Andrew Jarratt
YOU?
Author Swipe
View article: Olaparib, durvalumab, and cyclophosphamide, and a prognostic blood signature in platinum-sensitive ovarian cancer: the randomized phase 2 SOLACE2 trial
Olaparib, durvalumab, and cyclophosphamide, and a prognostic blood signature in platinum-sensitive ovarian cancer: the randomized phase 2 SOLACE2 trial Open
SOLACE2 (ACTRN12618000686202) investigates whether 12-weeks of olaparib, or cyclophosphamide-olaparib priming, improves subsequent durvalumab-olaparib progression-free survival (PFS), and is superior to olaparib monotherapy without any pri…
View article: Resolving hematopoietic stem versus progenitor cell potential in the mouse dorsal aorta by differential <i>Runx1</i> +110 enhancer activity
Resolving hematopoietic stem versus progenitor cell potential in the mouse dorsal aorta by differential <i>Runx1</i> +110 enhancer activity Open
SUMMARY Hematopoietic stem cells (HSCs) are important in cell-based therapies for blood-related disorders. While progress has been made in the directed differentiation of pluripotent PSCs, such cultures promote hematopoietic progenitor cel…
View article: Genomics of cervical, vulvar and vaginal cancers and the potential of precision medicine
Genomics of cervical, vulvar and vaginal cancers and the potential of precision medicine Open
Most cases of cervical cancer are still caused by persistent infection with high-risk human papillomavirus (HPV) variants, which also drives the development of ~30% of vulvar and ~76% of vaginal malignancies. Implementation of HPV vaccinat…
View article: Single-cell multiomics reveal the scale of multilayered adaptations enabling CLL relapse during venetoclax therapy
Single-cell multiomics reveal the scale of multilayered adaptations enabling CLL relapse during venetoclax therapy Open
Venetoclax (VEN) inhibits the prosurvival protein BCL2 to induce apoptosis and is a standard therapy for chronic lymphocytic leukemia (CLL), delivering high complete remission rates and prolonged progression-free survival in relapsed CLL b…
View article: An experimentally validated network of nine haematopoietic transcription factors reveals mechanisms of cell state stability
An experimentally validated network of nine haematopoietic transcription factors reveals mechanisms of cell state stability Open
Transcription factor (TF) networks determine cell-type identity by establishing and maintaining lineage-specific expression profiles, yet reconstruction of mammalian regulatory network models has been hampered by a lack of comprehensive fu…
View article: Author response: An experimentally validated network of nine haematopoietic transcription factors reveals mechanisms of cell state stability
Author response: An experimentally validated network of nine haematopoietic transcription factors reveals mechanisms of cell state stability Open
Full text Figures and data Side by side Abstract eLife digest Introduction Results Discussion Materials and methods Data availability References Decision letter Author response Article and author information Metrics Abstract Transcription …