assessment of in vivo neuroinflammatory processes in the central nervous system remains challenging. Diffusion weighted ma…
View article: Alterations of cerebrovascular reactivity following pediatric mild traumatic brain injury are independent of neurodevelopmental changes
Alterations of cerebrovascular reactivity following pediatric mild traumatic brain injury are independent of neurodevelopmental changes Open
Cerebrovascular dysfunction following mild traumatic brain injury (mTBI) is understudied relative to other microstructural injuries, especially during neurodevelopment. The blood-oxygen level dependent response was used to investigate cere…
View article: White Matter Hyperintensities and Mild TBI in Post-9/11 Veterans and Service Members
White Matter Hyperintensities and Mild TBI in Post-9/11 Veterans and Service Members Open
Introduction The neurobehavioral significance of white matter hyperintensities (WMHs) seen on magnetic resonance imaging after traumatic brain injury (TBI) remains unclear, especially in Veterans and Service Members with a history of mild …
View article: Abnormal Cerebrovascular Activity, Perfusion, and Glymphatic Clearance in Lewy Body Diseases
Abnormal Cerebrovascular Activity, Perfusion, and Glymphatic Clearance in Lewy Body Diseases Open
Cerebrovascular activity is not only crucial to optimal cerebral perfusion, but also plays an important role in the glymphatic clearance of interstitial waste, including α‐synuclein. This highlights a need to evaluate how cerebrovascular a…
View article: Exploring the kynurenine pathway in mild traumatic brain injury: A longitudinal study
Exploring the kynurenine pathway in mild traumatic brain injury: A longitudinal study Open
A potential source of novel biomarkers for mTBI is the kynurenine pathway (KP), a metabolic pathway of tryptophan (Trp), that is up‐regulated by neuroinflammation and stress. Considering that metabolites of the KP (kynurenines) are implica…
View article: A cautionary tale on the effects of different covariance structures in linear mixed effects modeling of <scp>fMRI</scp> data
A cautionary tale on the effects of different covariance structures in linear mixed effects modeling of <span>fMRI</span> data Open
With the steadily increasing abundance of longitudinal neuroimaging studies with large sample sizes and multiple repeated measures, questions arise regarding the appropriate modeling of variance and covariance. The current study examined t…
View article: Cerebral autoregulation, spreading depolarization, and implications for targeted therapy in brain injury and ischemia
Cerebral autoregulation, spreading depolarization, and implications for targeted therapy in brain injury and ischemia Open
Cerebral autoregulation is an intrinsic myogenic response of cerebral vasculature that allows for preservation of stable cerebral blood flow levels in response to changing systemic blood pressure. It is effective across a broad range of bl…
View article: Parkinson’s disease cerebrovascular reactivity pattern: A feasibility study
Parkinson’s disease cerebrovascular reactivity pattern: A feasibility study Open
A mounting body of research points to cerebrovascular dysfunction as a fundamental element in the pathophysiology of Parkinson’s disease (PD). In the current feasibility study, blood-oxygen-level-dependent (BOLD) MRI was used to measure ce…
View article: Standardizing Attention Process Training-III for a Multisite Clinical Trial of Neuromodulation
Standardizing Attention Process Training-III for a Multisite Clinical Trial of Neuromodulation Open
Introduction The Control Network Neuromodulation to Enhance Cognitive Training in Complex Traumatic Brain Injury (CONNECT-TBI) study is an ongoing randomized, double-blinded, sham-controlled multisite clinical trial to determine the enhanc…
View article: Validation of real-time fMRI neurofeedback procedure for cognitive training using counterbalanced active-sham study design
Validation of real-time fMRI neurofeedback procedure for cognitive training using counterbalanced active-sham study design Open
Investigation of neural mechanisms of real-time functional MRI neurofeedback (rtfMRI-nf) training requires an efficient study control approach. A common rtfMRI-nf study design involves an experimental group, receiving active rtfMRI-nf, and…
View article: Persistent MRI Findings Unique to Blast and Repetitive Mild TBI: Analysis of the CENC/LIMBIC Cohort Injury Characteristics
Persistent MRI Findings Unique to Blast and Repetitive Mild TBI: Analysis of the CENC/LIMBIC Cohort Injury Characteristics Open
Introduction MRI represents one of the clinical tools at the forefront of research efforts aimed at identifying diagnostic and prognostic biomarkers following traumatic brain injury (TBI). Both volumetric and diffusion MRI findings in mild…