Andrew Honda
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View article: Genomic Testing in Patients with Kidney Failure of an Unknown Cause
Genomic Testing in Patients with Kidney Failure of an Unknown Cause Open
Key Points Twenty-five percent of those with unexplained kidney failure have a monogenic cause. Whole genome sequencing with broad gene panel analysis is a feasible diagnostic approach in nephrology. Background The cause of kidney failure …
View article: Probing the antigenicity of hepatitis C virus envelope glycoprotein complex by high-throughput mutagenesis
Probing the antigenicity of hepatitis C virus envelope glycoprotein complex by high-throughput mutagenesis Open
The hepatitis C virus (HCV) envelope glycoproteins E1 and E2 form a non-covalently linked heterodimer on the viral surface that mediates viral entry. E1, E2 and the heterodimer complex E1E2 are candidate vaccine antigens, but are technical…
View article: Differential Antibody Responses to Conserved HIV-1 Neutralizing Epitopes in the Context of Multivalent Scaffolds and Native-Like gp140 Trimers
Differential Antibody Responses to Conserved HIV-1 Neutralizing Epitopes in the Context of Multivalent Scaffolds and Native-Like gp140 Trimers Open
Broadly neutralizing antibodies (bNAbs) have provided valuable insights into the humoral immune response to HIV-1. While rationally designed epitope scaffolds and well-folded gp140 trimers have been proposed as vaccine antigens, a comparat…