Andrew R. Green
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View article: Functional and clinical significance of the RNA m6A methyltransferase complex in breast cancer
Functional and clinical significance of the RNA m6A methyltransferase complex in breast cancer Open
The RNA modification N 6 -methyladenosine (m 6 A) plays a key role in RNA processing. It is catalysed by the RNA methyltransferase complex (MTC) which includes METTL3, METTL14 and CBLL1. Recently, a METTL3 inhibitor demonstrated promising …
View article: Les cigognes et les goélands transportent des centaines de kilos de plastique depuis les décharges jusqu’aux zones humides d’Andalousie
Les cigognes et les goélands transportent des centaines de kilos de plastique depuis les décharges jusqu’aux zones humides d’Andalousie Open
View article: Cigüeñas y gaviotas transportan cientos de kilos de plásticos desde los vertederos a los humedales de Andalucía
Cigüeñas y gaviotas transportan cientos de kilos de plásticos desde los vertederos a los humedales de Andalucía Open
View article: Phylogenetic analysis of paired breast carcinomas identifies genetic events associated with clonal recurrence and invasive progression
Phylogenetic analysis of paired breast carcinomas identifies genetic events associated with clonal recurrence and invasive progression Open
Development of ipsilateral breast carcinoma following a diagnosis of breast ductal carcinoma in situ (DCIS) has been assumed to represent recurrence of the primary tumour. However, this may not always be the case, and it is important to de…
View article: Clinicopathological Significance of Transcription Factor p73 in Breast Cancers: Protein Expression and Transcriptomic Study
Clinicopathological Significance of Transcription Factor p73 in Breast Cancers: Protein Expression and Transcriptomic Study Open
Background: p73, a member of the p53 family of transcription factors, plays important roles in DNA repair, cell proliferation, angiogenesis, invasion, metastasis, immune evasion, and cytotoxic therapy response. The clinicopathological sign…
View article: Investigating Total Petroleum Hydrocarbon (TPH) Level in the Gills, Tissues and Carapace of Blue Crab (Callinectes sapidus): A Study in the New Calabar River, Choba, Rivers State, Nigeria
Investigating Total Petroleum Hydrocarbon (TPH) Level in the Gills, Tissues and Carapace of Blue Crab (Callinectes sapidus): A Study in the New Calabar River, Choba, Rivers State, Nigeria Open
This study investigated the total petroleum hydrocarbon (TPH) concentrations in the gills, tissues, and carapace of Callinectes sapidus collected from three stations (Choba, Rumualogu and Ozuoba) along the Choba axis of the New Calabar Riv…
View article: Expression of the zinc-finger transcription factor Osterix (SP7) in invasive breast cancer and its prognostic significance
Expression of the zinc-finger transcription factor Osterix (SP7) in invasive breast cancer and its prognostic significance Open
View article: Organo-somatic Index and Condition Factor of Clarias gariepinus (Burchell, 1822) Sub-adult Exposed to Sub-lethal Concentrations of Gold Crew Oil Spill Dispersant
Organo-somatic Index and Condition Factor of Clarias gariepinus (Burchell, 1822) Sub-adult Exposed to Sub-lethal Concentrations of Gold Crew Oil Spill Dispersant Open
Organosomatic index and condition factor of fish is one way to assess the general health of fish and monitor the influence of environmental factors on fish. The organosomatic index and condition factor of Clarias gariepinus exposed to sub-…
View article: SLC1A5 is a key regulator of glutamine metabolism and a prognostic marker for aggressive luminal breast cancer
SLC1A5 is a key regulator of glutamine metabolism and a prognostic marker for aggressive luminal breast cancer Open
View article: A bispecific antibody-drug conjugate targeting pCAD and CDH17 has antitumor activity and improved tumor-specificity
A bispecific antibody-drug conjugate targeting pCAD and CDH17 has antitumor activity and improved tumor-specificity Open
P-cadherin (pCAD) and LI-cadherin (CDH17) are cell-surface proteins belonging to the cadherin superfamily that are both highly expressed in colorectal cancer. This co-expression profile presents a novel and attractive opportunity for a dua…
View article: Investigation and analysis of explosive traces in public locations with no military context: a critical review
Investigation and analysis of explosive traces in public locations with no military context: a critical review Open
This review examines the prevalence of high explosives and gunshot residue (GSR) in public areas with the primary focus on the likelihood of innocent contamination and its implication for forensic investigations.
View article: Deciphering the Role of ASPM in Breast Cancer: A Comprehensive Multicohort Study
Deciphering the Role of ASPM in Breast Cancer: A Comprehensive Multicohort Study Open
Background: Assembly factor for spindle microtubules (ASPM) has gained significant attention in cancer research due to its association with tumor growth and progression. Through the analysis of large-scale genomic datasets, ASPM has been i…
View article: Cell cycle traverse rate predicts long-term outcomes in a multi-institutional cohort of patients with triple-negative breast cancer
Cell cycle traverse rate predicts long-term outcomes in a multi-institutional cohort of patients with triple-negative breast cancer Open
View article: Hydroxyacid Oxidase 1, a Glutamine Metabolism-Associated Protein, Predicts Poor Patient Outcome in Luminal Breast Cancer
Hydroxyacid Oxidase 1, a Glutamine Metabolism-Associated Protein, Predicts Poor Patient Outcome in Luminal Breast Cancer Open
Breast cancer (BC), which remains the most prevalent malignancy among women, is characterised by significant heterogeneity across its molecular subtypes. Oestrogen receptor-positive (ER+) (luminal) BC represents approximately 75% of cases,…
View article: Protein Tyrosine Kinase 7 (PTK7) in Breast Cancer: A Retrospective Analysis of Tumour Expression and Association with Clinical Outcome
Protein Tyrosine Kinase 7 (PTK7) in Breast Cancer: A Retrospective Analysis of Tumour Expression and Association with Clinical Outcome Open
Protein tyrosine kinase 7 (PTK7), originally known as colon carcinoma kinase (CCK4), is an evolutionary conserved, catalytically defective transmembrane receptor involved in Wnt signalling. PTK7 has been identified as a potential therapeut…
View article: Prognostic and Clinical Significance of the Proliferation Marker MCM7 in Breast Cancer
Prognostic and Clinical Significance of the Proliferation Marker MCM7 in Breast Cancer Open
Introduction: Minichromosome maintenance complex component 7 (MCM7) plays an essential role in proliferation and DNA replication of cancer cells. However, the expression and prognostic significance of MCM7 in breast cancer (BC) remain to b…
View article: The role of the ALKBH5 RNA demethylase in invasive breast cancer
The role of the ALKBH5 RNA demethylase in invasive breast cancer Open
Background N6-methyladenosine (m 6 A) is the most common internal RNA modification and is involved in regulation of RNA and protein expression. AlkB family member 5 (ALKBH5) is a m 6 A demethylase. Given the important role of m 6 A in biol…
View article: Stromal lymphocytes are associated with upgrade of B3 breast lesions
Stromal lymphocytes are associated with upgrade of B3 breast lesions Open
Various histopathological, clinical and imaging parameters have been evaluated to identify a subset of women diagnosed with lesions with uncertain malignant potential (B3 or BIRADS 3/4A lesions) who could safely be observed rather than bei…
View article: Nottingham prognostic x (<scp>NPx</scp>): a risk stratification tool in <scp>ER</scp>‐positive <scp>HER2</scp>‐negative breast cancer: a validation study
Nottingham prognostic x (<span>NPx</span>): a risk stratification tool in <span>ER</span>‐positive <span>HER2</span>‐negative breast cancer: a validation study Open
Aims In this study, we validate the use of Nottingham Prognostic x (NPx), consisting of tumour size, tumour grade, progesterone receptor (PR) and Ki67 in luminal BC. Materials and methods Two large cohorts of luminal early‐stage BC ( n = 2…
View article: The characteristics and prognostic significance of histone H1 expression in breast cancer
The characteristics and prognostic significance of histone H1 expression in breast cancer Open
View article: ATF4 as a Prognostic Marker and Modulator of Glutamine Metabolism in Oestrogen Receptor-Positive Breast Cancer
ATF4 as a Prognostic Marker and Modulator of Glutamine Metabolism in Oestrogen Receptor-Positive Breast Cancer Open
Introduction: ATF4, a stress-responsive transcription factor that upregulates adaptive genes, is a potential prognostic marker and modulator of glutamine metabolism in breast cancer. However, its exact role remains to be elucidated. Method…
View article: An unusual case of nephrotic syndrome
An unusual case of nephrotic syndrome Open
Background Alport syndrome is a genetically heterogenous disorder resulting from variants in genes coding for alpha-3/4/5 chains of Collagen IV, which results in defective basement membranes in the kidney, cochlea and eye. The syndrome has…
View article: Phylogenetic analysis of paired breast carcinomas identifies genetic events associated with clonal recurrence and invasive progression
Phylogenetic analysis of paired breast carcinomas identifies genetic events associated with clonal recurrence and invasive progression Open
Development of ipsilateral breast carcinoma following diagnosis of breast ductal carcinoma in situ (DCIS) has been assumed to represent recurrence of the primary tumour. However, this may not be the case and it is important to know how oft…
View article: Tripartite Motif-Containing 2, a Glutamine Metabolism-Associated Protein, Predicts Poor Patient Outcome in Triple-Negative Breast Cancer Treated with Chemotherapy
Tripartite Motif-Containing 2, a Glutamine Metabolism-Associated Protein, Predicts Poor Patient Outcome in Triple-Negative Breast Cancer Treated with Chemotherapy Open
Background: Breast cancer (BC) remains heterogeneous in terms of prognosis and response to treatment. Metabolic reprogramming is a critical part of oncogenesis and a potential therapeutic target. Glutaminase (GLS), which generates glutamat…
View article: Deciphering the Clinical Behaviour of Invasive Lobular Carcinoma of the Breast Defines an Aggressive Subtype
Deciphering the Clinical Behaviour of Invasive Lobular Carcinoma of the Breast Defines an Aggressive Subtype Open
Background: Invasive lobular carcinoma (ILC), the most common special type of breast cancer (BC), has unique clinical behaviour and is different from invasive ductal carcinoma of no special type (IDC-NST). However, ILC further comprises a …
View article: Correction: Performance of a novel spectroscopy-based tool for adjuvant therapy decision-making in hormone receptor-positive breast cancer: a validation study
Correction: Performance of a novel spectroscopy-based tool for adjuvant therapy decision-making in hormone receptor-positive breast cancer: a validation study Open
View article: A bispecific antibody-drug conjugate targeting pCAD and CDH17 has antitumor activity and improved tumor specificity
A bispecific antibody-drug conjugate targeting pCAD and CDH17 has antitumor activity and improved tumor specificity Open
P-cadherin (pCAD) and LI-cadherin (CDH17) are cell surface proteins belonging to the cadherin superfamily that are both highly expressed in colorectal cancer. This co-expression profile presents a novel and attractive opportunity for a dua…
View article: Expression of Cathepsin D in early-stage breast cancer and its prognostic and predictive value
Expression of Cathepsin D in early-stage breast cancer and its prognostic and predictive value Open
Purpose Cathepsin D is a proteolytic enzyme that is normally localized in the lysosomes and is involved in the malignant progression of breast cancer. There are conflicting results regarding Cathepsin D significance as prognostic and predi…
View article: Sustainable Dengue Prevention and Management: Integrating Dengue Vaccination Strategies with Population Perspectives
Sustainable Dengue Prevention and Management: Integrating Dengue Vaccination Strategies with Population Perspectives Open
The GEMKAP study (2023) unveiled consistent knowledge, attitude, and practice (KAP) levels across Asia-Pacific (APAC) and Latin America (LATAM) countries regarding dengue, with variations in the willingness to vaccinate. Despite an overall…
View article: Maisara Azmi AlRayyes
Maisara Azmi AlRayyes Open