Explanipedia

Facilitators and barriers to neighborhood social integration Open

Joelle Fuchs, Deena Shariq, Emily Yang, Giselle Maya, Taylor L. Wilds , et al. · 2025

Social isolation has reached concerning rates, particularly in the wake of the COVID‐19 pandemic. Social integration is critical to combatting social isolation and loneliness by promoting a sense of community and belonging. Yet, most exist…

A Window Into the State of the Science: Current Reporting Practices Related to Generalizability in MRI and Functional-MRI Studies Open

Arianna M. Gard, Deena Shariq, A. Albrecht, Alaina Lurie, Hyung Cho Kim , et al. · 2025

Concerns for the replicability, reliability, and generalizability of MRI and functional MRI (fMRI) research have led to debates over the contributions of sample size, open-science practices, and recruitment methods, particularly in the psy…

Missing data approaches for longitudinal neuroimaging research: Examples from the Adolescent Brain and Cognitive Development (ABCD) Open

Lin Li, Mohammadreza Bayat, Timothy Hayes, Wesley K. Thompson, Michael C. Neale , et al. · 2025

This paper addresses the challenges of managing missing values within expansive longitudinal neuroimaging datasets, using the specific example of data derived from the Adolescent Brain and Cognitive Development (ABCD) Study^®. Th…

Cognitive resilience and vulnerability to socioeconomic disadvantage: Predictors across individual, family, school, and neighborhood contexts Open

Deena Shariq, Rachel Romeo, Arianna M. Gard · 2025

Though much research links socioeconomic disadvantage to cognitive difficulties during adolescence, many youth demonstrate resilience. Person-centered approaches can be used to quantify this developmental heterogeneity and challenge defici…

Facilitators and Barriers to Neighborhood Social Integration Open

Joelle Fuchs, Deena Shariq, Emily Yang, Giselle Maya, Taylor L. Wilds , et al. · 2024

Social isolation has reached concerning rates, particularly in the wake of COVID-19 pandemic. Social integration is critical to combatting social isolation and loneliness and for promoting feelings of belonging, however, most of this work …

Missing data approaches for longitudinal neuroimaging research: Examples from the Adolescent Brain and Cognitive Development (ABCD) Study Open

Lin Li, Mohammadreza Bayat, Timothy Hayes, Wesley K. Thompson, Arianna M. Gard , et al. · 2024

This paper addresses the challenges of managing missing values within expansive longitudinal neu-roimaging datasets, using the specific example of data derived from the Adolescent Brain and Cog-nitive Development (ABCD ® ) study. The conve…

Cognitive resilience and vulnerability to socioeconomic disadvantage: Individual, family, school, and neighborhood predictors Open

Deena Shariq, Rachel Romeo, Arianna M. Gard · 2024

Though much research links socioeconomic disadvantage to cognitive difficulties, many youth demonstrate resilience. Person-centered approaches can be used to quantify this developmental heterogeneity and challenge deficit-centered framewor…

Why weight? Analytic approaches for large-scale population neuroscience data Open

Arianna M. Gard, Luke W. Hyde, Steven G. Heeringa, Brady T. West, Colter Mitchell · 2023

Socioeconomic resources are associated with distributed alterations of the brain’s intrinsic functional architecture in youth Open

Chandra Sripada, Arianna M. Gard, Mike Angstadt, Aman Taxali, Tristan Greathouse , et al. · 2022

Little is known about how exposure to limited socioeconomic resources (SER) in childhood gets "under the skin" to shape brain development, especially using rigorous whole-brain multivariate methods in large, adequately powered samples. The…

Deadly gun violence, neighborhood collective efficacy, and adolescent neurobehavioral outcomes Open

Arianna M. Gard, Jeanne Brooks‐Gunn, Sara McLanahan, Colter Mitchell, Christopher S. Monk , et al. · 2022

Gun violence is a major public health problem and costs the United States $280 billion annually (1). Although adolescents are disproportionately impacted (e.g. premature death), we know little about how close adolescents live to deadly gun…

Amygdala reactivity during socioemotional processing and cortisol reactivity to a psychosocial stressor Open

Andrea Roberts, Melissa K. Peckins, Arianna M. Gard, Tyler C. Hein, Felicia A. Hardi , et al. · 2022

Socioeconomic Resources are Associated with Distributed Alterations of the Brain’s Intrinsic Functional Architecture in Youth Open

Chandra Sripada, Arianna M. Gard, Mike Angstadt, Aman Taxali, Tristan Greathouse , et al. · 2022

Little is known about how exposure to limited socioeconomic resources (SER) in childhood gets “under the skin” to shape brain development, especially using rigorous whole-brain multivariate methods in large, adequately powered samples. The…

Parents, neighborhoods, and the developing brain Open

Luke W. Hyde, Arianna M. Gard, Rachel C. Tomlinson, Gabriela L. Suarez, Heidi B. Westerman · 2022

Although a growing literature has linked extreme psychosocial adversity in early development to brain structure and function, recent studies highlight that differences in socioeconomic resources may also affect brain development. In this a…

The impact of neighborhood disadvantage on amygdala reactivity: Pathways through neighborhood social processes Open

Gabriela L. Suarez, S. Alexandra Burt, Arianna M. Gard, Jared Zachary Burton, David A. Clark , et al. · 2022

Youth growing up in disadvantaged neighborhoods are more likely than their advantaged peers to face negative behavioral and mental health outcomes. Although studies have shown that adversity can undermine positive development via its impac…

Brain-wide functional connectivity patterns support general cognitive ability and mediate effects of socioeconomic status in youth Open

Chandra Sripada, Mike Angstadt, Aman Taxali, David A. Clark, Tristan Greathouse , et al. · 2021

General cognitive ability (GCA) is an individual difference dimension linked to important academic, occupational, and health-related outcomes and its development is strongly linked to differences in socioeconomic status (SES). Complex abil…

Prenatal Particulate Matter Exposure Is Associated with Saliva DNA Methylation at Age 15: Applying Cumulative DNA Methylation Scores as an Exposure Biomarker Open

Kelly M. Bakulski, Jonah Fisher, John Dou, Arianna M. Gard, Lisa Schneper , et al. · 2021

Exposure in utero to particulate matter (PM2.5 and PM10) is associated with maladaptive health outcomes. Although exposure to prenatal PM2.5 and PM10 has cord blood DNA methylation signatures at birth, signature persistence into childhood …

Deadly Gun Violence, Neighborhood Collective Efficacy, and Adolescent Neurobehavioral Outcomes Open

Arianna M. Gard, Jeanne Brooks‐Gunn, Sara McLanahan, Colter Mitchell, Christopher S. Monk , et al. · 2021

Gun violence is a major public health problem and costs the United States $280 billion annually (1). Although adolescents are disproportionately impacted (e.g., premature death), we know little about how close adolescents live to deadly gu…

Phenotypic and genetic markers of psychopathology in a population-based sample of older adults Open

Arianna M. Gard, Erin B. Ware, Luke W. Hyde, Lauren Schmitz, Jessica D. Faul , et al. · 2021

Prospective longitudinal associations between harsh parenting and corticolimbic function during adolescence Open

Arianna M. Gard, Tyler C. Hein, Colter Mitchell, Jeanne Brooks‐Gunn, Sarah S. McLanahan , et al. · 2021

Childhood adversity is thought to undermine youth socioemotional development via altered neural function within regions that support emotion processing. These effects are hypothesized to be developmentally specific, with adversity in early…

Differentiated nomological networks of internalizing, externalizing, and the general factor of psychopathology (‘<i>p</i> factor’) in emerging adolescence in the ABCD study Open

Sarah J. Brislin, Meghan E. Martz, Sonalee Joshi, Elizabeth R. Duval, Arianna M. Gard , et al. · 2021

Background Structural models of psychopathology consistently identify internalizing (INT) and externalizing (EXT) specific factors as well as a superordinate factor that captures their shared variance, the p factor. Questions remain, howev…

Prospective Longitudinal Associations between Harsh Parenting and Corticolimbic Function during Adolescence Open

Arianna M. Gard, Tyler C. Hein, Colter Mitchell, Sara McLanahan, Luke W. Hyde · 2020

Manuscript in press at Development & Psychopathology (Submitted 8/17/2020, Accepted 11/08/2020). Childhood adversity is thought to undermine youth socioemotional development via altered neural function within regions that support emoti…

Sex Differences in Genetic Effects Using Two Gene Aggregation Techniques: Depression and Cognition Open

Erin B. Ware, Lauren Schmitz, Arianna M. Gard · 2020

The state of science has increasingly valued interdisciplinary training and research. As an early-stage investigator, interdisciplinary research, such as that supported by the Research Centers Collaborative Network through the National Ins…

An ecological approach to understanding the developing brain: Examples linking poverty, parenting, neighborhoods, and the brain. Open

Luke W. Hyde, Arianna M. Gard, Rachel C. Tomlinson, S. Alexandra Burt, Colter Mitchell , et al. · 2020

We describe an ecological approach to understanding the developing brain, with a focus on the effects of poverty-related adversity on brain function. We articulate how combining multilevel ecological models from developmental science and d…

Cognition, Depression, and Genetics: Examining Sex Differences Using Polygenic and Genetic Inference Techniques Open

Erin B. Ware, Arianna M. Gard, Mingzhou Fu, Lauren Schmitz, Kelly M. Bakulski , et al. · 2020

Alzheimer’s disease and its related dementias (ADRD) are debilitating neurodegenerative diseases. As nearly two-thirds of persons diagnosed with Alzheimer’s disease are women, more research is needed to understand sex differences in the bi…

Particulate matter exposure in utero is associated with childhood saliva DNA methylation at ages 9 and 15 Open

Kelly M. Bakulski, John Dou, Jonah Fisher, Arianna M. Gard, Erin B. Ware , et al. · 2020

Background: Exposure in utero to particulate matter (PM2.5 and PM10) is associated with health outcomes. Prenatal PM2.5 and PM10 exposures have cord blood DNA methylation signatures at birth, however signature persistence into childhood an…

Differentiated Nomological Networks of Internalizing, Externalizing, and the General Factor of Psychopathology (“P factor”) in Emerging Adolescence in the ABCD study Open

Sarah J. Brislin, Meghan E. Martz, Sonalee Joshi, Elizabeth R. Duval, Arianna M. Gard , et al. · 2020

Introduction: Structural models of psychopathology consistently identify internalizing (INT) and externalizing (EXT) specific factors as well as a superordinate factor that captures their shared variance, the P factor. Questions remain, ho…

Beyond family‐level adversities: Exploring the developmental timing of neighborhood disadvantage effects on the brain Open

Arianna M. Gard, Andrea M. Maxwell, Daniel S. Shaw, Colter Mitchell, Jeanne Brooks‐Gunn , et al. · 2020

A growing literature suggests that adversity is associated with later altered brain function, particularly within the corticolimbic system that supports emotion processing and salience detection (e.g., amygdala, prefrontal cortex [PFC]). A…

Evaluation of a longitudinal family stress model in a population‐based cohort Open

Arianna M. Gard, Vonnie C. McLoyd, Colter Mitchell, Luke W. Hyde · 2020

The family stress model (FSM) is an influential family process model that posits that socioeconomic disadvantage impacts child outcomes via its effects on the parents. Existing evaluations of the FSM are constrained by limited measures of …

Population Neuroscience Structured Review Open

Arianna M. Gard · 2020

Examining sex differences in pleiotropic effects for depression and smoking using polygenic and gene‐region aggregation techniques Open

Lauren Schmitz, Arianna M. Gard, Erin B. Ware · 2019

Sex differences in rates of depression are thought to contribute to sex differences in smoking initiation (SI) and number of cigarettes smoked per day (CPD). One hypothesis is that women smoke as a strategy to cope with anxiety and depress…

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