Explanipedia

TLR4 endocytosis and endosomal TLR4 signaling are distinct and independent outcomes of TLR4 activation Open

Thomas E Schultz, Carmen D Mathmann, Leslie C Domínguez Cadena, Timothy W. Muusse, Hyoyoung Kim , et al. · 2025

Toll-like receptor 4 (TLR4) signaling at the plasma membrane and in endosomes results in distinct contributions to inflammation and host defence. Current understanding indicates that endocytosis of cell surface-activated TLR4 is required t…

Harnessing cytokine immunocomplexes and cytokine fusion proteins for cancer Therapy: Mechanisms and clinical potential Open

Wei Yang Kong, Amelia T. Soderholm, Andrew J. Brooks, Jazmina L. Gonzalez Cruz, James W. Wells · 2025

Cytokines are pivotal regulators of cellular functions and immune responses, making them highly promising targets for cancer immunotherapy. Despite their widespread clinical application, the effectiveness of cytokine immunotherapy is often…

Enhancement of anti‐sarcoma immunity by NK cells engineered with mRNA for expression of a EphA2‐targeted CAR Open

Pui Yeng Lam, Natacha Omer, J. Wong, Cui Tu, Louisa Alim , et al. · 2025

Background Paediatric sarcomas, including rhabdomyosarcoma, Ewing sarcoma and osteosarcoma, represent a group of malignancies that significantly contribute to cancer‐related morbidity and mortality in children and young adults. These cance…

Roles of Growth Hormone–Dependent JAK-STAT5 and Lyn Kinase Signaling in Determining Lifespan and Cancer Incidence Open

Yash Chhabra, Helle Bielefeldt‐Ohmann, Tania Louise Brooks, Andrew J. Brooks, Michael J. Waters · 2024

In rodents, loss of growth hormone (GH) or its receptor is associated with extended lifespan. We aimed to determine the signaling process resulting in this longevity using GH receptor (GHR)-mutant mice with key signaling pathways deleted a…

The heavy subunit of ferritin stimulates NLRP3 inflammasomes in hepatic stellate cells through ICAM-1 to drive hepatic inflammation Open

Manuel A. Fernández‐Rojo, Michael A. Pearen, Anita G. Burgess, Maria P. Ikonomopoulou, D. Hoang-Le , et al. · 2024

Serum ferritin concentrations increase during hepatic inflammation and correlate with the severity of chronic liver disease. Here, we report a molecular mechanism whereby the heavy subunit of ferritin (FTH) contributes to hepatic inflammat…

Squamous cell carcinoma is associated with reduced IL34 expression, alterations in the Langerhans cell antigen‐processing‐presentation machinery and poor patient survival Open

Thi Viet Trinh Dang, Kevin R. Gillinder, Quan Nguyen, Onkar Mulay, Tuan Vo , et al. · 2024

Objectives Langerhans cells (LCs) are epithelial antigen‐presenting cells (APC) contributing to immune surveillance. LCs depend on interleukin 34 (IL34) production by epithelial cells. This study aimed to uncover mechanisms of alteration o…

Location, location, location: Protein kinase nanoclustering for optimised signalling output Open

Rachel S. Gormal, Ramón Martínez‐Mármol, Andrew J. Brooks, Frédéric A. Meunier · 2023

Protein kinases (PKs) are proteins at the core of cellular signalling and are thereby responsible for most cellular physiological processes and their regulations. As for all intracellular proteins, PKs are subjected to Brownian thermal ene…

Author Correction: Discovery of an exosite on the SOCS2-SH2 domain that enhances SH2 binding to phosphorylated ligands Open

Edmond M. Linossi, Kunlun Li, Gianluca Veggiani, Cyrus Tan, Farhad Dehkhoda , et al. · 2023

Location, Location, Location: Protein kinase nanoclustering for optimized signalling output Open

Rachel S. Gormal, Ramón Martínez‐Mármol, Andrew J. Brooks, Frédéric A. Meunier · 2023

Protein kinases (PKs) are proteins at the core of cellular signalling and are thereby responsible for most of the cellular physiological processes and their regulations. As for all cellular proteins, they are subjected to Brownian thermal …

68 The Diurnal and Seasonal Relationships of Young Pedestrian Injuries Secondary to Motor Vehicles Open

Amina Akhtar, Andrew J. Brooks, Steve Kitchen, Rory C. O’Connor · 2023

Aim There remains a significant morbidity and mortality in young pedestrians hit by motor vehicles. The of this study was to compare the incidence and injury severity of motor vehicle-related pedestrian trauma according to time of day and …

Tyrosine kinases compete for growth hormone receptor binding and regulate receptor mobility and degradation Open

Yash Chhabra, Pernille Seiffert, Rachel S. Gormal, Manon Vullings, Christine Mei Mei Lee , et al. · 2023

Growth hormone (GH) acts via JAK2 and LYN to regulate growth, metabolism, and neural function. However, the relationship between these tyrosine kinases remains enigmatic. Through an interdisciplinary approach combining cell biology, struct…

Tyrosine Kinases Compete for Growth Hormone Receptor Binding and Regulate Receptor Mobility and Degradation Open

Yash Chhabra, Pernille Seiffert, Rachel S. Gormal, Manon Vullings, Christine Mei Mei Lee , et al. · 2022

Discovery of an exosite on the SOCS2-SH2 domain that enhances SH2 binding to phosphorylated ligands Open

Edmond M. Linossi, Kunlun Li, Gianluca Veggiani, Cyrus Tan, Farhad Dehkhoda , et al. · 2021

Suppressor of cytokine signaling (SOCS)2 protein is a key negative regulator of the growth hormone (GH) and Janus kinase (JAK)-Signal Transducers and Activators of Transcription (STAT) signaling cascade. The central SOCS2-Src homology 2 (S…

664 The ICON Trauma Study: The Impact of the COVID-19 Lockdown on Major Trauma Workload in the UK Open

Alfred Adiamah, A i Thompson, C Lewis-Lloyd, Edward Dickson, Lauren Blackburn , et al. · 2021

Introduction Anecdotal evidence suggest a direct impact of the SARS-COV-2-pandemic on presentation and severity of major trauma. Method This observational study from a UK Major Trauma Centre matched a cohort of patients admitted during a 1…

Human anogenital monocyte-derived dendritic cells and langerin+cDC2 are major HIV target cells Open

Jake W. Rhodes, Rachel A. Botting, Kirstie M. Bertram, Erica E. Vine, Hafsa Rana , et al. · 2021

JAK-STAT Signalling Pathway in Cancer Open

Andrew J. Brooks, Tracy L. Putoczki · 2020

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Identification of HIV-Transmitting Sub-Epithelial Mononuclear Phagocytes in Human Anogenital and Colorectal Tissues Open

Jake W. Rhodes, Rachel A. Botting, Kirstie M. Bertram, Hafsa Rana, Heeva Baharlou , et al. · 2020

Tissue mononuclear phagocytes (MNP) are specialised in pathogen detection and antigen presentation. They are the first cells of the immune system to encounter HIV and play a key role in transmission as they deliver the virus to CD4 T cells…

Growth Hormone Stops Excessive Inflammation After Partial Hepatectomy, Allowing Liver Regeneration and Survival Through Induction of H2‐Bl/HLA‐G Open

Mayumi Ishikawa, Andrew J. Brooks, Manuel A. Fernández‐Rojo, Johan Medina, Yash Chhabra , et al. · 2020

Background and Aims Growth hormone (GH) is important for liver regeneration after partial hepatectomy (PHx). We investigated this process in C57BL/6 mice that express different forms of the GH receptor (GHR) with deletions in key signaling…

Novel drivers and modifiers of MPL-dependent oncogenic transformation identified by deep mutational scanning Open

Jessica L. Bridgford, Su Min Lee, Christine M. M. Lee, Paola Guglielmelli, Elisa Rumi , et al. · 2019

The single transmembrane domain (TMD) of the human thrombopoietin receptor (TpoR/myeloproliferative leukemia [MPL] protein), encoded by exon 10 of the MPL gene, is a hotspot for somatic mutations associated with myeloproliferative neoplasm…

THE MECHANISM OF ONCOGENIC MUTATIONS IN THE JUXTAMEMBRANE AND TRANSMEMBRANE REGION OF IL7RA AND TPOR/MPL Open

Andrew J. Brooks, L. W. Campos, Christine Lee, Yash Chhabra, Jessica L. Bridgford , et al. · 2019

Identification of HIV transmitting CD11c+ human epidermal dendritic cells Open

Kirstie M. Bertram, Rachel A. Botting, Heeva Baharlou, Jake W. Rhodes, Hafsa Rana , et al. · 2019

Loss of growth hormone–mediated signal transducer and activator of transcription 5 (STAT5) signaling in mice results in insulin sensitivity with obesity Open

Yash Chhabra, Caroline N. Nelson, Monika Plescher, Johanna L. Barclay, Aaron G. Smith , et al. · 2019

Growth hormone (GH) has an important function as an insulin antagonist with elevated insulin sensitivity evident in humans and mice lacking a functional GH receptor (GHR). We sought the molecular basis for this sensitivity by utilizing a p…

Oncogenic basic amino acid insertions at the extracellular juxtamembrane region of IL7RA cause receptor hypersensitivity Open

L. W. Campos, Priscila Pini Zenatti, Leonardo Granato Pissinato, Gisele Rodrigues, Leonardo Luís Artico , et al. · 2019

TO THE EDITOR: The receptor for interleukin-7 (IL-7) is formed by the IL7RA and the IL2RG (γc) chains. IL-7 leads to the reciprocal phosphorylation of IL7RA-associated JAK1 and γc-associated JAK3, followed by phosphorylation of IL7RA and …

A multidisciplinary team-oriented intervention to increase guideline recommended care for high-risk prostate cancer: A stepped-wedge cluster randomised implementation trial Open

Bernadette Brown, Jane Young, David P. Smith, Andrew Kneebone, Andrew J. Brooks , et al. · 2018

The Growth Hormone Receptor: Mechanism of Receptor Activation, Cell Signaling, and Physiological Aspects Open

Farhad Dehkhoda, Christine M. M. Lee, Johan Medina, Andrew J. Brooks · 2018

The growth hormone receptor (GHR), although most well known for regulating growth, has many other important biological functions including regulating metabolism and controlling physiological processes related to the hepatobiliary, cardiova…

DOP070 Development and pilot of an index to identify young people with inflammatory bowel disease at risk of psychological morbidity Open

Rick Lees, Andrew J. Brooks, Georgina Rowse, Priya Narula, Paul Norman , et al. · 2018

Young People (YP) living with inflammatory bowel disease (IBD) are at an increased risk of psychological morbidity. There is growing interest in risk factor stratification in psychological screening as a means of implementing the European …

AUTHOR INDEX Open

Abi Habib, Abou Hachem, Muayyad R. Al-Ubaidi, Arakawa Takatoshi, Arap Wadih , et al. · 2017

A growth hormone receptor SNP promotes lung cancer by impairment of SOCS2-mediated degradation Open

Yash Chhabra, Ho Yi Wong, Louise F. Nikolajsen, Helena Steinocher, Andreas Papadopulos , et al. · 2017

Author Index Open

Burt Adelman, Dante Avalos, B Bächinger, Hans Peter, Daniel L. Baker , et al. · 2017

Tmem2 Regulates Embryonic Vegf Signaling by Controlling Hyaluronic Acid Turnover Open

Jessica De Angelis, Anne K. Lagendijk, Huijun Chen, Alisha Tromp, Neil I. Bower , et al. · 2017

Andrew J. Brooks YOU? Author Swipe