Andrew Elvington
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View article: CC Chemokine Receptor 5 Targeted Nanoparticles Imaging the Progression and Regression of Atherosclerosis Using Positron Emission Tomography/Computed Tomography
CC Chemokine Receptor 5 Targeted Nanoparticles Imaging the Progression and Regression of Atherosclerosis Using Positron Emission Tomography/Computed Tomography Open
Chemokines and chemokine receptors play an important role in the initiation and progression of atherosclerosis by mediating the trafficking of inflammatory cells. Chemokine receptor 5 (CCR5) has major implications in promoting the developm…
View article: CXCR4-Binding Positron Emission Tomography Tracers Link Monocyte Recruitment and Endothelial Injury in Murine Atherosclerosis
CXCR4-Binding Positron Emission Tomography Tracers Link Monocyte Recruitment and Endothelial Injury in Murine Atherosclerosis Open
Objective: vMIP-II (viral macrophage inflammatory protein 2)/vCCL2 (viral chemotactic cytokine ligand 2) binds to multiple chemokine receptors, and vMIP-II-based positron emission tomography tracer ( 64 Cu-DOTA-vMIP-II: vMIP-II tracer) acc…
View article: CXCR4-binding PET tracers link monocyte recruitment and endothelial injury in murine atherosclerosis
CXCR4-binding PET tracers link monocyte recruitment and endothelial injury in murine atherosclerosis Open
Viral macrophage inflammatory protein 2 (vMIP-II/vCCL2) binds to multiple chemokine receptors, and vMIP-II based PET tracer ( 64 Cu-DOTA-vMIP-II: vMIP-II tracer) accumulates at atherosclerotic lesions in mice. The magnitude of 64 Cu-DOTA-v…
View article: <sup>64</sup> Cu-ATSM Positron Emission Tomography/Magnetic Resonance Imaging of Hypoxia in Human Atherosclerosis
<sup>64</sup> Cu-ATSM Positron Emission Tomography/Magnetic Resonance Imaging of Hypoxia in Human Atherosclerosis Open
he macrophage-rich core of advanced human atheroma has been shown to be hypoxic, which may have implications for plaque stability. 1Recently, we showed that the hypoxia positron emission tomography (PET) imaging agent 64 Cu-diacetyl-bis(N4…
View article: B Cell–Mediated Antigen Presentation through MHC Class II Is Dispensable for Atherosclerosis Progression
B Cell–Mediated Antigen Presentation through MHC Class II Is Dispensable for Atherosclerosis Progression Open
Depletion of B cells attenuates plaque development and modulates T cell responses in mouse models of atherosclerosis, suggesting that Ag presentation by B cells may promote disease progression. Thus, we set out to determine the role of B c…
View article: Schistosoma mansoni Infection-Induced Transcriptional Changes in Hepatic Macrophage Metabolism Correlate With an Athero-Protective Phenotype
Schistosoma mansoni Infection-Induced Transcriptional Changes in Hepatic Macrophage Metabolism Correlate With an Athero-Protective Phenotype Open
Hepatic macrophages play an essential role in the granulomatous response to infection with the parasitic helminth Schistosoma mansoni , but the transcriptional changes that underlie this effect are poorly understood. To explore this, we so…
View article: Thermoneutrality but Not UCP1 Deficiency Suppresses Monocyte Mobilization Into Blood
Thermoneutrality but Not UCP1 Deficiency Suppresses Monocyte Mobilization Into Blood Open
Rationale: Ambient temperature is a risk factor for cardiovascular disease. Cold weather increases cardiovascular events, but paradoxically, cold exposure is metabolically protective because of UCP1 (uncoupling protein 1)-dependent thermog…
View article: PET/MRI of Hypoxic Atherosclerosis Using <sup>64</sup>Cu-ATSM in a Rabbit Model
PET/MRI of Hypoxic Atherosclerosis Using <sup>64</sup>Cu-ATSM in a Rabbit Model Open
The results show that hypoxia is present in this rabbit model of atherosclerosis and suggest that 64Cu-ATSM PET/MR is a potentially promising method for the detection of hypoxic and potentially vulnerable atherosclerotic plaque in human su…
View article: Modulation of post-stroke degenerative and regenerative processes and subacute protection by site-targeted inhibition of the alternative pathway of complement
Modulation of post-stroke degenerative and regenerative processes and subacute protection by site-targeted inhibition of the alternative pathway of complement Open
Ischemic brain tissue-targeted and selective inhibition of alternative complement pathway provide self-limiting inhibition of complement activation and reduces acute injury while maintaining complement-dependent recovery mechanisms into th…
View article: The role of the lymphatic system in cholesterol transport
The role of the lymphatic system in cholesterol transport Open
Reverse cholesterol transport (RCT) is the pathway for removal of peripheral tissue cholesterol and involves transport of cholesterol back to liver for excretion, starting from cellular cholesterol efflux facilitated by lipid-free apolipop…
View article: Complement in the Homeostatic and Ischemic Brain
Complement in the Homeostatic and Ischemic Brain Open
The complement system is a component of the immune system involved in both recognition and response to pathogens, and it is implicated in an increasing number of homeostatic and disease processes. It is well documented that reperfusion of …
View article: Additional file 1: of Modulation of post-stroke degenerative and regenerative processes and subacute protection by site-targeted inhibition of the alternative pathway of complement
Additional file 1: of Modulation of post-stroke degenerative and regenerative processes and subacute protection by site-targeted inhibition of the alternative pathway of complement Open
List of 248 genes and results of Nanostring mRNA expression analysis comparing wild-type control to CR2-fH-treated mice.