Andrew G. Letizia
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View article: Detection of Tick-borne Encephalitis Virus in <i>Ixodes</i> Ticks Collected Near Ulaanbaatar, Mongolia
Detection of Tick-borne Encephalitis Virus in <i>Ixodes</i> Ticks Collected Near Ulaanbaatar, Mongolia Open
Background Tick-borne encephalitis virus (TBEV) is a flavivirus that causes a range of clinical presentations including severe neurological complications in humans. In Mongolia, TBEV is primarily transmitted by the Ixodes persulcatus tick,…
View article: Spatial distribution of <i>Anopheles</i> species across 3 different ecological zones in Ghana
Spatial distribution of <i>Anopheles</i> species across 3 different ecological zones in Ghana Open
Vector management of Anopheles mosquitoes in West Africa is challenged by limited data on distribution, species diversity, seasonal abundance, and lack of reporting mechanisms from sentinel sites. To improve the epidemiological risk assess…
View article: Influenza and respiratory syncytial virus dynamics in Lao PDR during the COVID-19 pandemic: a hospital-based surveillance study
Influenza and respiratory syncytial virus dynamics in Lao PDR during the COVID-19 pandemic: a hospital-based surveillance study Open
Objectives Globally, the circulation of influenza and other seasonal respiratory viruses changed dramatically during the COVID-19 pandemic. This study aims to determine the trends of acute respiratory infections (ARIs) caused by SARS-CoV-2…
View article: Serologic Evidence of Human Exposure to Bat-Borne Zoonotic Paramyxoviruses, Cambodia
Serologic Evidence of Human Exposure to Bat-Borne Zoonotic Paramyxoviruses, Cambodia Open
Fruit bats in the genus Pteropus are the natural reservoirs for zoonotic paramyxoviruses, notably henipaviruses and pararubulaviruses, which are found across Southeast Asia and Oceania. The genetic and antigenic diversity of viruses in bot…
View article: Comparison of Techniques for Respiratory Rate Extraction from Electrocardiogram and Photoplethysmogram
Comparison of Techniques for Respiratory Rate Extraction from Electrocardiogram and Photoplethysmogram Open
Background: Respiratory rate (RR) is a key vital sign and one of the most sensitive indicators of physiological conditions, playing a crucial role in the early identification of clinical deterioration. The monitoring of RR using electrocar…
View article: A standardized protocol for the detection of arboviruses in different Aedes mosquito species in North Borneo Sabah, Malaysia
A standardized protocol for the detection of arboviruses in different Aedes mosquito species in North Borneo Sabah, Malaysia Open
View article: A cascade approach for the early detection and localization of myocardial infarction in 2D-echocardiography
A cascade approach for the early detection and localization of myocardial infarction in 2D-echocardiography Open
Myocardial infarction (MI) detection and localization through echocardiography are crucial for effective patient management. However, current diagnostic approaches rely heavily on visual assessment, which can be subjective. In this work we…
View article: Clinical Manifestations, Risk Factors, and Disease Burden of Rickettsiosis, Cambodia, 2007–2020
Clinical Manifestations, Risk Factors, and Disease Burden of Rickettsiosis, Cambodia, 2007–2020 Open
During 2007-2020, we conducted a cross-sectional prevalence study among patients with acute undifferentiated febrile illness to describe the burden and long-term epidemiology of rickettsioses in Cambodia. Serum samples were collected from …
View article: High incidence of multidrug-resistant organisms and modifiable risk factors associated with surgical site infections: a cohort study in a tertiary medical center in Kuala Lumpur, Malaysia from 2020 to 2023
High incidence of multidrug-resistant organisms and modifiable risk factors associated with surgical site infections: a cohort study in a tertiary medical center in Kuala Lumpur, Malaysia from 2020 to 2023 Open
View article: Hantaan Virus (HTNV) Human Infection on Jeju Island, South Korea: Unique Phylogeny and Epidemiology of HTNV
Hantaan Virus (HTNV) Human Infection on Jeju Island, South Korea: Unique Phylogeny and Epidemiology of HTNV Open
View article: Improved limit of detection for zoonotic Plasmodium knowlesi and P. cynomolgi surveillance using reverse transcription for total nucleic acid preserved samples or dried blood spots
Improved limit of detection for zoonotic Plasmodium knowlesi and P. cynomolgi surveillance using reverse transcription for total nucleic acid preserved samples or dried blood spots Open
Background Zoonotic P . knowlesi and P . cynomolgi symptomatic and asymptomatic infections occur across endemic areas of Southeast Asia. Most infections are low-parasitemia, with an unknown proportion below routine microscopy detection thr…
View article: Characterization of Tick-Borne Encephalitis Virus Isolates from Ixodes persulcatus Ticks Collected During 2020 in Selenge, Mongolia
Characterization of Tick-Borne Encephalitis Virus Isolates from Ixodes persulcatus Ticks Collected During 2020 in Selenge, Mongolia Open
Tick-borne encephalitis virus (TBEV) causes neurological disease in humans, with varied clinical severity influenced by the viral subtype. TBEV is endemic to Mongolia, where both Siberian and Far-Eastern subtypes are present. Ixodes persul…
View article: Clinical and functional assessment of SARS-CoV-2 sequelae among young marines – a panel study
Clinical and functional assessment of SARS-CoV-2 sequelae among young marines – a panel study Open
BACKGROUND: Long-term SARS-CoV-2 adverse health outcomes are of significant concern, especially among young adults with the potential for the greatest long-term morbidity. We sought to assess and characterize these outcomes in a cohort of …
View article: Prevalence and macrolide resistance of Mycoplasma genitalium from patients seeking sexual health care in Southern Ghana
Prevalence and macrolide resistance of Mycoplasma genitalium from patients seeking sexual health care in Southern Ghana Open
While not commonly tested as a cause of STI symptoms, MG is widespread in Ghana, exhibiting symptoms and prevalence comparable to those in other countries and linked to antimicrobial resistance. Future research using various molecular tech…
View article: Dry Swabs and Dried Saliva as Alternative Samples for SARS-CoV-2 Detection in Remote Areas in Lao PDR
Dry Swabs and Dried Saliva as Alternative Samples for SARS-CoV-2 Detection in Remote Areas in Lao PDR Open
Background Surveillance of SARS-CoV-2 circulation is mainly based on real-time reverse transcription–polymerase chain reaction, which requires laboratory facilities and cold chain for sample transportation. This is difficult to achieve in …
View article: Integrated epigenomic exposure signature discovery
Integrated epigenomic exposure signature discovery Open
Aim: The epigenome influences gene regulation and phenotypes in response to exposures. Epigenome assessment can determine exposure history aiding in diagnosis.Materials & methods: Here we developed and implemented a machine l…
View article: Gene Expression Signatures in Blood that Predict Mortality in a West African Sepsis Cohort Define Host Response Phenotypes
Gene Expression Signatures in Blood that Predict Mortality in a West African Sepsis Cohort Define Host Response Phenotypes Open
Uploaded documents are in support of the manuscript and contain: \n\n\n\tGene-level quantitation values (transcripts per million - TPM) for the 573 subjects described in the study\n\tMetadata with basic information about 573 study subjects…
View article: Sepsis endotypes identified by host gene expression across global cohorts
Sepsis endotypes identified by host gene expression across global cohorts Open
View article: Gene expression signatures in blood from a West African sepsis cohort define host response phenotypes
Gene expression signatures in blood from a West African sepsis cohort define host response phenotypes Open
Our limited understanding of the pathophysiological mechanisms that operate during sepsis is an obstacle to rational treatment and clinical trial design. There is a critical lack of data from low- and middle-income countries where the seps…
View article: Informing the Need for a SARS-CoV-2 Booster Based on the Immune Responses Among Young Healthy Adults to Variants Circulating in Late 2023
Informing the Need for a SARS-CoV-2 Booster Based on the Immune Responses Among Young Healthy Adults to Variants Circulating in Late 2023 Open
Background COVID-19 remains a global public health challenge due to new immune-evasive SARS-CoV-2 variants and heterogeneous immunity. Methods In this cross-sectional study, we evaluated the adaptive immune responses in US active duty pers…
View article: Improved limit of detection for zoonotic<i>Plasmodium knowlesi</i>and<i>P. cynomolgi</i>surveillance using reverse transcription for total nucleic acid preserved samples or dried blood spots
Improved limit of detection for zoonotic<i>Plasmodium knowlesi</i>and<i>P. cynomolgi</i>surveillance using reverse transcription for total nucleic acid preserved samples or dried blood spots Open
Background Zoonotic P. knowlesi and P. cynomolgi symptomatic and asymptomatic infections occur across endemic areas of Southeast Asia. Most infections are low-parasitemia, with an unknown proportion below routine microscopy detection thres…
View article: Risk factors affecting the feeding site predilection of ticks on cattle in Ghana
Risk factors affecting the feeding site predilection of ticks on cattle in Ghana Open
Ticks are important disease vectors affecting animal health and causing substantial economic loss, especially in the tropics and subtropics. To examine the tick burden of cattle and associated risk factors for tick infestation, ticks were …
View article: Cohort Profile: Immune Responses to SARS-COV-2 Vaccination and Infection in a Longitudinal Sampling Amidst the COVID-19 Pandemic (LONGTONG-SARS2) in Malaysia
Cohort Profile: Immune Responses to SARS-COV-2 Vaccination and Infection in a Longitudinal Sampling Amidst the COVID-19 Pandemic (LONGTONG-SARS2) in Malaysia Open
Purpose This prospective, longitudinal study aims to evaluate the durability and functionality of SARS-CoV-2 Ancestral strain (Wuhan-Hu-1)-specific immune responses induced by COVID-19 vaccination and natural infection over a 12-month peri…
View article: Clinical Presentation, Risk Factors, and Comparison of Laboratory Diagnostics for Seasonal Influenza Virus Among Cambodians From 2007 to 2020
Clinical Presentation, Risk Factors, and Comparison of Laboratory Diagnostics for Seasonal Influenza Virus Among Cambodians From 2007 to 2020 Open
Background Despite its global significance, challenges associated with understanding the epidemiology and accurately detecting, measuring, and characterizing the true burden of seasonal influenza remain in many resource-poor settings. Meth…
View article: First Molecular Identification of Rickettsia aeschlimannii and Rickettsia africae in Ticks from Ghana
First Molecular Identification of Rickettsia aeschlimannii and Rickettsia africae in Ticks from Ghana Open
The threats from vector-borne pathogens transmitted by ticks place people (including deployed troops) at increased risk for infection, frequently contributing to undifferentiated febrile illness syndromes. Wild and domesticated animals are…
View article: A protocol and training guidelines for mosquito sampling in remote areas with limited power supply
A protocol and training guidelines for mosquito sampling in remote areas with limited power supply Open
View article: Nucleocapsid (NP) with NP-Specific IgG Induce M2b Macrophages (HLA-DRHighCCR7-CD86 ), Which Contribute to the Hyperproduction of IL-10 and L-6, in Severe and Critical COVID‐19 Patients
Nucleocapsid (NP) with NP-Specific IgG Induce M2b Macrophages (HLA-DRHighCCR7-CD86 ), Which Contribute to the Hyperproduction of IL-10 and L-6, in Severe and Critical COVID‐19 Patients Open
View article: Clinical and Functional Assessment of SARS-CoV-2 Sequelae Among Young Marines
Clinical and Functional Assessment of SARS-CoV-2 Sequelae Among Young Marines Open
View article: Informing the need for a SARS-CoV-2 booster based upon the immune response among young, healthy adults to variants circulating during late 2023
Informing the need for a SARS-CoV-2 booster based upon the immune response among young, healthy adults to variants circulating during late 2023 Open
COVID-19 remains a global public health challenge due to ongoing emergence of new immune-evasive SARS-CoV-2 variants, heterogeneous immunity, poor education campaigns, and suboptimal surveillance. In this cross-sectional study, we evaluate…
View article: Antimicrobial use of patients with sexually transmitted infection symptoms prior to presentation at five health facilities in Southern Ghana
Antimicrobial use of patients with sexually transmitted infection symptoms prior to presentation at five health facilities in Southern Ghana Open
Background Unregulated and inappropriate antimicrobial use are major contributors to the evolution of antimicrobial resistance worldwide. It is important to monitor and collect data on the use of antibiotics at health facilities and in the…