Andrew K. Dunn
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View article: Multi-exposure speckle imaging through an optical fiber bundle
Multi-exposure speckle imaging through an optical fiber bundle Open
MESI measurements through an optical fiber bundle show similar results to free-space MESI.
View article: Improving vascular retention of indocyanine green for in vivo two-photon microscopy using liposomal encapsulation
Improving vascular retention of indocyanine green for in vivo two-photon microscopy using liposomal encapsulation Open
The rapid clearance of ICG from the rodent body can be overcome using liposomal encapsulation, making prolonged in vivo imaging feasible.
View article: Improving retention time of Indocyanine Green for <i>in vivo</i> two-photon microscopy using liposomal encapsulation
Improving retention time of Indocyanine Green for <i>in vivo</i> two-photon microscopy using liposomal encapsulation Open
We propose a technique for improving the retention time of Indocyanine Green (ICG), an FDA-approved, widely available, near infrared (NIR) probe for in vivo imaging of the cerebrovascular structure in rodents. We present a synthesis proces…
View article: Microvascular plasticity in mouse stroke model recovery: Anatomy statistics, dynamics measured by longitudinal <i>in vivo</i> two-photon angiography, network vectorization
Microvascular plasticity in mouse stroke model recovery: Anatomy statistics, dynamics measured by longitudinal <i>in vivo</i> two-photon angiography, network vectorization Open
This manuscript quantitatively investigates remodeling dynamics of the cortical microvascular network (thousands of connected capillaries) following photothrombotic ischemia (cubic millimeter volume, imaged weekly) using a novel in vivo tw…
View article: Non-degenerate two-photon imaging of deep rodent cortex using indocyanine green in the water absorption window
Non-degenerate two-photon imaging of deep rodent cortex using indocyanine green in the water absorption window Open
We present a novel approach for deep vascular imaging in rodent cortex at excitation wavelengths susceptible to water absorption using two-photon microscopy with photons of dissimilar wavelengths. We demonstrate that non-degenerate two-pho…
View article: HARMONI at ELT: project status and instrument overview
HARMONI at ELT: project status and instrument overview Open
International audience
View article: Dynamic Light Scattering in Biomedical Applications: feature issue introduction
Dynamic Light Scattering in Biomedical Applications: feature issue introduction Open
The feature Issue on “Dynamic Light Scattering in Biomedical Applications” presents a compilation of research breakthroughs and technological advancements that have shaped the field of biophotonics, particularly in the non-invasive explora…
View article: A Deep Learning Approach for Improving Two-Photon Vascular Imaging Speeds
A Deep Learning Approach for Improving Two-Photon Vascular Imaging Speeds Open
A potential method for tracking neurovascular disease progression over time in preclinical models is multiphoton fluorescence microscopy (MPM), which can image cerebral vasculature with capillary-level resolution. However, obtaining high-q…
View article: Non-Degenerate Two-Photon Imaging of Deep Rodent Cortex using Indocyanine Green in the water absorption window
Non-Degenerate Two-Photon Imaging of Deep Rodent Cortex using Indocyanine Green in the water absorption window Open
We present a novel approach for deep vascular imaging in rodent cortex at excitation wavelengths susceptible to water absorption using two-photon microscopy with photons of dissimilar wavelengths. We demonstrate that non-degenerate two-pho…
View article: Wide-field intensity fluctuation imaging
Wide-field intensity fluctuation imaging Open
The temporal intensity fluctuations contain important information about the light source and light-medium interaction and are typically characterized by the intensity autocorrelation function, g 2 ( τ ). The measurement of g 2 ( τ ) is a c…
View article: Continuous hemodynamics monitoring during arteriovenous malformation microsurgical resection with laser speckle contrast imaging: case report
Continuous hemodynamics monitoring during arteriovenous malformation microsurgical resection with laser speckle contrast imaging: case report Open
AVM surgery is challenging due to progressive and often unforeseeable flow changes during its resection which involve both the AVM and the surrounding brain tissue. Hence, accurate monitoring of blood flow is crucial to minimize complicati…
View article: Intraoperative Laser Speckle Contrast Imaging to Assess Vessel Flow in Neurosurgery: A Pilot Study
Intraoperative Laser Speckle Contrast Imaging to Assess Vessel Flow in Neurosurgery: A Pilot Study Open
BACKGROUND AND OBJECTIVES: Laser speckle contrast imaging (LSCI) has emerged as a promising tool for assessment of vessel flow during neurosurgery. We aimed to investigate the feasibility of visualizing vessel flow in the macrocirculation …
View article: Pulse train gating to improve signal generation for in vivo two-photon fluorescence microscopy
Pulse train gating to improve signal generation for in vivo two-photon fluorescence microscopy Open
We demonstrate that a pulse gating strategy can either be used to limit heating when imaging superficial brain regions or used to increase signal generation in deep regions. These findings should encourage others to adopt similar pulse gat…
View article: Sedation with dexmedetomidine decreases skin perfusion in cats
Sedation with dexmedetomidine decreases skin perfusion in cats Open
OBJECTIVE To evaluate skin perfusion in cats receiving dexmedetomidine compared to a placebo. ANIMALS 9 healthy adult research cats. METHODS A randomized, blinded, placebo-controlled study design was used. Two sites, the dorsal metatarsus …
View article: Subventricular zone cytogenesis provides trophic support for neural repair in a mouse model of stroke
Subventricular zone cytogenesis provides trophic support for neural repair in a mouse model of stroke Open
Stroke enhances proliferation of neural precursor cells within the subventricular zone (SVZ) and induces ectopic migration of newborn cells towards the site of injury. Here, we characterize the identity of cells arising from the SVZ after …
View article: Wide-field Intensity Fluctuation Imaging
Wide-field Intensity Fluctuation Imaging Open
The temporal intensity fluctuations contain important information about the light source and light-medium interaction and are typically characterized by the intensity autocorrelation function, g 2 ( τ ). The measurement of g 2 ( τ ) is a c…
View article: Microvascular plasticity in stroke recovery: Longitudinal snapshots, network statistical analysis, and dynamics
Microvascular plasticity in stroke recovery: Longitudinal snapshots, network statistical analysis, and dynamics Open
This research article quantitatively investigates neuro-microvascular network remodeling dynamics following stroke using a novel in vivo two-photon angiography (cubic millimeter volume, weekly snapshots) and high throughput (thousands of c…
View article: Pulse train gating to improve signal generation for<i>in vivo</i>two-photon fluorescence microscopy
Pulse train gating to improve signal generation for<i>in vivo</i>two-photon fluorescence microscopy Open
Significance Two-photon microscopy is used routinely for in vivo imaging of neural and vascular structure and function in rodents with a high resolution. Image quality, however, often degrades in deeper portions of the cerebral cortex. Str…
View article: Using pressure-driven flow systems to evaluate laser speckle contrast imaging
Using pressure-driven flow systems to evaluate laser speckle contrast imaging Open
Pressure-regulated flow systems should be used instead of syringe pumps when assessing the performance of flow measurement techniques with microfluidic studies. MESI offers more accurate relative flow measurements than traditional LSCI acr…
View article: All fiber-based illumination system for multi-exposure speckle imaging
All fiber-based illumination system for multi-exposure speckle imaging Open
Monitoring blood flow is critical to treatment efficacy in many surgical settings. Laser speckle contrast imaging (LSCI) is a simple, real-time, label-free optical technique for monitoring blood flow that has emerged as a promising techniq…
View article: A deep learning approach for improving two-photon vascular imaging speeds
A deep learning approach for improving two-photon vascular imaging speeds Open
A potential method for tracking neurovascular disease progression over time in preclinical models is multiphoton fluorescence microscopy (MPM), which can image cerebral vasculature with capillary-level resolution. However, obtaining high-q…
View article: 945 Overlapping and distinct patterns of LILRB receptors support complementary targeting approach in cancer
945 Overlapping and distinct patterns of LILRB receptors support complementary targeting approach in cancer Open
Background Leukocyte immunoglobulin-like receptors (LILRBs) are cell surface immunoinhibitory proteins that have been recently recognized as therapeutic targets of interest in immuno-oncology. LILRB1, LILRB2 and LILRB4 among them are broad…
View article: Using pressure-driven flow systems to evaluate laser speckle contrast imaging
Using pressure-driven flow systems to evaluate laser speckle contrast imaging Open
Significance Microfluidic flow phantom studies are commonly used for characterizing the performance of laser speckle contrast imaging (LSCI) instruments. The selection of the flow control system is critical for the reliable generation of f…
View article: HARMONI- the Extremely Large Telescope first light integral field spectrograph: a novel functional model based system engineering methodology for the design of an integrated instrument control system architecture
HARMONI- the Extremely Large Telescope first light integral field spectrograph: a novel functional model based system engineering methodology for the design of an integrated instrument control system architecture Open
International audience