Andrew G. Harrison
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View article: Unanchored ubiquitin chains promote the non-canonical inflammasome via UBXN1 2222
Unanchored ubiquitin chains promote the non-canonical inflammasome via UBXN1 2222 Open
Description Ubiquitination is a major posttranslational covalent modification that regulates numerous cellular processes including inflammasome signaling. Cells also contain unanchored ubiquitin chains (polyUb) that bind protein targets no…
View article: Continuous reference intervals for total serum immunoglobulin E in neonates and children
Continuous reference intervals for total serum immunoglobulin E in neonates and children Open
Immunoglobulin E (IgE) is a group of antibodies involved with allergic sensitisation. Levels of total IgE change with age and tend to be higher in individuals with allergic diseases than in those without. To improve the clinical utility of…
View article: Exploring Meta-Cognitive Resilience and Psycho-Social Well-Being Among Bangladeshi University Students During COVID-19: A Mixed-Methods Primary Study of Adaptive Cognitive Strategies
Exploring Meta-Cognitive Resilience and Psycho-Social Well-Being Among Bangladeshi University Students During COVID-19: A Mixed-Methods Primary Study of Adaptive Cognitive Strategies Open
Introduction The COVID-19 pandemic disrupted the academic and social lives of university students, leading to heightened stress, anxiety, and isolation. This study investigates the meta-cognitive resilience of Bangladeshi university studen…
View article: Development and Preliminary Evaluation of a Behavioral Lifestyle Assessment Tool: A Methodological Case Study with Graduate-Level Women
Development and Preliminary Evaluation of a Behavioral Lifestyle Assessment Tool: A Methodological Case Study with Graduate-Level Women Open
Introduction: Obesity in adults remains a pressing public health issue in the United States, closely linked to modifiable behaviors such as diet, physical activity, stress, sleep, and substance use. This study aimed to develop and pilot a …
View article: Unanchored ubiquitin chains promote the non-canonical inflammasome via UBXN1
Unanchored ubiquitin chains promote the non-canonical inflammasome via UBXN1 Open
Ubiquitination is a major posttranslational covalent modification that regulates numerous cellular processes including inflammasome signaling. Cells also contain unanchored ubiquitin chains (polyUb) that bind protein targets non-covalently…
View article: UBXN9 governs GLUT4-mediated spatial confinement of RIG-I-like receptors and signaling
UBXN9 governs GLUT4-mediated spatial confinement of RIG-I-like receptors and signaling Open
The cytoplasmic RIG-I-like receptors (RLRs) recognize viral RNA and initiate innate antiviral immunity. RLR signaling also triggers glycolytic reprogramming through glucose transporters (GLUTs), whose role in antiviral immunity is elusive.…
View article: UBR5 promotes antiviral immunity by disengaging the transcriptional brake on RIG-I like receptors
UBR5 promotes antiviral immunity by disengaging the transcriptional brake on RIG-I like receptors Open
The Retinoic acid-Inducible Gene I (RIG-I) like receptors (RLRs) are the major viral RNA sensors essential for the initiation of antiviral immune responses. RLRs are subjected to stringent transcriptional and posttranslational regulations,…
View article: The glucose transporter GLUT4 tethers RIG-I-like receptors to suppress antiviral immunity
The glucose transporter GLUT4 tethers RIG-I-like receptors to suppress antiviral immunity Open
The current dogma of RIG-I-like receptor (RLR) regulation states that dysregulated interferon (IFN) production is predominantly repressed by reversible posttranslational modifications (e.g., ubiquitination). However, RLR activation has pro…
View article: Intrinsic cardiac adrenergic cells contribute to LPS-induced myocardial dysfunction
Intrinsic cardiac adrenergic cells contribute to LPS-induced myocardial dysfunction Open
Intrinsic cardiac adrenergic (ICA) cells regulate both developing and adult cardiac physiological and pathological processes. However, the role of ICA cells in septic cardiomyopathy is unknown. Here we show that norepinephrine (NE) secreti…
View article: Senescence‐induced changes in CD4 T cell differentiation can be alleviated by treatment with senolytics
Senescence‐induced changes in CD4 T cell differentiation can be alleviated by treatment with senolytics Open
Aging and senescence impact CD4 T helper cell (Th) subset differentiation during influenza infection. In the lungs of infected aged mice, there were significantly greater percentages of Th cells expressing the transcription factor FoxP3, i…
View article: UBX Domain Protein 6 Positively Regulates JAK-STAT1/2 Signaling
UBX Domain Protein 6 Positively Regulates JAK-STAT1/2 Signaling Open
Type I/III IFNs induce expression of hundreds of IFN-stimulated genes through the JAK/STAT pathway to combat viral infections. Although JAK/STAT signaling is seemingly straightforward, it is nevertheless subjected to complex cellular regul…
View article: An Essential Role of UBXN3B in B Lymphopoiesis
An Essential Role of UBXN3B in B Lymphopoiesis Open
Hematopoiesis is finely regulated to enable timely production of the right numbers and types of mature immune cells to maintain tissue homeostasis. Dysregulated hematopoiesis may compromise antiviral immunity and/or exacerbate immunopathog…
View article: Intrinsic cardiac adrenergic cells contribute to septic cardiomyopathy
Intrinsic cardiac adrenergic cells contribute to septic cardiomyopathy Open
Occurring independently of cardiac sympathetic nervous system, the intrinsic cardiac adrenergic (ICA) cells have been identified as an important regulator in both of developing and adult cardiac physiological and pathological processes. Ho…
View article: Differential roles of RIG-I-like receptors in SARS-CoV-2 infection
Differential roles of RIG-I-like receptors in SARS-CoV-2 infection Open
The retinoic acid-inducible gene I (RIG-I) and melanoma differentiation-associated protein 5 (MDA5) are the major viral RNA sensors that are essential for activation of antiviral immune responses. However, their roles in severe acute respi…
View article: Effect of the COVID-19 Pandemic on the Working Practices of Analytical Facilities II
Effect of the COVID-19 Pandemic on the Working Practices of Analytical Facilities II Open
COVID-19 has a substantial impact on the operations of analytical facilities that serve external users.1 At the end of April 2020, only a third of the surveyed research infrastructures (RIs) reported that they maintained such user access a…
View article: Vaccination Improves CD4 T Helper Subset Balance in Aged Mice by Overcoming the Effects of the Senescent Environment
Vaccination Improves CD4 T Helper Subset Balance in Aged Mice by Overcoming the Effects of the Senescent Environment Open
Influenza (flu) infection is a leading cause of morbidity and mortality in older adults. Although vaccination is the best strategy to combat the effects of flu infection, there is a marked decline in vaccine efficacy in older adults. We hy…
View article: CXCL10 Signaling Contributes to the Pathogenesis of Arthritogenic Alphaviruses
CXCL10 Signaling Contributes to the Pathogenesis of Arthritogenic Alphaviruses Open
Emerging and re-emerging arthritogenic alphaviruses, such as Chikungunya virus (CHIKV) and O’nyong nyong virus, cause acute and chronic crippling arthralgia associated with inflammatory immune responses. Approximately 50% of CHIKV-infected…
View article: A Critical Role for STING Signaling in Limiting Pathogenesis of Chikungunya Virus
A Critical Role for STING Signaling in Limiting Pathogenesis of Chikungunya Virus Open
The stimulator of interferon gene (STING) pathway controls both DNA and RNA virus infection. STING is essential for induction of innate immune responses during DNA virus infection, while its mechanism against RNA virus remains largely elus…
View article: Impact of the COVID-19 pandemic on paediatric orthopaedic trauma workload in central London: a multi-centre longitudinal observational study over the “golden weeks”
Impact of the COVID-19 pandemic on paediatric orthopaedic trauma workload in central London: a multi-centre longitudinal observational study over the “golden weeks” Open
Background and purpose - The COVID-19 pandemic has been recognised as an unprecedented global health crisis. This study assesses the impact on a large acute paediatric hospital service in London, evaluating the trends in the acute paediatr…
View article: A critical role for MSR1 in vesicular stomatitis virus infection of the central nervous system
A critical role for MSR1 in vesicular stomatitis virus infection of the central nervous system Open
Macrophage scavenger receptor 1 (MSR1) plays an important role in host defense to bacterial infections, M2 macrophage polarization and lipid homeostasis. However, its physiological function in viral pathogenesis remains poorly defined. Her…
View article: STING deficiency-associated aberrant CXCL10 expression contributes to pathogenesis of arthritogenic alphaviruses
STING deficiency-associated aberrant CXCL10 expression contributes to pathogenesis of arthritogenic alphaviruses Open
Arthritogenic alphaviruses such as Chikungunya virus and O’nyong nyong virus cause acute and chronic crippling arthralgia associated with inflammatory immune responses. However, the physiological functions of individual immune signaling pa…
View article: ERF's Review of Working Practices of Analytical Facilities During the Pandemic
ERF's Review of Working Practices of Analytical Facilities During the Pandemic Open
The on-going COVID-19 pandemic has strongly impacted the operations of analytical facilities. To protect their staff, several research infrastructures (RIs) are closed for operations or strongly limiting their activities while maximizing p…