Andrew L. Hook
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View article: Validation of the use of ToF-SIMS for analysis of glycosaminoglycans
Validation of the use of ToF-SIMS for analysis of glycosaminoglycans Open
Glycosaminoglycans (GAGs) have a range of biological roles and are of particular interest for their pharmaceutical efficacy and their potential as biomarkers or drug targets. Heparin, used globally as an anticoagulant and an antithrombotic…
View article: Cellular and microenvironmental cues that promote macrophage fusion and foreign body response
Cellular and microenvironmental cues that promote macrophage fusion and foreign body response Open
During the foreign body response (FBR), macrophages fuse to form foreign body giant cells (FBGCs). Modulation of FBGC formation can prevent biomaterial degradation and loss of therapeutic efficacy. However, the microenvironmental cues that…
View article: Targeting Macrophage Polarization for Reinstating Homeostasis following Tissue Damage
Targeting Macrophage Polarization for Reinstating Homeostasis following Tissue Damage Open
Tissue regeneration and remodeling involve many complex stages. Macrophages are critical in maintaining micro-environmental homeostasis by regulating inflammation and orchestrating wound healing. They display high plasticity in response to…
View article: PLGA‐PEG‐PLGA hydrogels induce cytotoxicity in conventional in vitro assays
PLGA‐PEG‐PLGA hydrogels induce cytotoxicity in conventional in vitro assays Open
Significance statement We identified that PLGA‐PEG‐PLGA hydrogels, which have been used in human clinical trials and possess a demonstrable safety profile, induced significant cytotoxicity in conventional in vitro assays. This major contra…
View article: Virtual High‐Throughput Screening of Vapor‐Deposited Amphiphilic Polymers for Inhibiting Biofilm Formation
Virtual High‐Throughput Screening of Vapor‐Deposited Amphiphilic Polymers for Inhibiting Biofilm Formation Open
Amphiphilic copolymers (AP) represent a class of novel antibiofouling materials whose chemistry and composition can be tuned to optimize their performance. However, the enormous chemistry‐composition design space associated with AP makes t…
View article: Identification of <i>Pseudomonas aeruginosa</i> exopolysaccharide Psl in biofilms using 3D OrbiSIMS
Identification of <i>Pseudomonas aeruginosa</i> exopolysaccharide Psl in biofilms using 3D OrbiSIMS Open
Secondary ion mass spectrometry (SIMS) offers advantages over both liquid extraction mass spectrometry and matrix assisted laser desorption mass spectrometry in that it provides the direct in situ analysis of molecules and has the potentia…
View article: Linear Binary Classifier to Predict Bacterial Biofilm Formation on Polyacrylates
Linear Binary Classifier to Predict Bacterial Biofilm Formation on Polyacrylates Open
Bacterial infections are increasingly problematic due to the rise of antimicrobial resistance. Consequently, the rational design of materials naturally resistant to biofilm formation is an important strategy for preventing medical device-a…
View article: Exploring the Relationship between Polymer Surface Chemistry and Bacterial Attachment Using ToF‐SIMS and Self‐Organizing maps
Exploring the Relationship between Polymer Surface Chemistry and Bacterial Attachment Using ToF‐SIMS and Self‐Organizing maps Open
Biofilm formation is a major cause of hospital‐acquired infections. Research into biofilm‐resistant materials is therefore critical to reduce the frequency of these events. Polymer microarrays offer a high‐throughput approach to enable the…
View article: Discovery of a polymer resistant to bacterial biofilm, swarming, and encrustation
Discovery of a polymer resistant to bacterial biofilm, swarming, and encrustation Open
Innovative approaches to prevent catheter-associated urinary tract infections (CAUTIs) are urgently required. Here, we describe the discovery of an acrylate copolymer capable of resisting single- and multispecies bacterial biofilm formatio…
View article: A potential alternative to fungicides using actives-free (meth)acrylate polymers for protection of wheat crops from fungal attachment and infection
A potential alternative to fungicides using actives-free (meth)acrylate polymers for protection of wheat crops from fungal attachment and infection Open
Fungicide-free (meth)acrylate polymer sprays help protect wheat crops from fungal infection.
View article: Polymer-directed inhibition of reversible to irreversible attachment prevents <i>Pseudomonas aeruginosa</i> biofilm formation
Polymer-directed inhibition of reversible to irreversible attachment prevents <i>Pseudomonas aeruginosa</i> biofilm formation Open
Non-toxic, biocompatible materials that inhibit bacterial biofilm formation on implanted medical devices and so prevent infection are urgently required. Weakly amphiphilic acrylate polymers with rigid hydrocarbon pendant groups resist bact…
View article: Exploiting Generative Design for 3D Printing of Bacterial Biofilm Resistant Composite Devices (Adv. Sci. 15/2021)
Exploiting Generative Design for 3D Printing of Bacterial Biofilm Resistant Composite Devices (Adv. Sci. 15/2021) Open
Bacterial Biofilm Resistant Composite Devices Medical implants would benefit from bespoke 3D printing, however microbial infection remains a challenge. By combining functional materials, voxelated manufacturing and algorithmic design, Morg…
View article: Exploiting Generative Design for 3D Printing of Bacterial Biofilm Resistant Composite Devices
Exploiting Generative Design for 3D Printing of Bacterial Biofilm Resistant Composite Devices Open
As the understanding of disease grows, so does the opportunity for personalization of therapies targeted to the needs of the individual. To bring about a step change in the personalization of medical devices it is shown that multi‐material…
View article: Navigating implementation dilemmas in technology-forcing policies: A comparative analysis of accelerated smart meter diffusion in the Netherlands, UK, Norway, and Portugal (2000-2019)
Navigating implementation dilemmas in technology-forcing policies: A comparative analysis of accelerated smart meter diffusion in the Netherlands, UK, Norway, and Portugal (2000-2019) Open
This paper addresses the implementation of technology-forcing policies in open-ended diffusion processes that involve companies and regulators as well as consumers and civil society actors. Mobilising insights from the societal embedding o…
View article: High sensitivity analysis of nanogram quantities of glycosaminoglycans using ToF-SIMS data repository
High sensitivity analysis of nanogram quantities of glycosaminoglycans using ToF-SIMS data repository Open
Data used to prepare figures in publication entitled 'High sensitivity analysis of nanogram quantities of glycosaminoglycans using ToF-SIMS' by Andrew L. Hook, John Hogwood, Elaine Gray, Barbara Mulloy and Catherine L. R. Merry.
View article: Single-Cell Tracking on Polymer Microarrays Reveals the Impact of Surface Chemistry on <i>Pseudomonas aeruginosa</i> Twitching Speed and Biofilm Development
Single-Cell Tracking on Polymer Microarrays Reveals the Impact of Surface Chemistry on <i>Pseudomonas aeruginosa</i> Twitching Speed and Biofilm Development Open
Bacterial biofilms exhibit up to 1000 times greater resistance to antibiotic or host immune clearance than planktonic cells. Pseudomonas aeruginosa produces retractable type IV pili (T4P) that facilitate twitching motility on surfaces. The…
View article: Micro topographical instruction of bacterial attachment, biofilm formation and<i>in vivo</i>host response
Micro topographical instruction of bacterial attachment, biofilm formation and<i>in vivo</i>host response Open
Bio-instructive materials that prevent bacterial biofilm formation and drive an appropriate host immune response have the potential to significantly reduce the burden of medical device-associated infections. Since bacterial surface attachm…
View article: Exploiting Generative Design for Multi-Material Inkjet 3D Printed Cell Instructive, Bacterial Biofilm Resistant Composites
Exploiting Generative Design for Multi-Material Inkjet 3D Printed Cell Instructive, Bacterial Biofilm Resistant Composites Open
As our understanding of disease grows, it is becoming established that treatment needs to be personalized and targeted to the needs of the individual. In this paper we show that multi-material inkjet-based 3D printing, when backed with gen…
View article: Inkjet based 3D Printing of bespoke medical devices that resist bacterial biofilm formation
Inkjet based 3D Printing of bespoke medical devices that resist bacterial biofilm formation Open
We demonstrate the formulation of advanced functional 3D printing inks that prevent the formation of bacterial biofilms in vivo . Starting from polymer libraries, we show that a biofilm resistant object can be 3D printed with the potential…
View article: Exploiting Generative Design for Multi-Material Inkjet 3D Printed Cell Instructive, Bacterial Biofilm Resistant Composites
Exploiting Generative Design for Multi-Material Inkjet 3D Printed Cell Instructive, Bacterial Biofilm Resistant Composites Open
As our understanding of disease grows, it is becoming established that treatment needs to be personalized and targeted to the needs of the individual. In this paper we show that multi-material inkjet-based 3D printing, when backed with gen…
View article: Discovery of (meth)acrylate polymers that resist colonization by fungi associated with pathogenesis and biodeterioration
Discovery of (meth)acrylate polymers that resist colonization by fungi associated with pathogenesis and biodeterioration Open
Anti-attachment materials that are sprayable and 3D-printable passively prevent colonization by harmful fungi.
View article: ToF-SIMS and Machine Learning for Single-Pixel Molecular Discrimination of an Acrylate Polymer Microarray
ToF-SIMS and Machine Learning for Single-Pixel Molecular Discrimination of an Acrylate Polymer Microarray Open
Combinatorial approaches to materials discovery offer promising potential for the rapid development of novel polymer systems. Polymer microarrays enable the high-throughput comparison of material physical and chemical properties-such as su…