Andrew J. Clulow
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View article: Structuring of lipid nanoparticle mRNA formulations at acidic and neutral pH: X-ray scattering and molecular dynamics studies
Structuring of lipid nanoparticle mRNA formulations at acidic and neutral pH: X-ray scattering and molecular dynamics studies Open
mRNA lipid nanoparticles (LNPs) effectively deliver mRNA into cells. However, the structure of these particles remains poorly understood. LNP formulations are manufactured by initially forming nanoparticles at pH 4, to incorporate the RNA,…
View article: Design and commissioning of the first superconducting undulator for the BioSAXS beamline at the Australian Synchrotron
Design and commissioning of the first superconducting undulator for the BioSAXS beamline at the Australian Synchrotron Open
A 1.6 m-long 16 mm-period superconducting undulator (SCU16) has been installed and commissioned at the Australian Synchrotron. The SCU16, developed by Bilfinger, is based on the SCU20 currently operating at Karlsruhe Institute of Technolog…
View article: Solid-state nanopore sensing reveals conformational changes induced by a mutation in a neuron-specific tRNA <sup>Arg</sup>
Solid-state nanopore sensing reveals conformational changes induced by a mutation in a neuron-specific tRNA <sup>Arg</sup> Open
We demonstrate that solid-state nanopore sensing is a powerful single-molecule method for analyzing RNA conformational ensembles. As a model, we employed n-Tr20, a neuron-specific cytoplasmic tRNA Arg UCU , whose C50U mutation is associate…
View article: Lipidic drug delivery systems are responsive to the human microbiome
Lipidic drug delivery systems are responsive to the human microbiome Open
In vitro and in vivo tests for therapeutic agents are typically conducted in sterile environments, but many target areas for drug delivery are home to thousands of microbial species. Here, we examine the behaviour of lipidic nanomaterials …
View article: Regulating the structural polymorphism and protein corona composition of phytantriol-based lipid nanoparticles using choline ionic liquids
Regulating the structural polymorphism and protein corona composition of phytantriol-based lipid nanoparticles using choline ionic liquids Open
Lipid-based lyotropic liquid crystalline nanoparticles (LCNPs) face stability challenges in biological fluids during clinical translation. Ionic Liquids (ILs) have emerged as effective solvent additives for tuning the structure of LCNP's a…
View article: The human factor: results of a small-angle scattering data analysis round robin
The human factor: results of a small-angle scattering data analysis round robin Open
A round-robin study has been carried out to estimate the impact of the human element in small-angle scattering data analysis. Four corrected datasets were provided to participants ready for analysis. All datasets were measured on samples c…
View article: Correlating vapour uptake with the luminescence quenching of poly(dendrimer)s for the detection of nitro group-containing explosives
Correlating vapour uptake with the luminescence quenching of poly(dendrimer)s for the detection of nitro group-containing explosives Open
Thin films of two poly(dendrimer)s were studied for the detection of trace quantities of nitro-based taggants and explosives. The poly(dendrimer) structures consist of side chain-conjugated triphenylamine-based dendritic chromophores attac…
View article: Evaluating human milk as a drug delivery vehicle for clofazimine to premature infants
Evaluating human milk as a drug delivery vehicle for clofazimine to premature infants Open
Human milk is proposed as a drug delivery vehicle suitable for use in neonatal patients. Clofazimine, traditionally used for the treatment of leprosy and tuberculosis, is emerging as a treatment for cryptosporidiosis in infants, however it…
View article: Influence of Casein and Milk Phospholipid Emulsifiers on the Digestion and Self-Assembled Structures of Milk Lipids
Influence of Casein and Milk Phospholipid Emulsifiers on the Digestion and Self-Assembled Structures of Milk Lipids Open
Interfacial compositions of fat globules modulate the digestion behaviour of milk triglycerides in the gastrointestinal tract, thereby affecting lipid metabolism and delivery of nutrients. In this study, we aim to understand the impact of …
View article: Interactions of biliary micelles with polar lipids and digestion products from milk
Interactions of biliary micelles with polar lipids and digestion products from milk Open
Milk or milk-like emulsions are our sole source of nutrition for the first six months of life, and milk lipids carry fat-soluble nutrients through the gut as well as providing most of the energy we consume from milk. The digestion and abso…
View article: Influence of Lyophilization and Cryoprotection on the Stability and Morphology of Drug-Loaded Poly(ethylene glycol-b-ε-caprolactone) Micelles
Influence of Lyophilization and Cryoprotection on the Stability and Morphology of Drug-Loaded Poly(ethylene glycol-b-ε-caprolactone) Micelles Open
Polymeric micelles are promising carriers for the delivery of poorly water-soluble drugs, providing enhanced drug solubility, blood circulation times, and bioavailability. Nevertheless, the storage and long-term stability of micelles in so…
View article: Implications of the Digestion of Milk-Based Formulations for the Solubilization of Lopinavir/Ritonavir in a Combination Therapy
Implications of the Digestion of Milk-Based Formulations for the Solubilization of Lopinavir/Ritonavir in a Combination Therapy Open
The development of formulation approaches to coadminister lopinavir and ritonavir antiretroviral drugs to children is necessary to ensure optimal treatment of human immunodeficiency virus (HIV) infection. It was previously shown that milk-…
View article: The human factor: results of a small-angle scattering data analysis Round Robin
The human factor: results of a small-angle scattering data analysis Round Robin Open
A Round Robin study has been carried out to estimate the impact of the human element in small-angle scattering data analysis. Four corrected datasets were provided to participants ready for analysis. All datasets were measured on samples c…
View article: Revisiting the Dissolution of Praziquantel in Biorelevant Media and the Impact of Digestion of Milk on Drug Dissolution
Revisiting the Dissolution of Praziquantel in Biorelevant Media and the Impact of Digestion of Milk on Drug Dissolution Open
Praziquantel is a poorly water-soluble drug used to treat parasitic infections. Previous studies have suggested that its rate and extent of dissolution in milk and biorelevant media are slow and limited compared to dissolution in the pharm…
View article: Microstructure—Thermal Property Relationships of Poly (Ethylene Glycol-b-Caprolactone) Copolymers and Their Micelles
Microstructure—Thermal Property Relationships of Poly (Ethylene Glycol-b-Caprolactone) Copolymers and Their Micelles Open
The crystallinity of polymers strongly affects their properties. For block copolymers, whereby two crystallisable blocks are covalently tethered to one another, the molecular weight of the individual blocks and their relative weight fracti…
View article: Towards mesoporous silica as a pharmaceutical treatment for obesity - impact on lipid digestion and absorption
Towards mesoporous silica as a pharmaceutical treatment for obesity - impact on lipid digestion and absorption Open
Mesoporous silica particles (MSPs) are emerging as an interesting option to reduce calorific uptake as a treatment for obesity and other metabolic conditions. However, their further development under the pharmaceutical regulatory framework…
View article: The influence of lipid digestion on the fate of orally administered drug delivery vehicles
The influence of lipid digestion on the fate of orally administered drug delivery vehicles Open
This review will focus on orally administered lipid-based drug delivery vehicles and specifically the influence of lipid digestion on the structure of the carrier lipids and their entrained drug cargoes. Digestion of the formulation lipids…
View article: Formation of Self-Assembled Mesophases During Lipid Digestion
Formation of Self-Assembled Mesophases During Lipid Digestion Open
Lipids play an important role in regulating bodily functions and providing a source of energy. Lipids enter the body primarily in the form of triglycerides in our diet. The gastrointestinal digestion of certain types of lipids has been sho…
View article: Chemistry and Geometry of Counterions Used in Hydrophobic Ion Pairing Control Internal Liquid Crystal Phase Behavior and Thereby Drug Release
Chemistry and Geometry of Counterions Used in Hydrophobic Ion Pairing Control Internal Liquid Crystal Phase Behavior and Thereby Drug Release Open
The combination of Flash NanoPrecipitation and hydrophobic ion pairing (HIP) is a valuable approach for generating nanocarrier formulations of ionic water-soluble drugs with controllable release properties dictated by liquid crystalline st…
View article: Aqueous ROPISA of α-amino acid <i>N</i>-carboxyanhydrides: polypeptide block secondary structure controls nanoparticle shape anisotropy
Aqueous ROPISA of α-amino acid <i>N</i>-carboxyanhydrides: polypeptide block secondary structure controls nanoparticle shape anisotropy Open
Ring-Opening Polymerization-Induced Self-Assembly (ROPISA) of N -carboxyanhydride is an efficient one-step process to obtain nanomaterials made of polypeptides.