Andrew K. Short
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View article: Studies of epitope restriction on myeloperoxidase (MPO), an important antigen in systemic vasculitis
Studies of epitope restriction on myeloperoxidase (MPO), an important antigen in systemic vasculitis Open
SUMMARY Anti-neutrophil cytoplasmic antibodies are important components of the inflammatory response in patients with systemic vasculitis. Their role in the pathogenesis of these conditions remains incompletely defined. Several antigens ha…
View article: Molecular characteristics of anti-self antibody fragments against neutrophil cytoplasmic antigens from human V gene phage display libraries
Molecular characteristics of anti-self antibody fragments against neutrophil cytoplasmic antigens from human V gene phage display libraries Open
SUMMARY Recently it has been demonstrated that human antibody fragments with binding activities against self antigens can be isolated from repertoires of rearranged V genes from non-immunized humans. We have applied phage display technolog…
View article: Neutrophil and recombinant myeloperoxidase as antigens in ANCA positive systemic vasculitis
Neutrophil and recombinant myeloperoxidase as antigens in ANCA positive systemic vasculitis Open
SUMMARY Myeloperoxidase (MPO) is one of the major autoantigens recognized by anti-neutrophil cytoplasm antibodies. The association of this antigen with specific disease entities requires that there is a source of pure antigen present in la…