Andrew J. Spieker
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View article: Adenovirus Types in US Children Hospitalized or Seen in the Emergency Department With Acute Respiratory Illness, 2016–2019
Adenovirus Types in US Children Hospitalized or Seen in the Emergency Department With Acute Respiratory Illness, 2016–2019 Open
Background Human adenovirus (HAdV) is a common cause of pediatric acute respiratory illness (ARI), contributing to 5–13% of cases worldwide. Clinical manifestations vary by HAdV species and type; therefore, delineating type-specific diseas…
View article: Changes in Antiviral Prescribing for Children With Influenza in US Emergency Departments
Changes in Antiviral Prescribing for Children With Influenza in US Emergency Departments Open
Importance Despite national recommendations, antiviral prescribing in emergency departments (EDs) for children at higher risk of severe influenza, such as those younger than 5 years and those with specific underlying conditions, remains lo…
View article: Epidemiology of respiratory syncytial virus in young, hospitalized children in Jordan: a prospective viral surveillance study
Epidemiology of respiratory syncytial virus in young, hospitalized children in Jordan: a prospective viral surveillance study Open
Respiratory syncytial virus (RSV) is a leading cause of hospitalization in young children. Understanding RSV burden and seasonality is crucial for implementing effective preventive strategies, especially in the wake of disruptions related …
View article: Commentary: Breaking tradition: should biostatistics doctoral qualifying exams evolve to better serve our students' ability to demonstrate readiness to conduct independent research?
Commentary: Breaking tradition: should biostatistics doctoral qualifying exams evolve to better serve our students' ability to demonstrate readiness to conduct independent research? Open
View article: Antiviral Prescription in Children With Influenza in US Emergency Departments: New Vaccine Surveillance Network (NVSN), 2016–2020
Antiviral Prescription in Children With Influenza in US Emergency Departments: New Vaccine Surveillance Network (NVSN), 2016–2020 Open
Background Influenza contributes to a high burden of pediatric emergency department (ED) visits annually. Guidelines recommend outpatient antiviral treatment for children at higher risk of severe influenza and recommend considering treatme…
View article: Life-Threatening Complications of Influenza vs Coronavirus Disease 2019 (COVID-19) in US Children
Life-Threatening Complications of Influenza vs Coronavirus Disease 2019 (COVID-19) in US Children Open
BACKGROUND: Clinical differences between critical illness from influenza infection vs coronavirus disease 2019 (COVID-19) have not been well characterized in pediatric patients. METHODS: We compared demographics, clinical characteristics, …
View article: Guidelines and Best Practices for the Use of Targeted Maximum Likelihood and Machine Learning When Estimating Causal Effects of Exposures on Time‐To‐Event Outcomes
Guidelines and Best Practices for the Use of Targeted Maximum Likelihood and Machine Learning When Estimating Causal Effects of Exposures on Time‐To‐Event Outcomes Open
Targeted maximum likelihood estimation (TMLE) is an increasingly popular framework for the estimation of causal effects. It requires modeling both the exposure and outcome but is doubly robust in the sense that it is valid if at least one …
View article: Antibiotic use among young, hospitalized children in Jordan, 2010–2023
Antibiotic use among young, hospitalized children in Jordan, 2010–2023 Open
Inappropriate antibiotic use drives antimicrobial resistance, a global health threat causing increased morbidity and mortality. Understanding antibiotic practices in low-resource settings is essential to identify intervention targets. This…
View article: Incidence of biliary atresia in the United States before and during the COVID‐19 pandemic
Incidence of biliary atresia in the United States before and during the COVID‐19 pandemic Open
Objectives The etiology of biliary atresia (BA) is unclear and potentially involves viral triggers. We aimed to compare the incidence of BA in the United States before and during the coronavirus disease 2019 (COVID‐19) pandemic, focusing o…
View article: P-670. Differences in Adenovirus Type Detection in Children with Acute Respiratory Illness versus Healthy Controls: New Vaccine Surveillance Network (NVSN) 2016-2019
P-670. Differences in Adenovirus Type Detection in Children with Acute Respiratory Illness versus Healthy Controls: New Vaccine Surveillance Network (NVSN) 2016-2019 Open
Background Human adenovirus (HAdV) is a common cause of acute respiratory illness (ARI) in children, ranging from asymptomatic to life-threatening disease. While previous studies have examined asymptomatic vs HAdV ARI infections, few have …
View article: P-2366. Influenza-Specific Antiviral Use in Hospitalized Children Before and During the COVID-19 Pandemic, New Vaccine Surveillance Network (2016–2023)
P-2366. Influenza-Specific Antiviral Use in Hospitalized Children Before and During the COVID-19 Pandemic, New Vaccine Surveillance Network (2016–2023) Open
Background Influenza-specific antivirals are recommended for all hospitalized children with suspected or confirmed influenza. However, antiviral use remains suboptimal. We investigated antiviral use in children hospitalized with influenza …
View article: P-1193. Epidemiology of Respiratory Syncytial Virus in Young, Hospitalized Children in Jordan: A Prospective Viral Surveillance Study
P-1193. Epidemiology of Respiratory Syncytial Virus in Young, Hospitalized Children in Jordan: A Prospective Viral Surveillance Study Open
Background Respiratory syncytial virus (RSV) is a leading cause of acute respiratory infections in young children worldwide. With the recent wave of regulatory approvals and authorizations for nirsevimab and maternal RSV vaccines across se…
View article: P-1209. Changes in Antiviral Prescription for Children with Influenza in U.S. Emergency Departments During the COVID-19 Pandemic: New Vaccine Surveillance Network (NVSN), 2016-2023
P-1209. Changes in Antiviral Prescription for Children with Influenza in U.S. Emergency Departments During the COVID-19 Pandemic: New Vaccine Surveillance Network (NVSN), 2016-2023 Open
Background Despite recommendations from CDC and ACIP, antiviral prescription for children who are at higher risk of severe influenza (including those < 5 years and those with certain underlying conditions) in emergency departments (EDs)…
View article: P-25. Evaluating the Immunogenicity and Safety of Either Two High-Dose or Two Standard-Dose Influenza Vaccines Over Two Consecutive Seasons in Adult Hematopoietic Cell Transplant Recipients
P-25. Evaluating the Immunogenicity and Safety of Either Two High-Dose or Two Standard-Dose Influenza Vaccines Over Two Consecutive Seasons in Adult Hematopoietic Cell Transplant Recipients Open
Background Adult hematopoietic cell transplant (HCT) recipients are at high risk of influenza complications but have suboptimal immune responses to influenza vaccines. Our previous phase II trial in adult HCT recipients demonstrated that t…
View article: An overview of methods for receiver operating characteristic analysis, with an application to SARS-CoV-2 vaccine-induced humoral responses in solid organ transplant recipients
An overview of methods for receiver operating characteristic analysis, with an application to SARS-CoV-2 vaccine-induced humoral responses in solid organ transplant recipients Open
Receiver operating characteristic (ROC) analysis is a tool to evaluate the capacity of an ordinal or numeric measure to distinguish between states, often employed in the evaluation of diagnostic tests. Assumptions regarding the nature of t…
View article: Antiviral Use Among Children Hospitalized With Laboratory-Confirmed Influenza Illness: A Prospective, Multicenter Surveillance Study
Antiviral Use Among Children Hospitalized With Laboratory-Confirmed Influenza Illness: A Prospective, Multicenter Surveillance Study Open
Background Guidelines state that all hospitalized children with suspected or confirmed influenza receive prompt treatment with influenza-specific antivirals. We sought to determine the frequency of, and factors associated with, antiviral r…
View article: Seasonal influenza vaccination: Attitudes and practices of healthcare providers in Jordan
Seasonal influenza vaccination: Attitudes and practices of healthcare providers in Jordan Open
Background Influenza is associated with significant global morbidity and mortality, with vaccination being the primary preventive strategy. Despite recommendations, influenza vaccine uptake among healthcare providers (HCPs) remains subopti…
View article: Opioid analgesic and antidepressant use during pregnancy and the risk of spontaneous preterm birth: A nested case–control study
Opioid analgesic and antidepressant use during pregnancy and the risk of spontaneous preterm birth: A nested case–control study Open
Background Given the high prevalence of both mental health and acute pain conditions during pregnancy, use of antidepressants and analgesic opioids in this period is widespread. Whether single and combined use of these medications is assoc…
View article: Demographic, Clinical, Psychosocial, and Behavioral Predictors of Continuous Glucose Monitor Use in Adults with Type 2 Diabetes
Demographic, Clinical, Psychosocial, and Behavioral Predictors of Continuous Glucose Monitor Use in Adults with Type 2 Diabetes Open
View article: Immunogenicity and Reactogenicity of High- or Standard-Dose Influenza Vaccine in a Second Consecutive Influenza Season
Immunogenicity and Reactogenicity of High- or Standard-Dose Influenza Vaccine in a Second Consecutive Influenza Season Open
Background Pediatric hematopoietic cell transplant (HCT) recipients are at high risk for morbidity from influenza virus infection. We demonstrated in a primary phase 2 randomized controlled trial that 2 post-HCT doses of high-dose trivalen…
View article: An overview of methods for receiver operating characteristic analysis, with an application to SARS-CoV-2 vaccine-induced humoral responses in solid organ transplant recipients
An overview of methods for receiver operating characteristic analysis, with an application to SARS-CoV-2 vaccine-induced humoral responses in solid organ transplant recipients Open
Receiver operating characteristic (ROC) analysis is a tool to evaluate the capacity of a numeric measure to distinguish between groups, often employed in the evaluation of diagnostic tests. Overall classification ability is sometimes crude…
View article: The impact of different strategies for modeling associations between medications at low doses and health outcomes: a simulation study and practical application to postpartum opioid use
The impact of different strategies for modeling associations between medications at low doses and health outcomes: a simulation study and practical application to postpartum opioid use Open
Pharmacoepidemiologic studies commonly examine the association between drug dose and adverse health outcomes. In situations where no safe dose exists, the choice of modeling strategy can lead to identification of an apparent safe low dose …
View article: Evaluating Acute Viral Gastroenteritis Severity: Modified Vesikari and Clark Scoring Systems
Evaluating Acute Viral Gastroenteritis Severity: Modified Vesikari and Clark Scoring Systems Open
OBJECTIVE Acute gastroenteritis (AGE) is the second leading cause of death in children worldwide. Objectively evaluating disease severity is critical for assessing future interventions. We used data from a large, prospective surveillance s…
View article: Accuracy of Influenza <i>ICD-10</i> Diagnosis Codes in Identifying Influenza Illness in Children
Accuracy of Influenza <i>ICD-10</i> Diagnosis Codes in Identifying Influenza Illness in Children Open
Importance Studies of influenza in children commonly rely on coded diagnoses, yet the ability of International Classification of Diseases, Ninth Revision codes to identify influenza in the emergency department (ED) and hospital is highly v…
View article: Immunophenotypic predictors of influenza vaccine immunogenicity in pediatric hematopoietic cell transplant recipients
Immunophenotypic predictors of influenza vaccine immunogenicity in pediatric hematopoietic cell transplant recipients Open
Pediatric hematopoietic cell transplant (HCT) recipients exhibit poor serologic responses to influenza vaccination early after transplant. To facilitate the optimization of influenza vaccination timing, we sought to identify B- and T-cell …
View article: Understanding Difference-in-differences methods to evaluate policy effects with staggered adoption: an application to Medicaid and HIV
Understanding Difference-in-differences methods to evaluate policy effects with staggered adoption: an application to Medicaid and HIV Open
While a randomized control trial is considered the gold standard for estimating causal treatment effects, there are many research settings in which randomization is infeasible or unethical. In such cases, researchers rely on analytical met…
View article: Seasonality, Clinical Characteristics, and Outcomes of Respiratory Syncytial Virus Disease by Subtype Among Children Aged &lt;5 Years: New Vaccine Surveillance Network, United States, 2016–2020
Seasonality, Clinical Characteristics, and Outcomes of Respiratory Syncytial Virus Disease by Subtype Among Children Aged <5 Years: New Vaccine Surveillance Network, United States, 2016–2020 Open
Background Respiratory syncytial virus (RSV) is a leading cause of acute respiratory illnesses in children. RSV can be broadly categorized into 2 major subtypes: A and B. RSV subtypes have been known to cocirculate with variability in diff…
View article: Prescription Opioid Exposure During Pregnancy and Risk of Spontaneous Preterm Delivery
Prescription Opioid Exposure During Pregnancy and Risk of Spontaneous Preterm Delivery Open
Importance Opioid exposure during pregnancy has been associated with preterm birth, but prior studies have not differentiated between spontaneous and indicated preterm birth or fully investigated these associations as functions of opioid d…
View article: Clinical prediction model: Multisystem inflammatory syndrome in children versus Kawasaki disease
Clinical prediction model: Multisystem inflammatory syndrome in children versus Kawasaki disease Open
Background Multisystem inflammatory syndrome in children (MIS‐C) is a rare but serious complication of severe acute respiratory syndrome coronavirus 2 infection. Features of MIS‐C overlap with those of Kawasaki disease (KD). Objective The …
View article: 124 Prescription opioid exposure and risk of spontaneous preterm delivery
124 Prescription opioid exposure and risk of spontaneous preterm delivery Open