Explanipedia

Racial and socioeconomic disparities in long term survival after surgery and radiation for spinal cord hemangioblastoma Open

Abdul Karim Ghaith, Xinlan Yang, Joshua Weinberg, Shaan Bhandarkar, Taha Khalilullah , et al. · 2025

Editorial: Surgical management of spine and spinal cord metastasis Open

Rouzbeh Motiei-Langroudi, Efstathios Papavassiliou, Andrew J. Grossbach, Ryan C. Hofler · 2025

Early outcomes with virtual surgical planning software and patient-specific instrumentation in adult spinal deformity Open

Joshua Weinberg, Nathan P. Ritchey, Joshua Wang, Ryan G. Eaton, Bryan Ladd , et al. · 2025

OBJECTIVE Software engineering innovations have led to the development of virtual surgical planning software (VSPS) for deformity correction. VSPS uses calibrated radiographs and machine learning predictive models to simulate postoperative…

Lumbar Fusion With Micro- & Nano-Textured, 3D Printed Porous Titanium Versus PEEK Interbody Cages in TLIF: A Single-Blinded, Randomized Controlled Trial Open

Joshua Weinberg, Nathan P. Ritchey, W. T. Kwok, Shravani Khisti, Bryan Ladd , et al. · 2025

Study Design Prospective, randomized controlled study. Objective Assess early radiological outcomes in transforaminal lumbar interbody fusion (TLIF) with 3D-printed porous titanium (3DPPT) compared to PEEK. Methods Single-blinded prospecti…

Litigation Involving Delay of Spinal Care During the COVID-19 Pandemic: A Review of Reported Legal Cases in the United States Open

Mayur Patel, Arianna Carfora, Kathleen Botterbush, Dominic Franceschelli, Justin C. Zhang , et al. · 2025

This study provides granular detail about the characteristics of litigation related to delay of spinal care secondary to the COVID-19 pandemic in the United States. Most plaintiffs were inmates who had difficulty obtaining a specialist app…

3D printed titanium banana interbody cages versus titanium-coated PEEK bullet cages for TLIF Open

Connor C. Jacob, Ryan G. Eaton, Jacob Ward, Katelyn Sette, Seth Wilson , et al. · 2025

While 3DPT and PEEK interbody cages demonstrated few adverse events at short- and long-term follow-up, 3DPT exhibited a higher rate of fusion and lower rate of subsidence at one year.

A novel technique for decortication of the lumbar facet joints for posterolateral fusion with percutaneous exposure: A cadaveric feasibility study Open

Alexander Keister, Olivia Duru, Andrew J. Grossbach, David S. Xu · 2024

This study demonstrates that percutaneous lumbar facet joint decortication is feasible with the CORUS™ Spinal System-X instruments, and warrants further, comparative study in the clinical setting.

CT guided biopsy for osteodiscitis reduces cost of hospitalization in the landscape of increasing intravenous drug use: A single center retrospective analysis Open

Seth Wilson, Jacob Ward, Joravar Dhaliwal, Katelyn Sette, Yamenah Ambreen , et al. · 2024

CTB was associated with significantly reduced cost of hospitalization and LOS compared to non-CTB. IVDU patients with osteodiscitis have significantly different clinical profiles than non-IVDU that may impact diagnosis and treatment. Furth…

Demineralized Bone Matrix and Fibers in Spinal Fusion Open

Joshua Wang, Ryan G. Eaton, Markus E. Harrigan, Vikas Munjal, Katelyn Sette , et al. · 2023

Formation of bony fusion after arthrodesis depends on osteoinduction, osteoconduction, and osteogenesis. Traditionally, the patient's own bone, or autograft, has been used to provide biological material necessary for these steps. However, …

Predicting the Need for Surgery in Patients with Lumbar Disc Herniation: A New Internally Validated Scoring System Open

Rouzbeh Motiei-Langroudi, Homa Sadeghian, Uduak-Obong I. Ekanem, Aleeza Safdar, Andrew J. Grossbach , et al. · 2023

Study Design: Prospective study.Purpose: To propose a scoring system for predicting the need for surgery in patients with lumbar disc herniation (LDH).Overview of Literature: The indications for surgery in patients with LDH are well establ…

Delayed stenosis associated with sublaminar band placement in the thoracic spine for proximal junctional kyphosis Open

David Gibbs, Andrew J. Grossbach, Noah Mallory, Nathaniel Toop, Stephanus Viljoen · 2023

Background: Proximal junctional thoracic kyphosis (PJK) is common following adult spinal deformity (ASD) surgery and may require revision operations. In this case series, we present delayed complications associated with the use of sublamin…

Exercise enhances hippocampal-cortical ripple interactions in the human brain Open

Araceli R. Cardenas, Juan F. Ramírez-Villegas, Christopher K. Kovach, Phillip E. Gander, Rachel C. Cole , et al. · 2023

Physical exercise acutely improves hippocampus-dependent memory. Whereas animal studies have offered cellular- and synaptic-level accounts of these effects, human neuroimaging studies show that exercise improves hippocampal-cortical connec…

D73. Multidisciplinary Approach to Cranioplasty - Outcomes from a 10-year Retrospective Study Open

Kerry‐Ann Mitchell, Minh Tho Nguyen, Hunter Stecko, Taborah Zaramo, Marilly Palettas , et al. · 2023

PURPOSE: Cranioplasty to reconstruct large-sized skull defect has a high risk of major complications, including 15- 30% reoperation rate. The objective of this study was to determine whether multidisciplinary surgical approach at a tertiar…

Subsidence Rates Associated With Porous 3D-Printed Versus Solid Titanium Cages in Transforaminal Lumbar Interbody Fusion Open

Nathaniel Toop, Joravar Dhaliwal, Andrew J. Grossbach, David Gibbs, Nihaal Reddy , et al. · 2023

Study Design Retrospective Cohort Study. Objective To determine whether 3D-printed porous titanium (3DPT) interbody cages offer any clinical or radiographic advantage over standard solid titanium (ST) interbody cages in transforaminal lumb…

Endoscopic endonasal resection of craniovertebral junction osteomyelitis: illustrative cases Open

Alexander Keister, Joshua Vignolles‐Jeong, Daniel Kreatsoulas, Kyle K. VanKoevering, Stephanus Viljoen , et al. · 2023

BACKGROUND Operative management of craniovertebral junction (CVJ) osteomyelitis has traditionally been extracranial and focused on debriding the infection. In select patients, the endoscopic endonasal approach (EEA) with a focus on additio…

Spinal deformity correction in ankylosing spondylitis Open

Dominic Maggio, Andrew J. Grossbach, David Gibbs, Robert Moranville, Nathaniel Toop , et al. · 2022

Background: Ankylosing spondylitis (AS) is a complex, debilitating disease with few available medical therapies in its later stages. Methods: We reviewed current clinical approaches for caring for AS patients with an emphasis on the risks …

Efficacy of Intravenous Tranexamic Acid in Reducing Perioperative Blood Loss and Blood Product Transfusion Requirements in Patients Undergoing Multilevel Thoracic and Lumbar Spinal Surgeries: A Retrospective Study Open

Alexandre B. Todeschini, Alberto Uribe, Marco Echeverria-Villalobos, Juan Fiorda‐Diaz, Mahmoud Abdel‐Rasoul , et al. · 2020

Introduction: Acute perioperative blood loss is a common and potentially major complication of multilevel spinal surgery, usually worsened by the number of levels fused and of osteotomies performed. Pharmacological approaches to blood cons…

Negative pressure wound therapy in spinal fusion patients Open

Asad S. Akhter, Benjamin McGahan, Liesl N. Close, David Dornbos, Nathaniel Toop , et al. · 2020

Post‐operative wound complications are some of the most common acute complications following spine surgery. These surgical site infections (SSI) contribute to increased healthcare related costs. Negative pressure wound therapy (NPWT) has l…

Acute presentation of spinal gouty arthritis: A case report and review of literature Open

Asad S. Akhter, Ahmed Mohyeldin, Andrew J. Grossbach · 2019

Background: Gout is an inflammatory arthritis that results from faulty purine metabolism, affecting approximately 4% of adults in the US, and predominately affects people in the fourth decade of life. Further, spinal gout is rarely the fir…

Genome-wide DNA methylation comparison between live human brain and peripheral tissues within individuals Open

Patricia Braun, Shizhong Han, Benjamin Hing, Yasunori Nagahama, Lindsey Gaul , et al. · 2019

Drug repositioning in epilepsy reveals novel antiseizure candidates Open

Leo Brueggeman, Morgan Sturgeon, Russell Martin, Andrew J. Grossbach, Yasunori Nagahama , et al. · 2018

Objective Epilepsy treatment falls short in ~30% of cases. A better understanding of epilepsy pathophysiology can guide rational drug development in this difficult to treat condition. We tested a low‐cost, drug‐repositioning strategy to id…

Biomechanical assessment of proximal junctional semi-rigid fixation in long-segment thoracolumbar constructs Open

Vibhu Krishnan Viswanathan, Ranjit Ganguly, Amy J. Minnema, Nicole A. DeVries Watson, Nicole M. Grosland , et al. · 2018

OBJECTIVE Proximal junctional kyphosis (PJK) and failure (PJF) are potentially catastrophic complications that result from abrupt changes in stress across rigid instrumented and mobile non-fused segments of the spine (transition zone) afte…

Heterogeneity within the PF-EPN-B ependymoma subgroup Open

Florence M.G. Cavalli, Jens-Martin Hübner, Tanvi Sharma, Betty Luu, Martin Sill , et al. · 2018

Catenin delta-1 (CTNND1) phosphorylation controls the mesenchymal to epithelial transition in astrocytic tumors Open

Jin Yang, Alexander G. Bassuk, Juliane Merl‐Pham, Chun-Wei Hsu, Diana F. Colgan , et al. · 2016

Inactivating mutations of the TSC1/TSC2 complex (TSC1/2) cause tuberous sclerosis (TSC), a hereditary syndrome with neurological symptoms and benign hamartoma tumours in the brain. Since TSC effectors are largely unknown in the human brain…

Therapeutic Impact of Cytoreductive Surgery and Irradiation of Posterior Fossa Ependymoma in the Molecular Era: A Retrospective Multicohort Analysis Open

Vijay Ramaswamy, Thomas Hielscher, Stephen C. Mack, Álvaro Lassaletta, Tong Lin , et al. · 2016

Purpose Posterior fossa ependymoma comprises two distinct molecular variants termed EPN_PFA and EPN_PFB that have a distinct biology and natural history. The therapeutic value of cytoreductive surgery and radiation therapy for posterior fo…

Therapeutic Impact of Cytoreductive Surgery and Irradiation of Posterior Fossa Ependymoma in the Molecular Era: A Retrospective Multicohort Analysis Open

Vijay Ramaswamy, Thomas Hielscher, Stephen C. Mack, Álvaro Lassaletta, Tong Lin , et al. · 2016

Posterior fossa ependymoma comprises two distinct molecular variants termed EPN_PFA and EPN_PFB that have a distinct biology and natural history. The therapeutic value of cytoreductive surgery and radiation therapy for posterior fossa epen…

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