Explanipedia

Cerebral haemodynamic responses to inspiratory muscle work Open

Andrew H. Ramsook, Morgan Hughes, Wyatt W. Pruter, Kevin L. Webb, Amin Ataie , et al. · 2025

Fatiguing inspiratory work has been shown to evoke a sympathetically mediated reflex that has systemic cardiovascular consequences, including increases in heart rate and blood pressure and a decrease in resting limb vascular conductance. M…

Greater large conducting airway luminal area in adult patients with interstitial lung disease Open

Alex J. Miller, Erik A. Ovrom, Solomiia Zaremba, Jonathon W. Senefeld, Chad C. Wiggins , et al. · 2025

Interstitial lung disease (ILD) encompasses pulmonary disorders characterized by chronic inflammation and fibrosis that disrupt pulmonary gas exchange. While ILD‐related changes in the lung parenchyma are well‐documented, less is known abo…

An anerobic boost to a sub-4-min mile Open

Shalaya Kipp, Andrew H. Ramsook, Michael J. Joyner · 2025

Greater Large Conducting Airway Luminal Area in Patients with Interstitial Lung Disease Open

Alex J. Miller, Erik A. Ovrom, Solomiia Zaremba, Jonathon W. Senefeld, Chad C. Wiggins , et al. · 2025

Interstitial lung disease (ILD) encompasses multiple pulmonary disorders characterized by damaged pulmonary tissue caused by a sequence of inflammation and fibrosis. While much is known about ILD-associated changes within the parenchyma an…

Increased luminal area of large conducting airways in patients with COVID-19 and post-acute sequelae of COVID-19: a retrospective case-control study Open

Solomiia Zaremba, Alex J. Miller, Erik A. Ovrom, Jonathon W. Senefeld, Chad C. Wiggins , et al. · 2024

Three-dimensional reconstruction of airways has shown increased luminal area in patients with COVID-19 and post-acute sequelae of COVID-19 when compared with healthy controls. These findings suggest the role of large conducting airways in …

Increased luminal area of large conducting airways in patients with COVID-19 and post-acute sequelae of COVID-19 A retrospective case-control study Open

Solomiia Zaremba, Alex J. Miller, Erik A. Ovrom, Jonathon W. Senefeld, Chad C. Wiggins , et al. · 2024

Summary Background Coronavirus disease 2019 (COVID-19) is associated with enlarged luminal areas of large conducting airways. In 10-30% of patients with acute COVID-19 infection, symptoms persist for more than 4 weeks (referred to as post-…

The oxygen transport cascade and exercise: Lessons from comparative physiology Open

Andrew H. Ramsook, Paolo B. Dominelli, Sarah A. Angus, Jonathon W. Senefeld, Chad C. Wiggins , et al. · 2023

Voluntary activation of the diaphragm after inspiratory pressure threshold loading Open

Andrew H. Ramsook, Michele R. Schaeffer, Reid Mitchell, Satvir S. Dhillon, Kathryn M. Milne , et al. · 2023

After a bout of isolated inspiratory work, such as inspiratory pressure threshold loading (IPTL), the human diaphragm can exhibit a reversible loss in contractile function, as evidenced by a decrease in transdiaphragmatic twitch pressure (…

296 Effects of salbutamol prior to diesel exhaust exposure does not affect dyspnea despite reducing the work of breathing in individuals with exercise-induced bronchoconstriction Open

Sarah Koch, Joseph F. Welch, Andrew H. Ramsook, Christopher Carlsten, Jordan A. Guenette , et al. · 2021

Background Individuals with exercise-induced bronchoconstriction (EIB) use inhaled ß₂-agonists prior to exercise to prevent respiratory symptoms. The resulting bronchodilation could increase the dose of inhaled pollutants and wo…

Effects of Traffic-Related Air Pollution on Exercise Endurance, Dyspnea, and Cardiorespiratory Responses in Health and COPD Open

Nafeez Syed, Min Hyung Ryu, Satvir S. Dhillon, Michele R. Schaeffer, Andrew H. Ramsook , et al. · 2021

Effect of Diesel Exhaust on Exercise Endurance and Cardiorespiratory Responses to Exercise in Chronic Obstructive Pulmonary Disease and Healthy Controls - A Randomized, Placebo Controlled, Crossover Study Open

Nafeez Syed, Min Hyung Ryu, S.S. Dhillon, Michele R. Schaeffer, C.J. Ryerson , et al. · 2021

Physiological Responses to Cardiopulmonary Exercise Testing in an Individual Four Years After an Extra-Pleural Pneumonectomy Open

Reid Mitchell, Scott Apperley, S.S. Dhillon, J. Zhang, Kyle G. Boyle , et al. · 2021

Ventilatory responses to constant load exercise following the inhalation of a short-acting ß2-agonist in a laboratory-controlled diesel exhaust exposure study in individuals with exercise-induced bronchoconstriction Open

Sarah Koch, Joseph F. Welch, Raymond Tran, Andrew H. Ramsook, Andy Hung , et al. · 2020

Near‐infrared spectroscopy measures of sternocleidomastoid blood flow during exercise and hyperpnoea Open

Andrew H. Ramsook, Carli M. Peters, Michael G. Leahy, Bruno Archiza, Reid Mitchell , et al. · 2020

New Findings What is the central question of this study? How does sternocleidomastoid blood flow change in response to increasing ventilation and whole‐body exercise intensity? What is the main finding and its importance? Sternocleidomasto…

Short-term effects of Lumacaftor/Ivacaftor (Orkambi™) on exertional symptoms, exercise performance, and ventilatory responses in adults with cystic fibrosis Open

Bradley S. Quon, Andrew H. Ramsook, Satvir S. Dhillon, Reid Mitchell, Kyle G. Boyle , et al. · 2020

Manipulation of mechanical ventilatory constraint during moderate intensity exercise does not influence dyspnoea in healthy older men and women Open

Yannick Molgat‐Seon, Andrew H. Ramsook, Carli M. Peters, Michele R. Schaeffer, Paolo B. Dominelli , et al. · 2018

Key points The perceived intensity of exertional breathlessness (i.e. dyspnoea) is higher in older women than in older men, possibly as a result of sex‐differences in respiratory system morphology. During exercise at a given absolute inten…

Ventilatory and sensory responses to incremental exercise in adults with a Fontan circulation Open

Jordan A. Guenette, Andrew H. Ramsook, Satvir S. Dhillon, Joseph H. Puyat, M. Riahi , et al. · 2018

Many adults with single-ventricle congenital heart disease who have undergone a Fontan procedure have abnormal pulmonary function resembling restrictive lung disease. Whether this contributes to ventilatory limitations and increased dyspne…

The effects of age and sex on mechanical ventilatory constraint and dyspnea during exercise in healthy humans Open

Yannick Molgat‐Seon, Paolo B. Dominelli, Andrew H. Ramsook, Michele R. Schaeffer, Stéfan Molgat Sereacki , et al. · 2018

We examined the effects of age, sex, and their interaction on mechanical ventilatory constraint and dyspnea during exercise in 22 older (age = 68 ± 1 yr; n = 12 women) and 22 younger (age = 25 ± 1 y, n = 11 women) subjects. During submaxim…

Neurophysiological mechanisms of exertional dyspnoea in fibrotic interstitial lung disease Open

Michele R. Schaeffer, Christopher J. Ryerson, Andrew H. Ramsook, Yannick Molgat‐Seon, Sabrina S. Wilkie , et al. · 2018

Our understanding of the mechanisms of dyspnoea in fibrotic interstitial lung disease (ILD) is incomplete. The aims of this study were two-fold: 1) to determine whether dyspnoea intensity is better predicted by neural respiratory drive (NR…

Effects of hyperoxia on dyspnoea and exercise endurance in fibrotic interstitial lung disease Open

Michele R. Schaeffer, Christopher J. Ryerson, Andrew H. Ramsook, Yannick Molgat‐Seon, Sabrina S. Wilkie , et al. · 2017

Dyspnoea is a major source of distress and is the hallmark symptom of patients with interstitial lung disease (ILD). Supplemental oxygen may alleviate dyspnoea by attenuating arterial oxygen desaturation, increasing oxygen delivery and red…

Effects of inspiratory muscle training on respiratory muscle electromyography and dyspnea during exercise in healthy men Open

Andrew H. Ramsook, Yannick Molgat‐Seon, Michele R. Schaeffer, Sabrina S. Wilkie, Pat G. Camp , et al. · 2017

Inspiratory muscle training (IMT) has consistently been shown to reduce exertional dyspnea in health and disease; however, the physiological mechanisms remain poorly understood. A growing body of literature suggests that dyspnea intensity …

<i>ERJ</i>Podcast September 2016: research priorities in bronchiectasis Open

Maria G. Belvisi, Rory E. Morty, Gernot Rohde, Marc Miravitlles, Kathryn A. Forrest , et al. · 2016

Predicting bacteraemia or rapid identification of the causative pathogen in community acquired pneumonia: where should the priority lie?

Mechanisms of exertional dyspnoea in symptomatic smokers without COPD Open

Amany F. Elbehairy, Jordan A. Guenette, Azmy Faisal, Casey E. Ciavaglia, Katherine A. Webb , et al. · 2016

Dyspnoea and activity limitation can occur in smokers who do not meet spirometric criteria for chronic obstructive pulmonary disease (COPD) but the underlying mechanisms are unknown. Detailed pulmonary function tests and sensory–mechanical…

The effects of inspiratory muscle training on physiological and sensory responses to exercise in healthy males Open

Andrew H. Ramsook · 2016

Inspiratory muscle training (IMT) is an efficacious intervention to reduce dyspnoea in health and disease. Growing evidence also suggests that IMT can improve whole body exercise performance. However, the physiological mechanisms for these…

Cardiorespiratory and sensory responses to exercise in adults with mild cystic fibrosis Open

Bradley S. Quon, Sabrina S. Wilkie, Yannick Molgat‐Seon, Michele R. Schaeffer, Andrew H. Ramsook , et al. · 2015

The purpose of this study was to evaluate cardiorespiratory fitness and reasons for exercise curtailment in a contemporary adult cystic fibrosis (CF) cohort with mild lung disease. Adults with mild CF ( n = 19, forced expiratory volume in …

Sex differences in the intensity and qualitative dimensions of exertional dyspnea in physically active young adults Open

Julia Cory, Michele R. Schaeffer, Sabrina S. Wilkie, Andrew H. Ramsook, Joseph H. Puyat , et al. · 2015

Understanding sex differences in the qualitative dimensions of exertional dyspnea may provide insight into why women are more affected by this symptom than men. This study explored the evolution of the qualitative dimensions of dyspnea in …

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