Explanipedia

Microangiopathic Hemolytic Anemia in Pregnancy Open

Chinmay Trivedi, Andrew Hsu · 2025

Microangiopathic hemolytic anemia (MAHA) in pregnancy is a rare but life-threatening condition with diverse etiologies. Differentiating pregnancy-related thrombotic microangiopathies (TMAs), such as thrombotic thrombocytopenic purpura (TTP…

Warren Alpert Medical School of Brown University: Clinicopathologic Conference: September 20th, 2024. A Woman in her 20s with Abdominal Pain, Anemia and Thrombocytopenia. Open

Prashanth Moku, Andrew Hsu, Kevin Eappen, M. V. P. Nadella, Arkadiy Finn · 2025

A case conference describing the presentation of a woman in her 20’s with anemia, abdominal pain and thrombocytopenia who was diagnosed with paroxysmal nocturnal hemoglobinuria and likely aplastic anemia.

Acute Liver Failure With Liver Enzymes >5,000 in Sickle Cell Disease Open

Neha Wadhavkar, John Paul Nsubuga, Nouran Ibrahim, Prasanna Kumar, Andrew Hsu , et al. · 2024

Sickle cell disease is a hemoglobinopathy often complicated by painful vaso-occlusive episodes, acute chest syndrome, stroke, and myocardial infarction. Sickle cell intrahepatic cholestasis (SCIC) is a rare and potentially fatal complicati…

Characterizing after-hours hematology/oncology clinic calls Open

Quan Phung, Rebecca H. Masel, Sharan Bijlani, Joshua Ray Tanzer, Andrew Hsu , et al. · 2024

This study explores the complexity and variety of after-hour cancer patient calls. By systematically exploring patient calls, this data can provide insight into patients' needs outside of regular clinic times and help practices develop str…

Data from Integrin α<sub>v</sub>β<sub>3</sub>-Targeted Radioimmunotherapy of Glioblastoma Multiforme Open

Anand Veeravagu, Zhaofei Liu, Gang Niu, Kai Chen, Bing Jia , et al. · 2023

Purpose: Abegrin is a monoclonal antibody to human integrin α_Vβ₃, a cell adhesion molecule highly expressed on actively angiogenic endothelium and glioblastoma multiforme tumor cells. The purpose of this study …

Postibrutinib relapse outcomes for patients with marginal zone lymphoma Open

Narendranath Epperla, Qiuhong Zhao, Sayan Mullick Chowdhury, Lauren Shea, Tamara K. Moyo , et al. · 2022

Predictive factors and outcomes for ibrutinib in relapsed/refractory marginal zone lymphoma: a multicenter cohort study Open

Narendranath Epperla, Qiuhong Zhao, Sayan Mullick Chowdhury, Lauren Shea, Tamara K. Moyo , et al. · 2022

Ibrutinib is effective in the treatment of relapsed/refractory (R/R) marginal zone lymphoma (MZL) with an overall response rate (ORR) of 48%. However, factors associated with response (or lack thereof) to ibrutinib in R/R MZL in clinical p…

Clinical activity of 9-ING-41, a small molecule selective glycogen synthase kinase-3 beta (GSK-3β) inhibitor, in refractory adult T-Cell leukemia/lymphoma Open

Andrew Hsu, Kelsey E. Huntington, André De Souza, Lanlan Zhou, Adam J. Olszewski , et al. · 2022

GSK-3β is a serine/threonine kinase implicated in tumorigenesis and chemotherapy resistance. GSK-3β blockade downregulates the NF-κB pathway, modulates immune cell PD-1 and tumor cell PD-L1 expression, and increases CD8 + T cell and NK cel…

Metformin suppresses pro-inflammatory cytokines in vitreous of diabetes patients and human retinal vascular endothelium Open

Yue Li, Shawn S. Gappy, Xiuli Liu, Thérèse M. Sassalos, Tongrong Zhou , et al. · 2022

Metformin is a traditional anti-hyperglycemic medication that has recently been shown to benefit vascular complications of diabetes via an anti-inflammatory mechanism other than glycemic control. This study aims to test the hypothesis that…

Metastatic Merkel Cell Carcinoma Open

Andrew Krane, Vijairam Selvaraj, Andrew Hsu · 2022

Merkel cell carcinoma is a rare, aggressive skin cancer that affects mainly the sun exposed areas in the elderly, especially the head and neck. Immunohistochemical analysis is necessary to establish diagnosis. We describe an elderly male w…

Metastatic Merkel Cell Carcinoma Open

Andrew Krane, Vijairam Selvaraj, Andrew Hsu · 2022

Merkel cell carcinoma is a rare, aggressive skin cancer that affects mainly the sun exposed areas in the elderly, especially the head and neck. Immunohistochemical analysis is necessary to establish diagnosis. We describe an elderly male w…

Treatment-induced sarcoidosis in a patient with metastatic clear cell ovarian cancer Open

Kathryn DeCarli, Rebecca Masel, Andrew Hsu, Mary Lorraine Lopresti · 2021

Sarcoidosis is a granulomatous disease that commonly presents with lung or lymphatic system manifestations. Diagnosis is often delayed due to variable clinical presentation. This is a case of a patient with metastatic clear cell ovarian ca…

Detection of clonotypic DNA in the cerebrospinal fluid as a marker of central nervous system invasion in lymphoma Open

Adam J. Olszewski, Anna Chorzalska, Max Petersen, Thomas Ollila, Adam Zayac , et al. · 2021

The diagnosis of parenchymal central nervous system (CNS) invasion and prediction of risk for future CNS recurrence are major challenges in the management of aggressive lymphomas, and accurate biomarkers are needed to supplement clinical r…

Vaccines in Gastrointestinal Malignancies: From Prevention to Treatment Open

Rani Chudasama, Quan Phung, Andrew Hsu, Khaldoun Almhanna · 2021

Gastrointestinal (GI) malignancies are some of the most common and devastating malignancies and include colorectal, gastric, esophageal, hepatocellular, and pancreatic carcinomas, among others. Five-year survival rates for many of these ma…

Intensity of anticoagulation and survival in patients hospitalized with COVID-19 pneumonia Open

Andrew Hsu, Yuchen Liu, Adam Zayac, Adam J. Olszewski, John L. Reagan · 2020

Treatment for metastatic adenocarcinoma of the stomach and gastroesophageal junction: 2020 Open

Andrew Hsu, Adam Zayac, Aditya Eturi, Khaldoun Almhanna · 2020

Gastric and gastroesophageal junction (GEJ) cancer is one of the most common malignancy worldwide. In unresectable or metastatic disease, the prognosis is poor and is generally less than a year. Standard front-line chemotherapy includes tw…

Targeted therapies for gastroesophageal cancers Open

Andrew Hsu, Rani Chudasama, Khaldoun Almhanna, Alexander G. Raufi · 2020

Gastroesophageal cancers are some of the most common malignancies worldwide. A significant portion of patients are diagnosed with advanced or metastatic disease given the insidious nature of gastroesophageal cancers. In the instance where …

Esophageal cancer in Aleppo, Syria 2010–2020: a rare cancer in a war zone Open

Samer Alhames, Andrew Hsu, Fadi Rustam, Rami Kassar, Mohamad bisher Shihade , et al. · 2020

The management of diseases such as cancer in developing countries are often suboptimal given a lack of resources and access to specialists and therapeutics. In March 2020, Syria descended into its ninth year of the war with a rising death …

Analysis of NMR Spin-Relaxation Data Using an Inverse Gaussian Distribution Function Open

Andrew Hsu, Fabien Ferrage, Arthur G. Palmer · 2020

Metformin suppresses retinal microglia activation in diabetic mice Open

Yue Li, Tongrong Zhou, Andrew Hsu, Paul Edwards, Xiaoxi Qiao · 2020

The fertile field of “isomopic” immune dysregulation as a nidus for lymphoproliferative disorders Open

Andrew Hsu, Nancy J. Freeman · 2020

Verruconis gallopava in a patient with myelofibrosis on ruxolitinib Open

Andrew Hsu, Veronica Ulici · 2020

Metformin inhibits oxidative stress in human retinal pigment epithelial cells Open

Xiaoxi Qiao, Yue Li, Tongrong Zhou, Andrew Hsu, Paul Edwards , et al. · 2019

Metformin reduces inflammation in diabetic human vitreous by activating AMPK and inhibiting NFκB signaling pathway Open

Yue Li, Tongrong Zhou, Andrew Hsu, Paul Edwards, H. Gao , et al. · 2019

A Case of Granulocytic Sarcoma or Extramedullary Acute Myelomonocytic Leukemia of the Gallbladder Open

Erik Holzwanger, Zainab Alam, Emily Hsu, Andrew Hsu, Mark Mangano , et al. · 2018

BACKGROUND Granulocytic sarcoma, or 'chloroma,' due to extramedullary acute myeloid leukemia (AML) or due to acute myelomonocytic leukemia (AML M5), is rare and is associated with a poor prognosis. This report is of a case of granulocytic …

Primary Cardiac Lymphoma: Importance of Tissue Diagnosis Open

Lauren Mendelson, Emily Hsu, Hojune Chung, Andrew Hsu · 2018

Primary cardiac lymphoma (PCL) is a rare disease entity that can present with severe cardiac and cardioembolic symptoms. We present a 79-year-old male with history of polymalgia rheumatica on chronic prednisone who presented with a two-wee…

Hyperviscosity Syndrome Provoking Heart Failure in a Patient with Waldenström macroglobinemia Open

Andrew Hsu · 2017

A 75year-old woman with past medical history of anemia presented with progressive, worsening shortness of breath.Upon arrival to the hospital, a chest x-ray revealed a moderate right-sided pleural effusion with a possible superimposed pneu…

Budd-Chiari Syndrome in a Patient with JAK-2 Mutation without Myeloprolifrative Disorder Open

Mohammed Salhab, Daniel Ellis, Andrew Hsu, Bradley Switzer · 2017

A 41-year-old woman presented with right upper quadrant abdominal pain, found to have a primary buddchiari syndrome secondary to right hepatic vein thrombosis. Her thrombophilia workup revealed a JAK2 mutation is a setting of no signs of m…

A Cross-sectional Study Investigating Associations Between Reticular Macular Disease (RMD) and Coronary Artery Disease (CAD) Open

Patrick A. Kaszubski, Meleha Ahmad, Andrew Hsu, Aushim Kokroo, Leyla Bayat , et al. · 2016

Choroidal Thickness (CTh) Patterns in Patients with Coronary Artery Disease (CAD) Open

Meleha Ahmad, Lucy Cobbs, Bertha Maria Nassani, Leyla Bayat, Andrew Hsu , et al. · 2016

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