Andrew J. Lautz
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View article: Neutrophil dysregulation differentiates pediatric septic shock biomarker-based mortality-risk strata: insights from weighted gene co-expression network and transcriptomic analyses
Neutrophil dysregulation differentiates pediatric septic shock biomarker-based mortality-risk strata: insights from weighted gene co-expression network and transcriptomic analyses Open
Background Pediatric sepsis is a leading cause of global mortality, particularly among children, with limited therapeutic options beyond antibiotics and organ support. The Pediatric Sepsis Biomarker Risk Model (PERSEVERE-II) stratifies mor…
View article: Characteristics of Hot and Cold Debriefs for In-hospital Cardiac Arrest in the Pediatric Intensive Care Unit: A Mixed-methods Analysis
Characteristics of Hot and Cold Debriefs for In-hospital Cardiac Arrest in the Pediatric Intensive Care Unit: A Mixed-methods Analysis Open
Introduction: This study examined a standardized event review approach, assessing hot and cold debriefs in pediatric in-hospital cardiac arrest (IHCA) to demonstrate their distinct but synergistic values. Methods: This retrospective mixed-…
View article: Evaluating Frequency and Yield of Echocardiography in a Pediatric Intensive Care Unit
Evaluating Frequency and Yield of Echocardiography in a Pediatric Intensive Care Unit Open
TTE frequently is used in the noncardiac PICU, but its diagnostic yield varies widely on the basis of clinical indications. This study emphasizes the need for careful use of TTE in the PICU, with consideration of pretest probability and cl…
View article: Identification and transcriptomic assessment of latent profile pediatric septic shock phenotypes
Identification and transcriptomic assessment of latent profile pediatric septic shock phenotypes Open
View article: Machine learning-driven identification of the gene-expression signature associated with a persistent multiple organ dysfunction trajectory in critical illness
Machine learning-driven identification of the gene-expression signature associated with a persistent multiple organ dysfunction trajectory in critical illness Open
View article: Derivation, validation, and transcriptomic assessment of pediatric septic shock phenotypes identified through latent profile analyses: Results from a prospective multi-center observational cohort
Derivation, validation, and transcriptomic assessment of pediatric septic shock phenotypes identified through latent profile analyses: Results from a prospective multi-center observational cohort Open
Background Sepsis poses a grave threat, especially among children, but treatments are limited due to clinical and biological heterogeneity among patients. Thus, there is an urgent need for precise subclassification of patients to guide the…
View article: External validation of the modified sepsis renal angina index for prediction of severe acute kidney injury in children with septic shock
External validation of the modified sepsis renal angina index for prediction of severe acute kidney injury in children with septic shock Open
View article: Machine learning driven identification of gene-expression signatures correlated with multiple organ dysfunction trajectories and complex sub-endotypes of pediatric septic shock
Machine learning driven identification of gene-expression signatures correlated with multiple organ dysfunction trajectories and complex sub-endotypes of pediatric septic shock Open
Background Multiple organ dysfunction syndrome (MODS) disproportionately drives sepsis morbidity and mortality among children. The biology of this heterogeneous syndrome is complex, dynamic, and incompletely understood. Gene expression sig…
View article: Haemodynamic-directed cardiopulmonary resuscitation promotes mitochondrial fusion and preservation of mitochondrial mass after successful resuscitation in a pediatric porcine model
Haemodynamic-directed cardiopulmonary resuscitation promotes mitochondrial fusion and preservation of mitochondrial mass after successful resuscitation in a pediatric porcine model Open
IAC 16-001023.
View article: Peri-Intubation Cardiac Arrest in the Pediatric Emergency Department: A Novel System of Care
Peri-Intubation Cardiac Arrest in the Pediatric Emergency Department: A Novel System of Care Open
Introduction: Patients with physiologic disorders, such as hypoxemia or hypotension, are at high risk of peri-intubation cardiac arrest. Standardization improves emergency tracheal intubation safety, but no published reports describe initi…
View article: Myocardial Dysfunction Is Independently Associated With Mortality in Pediatric Septic Shock
Myocardial Dysfunction Is Independently Associated With Mortality in Pediatric Septic Shock Open
Objectives: Circulatory dysfunction has been associated with mortality in children with septic shock. However, the mortality risk attributable to myocardial dysfunction per se has not been established, and the association between myocardia…
View article: Identification of the Physiologically Difficult Airway in the Pediatric Emergency Department
Identification of the Physiologically Difficult Airway in the Pediatric Emergency Department Open
Background The risk factors for peri‐intubation cardiac arrest in critically ill children are incompletely understood. The study objective was to derive physiologic risk factors for deterioration during tracheal intubation in a pediatric e…
View article: Age-Dependent Myocardial Dysfunction in Critically Ill Patients: Role of Mitochondrial Dysfunction
Age-Dependent Myocardial Dysfunction in Critically Ill Patients: Role of Mitochondrial Dysfunction Open
Myocardial dysfunction is common in septic shock and post-cardiac arrest but manifests differently in pediatric and adult patients. By conventional echocardiographic parameters, biventricular systolic dysfunction is more prevalent in child…
View article: Effect of the Procalcitonin Assay on Antibiotic Use in Critically Ill Children
Effect of the Procalcitonin Assay on Antibiotic Use in Critically Ill Children Open
We retrospectively studied the effect of introducing procalcitonin into clinical practice on antibiotic use within a large academic pediatric intensive care unit. In the absence of a standardized algorithm, availability of the procalcitoni…
View article: Pulmonary Vasodilator Therapy in Shock-associated Cardiac Arrest
Pulmonary Vasodilator Therapy in Shock-associated Cardiac Arrest Open
The addition of iNO to HD-CPR in LPS-induced shock-associated cardiac arrest improved short-term survival and intraarrest hemodynamics.
View article: Value of Procalcitonin Measurement for Early Evidence of Severe Bacterial Infections in the Pediatric Intensive Care Unit
Value of Procalcitonin Measurement for Early Evidence of Severe Bacterial Infections in the Pediatric Intensive Care Unit Open